Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              21     229
NP_005654                                                              17    4312
NP_006663                                                              17    4312
XP_006713980                                                           17    4312
XP_006713979                                                           17    4312
NP_696961                                                              17    4312
NP_940939                                                              16    7355
NP_001177257                                                           16    7355
NP_067545                                                              16    7355
NP_113602                                                              16    7355
NP_001247434                                                           16    7355
NP_079425                                                              16    7355
NP_001275899                                                           16    7355
NP_001127948                                                           16    7355
NP_056165                                                              16    7355
NP_116562                                                              16    7355
NP_001247433                                                           16    7355
NP_653292                                                              16    7355
NP_001035519                                                           16    7355
NP_001275897                                                           16    7355
XP_005259960                                                           16    7355
XP_006722173                                                           16    7355
XP_005266415                                                           16    7355
XP_005266414                                                           16    7355
XP_006715821                                                           16    7355
XP_005249868                                                           16    7355
XP_005245660                                                           16    7355
XP_005270761                                                           16    7355
XP_005270760                                                           16    7355
XP_005270759                                                           16    7355
XP_006710604                                                           16    7355
XP_005270758                                                           16    7355
NP_001073895                                                           16    7355
NP_001230913                                                           15    9605
NP_068810                                                              15    9605
NP_001138610                                                           15    9605
NP_001230914                                                           15    9605
NP_004949                                                              15    9605
NP_001124319                                                           15    9605
NP_004199                                                              15    9605
NP_060758                                                              15    9605
NP_579866                                                              15    9605
NP_006428                                                              15    9605
NP_008892                                                              15    9605
NP_536724                                                              15    9605
NP_940916                                                              15    9605
XP_005265204                                                           15    9605
XP_006713218                                                           15    9605
XP_006713214                                                           15    9605
XP_005263496                                                           15    9605
XP_005263495                                                           15    9605
NP_005889                                                              15    9605
NP_976240                                                              15    9605
>NP_002430
          Length = 1137

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YMPLELQYI 9
           Y PLELQYI
Sbjct: 229 YTPLELQYI 237
>NP_005654
          Length = 539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MPLELQYI 9
           +PLE QY+
Sbjct: 148 LPLECQYL 155
>NP_006663
          Length = 546

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPLELQYI 9
           MPLEL+++
Sbjct: 215 MPLELEWL 222
>XP_006713980
          Length = 458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MPLELQYI 9
          +PLE QY+
Sbjct: 67 LPLECQYL 74
>XP_006713979
          Length = 564

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MPLELQYI 9
           +PLE QY+
Sbjct: 173 LPLECQYL 180
>NP_696961
          Length = 548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPLELQYI 9
           MPLEL+++
Sbjct: 217 MPLELEWL 224
>NP_940939
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YMPLELQYI 9
           Y+P E+Q I
Sbjct: 177 YLPTEVQLI 185
>NP_001177257
          Length = 249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YMPLELQYI 9
           Y+P E+Q I
Sbjct: 127 YLPTEVQLI 135
>NP_067545
          Length = 254

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YMPLELQ 7
           ++PLELQ
Sbjct: 116 HLPLELQ 122
>NP_113602
          Length = 1019

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MPLELQY 8
           +PLELQ+
Sbjct: 130 IPLELQF 136
>NP_001247434
          Length = 996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MPLELQY 8
           +PLELQ+
Sbjct: 130 IPLELQF 136
>NP_079425
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YMPLELQYI 9
           Y  +EL+Y+
Sbjct: 158 YQAMELEYV 166
>NP_001275899
          Length = 572

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YMPLELQYI 9
           Y  +EL+Y+
Sbjct: 115 YQAMELEYV 123
>NP_001127948
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YMPLELQYI 9
           ++P E+QY+
Sbjct: 693 FIPEEIQYL 701
>NP_056165
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YMPLELQYI 9
           ++P E+QY+
Sbjct: 693 FIPEEIQYL 701
>NP_116562
          Length = 996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MPLELQY 8
           +PLELQ+
Sbjct: 107 IPLELQF 113
>NP_001247433
          Length = 996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MPLELQY 8
           +PLELQ+
Sbjct: 107 IPLELQF 113
>NP_653292
          Length = 719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YMPLEL 6
           Y+PLEL
Sbjct: 545 YLPLEL 550
>NP_001035519
          Length = 1159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    YMPLELQYI 9
            Y+P + QY+
Sbjct: 1071 YLPTDSQYL 1079
>NP_001275897
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YMPLELQYI 9
           Y  +EL+Y+
Sbjct: 183 YQAMELEYV 191
>XP_005259960
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YMPLELQYI 9
           Y+P E+Q I
Sbjct: 250 YLPTEVQLI 258
>XP_006722173
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YMPLELQYI 9
           Y  +EL+Y+
Sbjct: 158 YQAMELEYV 166
>XP_005266415
          Length = 1158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    YMPLELQYI 9
            Y+P + QY+
Sbjct: 1070 YLPTDSQYL 1078
>XP_005266414
          Length = 1159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    YMPLELQYI 9
            Y+P + QY+
Sbjct: 1071 YLPTDSQYL 1079
>XP_006715821
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MPLELQY 8
           +PLELQ+
Sbjct: 130 IPLELQF 136
>XP_005249868
          Length = 923

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MPLELQY 8
           +PLELQ+
Sbjct: 130 IPLELQF 136
>XP_005245660
          Length = 1158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YMPLELQYI 9
           Y  LE+QY+
Sbjct: 179 YTGLEIQYL 187
>XP_005270761
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YMPLELQYI 9
           ++P E+QY+
Sbjct: 693 FIPEEIQYL 701
>XP_005270760
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YMPLELQYI 9
           ++P E+QY+
Sbjct: 693 FIPEEIQYL 701
>XP_005270759
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YMPLELQYI 9
           ++P E+QY+
Sbjct: 693 FIPEEIQYL 701
>XP_006710604
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YMPLELQYI 9
           ++P E+QY+
Sbjct: 693 FIPEEIQYL 701
>XP_005270758
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YMPLELQYI 9
           ++P E+QY+
Sbjct: 693 FIPEEIQYL 701
>NP_001073895
          Length = 1158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YMPLELQYI 9
           Y  LE+QY+
Sbjct: 179 YTGLEIQYL 187
>NP_001230913
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   PLELQYI 9
           P+E QY+
Sbjct: 283 PMEFQYL 289
>NP_068810
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   PLELQYI 9
           P+E QY+
Sbjct: 283 PMEFQYL 289
>NP_001138610
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   PLELQYI 9
           P+E QY+
Sbjct: 280 PMEFQYL 286
>NP_001230914
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   PLELQYI 9
           P+E QY+
Sbjct: 283 PMEFQYL 289
>NP_004949
          Length = 2549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LELQYI 9
            LELQY+
Sbjct: 2121 LELQYV 2126
>NP_001124319
          Length = 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  YMPLELQ 7
          ++PLELQ
Sbjct: 43 HVPLELQ 49
>NP_004199
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  YMPLELQ 7
          ++PLELQ
Sbjct: 43 HVPLELQ 49
>NP_060758
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YMPLELQYI 9
           Y P EL+Y+
Sbjct: 269 YSPDELRYL 277
>NP_579866
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YMPLELQYI 9
           Y P EL+Y+
Sbjct: 267 YSPDELRYL 275
>NP_006428
          Length = 1724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YMPLELQYI 9
           ++P+E +YI
Sbjct: 650 HVPIEAKYI 658
>NP_008892
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  MPLELQY 8
          MPL+ QY
Sbjct: 4  MPLKAQY 10
>NP_536724
          Length = 435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   PLELQYI 9
           P+E++YI
Sbjct: 130 PMEMRYI 136
>NP_940916
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   PLELQYI 9
           P+EL+Y+
Sbjct: 719 PVELRYV 725
>XP_005265204
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YMPLEL 6
           Y+PLEL
Sbjct: 176 YVPLEL 181
>XP_006713218
          Length = 2282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YMPLEL 6
           Y+PLEL
Sbjct: 202 YVPLEL 207
>XP_006713214
          Length = 2311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YMPLEL 6
           Y+PLEL
Sbjct: 231 YVPLEL 236
>XP_005263496
          Length = 2322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LELQYI 9
            LELQY+
Sbjct: 1894 LELQYV 1899
>XP_005263495
          Length = 2549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LELQYI 9
            LELQY+
Sbjct: 2121 LELQYV 2126
>NP_005889
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LELQYI 9
           LELQY+
Sbjct: 150 LELQYV 155
>NP_976240
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LELQYI 9
           LELQY+
Sbjct: 150 LELQYV 155
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.151    0.459 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 714,772
Number of extensions: 1451
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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