Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_061720                                                              18    1482
NP_004403                                                              17    2528
XP_005252433                                                           17    2528
XP_005252432                                                           17    2528
XP_005252430                                                           17    2528
XP_006717451                                                           17    2528
NP_005449                                                              16    5631
XP_005252373                                                           16    5631
XP_006711056                                                           16    7355
NP_008914                                                              16    7355
NP_570853                                                              15    9605
NP_570854                                                              15    9605
NP_000453                                                              15    9605
NP_055873                                                              15    9605
NP_001009814                                                           15    9605
XP_005268328                                                           15    9605
XP_006720739                                                           15    9605
XP_005268327                                                           15    9605
XP_005268326                                                           15    9605
XP_005268324                                                           15    9605
XP_005268325                                                           15    9605
XP_006720738                                                           15    9605
XP_006720737                                                           15    9605
XP_006720736                                                           15    9605
XP_006719855                                                           15    9605
XP_006719854                                                           15    9605
XP_006719853                                                           15    9605
>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    YRIIANALN 9
            YRIIANAL+
Sbjct: 3334 YRIIANALS 3342
>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    YRIIANALN 9
            YRIIANAL+
Sbjct: 3334 YRIIANALS 3342
>NP_061720
          Length = 4024

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YRIIANALN 9
            YR++A ALN
Sbjct: 1619 YRVLAGALN 1627
>NP_004403
          Length = 391

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YRIIANALN 9
           YR++ N+LN
Sbjct: 370 YRLLGNSLN 378
>XP_005252433
          Length = 320

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YRIIANALN 9
           YR++ N+LN
Sbjct: 299 YRLLGNSLN 307
>XP_005252432
          Length = 345

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YRIIANALN 9
           YR++ N+LN
Sbjct: 324 YRLLGNSLN 332
>XP_005252430
          Length = 363

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YRIIANALN 9
           YR++ N+LN
Sbjct: 342 YRLLGNSLN 350
>XP_006717451
          Length = 384

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YRIIANALN 9
           YR++ N+LN
Sbjct: 363 YRLLGNSLN 371
>NP_005449
          Length = 941

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RIIANALN 9
           RII NA+N
Sbjct: 397 RIILNAMN 404
>XP_005252373
          Length = 683

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RIIANALN 9
           RII NA+N
Sbjct: 139 RIILNAMN 146
>XP_006711056
          Length = 389

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IIANALN 9
           IIANA+N
Sbjct: 357 IIANAVN 363
>NP_008914
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IIANALN 9
           IIANA+N
Sbjct: 358 IIANAVN 364
>NP_570853
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRIIANALN 9
           Y++I+N  N
Sbjct: 326 YKVISNEFN 334
>NP_570854
          Length = 872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRIIANALN 9
           Y++I+N  N
Sbjct: 346 YKVISNEFN 354
>NP_000453
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRIIANALN 9
           Y++I+N  N
Sbjct: 349 YKVISNEFN 357
>NP_055873
          Length = 1905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RIIANALN 9
           RI+AN+ N
Sbjct: 876 RIVANSAN 883
>NP_001009814
          Length = 1039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RIIANALN 9
           RI+AN+ N
Sbjct: 876 RIVANSAN 883
>XP_005268328
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRIIANALN 9
           Y++I+N  N
Sbjct: 326 YKVISNEFN 334
>XP_006720739
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRIIANALN 9
           Y++I+N  N
Sbjct: 326 YKVISNEFN 334
>XP_005268327
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRIIANALN 9
           Y++I+N  N
Sbjct: 326 YKVISNEFN 334
>XP_005268326
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRIIANALN 9
           Y++I+N  N
Sbjct: 326 YKVISNEFN 334
>XP_005268324
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRIIANALN 9
           Y++I+N  N
Sbjct: 326 YKVISNEFN 334
>XP_005268325
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRIIANALN 9
           Y++I+N  N
Sbjct: 326 YKVISNEFN 334
>XP_006720738
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRIIANALN 9
           Y++I+N  N
Sbjct: 326 YKVISNEFN 334
>XP_006720737
          Length = 872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRIIANALN 9
           Y++I+N  N
Sbjct: 346 YKVISNEFN 354
>XP_006720736
          Length = 872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRIIANALN 9
           Y++I+N  N
Sbjct: 346 YKVISNEFN 354
>XP_006719855
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RIIANALN 9
           RI+AN+ N
Sbjct: 876 RIVANSAN 883
>XP_006719854
          Length = 1550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RIIANALN 9
           RI+AN+ N
Sbjct: 521 RIVANSAN 528
>XP_006719853
          Length = 1809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RIIANALN 9
           RI+AN+ N
Sbjct: 780 RIVANSAN 787
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.141    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 262,315
Number of extensions: 450
Number of successful extensions: 29
Number of sequences better than 10000.0: 29
Number of HSP's gapped: 29
Number of HSP's successfully gapped: 29
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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