Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           21     175
NP_000170                                                              21     175
NP_001268422                                                           21     175
NP_001268423                                                           21     175
XP_005264328                                                           21     175
NP_009138                                                              19     869
NP_057480                                                              18    1482
XP_006720629                                                           18    1482
XP_005254498                                                           18    1482
XP_006720628                                                           18    1482
NP_000688                                                              18    1935
NP_001131                                                              18    1935
XP_006721560                                                           18    1935
XP_006721559                                                           18    1935
XP_005256645                                                           18    1935
NP_060718                                                              17    2528
NP_001136438                                                           17    3301
XP_006722611                                                           17    3301
XP_006722610                                                           17    3301
NP_005392                                                              17    4312
NP_060405                                                              17    4312
NP_001077376                                                           17    4312
NP_001120979                                                           17    4312
NP_008986                                                              16    5631
NP_057336                                                              16    5631
NP_705838                                                              16    5631
NP_060113                                                              16    5631
XP_006722025                                                           16    5631
XP_005257527                                                           16    5631
XP_005257526                                                           16    5631
XP_005257525                                                           16    5631
XP_005257524                                                           16    5631
XP_006717660                                                           16    5631
XP_006712120                                                           16    5631
XP_005264512                                                           16    5631
XP_005264511                                                           16    5631
XP_006712119                                                           16    5631
XP_005264510                                                           16    5631
XP_006712118                                                           16    5631
XP_005264509                                                           16    5631
XP_005264508                                                           16    5631
XP_006712117                                                           16    5631
XP_005264507                                                           16    5631
XP_005264506                                                           16    5631
NP_001138389                                                           16    7355
NP_001138386                                                           16    7355
NP_000132                                                              16    7355
NP_075259                                                              16    7355
NP_001138385                                                           16    7355
NP_001229725                                                           16    7355
NP_001229724                                                           16    7355
NP_055120                                                              16    7355
NP_006775                                                              16    7355
NP_055484                                                              16    7355
XP_005256320                                                           16    7355
XP_006717776                                                           16    7355
XP_006717773                                                           16    7355
XP_006717772                                                           16    7355
XP_006717771                                                           16    7355
NP_001139241                                                           15    9605
NP_004619                                                              15    9605
NP_000341                                                              15    9605
NP_001269550                                                           15    9605
NP_006658                                                              15    9605
NP_996847                                                              15    9605
NP_478066                                                              15    9605
NP_001122400                                                           15    9605
NP_001144                                                              15    9605
XP_006724087                                                           15    9605
XP_005246589                                                           15    9605
XP_006712561                                                           15    9605
XP_006712063                                                           15    9605
XP_003960979                                                           15    9605
NP_002185                                                              15    9605
>NP_001268421
          Length = 1230

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YKFIKGASP 9
            YKFIKGA P
Sbjct: 1157 YKFIKGACP 1165
>NP_000170
          Length = 1360

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YKFIKGASP 9
            YKFIKGA P
Sbjct: 1287 YKFIKGACP 1295
>NP_001268422
          Length = 1058

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YKFIKGASP 9
           YKFIKGA P
Sbjct: 985 YKFIKGACP 993
>NP_001268423
          Length = 1058

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YKFIKGASP 9
           YKFIKGA P
Sbjct: 985 YKFIKGACP 993
>XP_005264328
          Length = 1261

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YKFIKGASP 9
            YKFIKGA P
Sbjct: 1188 YKFIKGACP 1196
>NP_009138
          Length = 482

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YKFIKGASP 9
           YKF+KG  P
Sbjct: 435 YKFVKGKRP 443
>NP_057480
          Length = 466

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KFIKGASP 9
          KFIKG++P
Sbjct: 54 KFIKGSTP 61
>XP_006720629
          Length = 342

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KFIKGASP 9
          KFIKG++P
Sbjct: 54 KFIKGSTP 61
>XP_005254498
          Length = 466

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KFIKGASP 9
          KFIKG++P
Sbjct: 54 KFIKGSTP 61
>XP_006720628
          Length = 466

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KFIKGASP 9
          KFIKG++P
Sbjct: 54 KFIKGSTP 61
>NP_000688
          Length = 663

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YKFIKGASP 9
           Y+F+ GA+P
Sbjct: 230 YQFLNGANP 238
>NP_001131
          Length = 662

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YKFIKGASP 9
           Y+F+ GA+P
Sbjct: 230 YQFLNGANP 238
>XP_006721560
          Length = 479

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  YKFIKGASP 9
          Y+F+ GA+P
Sbjct: 46 YQFLNGANP 54
>XP_006721559
          Length = 500

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  YKFIKGASP 9
          Y+F+ GA+P
Sbjct: 67 YQFLNGANP 75
>XP_005256645
          Length = 541

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YKFIKGASP 9
           Y+F+ GA+P
Sbjct: 108 YQFLNGANP 116
>NP_060718
          Length = 605

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YKFIKGASP 9
           YK+  GASP
Sbjct: 109 YKYKNGASP 117
>NP_001136438
          Length = 1923

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    YKFIKGAS 8
            +KF+KGA+
Sbjct: 1865 FKFLKGAT 1872
>XP_006722611
          Length = 1034

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YKFIKGAS 8
           +KF+KGA+
Sbjct: 976 FKFLKGAT 983
>XP_006722610
          Length = 1967

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    YKFIKGAS 8
            +KF+KGA+
Sbjct: 1909 FKFLKGAT 1916
>NP_005392
          Length = 1187

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YKFIKGASP 9
           +K++ G+SP
Sbjct: 587 HKYVSGSSP 595
>NP_060405
          Length = 785

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YKFIKGASP 9
           Y FI GA P
Sbjct: 488 YVFIPGADP 496
>NP_001077376
          Length = 755

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YKFIKGASP 9
           Y FI GA P
Sbjct: 458 YVFIPGADP 466
>NP_001120979
          Length = 652

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YKFIKGASP 9
           Y FI GA P
Sbjct: 355 YVFIPGADP 363
>NP_008986
          Length = 1390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   KFIKGAS 8
           KFIKG S
Sbjct: 971 KFIKGVS 977
>NP_057336
          Length = 4857

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            KF+ G SP
Sbjct: 2764 KFLSGTSP 2771
>NP_705838
          Length = 4069

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    IKGASP 9
            IKGASP
Sbjct: 1421 IKGASP 1426
>NP_060113
          Length = 628

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKFIKGAS 8
           Y F++GAS
Sbjct: 605 YNFLQGAS 612
>XP_006722025
          Length = 464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKFIKGAS 8
           Y F++GAS
Sbjct: 441 YNFLQGAS 448
>XP_005257527
          Length = 628

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKFIKGAS 8
           Y F++GAS
Sbjct: 605 YNFLQGAS 612
>XP_005257526
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKFIKGAS 8
           Y F++GAS
Sbjct: 607 YNFLQGAS 614
>XP_005257525
          Length = 651

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKFIKGAS 8
           Y F++GAS
Sbjct: 628 YNFLQGAS 635
>XP_005257524
          Length = 653

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKFIKGAS 8
           Y F++GAS
Sbjct: 630 YNFLQGAS 637
>XP_006717660
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   KFIKGAS 8
           KFIKG S
Sbjct: 950 KFIKGVS 956
>XP_006712120
          Length = 4812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            KF+ G SP
Sbjct: 2719 KFLSGTSP 2726
>XP_005264512
          Length = 4840

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            KF+ G SP
Sbjct: 2747 KFLSGTSP 2754
>XP_005264511
          Length = 4847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            KF+ G SP
Sbjct: 2791 KFLSGTSP 2798
>XP_006712119
          Length = 4851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            KF+ G SP
Sbjct: 2758 KFLSGTSP 2765
>XP_005264510
          Length = 4861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            KF+ G SP
Sbjct: 2768 KFLSGTSP 2775
>XP_006712118
          Length = 4864

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            KF+ G SP
Sbjct: 2791 KFLSGTSP 2798
>XP_005264509
          Length = 4870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            KF+ G SP
Sbjct: 2777 KFLSGTSP 2784
>XP_005264508
          Length = 4875

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            KF+ G SP
Sbjct: 2782 KFLSGTSP 2789
>XP_006712117
          Length = 4878

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            KF+ G SP
Sbjct: 2785 KFLSGTSP 2792
>XP_005264507
          Length = 4880

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            KF+ G SP
Sbjct: 2787 KFLSGTSP 2794
>XP_005264506
          Length = 4884

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            KF+ G SP
Sbjct: 2791 KFLSGTSP 2798
>NP_001138389
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YKFIKGASP 9
          Y  IKGA+P
Sbjct: 91 YLQIKGATP 99
>NP_001138386
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YKFIKGASP 9
          Y  IKGA+P
Sbjct: 91 YLQIKGATP 99
>NP_000132
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YKFIKGASP 9
          Y  IKGA+P
Sbjct: 91 YLQIKGATP 99
>NP_075259
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YKFIKGASP 9
          Y  IKGA+P
Sbjct: 91 YLQIKGATP 99
>NP_001138385
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YKFIKGASP 9
          Y  IKGA+P
Sbjct: 91 YLQIKGATP 99
>NP_001229725
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YKFIKGASP 9
           +K +KG SP
Sbjct: 637 FKRLKGTSP 645
>NP_001229724
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YKFIKGASP 9
           +K +KG SP
Sbjct: 637 FKRLKGTSP 645
>NP_055120
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  YKFIKG 6
          YKFI+G
Sbjct: 70 YKFIQG 75
>NP_006775
          Length = 943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KFIKGASP 9
           K IKG+SP
Sbjct: 235 KKIKGSSP 242
>NP_055484
          Length = 819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YKFIKGASP 9
           +K +KG SP
Sbjct: 760 FKRLKGTSP 768
>XP_005256320
          Length = 819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YKFIKGASP 9
           +K +KG SP
Sbjct: 760 FKRLKGTSP 768
>XP_006717776
          Length = 806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YKFIKGASP 9
           Y  IKGA+P
Sbjct: 110 YLQIKGATP 118
>XP_006717773
          Length = 807

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YKFIKGASP 9
           Y  IKGA+P
Sbjct: 110 YLQIKGATP 118
>XP_006717772
          Length = 838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YKFIKGASP 9
           Y  IKGA+P
Sbjct: 110 YLQIKGATP 118
>XP_006717771
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YKFIKGASP 9
           Y  IKGA+P
Sbjct: 110 YLQIKGATP 118
>NP_001139241
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKFIKGAS 8
           YK +KG S
Sbjct: 667 YKMVKGFS 674
>NP_004619
          Length = 940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKFIKGAS 8
           YK +KG S
Sbjct: 704 YKMVKGFS 711
>NP_000341
          Length = 2273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KFIKGASP 9
            +FI G SP
Sbjct: 1713 QFISGVSP 1720
>NP_001269550
          Length = 143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  YKFIKGASP 9
          YK ++G  P
Sbjct: 43 YKIVRGDQP 51
>NP_006658
          Length = 195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  YKFIKGASP 9
          YK ++G  P
Sbjct: 43 YKIVRGDQP 51
>NP_996847
          Length = 187

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KFIKGASP 9
          KFI+ A+P
Sbjct: 92 KFIQSAAP 99
>NP_478066
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KFIKGASP 9
           KFI+ A+P
Sbjct: 140 KFIQSAAP 147
>NP_001122400
          Length = 399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YKFIKGAS 8
           Y++IKG++
Sbjct: 159 YQYIKGSA 166
>NP_001144
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YKFIKG 6
           Y FIKG
Sbjct: 298 YSFIKG 303
>XP_006724087
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KFIKGASP 9
           KFI+ A+P
Sbjct: 139 KFIQSAAP 146
>XP_005246589
          Length = 399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YKFIKGAS 8
           Y++IKG++
Sbjct: 159 YQYIKGSA 166
>XP_006712561
          Length = 399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YKFIKGAS 8
           Y++IKG++
Sbjct: 159 YQYIKGSA 166
>XP_006712063
          Length = 173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YKFIKG 6
           Y FIKG
Sbjct: 150 YSFIKG 155
>XP_003960979
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FIKGASP 9
           F+K ASP
Sbjct: 232 FLKSASP 238
>NP_002185
          Length = 399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YKFIKGAS 8
           Y++IKG++
Sbjct: 159 YQYIKGSA 166
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.141    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 602,183
Number of extensions: 963
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package