Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001136098                                                           18    1135
NP_000360                                                              18    1135
NP_001018046                                                           18    1135
XP_005268096                                                           18    1135
XP_006720308                                                           18    1135
XP_005268094                                                           18    1135
NP_055850                                                              18    1935
XP_005260398                                                           18    1935
XP_006723812                                                           18    1935
XP_006723811                                                           18    1935
XP_006723810                                                           18    1935
XP_005260400                                                           18    1935
NP_001367                                                              17    2528
NP_003242                                                              17    2528
XP_006714289                                                           17    3301
XP_006714287                                                           17    3301
XP_006714286                                                           17    3301
XP_005263076                                                           17    3301
NP_001107829                                                           17    3301
NP_001153698                                                           17    4312
NP_001153730                                                           17    4312
NP_149421                                                              17    4312
NP_001153731                                                           17    4312
NP_057167                                                              17    4312
XP_006715393                                                           17    4312
XP_005248707                                                           17    4312
NP_055423                                                              16    5631
NP_001274739                                                           16    5631
NP_001028200                                                           16    5631
NP_955453                                                              16    5631
XP_006722363                                                           16    5631
XP_005272600                                                           16    5631
NP_543143                                                              16    5631
NP_001020471                                                           16    5631
NP_000072                                                              16    7355
NP_000262                                                              16    7355
NP_001138624                                                           16    7355
NP_689628                                                              16    7355
NP_001186306                                                           16    7355
NP_055977                                                              16    7355
XP_006722542                                                           16    7355
XP_005258336                                                           16    7355
XP_005258335                                                           16    7355
XP_005258334                                                           16    7355
XP_005273458                                                           16    7355
XP_005273457                                                           16    7355
XP_006711794                                                           16    7355
XP_005273086                                                           16    7355
XP_005273085                                                           16    7355
XP_005273084                                                           16    7355
NP_057700                                                              15    9605
NP_037514                                                              15    9605
NP_001275582                                                           15    9605
NP_066564                                                              15    9605
NP_004850                                                              15    9605
NP_004288                                                              15    9605
NP_003875                                                              15    9605
NP_003694                                                              15    9605
XP_006721881                                                           15    9605
XP_006721880                                                           15    9605
XP_006713992                                                           15    9605
XP_005265585                                                           15    9605
>NP_001136098
          Length = 274

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YLTVIDKYA 9
           YLTVIDK A
Sbjct: 212 YLTVIDKDA 220
>NP_000360
          Length = 764

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YLTVIDKYA 9
           YLTVIDK A
Sbjct: 212 YLTVIDKDA 220
>NP_001018046
          Length = 253

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YLTVIDKYA 9
           YLTVIDK A
Sbjct: 212 YLTVIDKDA 220
>XP_005268096
          Length = 253

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YLTVIDKYA 9
           YLTVIDK A
Sbjct: 212 YLTVIDKDA 220
>XP_006720308
          Length = 274

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YLTVIDKYA 9
           YLTVIDK A
Sbjct: 212 YLTVIDKDA 220
>XP_005268094
          Length = 764

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YLTVIDKYA 9
           YLTVIDK A
Sbjct: 212 YLTVIDKDA 220
>NP_055850
          Length = 956

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           YLTV+ KY
Sbjct: 336 YLTVVTKY 343
>XP_005260398
          Length = 969

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           YLTV+ KY
Sbjct: 336 YLTVVTKY 343
>XP_006723812
          Length = 969

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           YLTV+ KY
Sbjct: 336 YLTVVTKY 343
>XP_006723811
          Length = 969

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           YLTV+ KY
Sbjct: 336 YLTVVTKY 343
>XP_006723810
          Length = 969

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           YLTV+ KY
Sbjct: 336 YLTVVTKY 343
>XP_005260400
          Length = 969

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           YLTV+ KY
Sbjct: 336 YLTVVTKY 343
>NP_001367
          Length = 4646

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    YLTVIDKY 8
            Y+T IDKY
Sbjct: 1738 YITWIDKY 1745
>NP_003242
          Length = 146

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LTVIDKYA 9
          LTV+D+YA
Sbjct: 14 LTVMDRYA 21
>XP_006714289
          Length = 169

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  YLTVIDKY 8
          Y+TV DKY
Sbjct: 21 YITVGDKY 28
>XP_006714287
          Length = 309

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  YLTVIDKY 8
          Y+TV DKY
Sbjct: 21 YITVGDKY 28
>XP_006714286
          Length = 309

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  YLTVIDKY 8
          Y+TV DKY
Sbjct: 21 YITVGDKY 28
>XP_005263076
          Length = 309

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  YLTVIDKY 8
          Y+TV DKY
Sbjct: 21 YITVGDKY 28
>NP_001107829
          Length = 309

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  YLTVIDKY 8
          Y+TV DKY
Sbjct: 21 YITVGDKY 28
>NP_001153698
          Length = 472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           +LT ID+Y
Sbjct: 208 FLTAIDRY 215
>NP_001153730
          Length = 472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           +LT ID+Y
Sbjct: 208 FLTAIDRY 215
>NP_149421
          Length = 439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           +LT ID+Y
Sbjct: 175 FLTAIDRY 182
>NP_001153731
          Length = 472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           +LT ID+Y
Sbjct: 208 FLTAIDRY 215
>NP_057167
          Length = 472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           +LT ID+Y
Sbjct: 208 FLTAIDRY 215
>XP_006715393
          Length = 472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           +LT ID+Y
Sbjct: 208 FLTAIDRY 215
>XP_005248707
          Length = 472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLTVIDKY 8
           +LT ID+Y
Sbjct: 208 FLTAIDRY 215
>NP_055423
          Length = 1253

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    LTVIDKY 8
            +T++DKY
Sbjct: 1219 ITILDKY 1225
>NP_001274739
          Length = 1253

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    LTVIDKY 8
            +T++DKY
Sbjct: 1219 ITILDKY 1225
>NP_001028200
          Length = 822

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LTVIDKY 8
           +T++DKY
Sbjct: 788 ITILDKY 794
>NP_955453
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YLTVIDKYA 9
           Y  V+DKYA
Sbjct: 287 YWGVMDKYA 295
>XP_006722363
          Length = 212

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLTVIDKYA 9
           ++ +IDKYA
Sbjct: 104 WMKMIDKYA 112
>XP_005272600
          Length = 1253

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    LTVIDKY 8
            +T++DKY
Sbjct: 1219 ITILDKY 1225
>NP_543143
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YLTVIDKYA 9
           Y  V+DKYA
Sbjct: 287 YWGVMDKYA 295
>NP_001020471
          Length = 244

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLTVIDKYA 9
           ++ +IDKYA
Sbjct: 136 WMKMIDKYA 144
>NP_000072
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    YLTVIDKY 8
            YLT+ +KY
Sbjct: 2966 YLTIPNKY 2973
>NP_000262
          Length = 1278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YLTVID 6
            YLT+ID
Sbjct: 1091 YLTIID 1096
>NP_001138624
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVIDKY 8
           TV+DKY
Sbjct: 271 TVLDKY 276
>NP_689628
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVIDKY 8
           TV+DKY
Sbjct: 296 TVLDKY 301
>NP_001186306
          Length = 720

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LTVIDKY 8
           LTV++KY
Sbjct: 701 LTVLEKY 707
>NP_055977
          Length = 724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LTVIDKY 8
           LTV++KY
Sbjct: 705 LTVLEKY 711
>XP_006722542
          Length = 1273

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YLTVID 6
            YLT+ID
Sbjct: 1108 YLTIID 1113
>XP_005258336
          Length = 1286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YLTVID 6
            YLT+ID
Sbjct: 1091 YLTIID 1096
>XP_005258335
          Length = 1295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YLTVID 6
            YLT+ID
Sbjct: 1108 YLTIID 1113
>XP_005258334
          Length = 1303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YLTVID 6
            YLT+ID
Sbjct: 1108 YLTIID 1113
>XP_005273458
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVIDKY 8
           TV+DKY
Sbjct: 206 TVLDKY 211
>XP_005273457
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TVIDKY 8
           TV+DKY
Sbjct: 206 TVLDKY 211
>XP_006711794
          Length = 3022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    YLTVIDKY 8
            YLT+ +KY
Sbjct: 2187 YLTIPNKY 2194
>XP_005273086
          Length = 3264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    YLTVIDKY 8
            YLT+ +KY
Sbjct: 2966 YLTIPNKY 2973
>XP_005273085
          Length = 3755

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    YLTVIDKY 8
            YLT+ +KY
Sbjct: 2920 YLTIPNKY 2927
>XP_005273084
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    YLTVIDKY 8
            YLT+ +KY
Sbjct: 2966 YLTIPNKY 2973
>NP_057700
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  LTVIDKY 8
          LTVID Y
Sbjct: 29 LTVIDVY 35
>NP_037514
          Length = 750

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YLTVID 6
           YLTV+D
Sbjct: 160 YLTVLD 165
>NP_001275582
          Length = 1679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YLTVIDK 7
            YLT +DK
Sbjct: 1610 YLTKVDK 1616
>NP_066564
          Length = 837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLTVIDKYA 9
           +LT  D+YA
Sbjct: 610 FLTYADEYA 618
>NP_004850
          Length = 1675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YLTVIDK 7
            YLT +DK
Sbjct: 1606 YLTKVDK 1612
>NP_004288
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YLTVIDKYA 9
           YLT ID+ A
Sbjct: 156 YLTDIDRIA 164
>NP_003875
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLTVIDKYA 9
           +LT  D+YA
Sbjct: 605 FLTYADEYA 613
>NP_003694
          Length = 857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LTVIDK 7
           LTVIDK
Sbjct: 492 LTVIDK 497
>XP_006721881
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLTVIDKYA 9
           +LT  D+YA
Sbjct: 249 FLTYADEYA 257
>XP_006721880
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLTVIDKYA 9
           +LT  D+YA
Sbjct: 610 FLTYADEYA 618
>XP_006713992
          Length = 857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LTVIDK 7
           LTVIDK
Sbjct: 492 LTVIDK 497
>XP_005265585
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLTVIDKYA 9
           +LT  D+YA
Sbjct: 605 FLTYADEYA 613
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.143    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 476,283
Number of extensions: 879
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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