Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              18    1135
XP_005248577                                                           18    1135
XP_005248576                                                           18    1135
NP_542407                                                              17    2528
NP_001028259                                                           17    2528
XP_006723607                                                           17    2528
XP_005260724                                                           17    2528
XP_006716197                                                           17    3301
XP_006716196                                                           17    3301
NP_036388                                                              17    3301
NP_775871                                                              17    4312
NP_002194                                                              16    5631
NP_001030014                                                           16    5631
NP_055461                                                              16    7355
NP_056467                                                              16    7355
NP_116319                                                              16    7355
XP_005260653                                                           16    7355
XP_005260652                                                           16    7355
XP_005260651                                                           16    7355
XP_005260650                                                           16    7355
XP_005260649                                                           16    7355
XP_005260648                                                           16    7355
XP_005260647                                                           16    7355
XP_005260646                                                           16    7355
XP_005260644                                                           16    7355
XP_005258236                                                           16    7355
XP_006722431                                                           16    7355
XP_005258235                                                           16    7355
XP_005258234                                                           16    7355
XP_005271770                                                           16    7355
XP_006717508                                                           16    7355
NP_003648                                                              16    7355
NP_071426                                                              16    7355
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_115518                                                              15    9605
NP_065914                                                              15    9605
NP_001167628                                                           15    9605
NP_001276323                                                           15    9605
NP_001025110                                                           15    9605
NP_001161055                                                           15    9605
NP_722576                                                              15    9605
XP_005262424                                                           15    9605
XP_006722395                                                           15    9605
XP_006722394                                                           15    9605
XP_005258167                                                           15    9605
XP_006722393                                                           15    9605
XP_006722392                                                           15    9605
XP_006722391                                                           15    9605
XP_006722390                                                           15    9605
XP_005258166                                                           15    9605
XP_006722389                                                           15    9605
XP_005258165                                                           15    9605
XP_005258164                                                           15    9605
XP_006716674                                                           15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
NP_001167629                                                           15    9605
>NP_005912
          Length = 1512

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YLETTEISS 9
           YLETTE SS
Sbjct: 893 YLETTENSS 901
>XP_005248577
          Length = 1349

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YLETTEISS 9
           YLETTE SS
Sbjct: 730 YLETTENSS 738
>XP_005248576
          Length = 1375

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YLETTEISS 9
           YLETTE SS
Sbjct: 756 YLETTENSS 764
>NP_542407
          Length = 425

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YLETTEISS 9
           Y+ET E+SS
Sbjct: 349 YMETEELSS 357
>NP_001028259
          Length = 213

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YLETTEISS 9
           Y+ET E+SS
Sbjct: 114 YMETEELSS 122
>XP_006723607
          Length = 447

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YLETTEISS 9
           Y+ET E+SS
Sbjct: 349 YMETEELSS 357
>XP_005260724
          Length = 448

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YLETTEISS 9
           Y+ET E+SS
Sbjct: 349 YMETEELSS 357
>XP_006716197
          Length = 500

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  YLETTEIS 8
          Y +TTEIS
Sbjct: 39 YFQTTEIS 46
>XP_006716196
          Length = 501

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  YLETTEIS 8
          Y +TTEIS
Sbjct: 39 YFQTTEIS 46
>NP_036388
          Length = 495

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  YLETTEIS 8
          Y +TTEIS
Sbjct: 33 YFQTTEIS 40
>NP_775871
          Length = 8384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LETTEISS 9
            LETTE+S+
Sbjct: 2924 LETTELSA 2931
>NP_002194
          Length = 1181

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ETTEISS 9
            ETTE+SS
Sbjct: 1175 ETTELSS 1181
>NP_001030014
          Length = 767

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   YLETTEISS 9
           +++TT++SS
Sbjct: 750 FIQTTDVSS 758
>NP_055461
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LETTEISS 9
           LE+T+ISS
Sbjct: 350 LESTQISS 357
>NP_056467
          Length = 1247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YLETTEISS 9
           +LETTE  S
Sbjct: 877 FLETTETRS 885
>NP_116319
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YLETTEI 7
           YLETT++
Sbjct: 190 YLETTKL 196
>XP_005260653
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  ETTEISS 9
          ETTEIS+
Sbjct: 65 ETTEISA 71
>XP_005260652
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  ETTEISS 9
          ETTEIS+
Sbjct: 65 ETTEISA 71
>XP_005260651
          Length = 551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  ETTEISS 9
          ETTEIS+
Sbjct: 65 ETTEISA 71
>XP_005260650
          Length = 570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  ETTEISS 9
          ETTEIS+
Sbjct: 65 ETTEISA 71
>XP_005260649
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  ETTEISS 9
          ETTEIS+
Sbjct: 26 ETTEISA 32
>XP_005260648
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  ETTEISS 9
          ETTEIS+
Sbjct: 65 ETTEISA 71
>XP_005260647
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  ETTEISS 9
          ETTEIS+
Sbjct: 65 ETTEISA 71
>XP_005260646
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  ETTEISS 9
          ETTEIS+
Sbjct: 65 ETTEISA 71
>XP_005260644
          Length = 629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  ETTEISS 9
          ETTEIS+
Sbjct: 65 ETTEISA 71
>XP_005258236
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LETTEISS 9
           LE+T+ISS
Sbjct: 350 LESTQISS 357
>XP_006722431
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LETTEISS 9
           LE+T+ISS
Sbjct: 350 LESTQISS 357
>XP_005258235
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LETTEISS 9
           LE+T+ISS
Sbjct: 350 LESTQISS 357
>XP_005258234
          Length = 933

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LETTEISS 9
           LE+T+ISS
Sbjct: 387 LESTQISS 394
>XP_005271770
          Length = 269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YLETTEI 7
           YLETT++
Sbjct: 190 YLETTKL 196
>XP_006717508
          Length = 259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTEISS 9
           + TTEISS
Sbjct: 152 IRTTEISS 159
>NP_003648
          Length = 584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  ETTEISS 9
          ETTEIS+
Sbjct: 65 ETTEISA 71
>NP_071426
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LETTEIS 8
           +ETTEIS
Sbjct: 459 VETTEIS 465
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2     LETTEISS 9
             +ETT ISS
Sbjct: 10074 IETTAISS 10081
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2     LETTEISS 9
             +ETT ISS
Sbjct: 10199 IETTAISS 10206
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2     LETTEISS 9
             +ETT ISS
Sbjct: 17498 IETTAISS 17505
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2     LETTEISS 9
             +ETT ISS
Sbjct: 16571 IETTAISS 16578
>NP_115518
          Length = 2537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLETTEIS 8
           YL+ TE+S
Sbjct: 784 YLKKTEVS 791
>NP_065914
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTEISS 9
           LETT +SS
Sbjct: 577 LETTVVSS 584
>NP_001167628
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTEISS 9
           LETT +SS
Sbjct: 515 LETTVVSS 522
>NP_001276323
          Length = 1231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTEISS 9
           LETT +SS
Sbjct: 565 LETTVVSS 572
>NP_001025110
          Length = 1231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTEISS 9
           LETT +SS
Sbjct: 565 LETTVVSS 572
>NP_001161055
          Length = 1231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTEISS 9
           LETT +SS
Sbjct: 565 LETTVVSS 572
>NP_722576
          Length = 3080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ETTEISS 9
            ETT+ISS
Sbjct: 1303 ETTKISS 1309
>XP_005262424
          Length = 2875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ETTEISS 9
            ETT+ISS
Sbjct: 1098 ETTKISS 1104
>XP_006722395
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLETTEIS 8
           YL+ TE+S
Sbjct: 784 YLKKTEVS 791
>XP_006722394
          Length = 1845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YLETTEIS 8
          YL+ TE+S
Sbjct: 91 YLKKTEVS 98
>XP_005258167
          Length = 1856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLETTEIS 8
           YL+ TE+S
Sbjct: 102 YLKKTEVS 109
>XP_006722393
          Length = 2199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLETTEIS 8
           YL+ TE+S
Sbjct: 445 YLKKTEVS 452
>XP_006722392
          Length = 2444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLETTEIS 8
           YL+ TE+S
Sbjct: 690 YLKKTEVS 697
>XP_006722391
          Length = 2448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLETTEIS 8
           YL+ TE+S
Sbjct: 694 YLKKTEVS 701
>XP_006722390
          Length = 2467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLETTEIS 8
           YL+ TE+S
Sbjct: 714 YLKKTEVS 721
>XP_005258166
          Length = 2468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLETTEIS 8
           YL+ TE+S
Sbjct: 714 YLKKTEVS 721
>XP_006722389
          Length = 2506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLETTEIS 8
           YL+ TE+S
Sbjct: 784 YLKKTEVS 791
>XP_005258165
          Length = 2534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLETTEIS 8
           YL+ TE+S
Sbjct: 780 YLKKTEVS 787
>XP_005258164
          Length = 2538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLETTEIS 8
           YL+ TE+S
Sbjct: 784 YLKKTEVS 791
>XP_006716674
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTEISS 9
           LETT +SS
Sbjct: 577 LETTVVSS 584
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LETTEISS 9
            +ETT ISS
Sbjct: 5811 IETTAISS 5818
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LETTEISS 9
            +ETT ISS
Sbjct: 7170 IETTAISS 7177
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2     LETTEISS 9
             +ETT ISS
Sbjct: 17126 IETTAISS 17133
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2     LETTEISS 9
             +ETT ISS
Sbjct: 18632 IETTAISS 18639
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2     LETTEISS 9
             +ETT ISS
Sbjct: 19139 IETTAISS 19146
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2     LETTEISS 9
             +ETT ISS
Sbjct: 10266 IETTAISS 10273
>NP_001167629
          Length = 1145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTEISS 9
           LETT +SS
Sbjct: 565 LETTVVSS 572
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.294    0.112    0.261 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 416,260
Number of extensions: 843
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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