Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              22     134
NP_001075109                                                           22     134
NP_001276928                                                           17    4312
NP_001276929                                                           17    4312
NP_005375                                                              17    4312
NP_001092286                                                           17    4312
XP_006718561                                                           17    4312
NP_114437                                                              16    5631
NP_060724                                                              16    5631
NP_001129695                                                           16    5631
NP_001129697                                                           16    5631
NP_001129696                                                           16    5631
NP_001092108                                                           16    5631
XP_006711507                                                           16    5631
XP_006711506                                                           16    5631
XP_006711505                                                           16    5631
XP_005273248                                                           16    5631
NP_951059                                                              16    7355
NP_060119                                                              16    7355
NP_951058                                                              16    7355
NP_036346                                                              16    7355
NP_000258                                                              16    7355
NP_001004339                                                           16    7355
NP_001035957                                                           16    7355
NP_001153626                                                           16    7355
NP_064569                                                              16    7355
NP_942600                                                              16    7355
XP_006721991                                                           16    7355
XP_006721990                                                           16    7355
XP_006721989                                                           16    7355
XP_005258041                                                           16    7355
XP_006721988                                                           16    7355
XP_006721987                                                           16    7355
XP_006721986                                                           16    7355
XP_005258040                                                           16    7355
XP_006721985                                                           16    7355
XP_005274448                                                           16    7355
XP_006717971                                                           16    7355
XP_005269990                                                           16    7355
XP_005263972                                                           16    7355
XP_005263971                                                           16    7355
NP_001191339                                                           15    9605
NP_002994                                                              15    9605
NP_001275915                                                           15    9605
NP_001275914                                                           15    9605
NP_009099                                                              15    9605
NP_001137473                                                           15    9605
NP_001137471                                                           15    9605
NP_001137470                                                           15    9605
NP_006412                                                              15    9605
NP_006411                                                              15    9605
NP_001191337                                                           15    9605
NP_835221                                                              15    9605
NP_001034662                                                           15    9605
XP_006723746                                                           15    9605
XP_005260309                                                           15    9605
XP_005256997                                                           15    9605
XP_005256995                                                           15    9605
XP_006716481                                                           15    9605
XP_005251193                                                           15    9605
XP_005251192                                                           15    9605
XP_005251191                                                           15    9605
XP_006710939                                                           15    9605
XP_005271228                                                           15    9605
XP_006710938                                                           15    9605
XP_006710937                                                           15    9605
>NP_008835
          Length = 4128

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YPDAKMDAM 9
            YPDAKMD M
Sbjct: 3168 YPDAKMDPM 3176
>NP_001075109
          Length = 4097

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YPDAKMDAM 9
            YPDAKMD M
Sbjct: 3168 YPDAKMDPM 3176
>NP_001276928
          Length = 462

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  PDAKMDAM 9
          PD K DAM
Sbjct: 68 PDEKKDAM 75
>NP_001276929
          Length = 462

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  PDAKMDAM 9
          PD K DAM
Sbjct: 68 PDEKKDAM 75
>NP_005375
          Length = 462

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  PDAKMDAM 9
          PD K DAM
Sbjct: 68 PDEKKDAM 75
>NP_001092286
          Length = 2769

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    YPDAKMDAM 9
            YP   MDAM
Sbjct: 2489 YPKPDMDAM 2497
>XP_006718561
          Length = 2794

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    YPDAKMDAM 9
            YP   MDAM
Sbjct: 2514 YPKPDMDAM 2522
>NP_114437
          Length = 1053

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YPDAKMDAM 9
           Y D+K+DA+
Sbjct: 317 YVDSKIDAL 325
>NP_060724
          Length = 495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  PDAKMD 7
          PDAK+D
Sbjct: 39 PDAKLD 44
>NP_001129695
          Length = 553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PDAKMD 7
           PDAK+D
Sbjct: 97  PDAKLD 102
>NP_001129697
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PDAKMD 7
           PDAK+D
Sbjct: 97  PDAKLD 102
>NP_001129696
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PDAKMD 7
           PDAK+D
Sbjct: 97  PDAKLD 102
>NP_001092108
          Length = 708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PDAKMD 7
           PDAK+D
Sbjct: 555 PDAKLD 560
>XP_006711507
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PDAKMD 7
           PDAK+D
Sbjct: 98  PDAKLD 103
>XP_006711506
          Length = 366

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PDAKMD 7
           PDAK+D
Sbjct: 98  PDAKLD 103
>XP_006711505
          Length = 437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PDAKMD 7
           PDAK+D
Sbjct: 98  PDAKLD 103
>XP_005273248
          Length = 554

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PDAKMD 7
           PDAK+D
Sbjct: 98  PDAKLD 103
>NP_951059
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YPDAKMDAM 9
           + D K+DAM
Sbjct: 526 FNDTKLDAM 534
>NP_060119
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YPDAKMDAM 9
           + D K+DAM
Sbjct: 526 FNDTKLDAM 534
>NP_951058
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YPDAKMDAM 9
           + D K+DAM
Sbjct: 526 FNDTKLDAM 534
>NP_036346
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YPDAKMDAM 9
           YP+ K+D +
Sbjct: 164 YPEEKLDCV 172
>NP_000258
          Length = 2818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           YP AKM+
Sbjct: 794 YPKAKME 800
>NP_001004339
          Length = 759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  PDAKMDAM 9
          PDA+ DA+
Sbjct: 17 PDAQKDAL 24
>NP_001035957
          Length = 2839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           YP AKM+
Sbjct: 794 YPKAKME 800
>NP_001153626
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  YPDAKMDAM 9
          YP+ K+D +
Sbjct: 36 YPEEKLDCV 44
>NP_064569
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YPDAKMDAM 9
           + D K+DAM
Sbjct: 453 FHDTKLDAM 461
>NP_942600
          Length = 364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PDAKMDAM 9
           PD++MD M
Sbjct: 222 PDSQMDDM 229
>XP_006721991
          Length = 1632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           YP AKM+
Sbjct: 804 YPKAKME 810
>XP_006721990
          Length = 2823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           YP AKM+
Sbjct: 804 YPKAKME 810
>XP_006721989
          Length = 2823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           YP AKM+
Sbjct: 804 YPKAKME 810
>XP_005258041
          Length = 2836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           YP AKM+
Sbjct: 794 YPKAKME 800
>XP_006721988
          Length = 2846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           YP AKM+
Sbjct: 804 YPKAKME 810
>XP_006721987
          Length = 2849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           YP AKM+
Sbjct: 804 YPKAKME 810
>XP_006721986
          Length = 2854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           YP AKM+
Sbjct: 791 YPKAKME 797
>XP_005258040
          Length = 2857

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           YP AKM+
Sbjct: 794 YPKAKME 800
>XP_006721985
          Length = 2867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           YP AKM+
Sbjct: 804 YPKAKME 810
>XP_005274448
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PDAKMDAM 9
           PD++MD M
Sbjct: 118 PDSQMDDM 125
>XP_006717971
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YPDAKMDAM 9
           + D K+DAM
Sbjct: 526 FNDTKLDAM 534
>XP_005269990
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YPDAKMDAM 9
           + D K+DAM
Sbjct: 526 FNDTKLDAM 534
>XP_005263972
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YPDAKMDAM 9
           + D K+DAM
Sbjct: 453 FHDTKLDAM 461
>XP_005263971
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YPDAKMDAM 9
           + D K+DAM
Sbjct: 453 FHDTKLDAM 461
>NP_001191339
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PDAKMDA 8
           PD K+DA
Sbjct: 235 PDDKLDA 241
>NP_002994
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PDAKMDA 8
           PD K+DA
Sbjct: 235 PDDKLDA 241
>NP_001275915
          Length = 1616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PDAKMDA 8
           PDAK+ A
Sbjct: 734 PDAKLSA 740
>NP_001275914
          Length = 1621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PDAKMDA 8
           PDAK+ A
Sbjct: 734 PDAKLSA 740
>NP_009099
          Length = 1581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PDAKMDA 8
           PDAK+ A
Sbjct: 694 PDAKLSA 700
>NP_001137473
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PDAKMDA 8
           PD K+DA
Sbjct: 201 PDDKLDA 207
>NP_001137471
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PDAKMDA 8
           PD K+DA
Sbjct: 235 PDDKLDA 241
>NP_001137470
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PDAKMDA 8
           PD K+DA
Sbjct: 235 PDDKLDA 241
>NP_006412
          Length = 1849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    YPDAKMDAM 9
            +PD  M+A+
Sbjct: 1336 FPDTSMEAI 1344
>NP_006411
          Length = 1785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    YPDAKMDAM 9
            +PD  M+A+
Sbjct: 1283 FPDTSMEAI 1291
>NP_001191337
          Length = 719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PDAKMDA 8
           PD K+DA
Sbjct: 235 PDDKLDA 241
>NP_835221
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YPDAKMDAM 9
           YP A  +AM
Sbjct: 241 YPSAHQEAM 249
>NP_001034662
          Length = 719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PDAKMDA 8
           PD K+DA
Sbjct: 235 PDDKLDA 241
>XP_006723746
          Length = 1177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YPDAKMDAM 9
           +PD  M+A+
Sbjct: 675 FPDTSMEAI 683
>XP_005260309
          Length = 1784

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    YPDAKMDAM 9
            +PD  M+A+
Sbjct: 1282 FPDTSMEAI 1290
>XP_005256997
          Length = 1560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PDAKMDA 8
           PDAK+ A
Sbjct: 673 PDAKLSA 679
>XP_005256995
          Length = 1621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PDAKMDA 8
           PDAK+ A
Sbjct: 734 PDAKLSA 740
>XP_006716481
          Length = 1649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    YPDAKMDAM 9
            +PD  M+A+
Sbjct: 1136 FPDTSMEAI 1144
>XP_005251193
          Length = 1800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    YPDAKMDAM 9
            +PD  M+A+
Sbjct: 1336 FPDTSMEAI 1344
>XP_005251192
          Length = 1843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    YPDAKMDAM 9
            +PD  M+A+
Sbjct: 1336 FPDTSMEAI 1344
>XP_005251191
          Length = 1849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    YPDAKMDAM 9
            +PD  M+A+
Sbjct: 1336 FPDTSMEAI 1344
>XP_006710939
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           Y DA+MD
Sbjct: 378 YSDAEMD 384
>XP_005271228
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           Y DA+MD
Sbjct: 432 YSDAEMD 438
>XP_006710938
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           Y DA+MD
Sbjct: 432 YSDAEMD 438
>XP_006710937
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YPDAKMD 7
           Y DA+MD
Sbjct: 432 YSDAEMD 438
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.128    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 657,002
Number of extensions: 1229
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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