Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_060676                                                              17    3301
XP_005256102                                                           17    3301
NP_064695                                                              16    5631
NP_001074007                                                           16    5631
NP_001269346                                                           16    5631
NP_001035915                                                           16    5631
NP_689564                                                              16    5631
NP_001257578                                                           16    5631
NP_001257577                                                           16    5631
XP_006721514                                                           16    5631
XP_006721513                                                           16    5631
XP_005256514                                                           16    5631
XP_006716123                                                           16    5631
XP_005250421                                                           16    5631
XP_005249902                                                           16    5631
NP_076972                                                              16    5631
NP_056525                                                              16    5631
NP_001228                                                              16    7355
NP_001058                                                              16    7355
NP_055828                                                              16    7355
NP_001009999                                                           16    7355
NP_003669                                                              16    7355
NP_001002878                                                           16    7355
NP_001002879                                                           16    7355
NP_001002877                                                           16    7355
NP_061060                                                              16    7355
XP_005261858                                                           16    7355
XP_005261857                                                           16    7355
XP_005261856                                                           16    7355
XP_006724410                                                           16    7355
XP_005261855                                                           16    7355
XP_005261854                                                           16    7355
XP_005257689                                                           16    7355
XP_006710537                                                           16    7355
XP_006710536                                                           16    7355
XP_006710535                                                           16    7355
XP_005245843                                                           16    7355
NP_001138743                                                           16    7355
NP_055294                                                              16    7355
NP_001138744                                                           16    7355
NP_001240838                                                           15    9605
NP_003730                                                              15    9605
NP_001240837                                                           15    9605
NP_995317                                                              15    9605
NP_001345                                                              15    9605
NP_001809                                                              15    9605
NP_821138                                                              15    9605
NP_848635                                                              15    9605
NP_001128713                                                           15    9605
NP_037440                                                              15    9605
NP_006853                                                              15    9605
NP_001077434                                                           15    9605
NP_001077433                                                           15    9605
NP_001077432                                                           15    9605
NP_001245219                                                           15    9605
NP_775773                                                              15    9605
NP_001245220                                                           15    9605
XP_005254804                                                           15    9605
XP_006720791                                                           15    9605
XP_005254803                                                           15    9605
XP_005254800                                                           15    9605
XP_005254799                                                           15    9605
XP_005247460                                                           15    9605
XP_005247459                                                           15    9605
XP_005244913                                                           15    9605
XP_005244911                                                           15    9605
XP_005244910                                                           15    9605
XP_005276151                                                           15    9605
NP_001344                                                              15    9605
NP_003913                                                              15    9605
>NP_060676
          Length = 796

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  YIDVYLSSE 9
          Y++VYL+ E
Sbjct: 76 YLEVYLTDE 84
>XP_005256102
          Length = 729

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  YIDVYLSSE 9
          Y++VYL+ E
Sbjct: 9  YLEVYLTDE 17
>NP_064695
          Length = 316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+DVYL
Sbjct: 104 YLDVYL 109
>NP_001074007
          Length = 344

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+DVYL
Sbjct: 132 YLDVYL 137
>NP_001269346
          Length = 566

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YIDVYLSSE 9
          ++ +Y+SSE
Sbjct: 52 FVPIYISSE 60
>NP_001035915
          Length = 596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YIDVYLSSE 9
           ++ +Y+SSE
Sbjct: 108 FVPIYISSE 116
>NP_689564
          Length = 612

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YIDVYLSSE 9
           ++ +Y+SSE
Sbjct: 108 FVPIYISSE 116
>NP_001257578
          Length = 560

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YIDVYLSSE 9
           ++ +Y+SSE
Sbjct: 108 FVPIYISSE 116
>NP_001257577
          Length = 569

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YIDVYLSSE 9
           ++ +Y+SSE
Sbjct: 108 FVPIYISSE 116
>XP_006721514
          Length = 596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YIDVYLSSE 9
           ++ +Y+SSE
Sbjct: 108 FVPIYISSE 116
>XP_006721513
          Length = 598

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YIDVYLSSE 9
           ++ +Y+SSE
Sbjct: 108 FVPIYISSE 116
>XP_005256514
          Length = 633

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YIDVYLSSE 9
           ++ +Y+SSE
Sbjct: 108 FVPIYISSE 116
>XP_006716123
          Length = 169

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+DVYL
Sbjct: 104 YLDVYL 109
>XP_005250421
          Length = 316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+DVYL
Sbjct: 104 YLDVYL 109
>XP_005249902
          Length = 589

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YIDVYLSSE 9
          ++D+Y SS+
Sbjct: 23 HLDIYFSSQ 31
>NP_076972
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YIDVYLSSE 9
          ++D+Y SS+
Sbjct: 23 HLDIYFSSQ 31
>NP_056525
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IDVYLSSE 9
           IDV LSSE
Sbjct: 416 IDVQLSSE 423
>NP_001228
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YIDVYLSS 8
           YID +LSS
Sbjct: 238 YIDRFLSS 245
>NP_001058
          Length = 1531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YIDVYLSSE 9
           Y+D+YL  +
Sbjct: 270 YVDMYLKDK 278
>NP_055828
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DVYLSS 8
           DVYLSS
Sbjct: 518 DVYLSS 523
>NP_001009999
          Length = 876

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DVYLSS 8
           DVYLSS
Sbjct: 542 DVYLSS 547
>NP_003669
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IDVYLSSE 9
           +DVYL +E
Sbjct: 633 LDVYLETE 640
>NP_001002878
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IDVYLSSE 9
           +DVYL +E
Sbjct: 633 LDVYLETE 640
>NP_001002879
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IDVYLSSE 9
           +DVYL +E
Sbjct: 633 LDVYLETE 640
>NP_001002877
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IDVYLSSE 9
           +DVYL +E
Sbjct: 633 LDVYLETE 640
>NP_061060
          Length = 542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IDVYLSSE 9
           +D+Y S+E
Sbjct: 368 VDIYFSAE 375
>XP_005261858
          Length = 344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IDVYLSSE 9
           +DVYL +E
Sbjct: 294 LDVYLETE 301
>XP_005261857
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IDVYLSSE 9
           +DVYL +E
Sbjct: 360 LDVYLETE 367
>XP_005261856
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IDVYLSSE 9
           +DVYL +E
Sbjct: 644 LDVYLETE 651
>XP_006724410
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IDVYLSSE 9
           +DVYL +E
Sbjct: 644 LDVYLETE 651
>XP_005261855
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IDVYLSSE 9
           +DVYL +E
Sbjct: 644 LDVYLETE 651
>XP_005261854
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IDVYLSSE 9
           +DVYL +E
Sbjct: 644 LDVYLETE 651
>XP_005257689
          Length = 1519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YIDVYLSSE 9
           Y+D+YL  +
Sbjct: 258 YVDMYLKDK 266
>XP_006710537
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DVYLSS 8
           DVYLSS
Sbjct: 544 DVYLSS 549
>XP_006710536
          Length = 828

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DVYLSS 8
           DVYLSS
Sbjct: 544 DVYLSS 549
>XP_006710535
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DVYLSS 8
           DVYLSS
Sbjct: 524 DVYLSS 529
>XP_005245843
          Length = 872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DVYLSS 8
           DVYLSS
Sbjct: 538 DVYLSS 543
>NP_001138743
          Length = 391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           YID+YL
Sbjct: 140 YIDLYL 145
>NP_055294
          Length = 470

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           YID+YL
Sbjct: 219 YIDLYL 224
>NP_001138744
          Length = 391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           YID+YL
Sbjct: 140 YIDLYL 145
>NP_001240838
          Length = 138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+D+YL
Sbjct: 110 YVDLYL 115
>NP_003730
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+D+YL
Sbjct: 110 YVDLYL 115
>NP_001240837
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+D+YL
Sbjct: 110 YVDLYL 115
>NP_995317
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+D+YL
Sbjct: 110 YVDLYL 115
>NP_001345
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+D+YL
Sbjct: 110 YVDLYL 115
>NP_001809
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+D+YL
Sbjct: 110 YVDLYL 115
>NP_821138
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YIDVYLSS 8
           +ID+Y S+
Sbjct: 348 FIDIYFST 355
>NP_848635
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DVYLSSE 9
           D Y+SSE
Sbjct: 278 DAYMSSE 284
>NP_001128713
          Length = 139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+D+YL
Sbjct: 110 YVDLYL 115
>NP_037440
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YIDVYLS 7
           YI++YLS
Sbjct: 95  YINMYLS 101
>NP_006853
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YIDVYLSS 8
           Y++VY+S+
Sbjct: 307 YLEVYVSA 314
>NP_001077434
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YIDVYLSS 8
           Y++VY+S+
Sbjct: 307 YLEVYVSA 314
>NP_001077433
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YIDVYLSS 8
           Y++VY+S+
Sbjct: 262 YLEVYVSA 269
>NP_001077432
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YIDVYLSS 8
           Y++VY+S+
Sbjct: 307 YLEVYVSA 314
>NP_001245219
          Length = 850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           YI+VYL
Sbjct: 637 YIEVYL 642
>NP_775773
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           YI+VYL
Sbjct: 642 YIEVYL 647
>NP_001245220
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           YI+VYL
Sbjct: 642 YIEVYL 647
>XP_005254804
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YIDVYLSSE 9
          Y+D  LSS+
Sbjct: 78 YLDALLSSQ 86
>XP_006720791
          Length = 4853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YIDVYLSSE 9
          Y+D  LSS+
Sbjct: 78 YLDALLSSQ 86
>XP_005254803
          Length = 4854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YIDVYLSSE 9
          Y+D  LSS+
Sbjct: 78 YLDALLSSQ 86
>XP_005254800
          Length = 4861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YIDVYLSSE 9
          Y+D  LSS+
Sbjct: 78 YLDALLSSQ 86
>XP_005254799
          Length = 4861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YIDVYLSSE 9
          Y+D  LSS+
Sbjct: 78 YLDALLSSQ 86
>XP_005247460
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YIDVYLS 7
           YI++YLS
Sbjct: 95  YINMYLS 101
>XP_005247459
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YIDVYLS 7
           YI++YLS
Sbjct: 95  YINMYLS 101
>XP_005244913
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  YIDVYLSS 8
          Y++VY+S+
Sbjct: 83 YLEVYVSA 90
>XP_005244911
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YIDVYLSS 8
           Y++VY+S+
Sbjct: 307 YLEVYVSA 314
>XP_005244910
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YIDVYLSS 8
           Y++VY+S+
Sbjct: 307 YLEVYVSA 314
>XP_005276151
          Length = 146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+D+YL
Sbjct: 110 YVDLYL 115
>NP_001344
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   YIDVYL 6
           Y+D+YL
Sbjct: 110 YVDLYL 115
>NP_003913
          Length = 4861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YIDVYLSSE 9
          Y+D  LSS+
Sbjct: 78 YLDALLSSQ 86
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.136    0.360 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 462,332
Number of extensions: 689
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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