Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              19     869
XP_006718907                                                           19     869
XP_006718906                                                           19     869
XP_005271619                                                           19     869
XP_005271618                                                           19     869
NP_008927                                                              17    4312
NP_001239200                                                           17    4312
NP_079435                                                              17    4312
NP_001006606                                                           17    4312
NP_001239199                                                           17    4312
NP_001239198                                                           17    4312
NP_001138519                                                           16    5631
NP_009197                                                              16    5631
NP_003733                                                              16    5631
NP_003175                                                              16    5631
XP_006716684                                                           16    5631
XP_006712881                                                           16    5631
XP_006712880                                                           16    5631
NP_940894                                                              16    7355
NP_848599                                                              16    7355
NP_071379                                                              16    7355
XP_005260849                                                           16    7355
XP_006713081                                                           16    7355
NP_061720                                                              16    7355
NP_942093                                                              16    7355
NP_001135771                                                           15    9605
NP_003891                                                              15    9605
NP_000123                                                              15    9605
NP_001135770                                                           15    9605
NP_001036216                                                           15    9605
NP_005853                                                              15    9605
NP_002706                                                              15    9605
NP_001036214                                                           15    9605
NP_006594                                                              15    9605
NP_001036215                                                           15    9605
NP_001269347                                                           15    9605
NP_004534                                                              15    9605
NP_001009552                                                           15    9605
NP_001258137                                                           15    9605
NP_001157980                                                           15    9605
NP_001157979                                                           15    9605
XP_006724791                                                           15    9605
XP_005262418                                                           15    9605
XP_005262417                                                           15    9605
XP_005262416                                                           15    9605
XP_005262415                                                           15    9605
XP_006724790                                                           15    9605
XP_005262414                                                           15    9605
XP_006713534                                                           15    9605
XP_005246674                                                           15    9605
XP_005246673                                                           15    9605
XP_005246672                                                           15    9605
XP_005246670                                                           15    9605
XP_005246669                                                           15    9605
XP_005246668                                                           15    9605
XP_005246667                                                           15    9605
XP_005246665                                                           15    9605
XP_006712605                                                           15    9605
XP_006712604                                                           15    9605
XP_005246663                                                           15    9605
XP_005246660                                                           15    9605
XP_005246661                                                           15    9605
XP_005246659                                                           15    9605
XP_005246658                                                           15    9605
XP_005246657                                                           15    9605
XP_005246656                                                           15    9605
XP_005246655                                                           15    9605
XP_005246654                                                           15    9605
XP_005246653                                                           15    9605
XP_005246652                                                           15    9605
XP_005246649                                                           15    9605
XP_005246651                                                           15    9605
XP_005246650                                                           15    9605
XP_005246648                                                           15    9605
XP_005246647                                                           15    9605
>NP_000042
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YIMDTVKYS 9
           YIMDTVK S
Sbjct: 123 YIMDTVKDS 131
>XP_006718907
          Length = 3050

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YIMDTVKYS 9
           YIMDTVK S
Sbjct: 123 YIMDTVKDS 131
>XP_006718906
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YIMDTVKYS 9
           YIMDTVK S
Sbjct: 123 YIMDTVKDS 131
>XP_005271619
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YIMDTVKYS 9
           YIMDTVK S
Sbjct: 123 YIMDTVKDS 131
>XP_005271618
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YIMDTVKYS 9
           YIMDTVK S
Sbjct: 123 YIMDTVKDS 131
>NP_008927
          Length = 497

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           YIMDTV
Sbjct: 378 YIMDTV 383
>NP_001239200
          Length = 403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   YIMDTVKYS 9
           Y+M++V+Y+
Sbjct: 201 YVMESVEYT 209
>NP_079435
          Length = 301

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           YIMDTV
Sbjct: 225 YIMDTV 230
>NP_001006606
          Length = 428

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   YIMDTVKYS 9
           Y+M++V+Y+
Sbjct: 226 YVMESVEYT 234
>NP_001239199
          Length = 369

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   YIMDTVKYS 9
           Y+M++V+Y+
Sbjct: 167 YVMESVEYT 175
>NP_001239198
          Length = 383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   YIMDTVKYS 9
           Y+M++V+Y+
Sbjct: 181 YVMESVEYT 189
>NP_001138519
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  IMDTVKY 8
          I DTVKY
Sbjct: 58 IRDTVKY 64
>NP_009197
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  IMDTVKY 8
          I DTVKY
Sbjct: 84 IRDTVKY 90
>NP_003733
          Length = 1321

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    IMDTVKY 8
            IMD +KY
Sbjct: 1170 IMDNIKY 1176
>NP_003175
          Length = 1199

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YIMDTVKYS 9
           +I+D +KY+
Sbjct: 774 FILDLIKYN 782
>XP_006716684
          Length = 1251

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YIMDTVKYS 9
           +I+D +KY+
Sbjct: 774 FILDLIKYN 782
>XP_006712881
          Length = 1335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    IMDTVKY 8
            IMD +KY
Sbjct: 1184 IMDNIKY 1190
>XP_006712880
          Length = 1335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    IMDTVKY 8
            IMD +KY
Sbjct: 1184 IMDNIKY 1190
>NP_940894
          Length = 293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3 MDTVKYS 9
         MDT +YS
Sbjct: 1 MDTTRYS 7
>NP_848599
          Length = 3092

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    MDTVKYS 9
            MDT++Y+
Sbjct: 1869 MDTIRYT 1875
>NP_071379
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MDTVKY 8
           +DTVKY
Sbjct: 604 LDTVKY 609
>XP_005260849
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MDTVKY 8
           +DTVKY
Sbjct: 415 LDTVKY 420
>XP_006713081
          Length = 3964

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    MDTVKYS 9
            MDT++Y+
Sbjct: 1892 MDTIRYT 1898
>NP_061720
          Length = 4024

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    MDTVKYS 9
            +DT++YS
Sbjct: 1953 LDTIRYS 1959
>NP_942093
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MDTVKY 8
           +DTVKY
Sbjct: 604 LDTVKY 609
>NP_001135771
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MDTVKYS 9
           +DT++YS
Sbjct: 344 LDTIQYS 350
>NP_003891
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MDTVKYS 9
           +DT++YS
Sbjct: 428 LDTIQYS 434
>NP_000123
          Length = 2351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YIMDTV 6
            YIMDT+
Sbjct: 1943 YIMDTL 1948
>NP_001135770
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MDTVKYS 9
           +DT++YS
Sbjct: 344 LDTIQYS 350
>NP_001036216
          Length = 1231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 195 YMMDTV 200
>NP_005853
          Length = 1258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 198 YMMDTV 203
>NP_002706
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DTVKYS 9
           DT+KYS
Sbjct: 280 DTLKYS 285
>NP_001036214
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 195 YMMDTV 200
>NP_006594
          Length = 1231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 195 YMMDTV 200
>NP_001036215
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 195 YMMDTV 200
>NP_001269347
          Length = 1231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 195 YMMDTV 200
>NP_004534
          Length = 6669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>NP_001009552
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DTVKYS 9
           DT+KYS
Sbjct: 280 DTLKYS 285
>NP_001258137
          Length = 8560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>NP_001157980
          Length = 8525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>NP_001157979
          Length = 8525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_006724791
          Length = 1199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 126 YMMDTV 131
>XP_005262418
          Length = 1231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 195 YMMDTV 200
>XP_005262417
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 195 YMMDTV 200
>XP_005262416
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 195 YMMDTV 200
>XP_005262415
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 195 YMMDTV 200
>XP_006724790
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 195 YMMDTV 200
>XP_005262414
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 195 YMMDTV 200
>XP_006713534
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIMDTV 6
           Y+MDTV
Sbjct: 198 YMMDTV 203
>XP_005246674
          Length = 7553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246673
          Length = 8018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246672
          Length = 8277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246670
          Length = 8282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246669
          Length = 8282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246668
          Length = 8308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246667
          Length = 8308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246665
          Length = 8339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_006712605
          Length = 8370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_006712604
          Length = 8370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246663
          Length = 8370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246660
          Length = 8370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246661
          Length = 8370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246659
          Length = 8401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246658
          Length = 8401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246657
          Length = 8432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246656
          Length = 8432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246655
          Length = 8463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246654
          Length = 8463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246653
          Length = 8463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246652
          Length = 8494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246649
          Length = 8494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246651
          Length = 8494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246650
          Length = 8494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246648
          Length = 8494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
>XP_005246647
          Length = 8494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    DTVKYS 9
            DT+KYS
Sbjct: 1965 DTLKYS 1970
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.134    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 435,218
Number of extensions: 849
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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