Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001261                                                              19     665
XP_005271924                                                           19     665
XP_005271923                                                           19     665
NP_078951                                                              17    2528
NP_689655                                                              17    2528
NP_001273460                                                           17    2528
NP_065768                                                              17    2528
NP_001273464                                                           17    2528
NP_001273461                                                           17    2528
XP_006724654                                                           17    2528
XP_006724653                                                           17    2528
NP_789744                                                              17    3301
NP_036459                                                              17    3301
NP_001059                                                              17    3301
XP_005265484                                                           17    3301
NP_009049                                                              17    4312
XP_006714558                                                           17    4312
XP_005273127                                                           17    4312
NP_775779                                                              17    4312
NP_004704                                                              16    5631
XP_005268258                                                           16    5631
XP_005268257                                                           16    5631
XP_005268256                                                           16    5631
NP_001005490                                                           16    7355
NP_001127845                                                           16    7355
NP_036361                                                              16    7355
NP_001159734                                                           16    7355
NP_690876                                                              16    7355
NP_001159733                                                           16    7355
NP_001159735                                                           16    7355
XP_006719836                                                           16    7355
XP_006719835                                                           16    7355
XP_006719834                                                           16    7355
XP_005266340                                                           16    7355
XP_005269693                                                           16    7355
XP_005269692                                                           16    7355
XP_005269691                                                           16    7355
XP_005269690                                                           16    7355
XP_005269689                                                           16    7355
NP_005111                                                              15    9605
NP_940820                                                              15    9605
NP_060626                                                              15    9605
NP_001028776                                                           15    9605
NP_056193                                                              15    9605
NP_001028777                                                           15    9605
NP_055266                                                              15    9605
NP_997244                                                              15    9605
NP_001189404                                                           15    9605
NP_001874                                                              15    9605
NP_001189411                                                           15    9605
NP_001186713                                                           15    9605
NP_536737                                                              15    9605
NP_056500                                                              15    9605
NP_001189410                                                           15    9605
NP_663630                                                              15    9605
NP_002355                                                              15    9605
XP_005262376                                                           15    9605
XP_005262374                                                           15    9605
XP_005249758                                                           15    9605
XP_006715751                                                           15    9605
XP_005249757                                                           15    9605
XP_006715750                                                           15    9605
XP_006715714                                                           15    9605
XP_005247024                                                           15    9605
XP_005247023                                                           15    9605
NP_004783                                                              15    9605
>NP_001261
          Length = 1710

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    YKHAIKK 7
            YKHAIKK
Sbjct: 1497 YKHAIKK 1503
>XP_005271924
          Length = 1710

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    YKHAIKK 7
            YKHAIKK
Sbjct: 1497 YKHAIKK 1503
>XP_005271923
          Length = 1798

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    YKHAIKK 7
            YKHAIKK
Sbjct: 1585 YKHAIKK 1591
>NP_078951
          Length = 1186

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  KHAIKKT 8
          KH+IKKT
Sbjct: 45 KHSIKKT 51
>NP_689655
          Length = 429

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKHAIKKT 8
           Y+H IK+T
Sbjct: 127 YRHGIKRT 134
>NP_001273460
          Length = 345

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YKHAIKKT 8
          Y+H IK+T
Sbjct: 55 YRHGIKRT 62
>NP_065768
          Length = 1493

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    YKHAIKKT 8
            +KHA+KK+
Sbjct: 1027 FKHALKKS 1034
>NP_001273464
          Length = 417

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKHAIKKT 8
           Y+H IK+T
Sbjct: 127 YRHGIKRT 134
>NP_001273461
          Length = 345

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YKHAIKKT 8
          Y+H IK+T
Sbjct: 55 YRHGIKRT 62
>XP_006724654
          Length = 1335

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YKHAIKKT 8
           +KHA+KK+
Sbjct: 869 FKHALKKS 876
>XP_006724653
          Length = 1377

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YKHAIKKT 8
           +KHA+KK+
Sbjct: 911 FKHALKKS 918
>NP_789744
          Length = 931

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YKHAIKK 7
           YKH IKK
Sbjct: 227 YKHNIKK 233
>NP_036459
          Length = 931

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YKHAIKK 7
           YKH IKK
Sbjct: 227 YKHNIKK 233
>NP_001059
          Length = 1621

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKHAIKKT 8
           YKH+ K+T
Sbjct: 202 YKHSFKQT 209
>XP_005265484
          Length = 1626

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKHAIKKT 8
           YKH+ K+T
Sbjct: 207 YKHSFKQT 214
>NP_009049
          Length = 3097

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YKHAIKKT 8
           ++HAI+KT
Sbjct: 953 FQHAIEKT 960
>XP_006714558
          Length = 2612

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YKHAIKKT 8
           ++HAI+KT
Sbjct: 468 FQHAIEKT 475
>XP_005273127
          Length = 421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YKHAIKK 7
           Y HAIKK
Sbjct: 168 YLHAIKK 174
>NP_775779
          Length = 490

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YKHAIKK 7
           Y HAIKK
Sbjct: 237 YLHAIKK 243
>NP_004704
          Length = 1076

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YKHAIKKTA 9
           Y H + KTA
Sbjct: 616 YHHQVSKTA 624
>XP_005268258
          Length = 847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YKHAIKKTA 9
           Y H + KTA
Sbjct: 387 YHHQVSKTA 395
>XP_005268257
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YKHAIKKTA 9
           Y H + KTA
Sbjct: 402 YHHQVSKTA 410
>XP_005268256
          Length = 1055

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YKHAIKKTA 9
           Y H + KTA
Sbjct: 595 YHHQVSKTA 603
>NP_001005490
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YKHAIKK 7
           +KH +KK
Sbjct: 299 FKHTVKK 305
>NP_001127845
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  KHAIKK 7
          KHA+KK
Sbjct: 21 KHALKK 26
>NP_036361
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  KHAIKK 7
          KHA+KK
Sbjct: 21 KHALKK 26
>NP_001159734
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KHAIKKTA 9
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>NP_690876
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KHAIKKTA 9
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>NP_001159733
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KHAIKKTA 9
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>NP_001159735
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KHAIKKTA 9
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>XP_006719836
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KHAIKKTA 9
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>XP_006719835
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KHAIKKTA 9
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>XP_006719834
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KHAIKKTA 9
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>XP_005266340
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KHAIKKTA 9
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>XP_005269693
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  KHAIKK 7
          KHA+KK
Sbjct: 21 KHALKK 26
>XP_005269692
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  KHAIKK 7
          KHA+KK
Sbjct: 21 KHALKK 26
>XP_005269691
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  KHAIKK 7
          KHA+KK
Sbjct: 21 KHALKK 26
>XP_005269690
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  KHAIKK 7
          KHA+KK
Sbjct: 21 KHALKK 26
>XP_005269689
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  KHAIKK 7
          KHA+KK
Sbjct: 21 KHALKK 26
>NP_005111
          Length = 2177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KHAIKK 7
           +HAIKK
Sbjct: 768 RHAIKK 773
>NP_940820
          Length = 887

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YKHAIKKTA 9
           Y+H +++TA
Sbjct: 127 YEHNLQRTA 135
>NP_060626
          Length = 4363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    KHAIKKT 8
            KH+++KT
Sbjct: 2085 KHSLRKT 2091
>NP_001028776
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YKHAIKKTA 9
           Y+H +++TA
Sbjct: 127 YEHNLQRTA 135
>NP_056193
          Length = 4388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    KHAIKKT 8
            KH+++KT
Sbjct: 2085 KHSLRKT 2091
>NP_001028777
          Length = 882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YKHAIKKTA 9
           Y+H +++TA
Sbjct: 127 YEHNLQRTA 135
>NP_055266
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YKHAIKKTA 9
           Y+H +++TA
Sbjct: 127 YEHNLQRTA 135
>NP_997244
          Length = 3169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    KHAIKKT 8
            KH+++KT
Sbjct: 1285 KHSVEKT 1291
>NP_001189404
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HAIKKTA 9
           H+IK+TA
Sbjct: 430 HSIKQTA 436
>NP_001874
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HAIKKTA 9
           H+IK+TA
Sbjct: 403 HSIKQTA 409
>NP_001189411
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HAIKKTA 9
           H+IK+TA
Sbjct: 402 HSIKQTA 408
>NP_001186713
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YKHAIKK 7
           Y+H +KK
Sbjct: 269 YEHMVKK 275
>NP_536737
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YKHAIKK 7
           Y+H +KK
Sbjct: 269 YEHMVKK 275
>NP_056500
          Length = 207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YKHAIKK 7
           Y+H +KK
Sbjct: 184 YEHMVKK 190
>NP_001189410
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HAIKKTA 9
           H+IK+TA
Sbjct: 389 HSIKQTA 395
>NP_663630
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HAIKKT 8
           HAIK+T
Sbjct: 224 HAIKRT 229
>NP_002355
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKHAIKKT 8
           YK+ IKK+
Sbjct: 124 YKYKIKKS 131
>XP_005262376
          Length = 2155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KHAIKK 7
           +HAIKK
Sbjct: 768 RHAIKK 773
>XP_005262374
          Length = 2180

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KHAIKK 7
           +HAIKK
Sbjct: 768 RHAIKK 773
>XP_005249758
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YKHAIKKTA 9
           Y+H +++TA
Sbjct: 127 YEHNLQRTA 135
>XP_006715751
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YKHAIKKTA 9
          Y+H +++TA
Sbjct: 36 YEHNLQRTA 44
>XP_005249757
          Length = 886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YKHAIKKTA 9
           Y+H +++TA
Sbjct: 127 YEHNLQRTA 135
>XP_006715750
          Length = 887

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YKHAIKKTA 9
           Y+H +++TA
Sbjct: 127 YEHNLQRTA 135
>XP_006715714
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HAIKKTA 9
           H+IK+TA
Sbjct: 403 HSIKQTA 409
>XP_005247024
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YKHAIKKTA 9
           YK+ +KK A
Sbjct: 448 YKNKVKKRA 456
>XP_005247023
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YKHAIKKTA 9
           YK+ +KK A
Sbjct: 448 YKNKVKKRA 456
>NP_004783
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YKHAIKKTA 9
           YK+ +KK A
Sbjct: 448 YKNKVKKRA 456
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.121    0.338 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 563,135
Number of extensions: 1150
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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