Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_000520                                                              17    3301
NP_001186020                                                           16    5631
NP_001186014                                                           16    5631
NP_775804                                                              16    5631
NP_001186018                                                           16    5631
NP_001159764                                                           16    5631
NP_003729                                                              16    5631
XP_005244992                                                           16    5631
XP_006711258                                                           16    5631
XP_005244991                                                           16    5631
NP_443099                                                              16    7355
NP_055423                                                              16    7355
NP_001274739                                                           16    7355
NP_001032409                                                           16    7355
NP_001028200                                                           16    7355
NP_112180                                                              16    7355
NP_775922                                                              16    7355
XP_005272600                                                           16    7355
XP_006720008                                                           16    7355
XP_006720007                                                           16    7355
XP_006720006                                                           16    7355
XP_005245569                                                           16    7355
XP_005245568                                                           16    7355
XP_005245567                                                           16    7355
XP_005245566                                                           16    7355
NP_001032410                                                           16    7355
NP_055191                                                              16    7355
NP_056099                                                              15    9605
NP_060596                                                              15    9605
NP_004696                                                              15    9605
XP_005248174                                                           15    9605
XP_005248173                                                           15    9605
XP_006710565                                                           15    9605
XP_006710564                                                           15    9605
XP_005270743                                                           15    9605
>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YMSLFEVLL 9
           Y+SLFEVLL
Sbjct: 290 YVSLFEVLL 298
>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YMSLFEVLL 9
           Y+SLFEVLL
Sbjct: 290 YVSLFEVLL 298
>NP_000520
          Length = 297

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   YMSLFEV 7
           YMSLF+V
Sbjct: 254 YMSLFQV 260
>NP_001186020
          Length = 981

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YMSLFEVL 8
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>NP_001186014
          Length = 1035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YMSLFEVL 8
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>NP_775804
          Length = 981

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YMSLFEVL 8
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>NP_001186018
          Length = 1035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YMSLFEVL 8
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>NP_001159764
          Length = 1146

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YMSLFEVLL 9
           Y SL+EV L
Sbjct: 733 YFSLYEVAL 741
>NP_003729
          Length = 1203

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YMSLFEVLL 9
           Y SL+EV L
Sbjct: 733 YFSLYEVAL 741
>XP_005244992
          Length = 1035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YMSLFEVL 8
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>XP_006711258
          Length = 1035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YMSLFEVL 8
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>XP_005244991
          Length = 1035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YMSLFEVL 8
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>NP_443099
          Length = 1738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YMSLFEVL 8
           +MS+F++L
Sbjct: 544 FMSMFQIL 551
>NP_055423
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    MSLFEVLL 9
            +S+FEV+L
Sbjct: 1090 LSMFEVIL 1097
>NP_001274739
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    MSLFEVLL 9
            +S+FEV+L
Sbjct: 1090 LSMFEVIL 1097
>NP_001032409
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    MSLFEVLL 9
            +S+FEV+L
Sbjct: 1089 LSMFEVIL 1096
>NP_001028200
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MSLFEVLL 9
           +S+FEV+L
Sbjct: 659 LSMFEVIL 666
>NP_112180
          Length = 528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YMSLFEVL 8
           Y +LFEV+
Sbjct: 317 YFALFEVI 324
>NP_775922
          Length = 6996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    YMSLFEV 7
            Y+SLF+V
Sbjct: 1321 YLSLFDV 1327
>XP_005272600
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    MSLFEVLL 9
            +S+FEV+L
Sbjct: 1090 LSMFEVIL 1097
>XP_006720008
          Length = 1645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YMSLFEVL 8
           +MS+F++L
Sbjct: 544 FMSMFQIL 551
>XP_006720007
          Length = 1709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YMSLFEVL 8
           +MS+F++L
Sbjct: 515 FMSMFQIL 522
>XP_006720006
          Length = 1713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YMSLFEVL 8
           +MS+F++L
Sbjct: 544 FMSMFQIL 551
>XP_005245569
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YMSLFEVL 8
           Y +LFEV+
Sbjct: 131 YFALFEVI 138
>XP_005245568
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YMSLFEVL 8
           Y +LFEV+
Sbjct: 131 YFALFEVI 138
>XP_005245567
          Length = 438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YMSLFEVL 8
           Y +LFEV+
Sbjct: 214 YFALFEVI 221
>XP_005245566
          Length = 541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YMSLFEVL 8
           Y +LFEV+
Sbjct: 317 YFALFEVI 324
>NP_001032410
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    MSLFEVLL 9
            +S+FEV+L
Sbjct: 1089 LSMFEVIL 1096
>NP_055191
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    MSLFEVLL 9
            +S+FEV+L
Sbjct: 1089 LSMFEVIL 1096
>NP_056099
          Length = 3375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    YMSLFEVLL 9
            Y SL +VLL
Sbjct: 3277 YQSLIKVLL 3285
>NP_060596
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MSLFEVLL 9
           MS+F VLL
Sbjct: 110 MSIFPVLL 117
>NP_004696
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SLFEVLL 9
           SLFE+L+
Sbjct: 168 SLFEILI 174
>XP_005248174
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MSLFEVLL 9
           MS+F VLL
Sbjct: 110 MSIFPVLL 117
>XP_005248173
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MSLFEVLL 9
           MS+F VLL
Sbjct: 110 MSIFPVLL 117
>XP_006710565
          Length = 3140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    YMSLFEVLL 9
            Y SL +VLL
Sbjct: 3042 YQSLIKVLL 3050
>XP_006710564
          Length = 3432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    YMSLFEVLL 9
            Y SL +VLL
Sbjct: 3334 YQSLIKVLL 3342
>XP_005270743
          Length = 3453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    YMSLFEVLL 9
            Y SL +VLL
Sbjct: 3355 YQSLIKVLL 3363
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.342    0.153    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 322,964
Number of extensions: 427
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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