Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              19     869
NP_001087241                                                           19     869
XP_005265799                                                           19     869
XP_005265798                                                           19     869
XP_005265797                                                           19     869
NP_060918                                                              17    2528
NP_005086                                                              17    3301
XP_005271388                                                           17    3301
XP_006711098                                                           17    3301
XP_006711097                                                           17    3301
XP_005271387                                                           17    3301
XP_005271385                                                           17    3301
NP_008832                                                              17    4312
NP_009098                                                              17    4312
XP_005254461                                                           17    4312
XP_006720603                                                           17    4312
XP_006720602                                                           17    4312
NP_065858                                                              16    5631
XP_005256126                                                           16    5631
NP_004645                                                              16    7355
NP_001034680                                                           16    7355
NP_001034679                                                           16    7355
NP_003836                                                              16    7355
NP_653267                                                              16    7355
NP_001258867                                                           16    7355
NP_689835                                                              16    7355
NP_001401                                                              16    7355
XP_005272733                                                           16    7355
XP_005272732                                                           16    7355
XP_006718373                                                           16    7355
XP_006718372                                                           16    7355
XP_005253186                                                           16    7355
XP_006718371                                                           16    7355
XP_005253185                                                           16    7355
XP_005248505                                                           16    7355
NP_037381                                                              16    7355
NP_001796                                                              15    9605
NP_055928                                                              15    9605
NP_001269109                                                           15    9605
NP_001020016                                                           15    9605
NP_964012                                                              15    9605
NP_008865                                                              15    9605
NP_001248309                                                           15    9605
NP_006237                                                              15    9605
NP_001269111                                                           15    9605
NP_001269110                                                           15    9605
NP_001269108                                                           15    9605
NP_115515                                                              15    9605
NP_071926                                                              15    9605
XP_005259367                                                           15    9605
XP_006723476                                                           15    9605
XP_006723475                                                           15    9605
XP_005256618                                                           15    9605
XP_005256617                                                           15    9605
XP_006714856                                                           15    9605
XP_005268556                                                           15    9605
XP_006714855                                                           15    9605
XP_006714854                                                           15    9605
XP_005268555                                                           15    9605
XP_005268554                                                           15    9605
XP_006710903                                                           15    9605
NP_001129386                                                           15    9605
>NP_000213
          Length = 976

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YQVAKCMAF 9
           YQVAK MAF
Sbjct: 774 YQVAKGMAF 782
>NP_001087241
          Length = 972

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YQVAKCMAF 9
           YQVAK MAF
Sbjct: 770 YQVAKGMAF 778
>XP_005265799
          Length = 973

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YQVAKCMAF 9
           YQVAK MAF
Sbjct: 771 YQVAKGMAF 779
>XP_005265798
          Length = 976

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YQVAKCMAF 9
           YQVAK MAF
Sbjct: 774 YQVAKGMAF 782
>XP_005265797
          Length = 977

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YQVAKCMAF 9
           YQVAK MAF
Sbjct: 775 YQVAKGMAF 783
>NP_060918
          Length = 1230

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YQVAKCMA 8
           Y +AKC+A
Sbjct: 797 YSIAKCVA 804
>NP_005086
          Length = 1548

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YQVAKCMA 8
           YQ+AKC A
Sbjct: 811 YQMAKCDA 818
>XP_005271388
          Length = 1224

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YQVAKCMA 8
           YQ+AKC A
Sbjct: 487 YQMAKCDA 494
>XP_006711098
          Length = 1516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YQVAKCMA 8
           YQ+AKC A
Sbjct: 779 YQMAKCDA 786
>XP_006711097
          Length = 1542

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YQVAKCMA 8
           YQ+AKC A
Sbjct: 805 YQMAKCDA 812
>XP_005271387
          Length = 1545

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YQVAKCMA 8
           YQ+AKC A
Sbjct: 808 YQMAKCDA 815
>XP_005271385
          Length = 1551

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YQVAKCMA 8
           YQ+AKC A
Sbjct: 814 YQMAKCDA 821
>NP_008832
          Length = 2548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    YQVAKCMAF 9
            YQV K M F
Sbjct: 994  YQVGKTMVF 1002
>NP_009098
          Length = 1325

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YQVAKC 6
           YQ+AKC
Sbjct: 554 YQMAKC 559
>XP_005254461
          Length = 2600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YQVAKCMAF 9
           YQV K M F
Sbjct: 975 YQVGKTMVF 983
>XP_006720603
          Length = 2619

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    YQVAKCMAF 9
            YQV K M F
Sbjct: 994  YQVGKTMVF 1002
>XP_006720602
          Length = 2619

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    YQVAKCMAF 9
            YQV K M F
Sbjct: 994  YQVGKTMVF 1002
>NP_065858
          Length = 582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YQVAKCM 7
           YQVA C+
Sbjct: 575 YQVAACL 581
>XP_005256126
          Length = 582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YQVAKCM 7
           YQVA C+
Sbjct: 575 YQVAACL 581
>NP_004645
          Length = 2555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    YQVAKCM 7
            YQ  KCM
Sbjct: 2386 YQCIKCM 2392
>NP_001034680
          Length = 2554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    YQVAKCM 7
            YQ  KCM
Sbjct: 2385 YQCIKCM 2391
>NP_001034679
          Length = 2570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    YQVAKCM 7
            YQ  KCM
Sbjct: 2385 YQCIKCM 2391
>NP_003836
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QVAKCM 7
           QVAKC+
Sbjct: 117 QVAKCL 122
>NP_653267
          Length = 4753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5    KCMAF 9
            KCMAF
Sbjct: 1036 KCMAF 1040
>NP_001258867
          Length = 2845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    YQVAKC 6
            YQ AKC
Sbjct: 2422 YQCAKC 2427
>NP_689835
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VAKCMAF 9
           VA+C+AF
Sbjct: 313 VAECVAF 319
>NP_001401
          Length = 2778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    YQVAKC 6
            YQ AKC
Sbjct: 2355 YQCAKC 2360
>XP_005272733
          Length = 2559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    YQVAKCM 7
            YQ  KCM
Sbjct: 2390 YQCIKCM 2396
>XP_005272732
          Length = 2575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    YQVAKCM 7
            YQ  KCM
Sbjct: 2390 YQCIKCM 2396
>XP_006718373
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YQVAKC 6
           YQ AKC
Sbjct: 478 YQCAKC 483
>XP_006718372
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YQVAKC 6
           YQ AKC
Sbjct: 540 YQCAKC 545
>XP_005253186
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YQVAKC 6
           YQ AKC
Sbjct: 540 YQCAKC 545
>XP_006718371
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YQVAKC 6
           YQ AKC
Sbjct: 554 YQCAKC 559
>XP_005253185
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YQVAKC 6
           YQ AKC
Sbjct: 554 YQCAKC 559
>XP_005248505
          Length = 550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VAKCMAF 9
           VA+C+AF
Sbjct: 314 VAECVAF 320
>NP_037381
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YQVAKC 6
           YQ AKC
Sbjct: 554 YQCAKC 559
>NP_001796
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YQVAKC 6
           YQVA C
Sbjct: 143 YQVAHC 148
>NP_055928
          Length = 2961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VAKCMAF 9
           VAKC A+
Sbjct: 249 VAKCYAY 255
>NP_001269109
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QVAKCMA 8
           Q+AKC++
Sbjct: 347 QIAKCVS 353
>NP_001020016
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQVAKCMAF 9
           Y V  C+AF
Sbjct: 123 YNVVICIAF 131
>NP_964012
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQVAKCMAF 9
           Y V  C+AF
Sbjct: 196 YNVVICIAF 204
>NP_008865
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQVAKCMAF 9
           Y V  C+AF
Sbjct: 142 YNVVICIAF 150
>NP_001248309
          Length = 637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQVAKCMAF 9
           Y V  C+AF
Sbjct: 127 YNVVICIAF 135
>NP_006237
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QVAKCMA 8
           Q+AKC++
Sbjct: 347 QIAKCVS 353
>NP_001269111
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QVAKCMA 8
           Q+AKC++
Sbjct: 271 QIAKCVS 277
>NP_001269110
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QVAKCMA 8
           Q+AKC++
Sbjct: 271 QIAKCVS 277
>NP_001269108
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QVAKCMA 8
           Q+AKC++
Sbjct: 347 QIAKCVS 353
>NP_115515
          Length = 1050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YQVAKCM 7
           +QV KC+
Sbjct: 790 FQVVKCL 796
>NP_071926
          Length = 1544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    YQVAKCMA 8
            Y+V KC A
Sbjct: 1039 YRVQKCAA 1046
>XP_005259367
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YQVAKCM 7
           +QV KC+
Sbjct: 594 FQVVKCL 600
>XP_006723476
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YQVAKCM 7
           +QV KC+
Sbjct: 790 FQVVKCL 796
>XP_006723475
          Length = 1050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YQVAKCM 7
           +QV KC+
Sbjct: 790 FQVVKCL 796
>XP_005256618
          Length = 2962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VAKCMAF 9
           VAKC A+
Sbjct: 249 VAKCYAY 255
>XP_005256617
          Length = 2966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VAKCMAF 9
           VAKC A+
Sbjct: 249 VAKCYAY 255
>XP_006714856
          Length = 1346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YQVAKCMA 8
           Y+V KC A
Sbjct: 841 YRVQKCAA 848
>XP_005268556
          Length = 1466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YQVAKCMA 8
           Y+V KC A
Sbjct: 961 YRVQKCAA 968
>XP_006714855
          Length = 1473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YQVAKCMA 8
           Y+V KC A
Sbjct: 968 YRVQKCAA 975
>XP_006714854
          Length = 1486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YQVAKCMA 8
           Y+V KC A
Sbjct: 981 YRVQKCAA 988
>XP_005268555
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    YQVAKCMA 8
            Y+V KC A
Sbjct: 1019 YRVQKCAA 1026
>XP_005268554
          Length = 1531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    YQVAKCMA 8
            Y+V KC A
Sbjct: 1039 YRVQKCAA 1046
>XP_006710903
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQVAKCMAF 9
           Y V  C+AF
Sbjct: 196 YNVVICIAF 204
>NP_001129386
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    AKCMAF 9
            A CMAF
Sbjct: 1148 ASCMAF 1153
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.344    0.135    0.463 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 502,896
Number of extensions: 761
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.8 bits)
S2: 28 (15.4 bits)

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