Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              20     509
XP_006716142                                                           20     509
XP_005250088                                                           20     509
XP_006716141                                                           20     509
XP_005250085                                                           20     509
XP_006716140                                                           20     509
XP_005250084                                                           20     509
XP_005250083                                                           20     509
XP_005250082                                                           20     509
NP_001029031                                                           17    4312
NP_001257377                                                           17    4312
NP_000009                                                              17    4312
NP_001257376                                                           17    4312
XP_006721579                                                           17    4312
NP_001073893                                                           16    5631
XP_006721547                                                           16    5631
XP_005256611                                                           16    5631
XP_005256609                                                           16    5631
XP_005256607                                                           16    5631
XP_005256608                                                           16    5631
XP_006721546                                                           16    5631
XP_005256606                                                           16    5631
NP_000757                                                              16    7355
NP_000753                                                              16    7355
NP_001129977                                                           16    7355
NP_001009571                                                           16    7355
NP_060424                                                              16    7355
NP_001161412                                                           16    7355
NP_060547                                                              16    7355
NP_085079                                                              16    7355
NP_000755                                                              16    7355
XP_006721240                                                           16    7355
XP_005250765                                                           16    7355
XP_005250764                                                           16    7355
XP_005250763                                                           16    7355
XP_005250762                                                           16    7355
XP_005250761                                                           16    7355
XP_005250760                                                           16    7355
XP_005250759                                                           16    7355
XP_005250758                                                           16    7355
XP_005250757                                                           16    7355
XP_005250756                                                           16    7355
XP_005250755                                                           16    7355
XP_005250754                                                           16    7355
XP_005250753                                                           16    7355
XP_005250752                                                           16    7355
XP_006716105                                                           16    7355
NP_001159607                                                           16    7355
NP_005338                                                              15    9605
NP_001005191                                                           15    9605
NP_001034852                                                           15    9605
NP_001091873                                                           15    9605
NP_001091872                                                           15    9605
NP_065778                                                              15    9605
NP_004555                                                              15    9605
XP_005261180                                                           15    9605
XP_005261178                                                           15    9605
XP_006714733                                                           15    9605
XP_005263120                                                           15    9605
>NP_733751
          Length = 4911

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LAKSVDHS 9
            LAKSVDHS
Sbjct: 1452 LAKSVDHS 1459
>XP_006716142
          Length = 4927

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LAKSVDHS 9
            LAKSVDHS
Sbjct: 1453 LAKSVDHS 1460
>XP_005250088
          Length = 4928

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LAKSVDHS 9
            LAKSVDHS
Sbjct: 1453 LAKSVDHS 1460
>XP_006716141
          Length = 4959

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LAKSVDHS 9
            LAKSVDHS
Sbjct: 1453 LAKSVDHS 1460
>XP_005250085
          Length = 4979

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LAKSVDHS 9
            LAKSVDHS
Sbjct: 1453 LAKSVDHS 1460
>XP_006716140
          Length = 4982

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LAKSVDHS 9
            LAKSVDHS
Sbjct: 1453 LAKSVDHS 1460
>XP_005250084
          Length = 4982

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LAKSVDHS 9
            LAKSVDHS
Sbjct: 1453 LAKSVDHS 1460
>XP_005250083
          Length = 4982

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LAKSVDHS 9
            LAKSVDHS
Sbjct: 1452 LAKSVDHS 1459
>XP_005250082
          Length = 4983

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LAKSVDHS 9
            LAKSVDHS
Sbjct: 1453 LAKSVDHS 1460
>NP_001029031
          Length = 633

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAKSVDHS 9
           +AK+VDH+
Sbjct: 334 IAKAVDHA 341
>NP_001257377
          Length = 579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAKSVDHS 9
           +AK+VDH+
Sbjct: 280 IAKAVDHA 287
>NP_000009
          Length = 655

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAKSVDHS 9
           +AK+VDH+
Sbjct: 356 IAKAVDHA 363
>NP_001257376
          Length = 678

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAKSVDHS 9
           +AK+VDH+
Sbjct: 379 IAKAVDHA 386
>XP_006721579
          Length = 708

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAKSVDHS 9
           +AK+VDH+
Sbjct: 402 IAKAVDHA 409
>NP_001073893
          Length = 1682

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YLAKSVD 7
           YLA+S+D
Sbjct: 576 YLARSID 582
>XP_006721547
          Length = 1638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YLAKSVD 7
           YLA+S+D
Sbjct: 576 YLARSID 582
>XP_005256611
          Length = 1643

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YLAKSVD 7
           YLA+S+D
Sbjct: 576 YLARSID 582
>XP_005256609
          Length = 1682

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YLAKSVD 7
           YLA+S+D
Sbjct: 576 YLARSID 582
>XP_005256607
          Length = 1682

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YLAKSVD 7
           YLA+S+D
Sbjct: 576 YLARSID 582
>XP_005256608
          Length = 1682

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YLAKSVD 7
           YLA+S+D
Sbjct: 576 YLARSID 582
>XP_006721546
          Length = 1682

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YLAKSVD 7
           YLA+S+D
Sbjct: 576 YLARSID 582
>XP_005256606
          Length = 1682

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YLAKSVD 7
           YLA+S+D
Sbjct: 576 YLARSID 582
>NP_000757
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           ++AK V+H+
Sbjct: 247 FIAKKVEHN 255
>NP_000753
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           ++AK V+H+
Sbjct: 247 FIAKKVEHN 255
>NP_001129977
          Length = 727

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LAKSVDHS 9
          LAKS +HS
Sbjct: 66 LAKSSEHS 73
>NP_001009571
          Length = 1255

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 692 YLAELMEHS 700
>NP_060424
          Length = 1296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 695 YLAELMEHS 703
>NP_001161412
          Length = 1300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 695 YLAELMEHS 703
>NP_060547
          Length = 759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AKSVDHS 9
           AKS DHS
Sbjct: 278 AKSSDHS 284
>NP_085079
          Length = 443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           ++AK V+H+
Sbjct: 196 FIAKKVEHN 204
>NP_000755
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           ++AK V+H+
Sbjct: 247 FIAKKVEHN 255
>XP_006721240
          Length = 727

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LAKSVDHS 9
          LAKS +HS
Sbjct: 66 LAKSSEHS 73
>XP_005250765
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 692 YLAELMEHS 700
>XP_005250764
          Length = 1258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 695 YLAELMEHS 703
>XP_005250763
          Length = 1260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 692 YLAELMEHS 700
>XP_005250762
          Length = 1260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 695 YLAELMEHS 703
>XP_005250761
          Length = 1265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 695 YLAELMEHS 703
>XP_005250760
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 695 YLAELMEHS 703
>XP_005250759
          Length = 1293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 692 YLAELMEHS 700
>XP_005250758
          Length = 1298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 695 YLAELMEHS 703
>XP_005250757
          Length = 1300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 692 YLAELMEHS 700
>XP_005250756
          Length = 1301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 695 YLAELMEHS 703
>XP_005250755
          Length = 1303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 695 YLAELMEHS 703
>XP_005250754
          Length = 1305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 692 YLAELMEHS 700
>XP_005250753
          Length = 1305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 695 YLAELMEHS 703
>XP_005250752
          Length = 1308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLAKSVDHS 9
           YLA+ ++HS
Sbjct: 695 YLAELMEHS 703
>XP_006716105
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AKSVDHS 9
           AKS DHS
Sbjct: 278 AKSSDHS 284
>NP_001159607
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AKSVDHS 9
           AKS DHS
Sbjct: 137 AKSSDHS 143
>NP_005338
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YLAKSVDHS 9
           YL K V H+
Sbjct: 160 YLGKKVTHA 168
>NP_001005191
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YLAKSVDHS 9
           YL+ +V HS
Sbjct: 259 YLSSAVTHS 267
>NP_001034852
          Length = 657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LAKSVDH 8
           LAK +DH
Sbjct: 592 LAKIIDH 598
>NP_001091873
          Length = 865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AKSVDHS 9
           AKS++HS
Sbjct: 217 AKSLEHS 223
>NP_001091872
          Length = 1066

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AKSVDHS 9
           AKS++HS
Sbjct: 217 AKSLEHS 223
>NP_065778
          Length = 1066

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AKSVDHS 9
           AKS++HS
Sbjct: 217 AKSLEHS 223
>NP_004555
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YLAKSVDH 8
           +LAK++D+
Sbjct: 287 FLAKAIDY 294
>XP_005261180
          Length = 865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AKSVDHS 9
           AKS++HS
Sbjct: 217 AKSLEHS 223
>XP_005261178
          Length = 1066

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AKSVDHS 9
           AKS++HS
Sbjct: 217 AKSLEHS 223
>XP_006714733
          Length = 657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LAKSVDH 8
           LAK +DH
Sbjct: 592 LAKIIDH 598
>XP_005263120
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YLAKSVDH 8
           +LAK++D+
Sbjct: 287 FLAKAIDY 294
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.121    0.334 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 433,854
Number of extensions: 597
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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