Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              22     134
NP_005913                                                              22     134
XP_005267046                                                           22     134
XP_005267045                                                           22     134
NP_064590                                                              18    1482
XP_005277471                                                           18    1482
XP_006711526                                                           18    1482
XP_006711525                                                           18    1482
XP_006711524                                                           18    1482
NP_036423                                                              17    3301
NP_852669                                                              17    3301
NP_059129                                                              17    3301
XP_006719768                                                           17    3301
NP_055553                                                              16    5631
NP_005946                                                              16    5631
XP_005257925                                                           16    5631
XP_005257924                                                           16    5631
XP_005257923                                                           16    5631
XP_005257922                                                           16    5631
XP_005257921                                                           16    5631
XP_006722263                                                           16    5631
XP_005257920                                                           16    5631
NP_005623                                                              16    7355
NP_001273081                                                           16    7355
NP_006384                                                              16    7355
NP_998734                                                              16    7355
NP_001166955                                                           16    7355
XP_005255575                                                           16    7355
XP_005255574                                                           16    7355
XP_005255573                                                           16    7355
XP_006720998                                                           16    7355
XP_005255571                                                           16    7355
XP_006720997                                                           16    7355
XP_006720996                                                           16    7355
XP_006720995                                                           16    7355
XP_006720994                                                           16    7355
XP_005252400                                                           16    7355
XP_005252399                                                           16    7355
NP_570912                                                              15    9605
NP_001193                                                              15    9605
NP_570911                                                              15    9605
NP_000737                                                              15    9605
NP_001177384                                                           15    9605
NP_444252                                                              15    9605
NP_683709                                                              15    9605
NP_647536                                                              15    9605
NP_079425                                                              15    9605
NP_001275899                                                           15    9605
NP_068817                                                              15    9605
NP_002619                                                              15    9605
NP_001317                                                              15    9605
NP_001239160                                                           15    9605
NP_001275898                                                           15    9605
NP_001275897                                                           15    9605
XP_005276529                                                           15    9605
XP_006725626                                                           15    9605
XP_006722173                                                           15    9605
XP_005254807                                                           15    9605
XP_005268072                                                           15    9605
XP_006718217                                                           15    9605
XP_005271911                                                           15    9605
XP_006714586                                                           15    9605
>NP_006715
          Length = 1558

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    YQEAMIQGY 9
            Y+EAMIQGY
Sbjct: 1032 YREAMIQGY 1040
>NP_005913
          Length = 1608

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    YQEAMIQGY 9
            Y+EAMIQGY
Sbjct: 1032 YREAMIQGY 1040
>XP_005267046
          Length = 1554

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    YQEAMIQGY 9
            Y+EAMIQGY
Sbjct: 1032 YREAMIQGY 1040
>XP_005267045
          Length = 1604

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    YQEAMIQGY 9
            Y+EAMIQGY
Sbjct: 1032 YREAMIQGY 1040
>NP_064590
          Length = 843

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   YQEAMIQGY 9
           YQE MIQ Y
Sbjct: 623 YQEEMIQRY 631
>XP_005277471
          Length = 764

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   YQEAMIQGY 9
           YQE MIQ Y
Sbjct: 544 YQEEMIQRY 552
>XP_006711526
          Length = 843

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   YQEAMIQGY 9
           YQE MIQ Y
Sbjct: 623 YQEEMIQRY 631
>XP_006711525
          Length = 843

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   YQEAMIQGY 9
           YQE MIQ Y
Sbjct: 623 YQEEMIQRY 631
>XP_006711524
          Length = 843

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   YQEAMIQGY 9
           YQE MIQ Y
Sbjct: 623 YQEEMIQRY 631
>NP_036423
          Length = 2120

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YQEAMIQGY 9
            Y EA++QG+
Sbjct: 2072 YTEALLQGW 2080
>NP_852669
          Length = 111

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YQEAMIQGY 9
           Y+E+  QGY
Sbjct: 103 YEESTFQGY 111
>NP_059129
          Length = 1616

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    QEAMIQGY 9
            +EAMIQ Y
Sbjct: 1233 EEAMIQSY 1240
>XP_006719768
          Length = 2120

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YQEAMIQGY 9
            Y EA++QG+
Sbjct: 2072 YTEALLQGW 2080
>NP_055553
          Length = 1356

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQEAMIQGY 9
           YQ A + GY
Sbjct: 737 YQRACLSGY 745
>NP_005946
          Length = 753

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  EAMIQGY 9
          EAM QGY
Sbjct: 87 EAMSQGY 93
>XP_005257925
          Length = 850

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQEAMIQGY 9
           YQ A + GY
Sbjct: 201 YQRACLSGY 209
>XP_005257924
          Length = 1122

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQEAMIQGY 9
           YQ A + GY
Sbjct: 473 YQRACLSGY 481
>XP_005257923
          Length = 1131

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQEAMIQGY 9
           YQ A + GY
Sbjct: 482 YQRACLSGY 490
>XP_005257922
          Length = 1366

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQEAMIQGY 9
           YQ A + GY
Sbjct: 747 YQRACLSGY 755
>XP_005257921
          Length = 1370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQEAMIQGY 9
           YQ A + GY
Sbjct: 751 YQRACLSGY 759
>XP_006722263
          Length = 1390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQEAMIQGY 9
           YQ A + GY
Sbjct: 741 YQRACLSGY 749
>XP_005257920
          Length = 1390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQEAMIQGY 9
           YQ A + GY
Sbjct: 741 YQRACLSGY 749
>NP_005623
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           +QEA +QG
Sbjct: 796 WQEARVQG 803
>NP_001273081
          Length = 223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YQEAMIQGY 9
          +Q+A ++GY
Sbjct: 23 FQDAHVRGY 31
>NP_006384
          Length = 1014

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YQEAMIQGY 9
           YQ++  QGY
Sbjct: 928 YQQSHSQGY 936
>NP_998734
          Length = 270

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YQEAMIQGY 9
           YQ++  QGY
Sbjct: 184 YQQSHSQGY 192
>NP_001166955
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YQEAMIQGY 9
           YQ++  QGY
Sbjct: 184 YQQSHSQGY 192
>XP_005255575
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           +QEA +QG
Sbjct: 796 WQEARVQG 803
>XP_005255574
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           +QEA +QG
Sbjct: 796 WQEARVQG 803
>XP_005255573
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           +QEA +QG
Sbjct: 796 WQEARVQG 803
>XP_006720998
          Length = 1098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           +QEA +QG
Sbjct: 864 WQEARVQG 871
>XP_005255571
          Length = 1112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           +QEA +QG
Sbjct: 822 WQEARVQG 829
>XP_006720997
          Length = 1124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           +QEA +QG
Sbjct: 834 WQEARVQG 841
>XP_006720996
          Length = 1153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           +QEA +QG
Sbjct: 863 WQEARVQG 870
>XP_006720995
          Length = 1154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           +QEA +QG
Sbjct: 864 WQEARVQG 871
>XP_006720994
          Length = 1154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           +QEA +QG
Sbjct: 864 WQEARVQG 871
>XP_005252400
          Length = 933

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YQEAMIQGY 9
           YQ++  QGY
Sbjct: 847 YQQSHSQGY 855
>XP_005252399
          Length = 980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YQEAMIQGY 9
           YQ++  QGY
Sbjct: 894 YQQSHSQGY 902
>NP_570912
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           YQE +++G
Sbjct: 397 YQEMVVEG 404
>NP_001193
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           YQE +++G
Sbjct: 397 YQEMVVEG 404
>NP_570911
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           YQE +++G
Sbjct: 397 YQEMVVEG 404
>NP_000737
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QEAMIQGY 9
           QEA I GY
Sbjct: 183 QEADISGY 190
>NP_001177384
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QEAMIQGY 9
           QEA I GY
Sbjct: 212 QEADISGY 219
>NP_444252
          Length = 140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  QEAMIQGY 9
          QEA I GY
Sbjct: 18 QEAAIVGY 25
>NP_683709
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2 QEAMIQGY 9
         QEA I GY
Sbjct: 2 QEADISGY 9
>NP_647536
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QEAMIQGY 9
           QEA I GY
Sbjct: 93  QEADISGY 100
>NP_079425
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YQEAMIQG 8
          +QEA +QG
Sbjct: 31 WQEARLQG 38
>NP_001275899
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YQEAMIQG 8
          +QEA +QG
Sbjct: 31 WQEARLQG 38
>NP_068817
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  QEAMIQGY 9
          QE++ QGY
Sbjct: 43 QESVSQGY 50
>NP_002619
          Length = 140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  QEAMIQGY 9
          QEA I GY
Sbjct: 18 QEAAIVGY 25
>NP_001317
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQEAMIQGY 9
           Y+E M Q Y
Sbjct: 118 YKEKMAQAY 126
>NP_001239160
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  QEAMIQGY 9
          QE++ QGY
Sbjct: 43 QESVSQGY 50
>NP_001275898
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YQEAMIQG 8
          +QEA +QG
Sbjct: 31 WQEARLQG 38
>NP_001275897
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YQEAMIQG 8
          +QEA +QG
Sbjct: 31 WQEARLQG 38
>XP_005276529
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QEAMIQGY 9
           QEA I GY
Sbjct: 93  QEADISGY 100
>XP_006725626
          Length = 290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QEAMIQGY 9
           QEA I GY
Sbjct: 93  QEADISGY 100
>XP_006722173
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YQEAMIQG 8
          +QEA +QG
Sbjct: 31 WQEARLQG 38
>XP_005254807
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2 QEAMIQGY 9
         QEA I GY
Sbjct: 2 QEADISGY 9
>XP_005268072
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YQEAMIQG 8
           YQE +++G
Sbjct: 397 YQEMVVEG 404
>XP_006718217
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YQEAMIQGY 9
           Y+E M Q Y
Sbjct: 118 YKEKMAQAY 126
>XP_005271911
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  QEAMIQGY 9
          QE++ QGY
Sbjct: 43 QESVSQGY 50
>XP_006714586
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  QEAMIQGY 9
          QE++ QGY
Sbjct: 43 QESVSQGY 50
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.135    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 421,556
Number of extensions: 954
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package