Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              22     134
XP_006714104                                                           22     134
XP_005265800                                                           22     134
XP_006714103                                                           22     134
XP_006714102                                                           22     134
NP_722520                                                              18    1935
NP_001171616                                                           17    4312
NP_001171617                                                           17    4312
NP_001158146                                                           17    4312
NP_877437                                                              17    4312
NP_001158147                                                           17    4312
NP_849144                                                              17    4312
XP_006713663                                                           17    4312
XP_006713660                                                           17    4312
XP_005247434                                                           17    4312
XP_006713659                                                           17    4312
NP_055872                                                              16    5631
NP_003787                                                              16    5631
NP_001239570                                                           16    5631
XP_005259420                                                           16    5631
XP_005259419                                                           16    5631
XP_006719852                                                           16    5631
XP_005266357                                                           16    5631
XP_006719851                                                           16    5631
XP_006719850                                                           16    5631
XP_006719849                                                           16    5631
XP_006719848                                                           16    5631
XP_005266356                                                           16    5631
XP_006719847                                                           16    5631
XP_006719846                                                           16    5631
XP_006719845                                                           16    5631
XP_006719844                                                           16    5631
XP_006719843                                                           16    5631
XP_006719842                                                           16    5631
XP_006714837                                                           16    7355
NP_001166902                                                           15    9605
NP_056126                                                              15    9605
NP_001166879                                                           15    9605
NP_060396                                                              15    9605
NP_056243                                                              15    9605
NP_001006657                                                           15    9605
NP_060442                                                              15    9605
XP_006720255                                                           15    9605
XP_006720254                                                           15    9605
XP_005246484                                                           15    9605
XP_005246482                                                           15    9605
XP_005246481                                                           15    9605
XP_006712450                                                           15    9605
XP_005246480                                                           15    9605
XP_006712449                                                           15    9605
XP_005246478                                                           15    9605
>NP_006197
          Length = 1089

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YKCAARQAT 9
           Y+CAARQAT
Sbjct: 288 YECAARQAT 296
>XP_006714104
          Length = 832

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YKCAARQAT 9
           Y+CAARQAT
Sbjct: 313 YECAARQAT 321
>XP_005265800
          Length = 1089

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YKCAARQAT 9
           Y+CAARQAT
Sbjct: 288 YECAARQAT 296
>XP_006714103
          Length = 1111

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YKCAARQAT 9
           Y+CAARQAT
Sbjct: 310 YECAARQAT 318
>XP_006714102
          Length = 1114

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YKCAARQAT 9
           Y+CAARQAT
Sbjct: 313 YECAARQAT 321
>NP_722520
          Length = 1006

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YKCAARQAT 9
           Y CA+RQ T
Sbjct: 262 YYCASRQGT 270
>NP_001171616
          Length = 650

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YKCAAR 6
           Y+CAAR
Sbjct: 436 YRCAAR 441
>NP_001171617
          Length = 602

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YKCAAR 6
           Y+CAAR
Sbjct: 388 YRCAAR 393
>NP_001158146
          Length = 349

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YKCAAR 6
           Y+CAAR
Sbjct: 319 YRCAAR 324
>NP_877437
          Length = 374

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YKCAAR 6
           Y+CAAR
Sbjct: 344 YRCAAR 349
>NP_001158147
          Length = 354

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YKCAAR 6
           Y+CAAR
Sbjct: 324 YRCAAR 329
>NP_849144
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YKCAAR 6
            Y+CAAR
Sbjct: 2409 YRCAAR 2414
>XP_006713663
          Length = 602

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YKCAAR 6
           Y+CAAR
Sbjct: 388 YRCAAR 393
>XP_006713660
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YKCAAR 6
            Y+CAAR
Sbjct: 2409 YRCAAR 2414
>XP_005247434
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YKCAAR 6
            Y+CAAR
Sbjct: 2409 YRCAAR 2414
>XP_006713659
          Length = 2695

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YKCAAR 6
            Y+CAAR
Sbjct: 2481 YRCAAR 2486
>NP_055872
          Length = 4678

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>NP_003787
          Length = 535

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KCAARQA 8
           KC+A+QA
Sbjct: 107 KCSAKQA 113
>NP_001239570
          Length = 475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  KCAARQA 8
          KC+A+QA
Sbjct: 89 KCSAKQA 95
>XP_005259420
          Length = 493

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KCAARQA 8
           KC+A+QA
Sbjct: 107 KCSAKQA 113
>XP_005259419
          Length = 517

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  KCAARQA 8
          KC+A+QA
Sbjct: 89 KCSAKQA 95
>XP_006719852
          Length = 4752

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>XP_005266357
          Length = 4600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>XP_006719851
          Length = 4689

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>XP_006719850
          Length = 4697

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>XP_006719849
          Length = 4703

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>XP_006719848
          Length = 4737

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>XP_005266356
          Length = 4755

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>XP_006719847
          Length = 4761

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1271 YDCAARE 1277
>XP_006719846
          Length = 4763

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>XP_006719845
          Length = 4772

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>XP_006719844
          Length = 4789

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>XP_006719843
          Length = 4794

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>XP_006719842
          Length = 4797

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YKCAARQ 7
            Y CAAR+
Sbjct: 1307 YDCAARE 1313
>XP_006714837
          Length = 628

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KCAARQAT 9
           KC+  QAT
Sbjct: 600 KCSCNQAT 607
>NP_001166902
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKCAARQA 8
           Y CAAR +
Sbjct: 317 YVCAARNS 324
>NP_056126
          Length = 1896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKCAARQA 8
           Y CAAR +
Sbjct: 317 YVCAARNS 324
>NP_001166879
          Length = 1025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKCAARQA 8
           Y CAAR +
Sbjct: 317 YVCAARNS 324
>NP_060396
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CAARQA 8
           C+ARQA
Sbjct: 395 CSARQA 400
>NP_056243
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YKCAARQAT 9
           Y+C+  QAT
Sbjct: 347 YECSKCQAT 355
>NP_001006657
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YKCAARQAT 9
           Y+C+  QAT
Sbjct: 347 YECSKCQAT 355
>NP_060442
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CAARQA 8
           C+ARQA
Sbjct: 390 CSARQA 395
>XP_006720255
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CAARQA 8
           C+ARQA
Sbjct: 395 CSARQA 400
>XP_006720254
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CAARQA 8
           C+ARQA
Sbjct: 390 CSARQA 395
>XP_005246484
          Length = 1359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKCAARQA 8
           Y CAAR +
Sbjct: 317 YVCAARNS 324
>XP_005246482
          Length = 1724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKCAARQA 8
           Y CAAR +
Sbjct: 317 YVCAARNS 324
>XP_005246481
          Length = 1804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKCAARQA 8
           Y CAAR +
Sbjct: 317 YVCAARNS 324
>XP_006712450
          Length = 1816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKCAARQA 8
           Y CAAR +
Sbjct: 317 YVCAARNS 324
>XP_005246480
          Length = 1816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKCAARQA 8
           Y CAAR +
Sbjct: 317 YVCAARNS 324
>XP_006712449
          Length = 1908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKCAARQA 8
           Y CAAR +
Sbjct: 317 YVCAARNS 324
>XP_005246478
          Length = 1908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKCAARQA 8
           Y CAAR +
Sbjct: 317 YVCAARNS 324
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.118    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 527,077
Number of extensions: 403
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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