Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              20     299
NP_002600                                                              20     299
XP_005268521                                                           20     299
XP_006714104                                                           20     299
XP_005265800                                                           20     299
XP_006714103                                                           20     299
XP_006714102                                                           20     299
NP_877439                                                              18    1935
NP_694999                                                              17    2528
NP_689829                                                              17    3301
NP_001258941                                                           17    3301
NP_060661                                                              17    3301
NP_203755                                                              17    3301
NP_001258942                                                           17    3301
XP_006719906                                                           17    3301
XP_005266498                                                           17    3301
XP_005270314                                                           17    3301
XP_006713671                                                           17    3301
NP_008864                                                              16    7355
NP_000334                                                              16    7355
NP_001243243                                                           16    7355
NP_037423                                                              16    7355
NP_055042                                                              16    7355
XP_006724371                                                           16    7355
XP_006716613                                                           16    7355
XP_006716612                                                           16    7355
XP_006716611                                                           16    7355
NP_056289                                                              15    9605
NP_149091                                                              15    9605
NP_001269378                                                           15    9605
NP_001165442                                                           15    9605
NP_056646                                                              15    9605
NP_000656                                                              15    9605
NP_001452                                                              15    9605
XP_005260441                                                           15    9605
XP_005250415                                                           15    9605
XP_006716058                                                           15    9605
XP_005250414                                                           15    9605
XP_006716057                                                           15    9605
XP_005273004                                                           15    9605
XP_005273005                                                           15    9605
XP_005273003                                                           15    9605
>NP_006197
          Length = 1089

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YIYVDTMQL 9
           YIYVD MQL
Sbjct: 572 YIYVDPMQL 580
>NP_002600
          Length = 1106

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YIYVDTMQL 9
           YIYVD MQL
Sbjct: 579 YIYVDPMQL 587
>XP_005268521
          Length = 1042

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YIYVDTMQL 9
           YIYVD MQL
Sbjct: 515 YIYVDPMQL 523
>XP_006714104
          Length = 832

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YIYVDTMQL 9
           YIYVD MQL
Sbjct: 597 YIYVDPMQL 605
>XP_005265800
          Length = 1089

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YIYVDTMQL 9
           YIYVD MQL
Sbjct: 572 YIYVDPMQL 580
>XP_006714103
          Length = 1111

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YIYVDTMQL 9
           YIYVD MQL
Sbjct: 594 YIYVDPMQL 602
>XP_006714102
          Length = 1114

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YIYVDTMQL 9
           YIYVD MQL
Sbjct: 597 YIYVDPMQL 605
>NP_877439
          Length = 852

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YIYVDTMQL 9
           YIY DT+Q+
Sbjct: 327 YIYKDTIQV 335
>NP_694999
          Length = 686

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  YIYVDT 6
          YIYVDT
Sbjct: 52 YIYVDT 57
>NP_689829
          Length = 723

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YIYVDTMQL 9
           Y+YV TM++
Sbjct: 412 YVYVTTMKV 420
>NP_001258941
          Length = 547

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IYVDTMQL 9
           +Y+DTMQ+
Sbjct: 293 LYLDTMQV 300
>NP_060661
          Length = 531

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YIYVDTMQL 9
           Y+Y DT+ L
Sbjct: 427 YLYTDTVDL 435
>NP_203755
          Length = 547

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IYVDTMQL 9
           +Y+DTMQ+
Sbjct: 293 LYLDTMQV 300
>NP_001258942
          Length = 547

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IYVDTMQL 9
           +Y+DTMQ+
Sbjct: 293 LYLDTMQV 300
>XP_006719906
          Length = 338

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YIYVDTMQL 9
           Y+Y DT+ L
Sbjct: 234 YLYTDTVDL 242
>XP_005266498
          Length = 531

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YIYVDTMQL 9
           Y+Y DT+ L
Sbjct: 427 YLYTDTVDL 435
>XP_005270314
          Length = 552

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IYVDTMQL 9
           +Y+DTMQ+
Sbjct: 298 LYLDTMQV 305
>XP_006713671
          Length = 576

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YIYVDTMQL 9
           Y+YV TM++
Sbjct: 265 YVYVTTMKV 273
>NP_008864
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IYVDTMQ 8
           IY DT+Q
Sbjct: 182 IYTDTLQ 188
>NP_000334
          Length = 664

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IYVDTMQ 8
           IY DT+Q
Sbjct: 201 IYTDTLQ 207
>NP_001243243
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  IYVDTMQ 8
          IY DT+Q
Sbjct: 74 IYTDTLQ 80
>NP_037423
          Length = 1443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    YIYVDTMQ 8
            Y+Y+ TM+
Sbjct: 1407 YLYLSTME 1414
>NP_055042
          Length = 659

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IYVDTMQ 8
           IY DT+Q
Sbjct: 201 IYTDTLQ 207
>XP_006724371
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IYVDTMQ 8
           IY DT+Q
Sbjct: 155 IYTDTLQ 161
>XP_006716613
          Length = 785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YIYVDTMQ 8
           Y+Y+ TM+
Sbjct: 749 YLYLSTME 756
>XP_006716612
          Length = 1365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    YIYVDTMQ 8
            Y+Y+ TM+
Sbjct: 1329 YLYLSTME 1336
>XP_006716611
          Length = 1440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    YIYVDTMQ 8
            Y+Y+ TM+
Sbjct: 1404 YLYLSTME 1411
>NP_056289
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IYVDTMQL 9
           I+VDTM++
Sbjct: 110 IHVDTMKV 117
>NP_149091
          Length = 859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YIYVDTM 7
           Y+Y DT+
Sbjct: 254 YVYEDTL 260
>NP_001269378
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YIYVDTM 7
           Y YVDT+
Sbjct: 101 YQYVDTL 107
>NP_001165442
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YIYVDTM 7
           Y+Y DT+
Sbjct: 254 YVYEDTL 260
>NP_056646
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YIYVDTM 7
           Y YVDT+
Sbjct: 101 YQYVDTL 107
>NP_000656
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YIYVDTM 7
           Y YVDT+
Sbjct: 101 YQYVDTL 107
>NP_001452
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   YVDTMQ 8
           Y+DTM+
Sbjct: 432 YIDTME 437
>XP_005260441
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IYVDTMQL 9
           I+VDTM++
Sbjct: 110 IHVDTMKV 117
>XP_005250415
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YIYVDTM 7
           Y YVDT+
Sbjct: 101 YQYVDTL 107
>XP_006716058
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YIYVDTM 7
           Y YVDT+
Sbjct: 101 YQYVDTL 107
>XP_005250414
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YIYVDTM 7
           Y YVDT+
Sbjct: 101 YQYVDTL 107
>XP_006716057
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YIYVDTM 7
           Y YVDT+
Sbjct: 168 YQYVDTL 174
>XP_005273004
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   YVDTMQ 8
           Y+DTM+
Sbjct: 432 YIDTME 437
>XP_005273005
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   YVDTMQ 8
           Y+DTM+
Sbjct: 432 YIDTME 437
>XP_005273003
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   YVDTMQ 8
           Y+DTM+
Sbjct: 432 YIDTME 437
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.146    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 406,878
Number of extensions: 662
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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