Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001257436                                                           20     509
NP_001257437                                                           20     509
NP_006281                                                              20     509
XP_006715618                                                           20     509
XP_005267176                                                           20     509
NP_003571                                                              17    4312
NP_001138244                                                           17    4312
NP_071355                                                              17    4312
NP_001184113                                                           16    7355
NP_065990                                                              15    9605
NP_004707                                                              15    9605
NP_055455                                                              15    9605
XP_006719003                                                           15    9605
XP_006719002                                                           15    9605
XP_006719001                                                           15    9605
XP_005249309                                                           15    9605
XP_006715216                                                           15    9605
XP_006715215                                                           15    9605
XP_005249306                                                           15    9605
XP_005249305                                                           15    9605
XP_005249304                                                           15    9605
XP_005247035                                                           15    9605
XP_006712939                                                           15    9605
XP_006712938                                                           15    9605
XP_006712937                                                           15    9605
XP_006712936                                                           15    9605
XP_005247034                                                           15    9605

>NP_001257436
          Length = 790

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YLINAAKLD 9
           +LINAAKLD
Sbjct: 323 HLINAAKLD 331



>NP_001257437
          Length = 790

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YLINAAKLD 9
           +LINAAKLD
Sbjct: 323 HLINAAKLD 331



>NP_006281
          Length = 790

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YLINAAKLD 9
           +LINAAKLD
Sbjct: 323 HLINAAKLD 331



>XP_006715618
          Length = 577

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YLINAAKLD 9
           +LINAAKLD
Sbjct: 110 HLINAAKLD 118



>XP_005267176
          Length = 790

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YLINAAKLD 9
           +LINAAKLD
Sbjct: 323 HLINAAKLD 331



>NP_003571
          Length = 917

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLINAAKLD 9
           +L+N+ KLD
Sbjct: 456 FLVNSLKLD 464



>NP_001138244
          Length = 948

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLINAAKLD 9
           +L+N+ KLD
Sbjct: 487 FLVNSLKLD 495



>NP_071355
          Length = 340

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YLINAAKL 8
           YL+NAA L
Sbjct: 114 YLLNAASL 121



>NP_001184113
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  YLINAAKL 8
          YLINA+ L
Sbjct: 9  YLINASTL 16



>NP_065990
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LINAAKL 8
           ++NAAKL
Sbjct: 475 IVNAAKL 481



>NP_004707
          Length = 785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LINAAKL 8
           L+NAAK+
Sbjct: 472 LVNAAKI 478



>NP_055455
          Length = 1199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLINAAKLD 9
           YLI+ +K D
Sbjct: 756 YLISGSKFD 764



>XP_006719003
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LINAAKL 8
           L+NAAK+
Sbjct: 113 LVNAAKI 119



>XP_006719002
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LINAAKL 8
           L+NAAK+
Sbjct: 472 LVNAAKI 478



>XP_006719001
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LINAAKL 8
           L+NAAK+
Sbjct: 472 LVNAAKI 478



>XP_005249309
          Length = 301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LINAAKL 8
           ++NAAKL
Sbjct: 183 IVNAAKL 189



>XP_006715216
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LINAAKL 8
           ++NAAKL
Sbjct: 306 IVNAAKL 312



>XP_006715215
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LINAAKL 8
           ++NAAKL
Sbjct: 454 IVNAAKL 460



>XP_005249306
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LINAAKL 8
           ++NAAKL
Sbjct: 492 IVNAAKL 498



>XP_005249305
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LINAAKL 8
           ++NAAKL
Sbjct: 491 IVNAAKL 497



>XP_005249304
          Length = 610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LINAAKL 8
           ++NAAKL
Sbjct: 492 IVNAAKL 498



>XP_005247035
          Length = 971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLINAAKLD 9
           YLI+ +K D
Sbjct: 756 YLISGSKFD 764



>XP_006712939
          Length = 972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLINAAKLD 9
           YLI+ +K D
Sbjct: 756 YLISGSKFD 764



>XP_006712938
          Length = 1138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLINAAKLD 9
           YLI+ +K D
Sbjct: 756 YLISGSKFD 764



>XP_006712937
          Length = 1199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLINAAKLD 9
           YLI+ +K D
Sbjct: 756 YLISGSKFD 764



>XP_006712936
          Length = 1199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLINAAKLD 9
           YLI+ +K D
Sbjct: 756 YLISGSKFD 764



>XP_005247034
          Length = 1199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLINAAKLD 9
           YLI+ +K D
Sbjct: 756 YLISGSKFD 764



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.139    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 292,338
Number of extensions: 367
Number of successful extensions: 27
Number of sequences better than 10000.0: 27
Number of HSP's gapped: 27
Number of HSP's successfully gapped: 27
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)