Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001032903                                                           17    2528
NP_055811                                                              17    3301
XP_005247296                                                           17    3301
XP_006713604                                                           17    3301
XP_005247295                                                           17    3301
NP_001124432                                                           17    3301
NP_848622                                                              17    4312
NP_114174                                                              17    4312
NP_036468                                                              17    4312
XP_005256397                                                           17    4312
XP_006722341                                                           17    4312
NP_001033707                                                           17    4312
NP_065816                                                              16    5631
XP_006710573                                                           16    5631
XP_006710572                                                           16    5631
XP_006710571                                                           16    5631
XP_006710570                                                           16    5631
XP_006710569                                                           16    5631
XP_006710568                                                           16    5631
XP_006710567                                                           16    5631
XP_006710566                                                           16    5631
XP_005245859                                                           16    5631
NP_055592                                                              16    7355
NP_056175                                                              16    7355
NP_060158                                                              16    7355
XP_005252119                                                           16    7355
XP_006717212                                                           16    7355
XP_005273417                                                           16    7355
NP_001139669                                                           16    7355
NP_940980                                                              15    9605
NP_689846                                                              15    9605
NP_001017420                                                           15    9605
NP_001018123                                                           15    9605
NP_683515                                                              15    9605
NP_059138                                                              15    9605
NP_957716                                                              15    9605
NP_957719                                                              15    9605
NP_061004                                                              15    9605
NP_003863                                                              15    9605
NP_958436                                                              15    9605
NP_957718                                                              15    9605
NP_001139627                                                           15    9605
NP_001139626                                                           15    9605
NP_998821                                                              15    9605
NP_689657                                                              15    9605
NP_055506                                                              15    9605
NP_005716                                                              15    9605
NP_542179                                                              15    9605
NP_001075042                                                           15    9605
XP_006724868                                                           15    9605
XP_005274706                                                           15    9605
XP_005274705                                                           15    9605
XP_006724867                                                           15    9605
XP_005268686                                                           15    9605
XP_006716360                                                           15    9605
XP_005246991                                                           15    9605
XP_005246990                                                           15    9605
XP_005246783                                                           15    9605
XP_005270397                                                           15    9605
NP_065994                                                              15    9605
>NP_001032903
          Length = 574

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVLNFNKK 9
           + LNFNKK
Sbjct: 106 VTLNFNKK 113
>NP_055811
          Length = 1655

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LNFNKK 9
           LNFNKK
Sbjct: 981 LNFNKK 986
>XP_005247296
          Length = 1673

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LNFNKK 9
            LNFNKK
Sbjct: 999  LNFNKK 1004
>XP_006713604
          Length = 1685

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LNFNKK 9
            LNFNKK
Sbjct: 1011 LNFNKK 1016
>XP_005247295
          Length = 1705

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LNFNKK 9
            LNFNKK
Sbjct: 1031 LNFNKK 1036
>NP_001124432
          Length = 1693

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LNFNKK 9
            LNFNKK
Sbjct: 1019 LNFNKK 1024
>NP_848622
          Length = 1124

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLVLNFNK 8
           Y+V+ FNK
Sbjct: 137 YVVIKFNK 144
>NP_114174
          Length = 502

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YLVLNFNKK 9
          + VLN NKK
Sbjct: 77 FRVLNLNKK 85
>NP_036468
          Length = 456

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YLVLNFNKK 9
          + VLN NKK
Sbjct: 77 FRVLNLNKK 85
>XP_005256397
          Length = 397

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YLVLNFNKK 9
          + VLN NKK
Sbjct: 18 FRVLNLNKK 26
>XP_006722341
          Length = 411

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YLVLNFNKK 9
          + VLN NKK
Sbjct: 77 FRVLNLNKK 85
>NP_001033707
          Length = 397

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YLVLNFNKK 9
          + VLN NKK
Sbjct: 18 FRVLNLNKK 26
>NP_065816
          Length = 5183

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YLVLNFNKK 9
            YL+ NFN++
Sbjct: 1176 YLLQNFNEE 1184
>XP_006710573
          Length = 5177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YLVLNFNKK 9
            YL+ NFN++
Sbjct: 1176 YLLQNFNEE 1184
>XP_006710572
          Length = 5188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YLVLNFNKK 9
            YL+ NFN++
Sbjct: 1176 YLLQNFNEE 1184
>XP_006710571
          Length = 5194

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YLVLNFNKK 9
            YL+ NFN++
Sbjct: 1176 YLLQNFNEE 1184
>XP_006710570
          Length = 5195

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YLVLNFNKK 9
            YL+ NFN++
Sbjct: 1176 YLLQNFNEE 1184
>XP_006710569
          Length = 5212

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YLVLNFNKK 9
            YL+ NFN++
Sbjct: 1176 YLLQNFNEE 1184
>XP_006710568
          Length = 5221

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YLVLNFNKK 9
            YL+ NFN++
Sbjct: 1176 YLLQNFNEE 1184
>XP_006710567
          Length = 5222

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YLVLNFNKK 9
            YL+ NFN++
Sbjct: 1176 YLLQNFNEE 1184
>XP_006710566
          Length = 5222

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YLVLNFNKK 9
            YL+ NFN++
Sbjct: 1176 YLLQNFNEE 1184
>XP_005245859
          Length = 5223

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YLVLNFNKK 9
            YL+ NFN++
Sbjct: 1176 YLLQNFNEE 1184
>NP_055592
          Length = 1524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    LVLNFNK 8
            LVLNF K
Sbjct: 1019 LVLNFRK 1025
>NP_056175
          Length = 1042

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LVLNFNKK 9
           +V+NF+KK
Sbjct: 673 VVVNFSKK 680
>NP_060158
          Length = 402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLNFNKK 9
           +LNFN+K
Sbjct: 201 MLNFNEK 207
>XP_005252119
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLNFNKK 9
           +LNFN+K
Sbjct: 124 MLNFNEK 130
>XP_006717212
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLNFNKK 9
           +LNFN+K
Sbjct: 200 MLNFNEK 206
>XP_005273417
          Length = 1487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    LVLNFNK 8
            LVLNF K
Sbjct: 1019 LVLNFRK 1025
>NP_001139669
          Length = 7081

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    LVLNFNK 8
            LVLN NK
Sbjct: 5527 LVLNINK 5533
>NP_940980
          Length = 2527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LVLNFNKK 9
            LVL +N+K
Sbjct: 2471 LVLGYNRK 2478
>NP_689846
          Length = 859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLVLNFNKK 9
           Y+V+  NKK
Sbjct: 93  YIVIEKNKK 101
>NP_001017420
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YLVLNFN 7
           +LV NFN
Sbjct: 594 FLVYNFN 600
>NP_001018123
          Length = 859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLVLNFNKK 9
           Y+V+  NKK
Sbjct: 93  YIVIEKNKK 101
>NP_683515
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   NFNKK 9
           NFNKK
Sbjct: 185 NFNKK 189
>NP_059138
          Length = 1032

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YLVLNFNK 8
           YL+L++N+
Sbjct: 224 YLLLSYNR 231
>NP_957716
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LVLNFN 7
          +VLNFN
Sbjct: 68 IVLNFN 73
>NP_957719
          Length = 901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LVLNFN 7
          +VLNFN
Sbjct: 68 IVLNFN 73
>NP_061004
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LVLNFN 7
          +VLNFN
Sbjct: 68 IVLNFN 73
>NP_003863
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LVLNFN 7
          +VLNFN
Sbjct: 68 IVLNFN 73
>NP_958436
          Length = 909

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LVLNFN 7
          +VLNFN
Sbjct: 68 IVLNFN 73
>NP_957718
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LVLNFN 7
          +VLNFN
Sbjct: 68 IVLNFN 73
>NP_001139627
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLVLNFNKK 9
           +LVLN+  K
Sbjct: 287 FLVLNYKDK 295
>NP_001139626
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLVLNFNKK 9
           +LVLN+  K
Sbjct: 287 FLVLNYKDK 295
>NP_998821
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YLVLNFNKK 9
          YL+ NFN +
Sbjct: 71 YLMNNFNAR 79
>NP_689657
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLVLNFNKK 9
           +LVLN+  K
Sbjct: 287 FLVLNYKDK 295
>NP_055506
          Length = 1485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YLVLNFN 7
           YL+ NFN
Sbjct: 465 YLLRNFN 471
>NP_005716
          Length = 221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  YLVLNFN 7
          YL+L FN
Sbjct: 13 YLLLGFN 19
>NP_542179
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YLVLNFN 7
           YL L+FN
Sbjct: 533 YLALDFN 539
>NP_001075042
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YLVLNFN 7
           YL L+FN
Sbjct: 534 YLALDFN 540
>XP_006724868
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YLVLNFN 7
           YL L+FN
Sbjct: 511 YLALDFN 517
>XP_005274706
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YLVLNFN 7
           YL L+FN
Sbjct: 512 YLALDFN 518
>XP_005274705
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YLVLNFN 7
           YL L+FN
Sbjct: 534 YLALDFN 540
>XP_006724867
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YLVLNFN 7
           YL L+FN
Sbjct: 534 YLALDFN 540
>XP_005268686
          Length = 2521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LVLNFNKK 9
            LVL +N+K
Sbjct: 2471 LVLGYNRK 2478
>XP_006716360
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YLVLNFN 7
           +LV NFN
Sbjct: 594 FLVYNFN 600
>XP_005246991
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LVLNFN 7
          +VLNFN
Sbjct: 68 IVLNFN 73
>XP_005246990
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LVLNFN 7
          +VLNFN
Sbjct: 68 IVLNFN 73
>XP_005246783
          Length = 908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LVLNFNK 8
           L+LNF K
Sbjct: 237 LILNFRK 243
>XP_005270397
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  YLVLNFN 7
          YL+L FN
Sbjct: 13 YLLLGFN 19
>NP_065994
          Length = 908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LVLNFNK 8
           L+LNF K
Sbjct: 237 LILNFRK 243
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.146    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 509,911
Number of extensions: 935
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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