Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     665
NP_001075109                                                           19     665
NP_001361                                                              17    3301
XP_006712019                                                           17    3301
NP_620687                                                              17    4312
NP_001136018                                                           17    4312
NP_002772                                                              17    4312
NP_361013                                                              17    4312
NP_000360                                                              17    4312
XP_005268094                                                           17    4312
NP_001123486                                                           17    4312
NP_057531                                                              16    5631
XP_005249832                                                           16    5631
XP_006715803                                                           16    5631
XP_006715802                                                           16    5631
XP_006715801                                                           16    5631
NP_004925                                                              16    7355
NP_852111                                                              16    7355
NP_000136                                                              16    7355
NP_001127923                                                           16    7355
NP_001127922                                                           16    7355
NP_056299                                                              16    7355
NP_690877                                                              16    7355
NP_006055                                                              16    7355
NP_057740                                                              16    7355
XP_005262030                                                           16    7355
XP_006714498                                                           16    7355
XP_005248285                                                           16    7355
NP_997053                                                              16    7355
NP_006561                                                              16    7355
NP_004987                                                              15    9605
NP_001010892                                                           15    9605
NP_001155136                                                           15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
XP_006720948                                                           15    9605
XP_006720947                                                           15    9605
XP_005255386                                                           15    9605
XP_005255385                                                           15    9605
XP_005255384                                                           15    9605
XP_006715532                                                           15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_008835
          Length = 4128

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ITVRNAKK 9
           ITVRNAKK
Sbjct: 672 ITVRNAKK 679
>NP_001075109
          Length = 4097

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ITVRNAKK 9
           ITVRNAKK
Sbjct: 672 ITVRNAKK 679
>NP_001361
          Length = 4158

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    ITVRNAK 8
            IT+RNAK
Sbjct: 1542 ITIRNAK 1548
>XP_006712019
          Length = 4158

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    ITVRNAK 8
            IT+RNAK
Sbjct: 1542 ITIRNAK 1548
>NP_620687
          Length = 1224

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   YITVRNA 7
           YI+VRNA
Sbjct: 785 YISVRNA 791
>NP_001136018
          Length = 1076

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YITVRNAKK 9
           ++TVRNA K
Sbjct: 917 HVTVRNAWK 925
>NP_002772
          Length = 335

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YITVRNAK 8
           YIT+ N+K
Sbjct: 150 YITINNSK 157
>NP_361013
          Length = 1076

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YITVRNAKK 9
           ++TVRNA K
Sbjct: 917 HVTVRNAWK 925
>NP_000360
          Length = 764

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YITVRN 6
           YITVRN
Sbjct: 605 YITVRN 610
>XP_005268094
          Length = 764

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YITVRN 6
           YITVRN
Sbjct: 605 YITVRN 610
>NP_001123486
          Length = 335

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YITVRNAK 8
           YIT+ N+K
Sbjct: 150 YITINNSK 157
>NP_057531
          Length = 540

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YITVRNAK 8
           Y+T RNA+
Sbjct: 311 YLTTRNAE 318
>XP_005249832
          Length = 428

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YITVRNAK 8
           Y+T RNA+
Sbjct: 199 YLTTRNAE 206
>XP_006715803
          Length = 540

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YITVRNAK 8
           Y+T RNA+
Sbjct: 311 YLTTRNAE 318
>XP_006715802
          Length = 540

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YITVRNAK 8
           Y+T RNA+
Sbjct: 311 YLTTRNAE 318
>XP_006715801
          Length = 540

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YITVRNAK 8
           Y+T RNA+
Sbjct: 311 YLTTRNAE 318
>NP_004925
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YITVRNAKK 9
           +IT+R +KK
Sbjct: 633 FITLRRSKK 641
>NP_852111
          Length = 669

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YITVRN 6
           Y+TVRN
Sbjct: 527 YLTVRN 532
>NP_000136
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YITVRN 6
           Y+TVRN
Sbjct: 553 YLTVRN 558
>NP_001127923
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YITVRNA 7
           Y+T+RNA
Sbjct: 257 YMTLRNA 263
>NP_001127922
          Length = 435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YITVRNA 7
           Y+T+RNA
Sbjct: 359 YMTLRNA 365
>NP_056299
          Length = 243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   YITVRNAK 8
           YI  RNAK
Sbjct: 210 YINERNAK 217
>NP_690877
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YITVRNA 7
           Y+T+RNA
Sbjct: 359 YMTLRNA 365
>NP_006055
          Length = 346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITVRNAKK 9
           I +RNA+K
Sbjct: 321 INIRNARK 328
>NP_057740
          Length = 374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITVRNAKK 9
           I +RNA+K
Sbjct: 349 INIRNARK 356
>XP_005262030
          Length = 336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITVRNAKK 9
           I +RNA+K
Sbjct: 311 INIRNARK 318
>XP_006714498
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YITVRNAKK 9
           +IT+R +KK
Sbjct: 633 FITLRRSKK 641
>XP_005248285
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YITVRNAKK 9
           +IT+R +KK
Sbjct: 633 FITLRRSKK 641
>NP_997053
          Length = 201

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   YITVRNAK 8
           YI  RNAK
Sbjct: 168 YINERNAK 175
>NP_006561
          Length = 313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITVRNAKK 9
           I +RNA+K
Sbjct: 288 INIRNARK 295
>NP_004987
          Length = 1531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ITVRNA 7
           ITVRNA
Sbjct: 644 ITVRNA 649
>NP_001010892
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITVRNAK 8
           IT++NAK
Sbjct: 209 ITIQNAK 215
>NP_001155136
          Length = 600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITVRNAK 8
           IT++NAK
Sbjct: 209 ITIQNAK 215
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2     ITVRNAKK 9
             ++++NAKK
Sbjct: 21124 LSIKNAKK 21131
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2     ITVRNAKK 9
             ++++NAKK
Sbjct: 21249 LSIKNAKK 21256
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2     ITVRNAKK 9
             ++++NAKK
Sbjct: 28548 LSIKNAKK 28555
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2     ITVRNAKK 9
             ++++NAKK
Sbjct: 27621 LSIKNAKK 27628
>XP_006720948
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ITVRNA 7
           ITVRNA
Sbjct: 514 ITVRNA 519
>XP_006720947
          Length = 1466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ITVRNA 7
           ITVRNA
Sbjct: 644 ITVRNA 649
>XP_005255386
          Length = 1472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ITVRNA 7
           ITVRNA
Sbjct: 644 ITVRNA 649
>XP_005255385
          Length = 1485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ITVRNA 7
           ITVRNA
Sbjct: 598 ITVRNA 603
>XP_005255384
          Length = 1489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ITVRNA 7
           ITVRNA
Sbjct: 602 ITVRNA 607
>XP_006715532
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITVRNAK 8
           IT++NAK
Sbjct: 209 ITIQNAK 215
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2     ITVRNAKK 9
             ++++NAKK
Sbjct: 16861 LSIKNAKK 16868
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2     ITVRNAKK 9
             ++++NAKK
Sbjct: 18220 LSIKNAKK 18227
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2     ITVRNAKK 9
             ++++NAKK
Sbjct: 28176 LSIKNAKK 28183
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2     ITVRNAKK 9
             ++++NAKK
Sbjct: 29682 LSIKNAKK 29689
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2     ITVRNAKK 9
             ++++NAKK
Sbjct: 30189 LSIKNAKK 30196
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2     ITVRNAKK 9
             ++++NAKK
Sbjct: 21316 LSIKNAKK 21323
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.129    0.341 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 341,257
Number of extensions: 543
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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