Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_073713                                                              20     299
NP_001244953                                                           17    3301
NP_002007                                                              17    4312
NP_150231                                                              17    4312
NP_150230                                                              17    4312
NP_001647                                                              17    4312
NP_056303                                                              16    5631
NP_072094                                                              16    5631
NP_115992                                                              16    5631
NP_002401                                                              16    5631
NP_001276093                                                           16    5631
NP_443125                                                              16    5631
NP_001165889                                                           16    5631
NP_115587                                                              16    5631
XP_006718083                                                           16    5631
XP_005270273                                                           16    5631
XP_005248898                                                           16    5631
XP_005263727                                                           16    5631
XP_005263726                                                           16    5631
XP_006712598                                                           16    5631
XP_005263725                                                           16    5631
XP_006712597                                                           16    5631
XP_005263723                                                           16    5631
NP_001092742                                                           16    5631
NP_001123579                                                           16    7355
NP_001136076                                                           16    7355
NP_000301                                                              16    7355
NP_598408                                                              16    7355
NP_001035962                                                           16    7355
NP_001035961                                                           16    7355
NP_001005735                                                           16    7355
NP_009125                                                              16    7355
NP_001244316                                                           16    7355
NP_665861                                                              16    7355
NP_009152                                                              16    7355
NP_001186582                                                           16    7355
NP_001186583                                                           16    7355
NP_065202                                                              16    7355
NP_001186591                                                           16    7355
NP_001186592                                                           16    7355
NP_001186590                                                           16    7355
NP_001186593                                                           16    7355
XP_006724179                                                           16    7355
XP_006724178                                                           16    7355
XP_006724177                                                           16    7355
XP_006720856                                                           16    7355
XP_005271064                                                           16    7355
NP_002309                                                              15    9605
NP_001157666                                                           15    9605
NP_001157661                                                           15    9605
NP_005808                                                              15    9605
NP_775267                                                              15    9605
NP_775268                                                              15    9605
NP_003238                                                              15    9605
NP_775266                                                              15    9605
NP_004094                                                              15    9605
NP_001273661                                                           15    9605
NP_940931                                                              15    9605
NP_001138525                                                           15    9605
NP_542173                                                              15    9605
NP_060586                                                              15    9605
XP_006721944                                                           15    9605
XP_006721943                                                           15    9605
XP_006721942                                                           15    9605
XP_006720042                                                           15    9605
XP_005268391                                                           15    9605
XP_005268390                                                           15    9605
XP_005273505                                                           15    9605
XP_005273504                                                           15    9605
XP_006711487                                                           15    9605
XP_006711486                                                           15    9605
XP_006711484                                                           15    9605
XP_006711483                                                           15    9605
XP_006711475                                                           15    9605
>NP_073713
          Length = 985

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YGSARESIP 9
           YG ARESIP
Sbjct: 257 YGPARESIP 265
>NP_001244953
          Length = 868

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   YGSARES 7
           YGSARE+
Sbjct: 549 YGSAREA 555
>NP_002007
          Length = 4061

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    YGSARE 6
            YGSARE
Sbjct: 1619 YGSARE 1624
>NP_150231
          Length = 546

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YGSARESI 8
           YG+A ESI
Sbjct: 110 YGAAEESI 117
>NP_150230
          Length = 569

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YGSARESI 8
           YG+A ESI
Sbjct: 110 YGAAEESI 117
>NP_001647
          Length = 574

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YGSARESI 8
           YG+A ESI
Sbjct: 110 YGAAEESI 117
>NP_056303
          Length = 385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YGSARESIP 9
           YGS ++ IP
Sbjct: 194 YGSPQDGIP 202
>NP_072094
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YGSARESIP 9
           YGS ++ IP
Sbjct: 170 YGSPQDGIP 178
>NP_115992
          Length = 753

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YGSARESI 8
           +GSARE++
Sbjct: 350 FGSAREAL 357
>NP_002401
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YGSARESIP 9
           YGS+ ++IP
Sbjct: 480 YGSSTKNIP 488
>NP_001276093
          Length = 608

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YGSARESI 8
           +GSARE++
Sbjct: 205 FGSAREAL 212
>NP_443125
          Length = 612

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  YGSARESIP 9
          YG  RES P
Sbjct: 66 YGGMRESQP 74
>NP_001165889
          Length = 582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  YGSARESIP 9
          YG  RES P
Sbjct: 7  YGGMRESQP 15
>NP_115587
          Length = 756

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YGSARESI 8
           +GSARE++
Sbjct: 354 FGSAREAL 361
>XP_006718083
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YGSARESI 8
           +GSARE++
Sbjct: 355 FGSAREAL 362
>XP_005270273
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YGSARESI 8
           +GSARE++
Sbjct: 355 FGSAREAL 362
>XP_005248898
          Length = 612

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  YGSARESIP 9
          YG  RES P
Sbjct: 66 YGGMRESQP 74
>XP_005263727
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YGSARESIP 9
           YGS+ ++IP
Sbjct: 480 YGSSTKNIP 488
>XP_005263726
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YGSARESIP 9
           YGS+ ++IP
Sbjct: 480 YGSSTKNIP 488
>XP_006712598
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YGSARESIP 9
           YGS+ ++IP
Sbjct: 480 YGSSTKNIP 488
>XP_005263725
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YGSARESIP 9
           YGS+ ++IP
Sbjct: 480 YGSSTKNIP 488
>XP_006712597
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YGSARESIP 9
           YGS+ ++IP
Sbjct: 480 YGSSTKNIP 488
>XP_005263723
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YGSARESIP 9
           YGS+ ++IP
Sbjct: 480 YGSSTKNIP 488
>NP_001092742
          Length = 612

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  YGSARESIP 9
          YG  RES P
Sbjct: 66 YGGMRESQP 74
>NP_001123579
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           GS+RES P
Sbjct: 583 GSSRESEP 590
>NP_001136076
          Length = 203

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G A+E+IP
Sbjct: 147 GQAKETIP 154
>NP_000301
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G A+E+IP
Sbjct: 250 GQAKETIP 257
>NP_598408
          Length = 1150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARESIP 9
          S+RES+P
Sbjct: 46 SSRESVP 52
>NP_001035962
          Length = 1135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARESIP 9
          S+RES+P
Sbjct: 46 SSRESVP 52
>NP_001035961
          Length = 1141

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARESIP 9
          S+RES+P
Sbjct: 37 SSRESVP 43
>NP_001005735
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           GSARE+ P
Sbjct: 302 GSAREADP 309
>NP_009125
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           GSARE+ P
Sbjct: 259 GSAREADP 266
>NP_001244316
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GSARESIP 9
          GSARE+ P
Sbjct: 38 GSAREADP 45
>NP_665861
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           GSARE+ P
Sbjct: 259 GSAREADP 266
>NP_009152
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GSARESIP 9
          GS+ ES+P
Sbjct: 20 GSSSESVP 27
>NP_001186582
          Length = 180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GSARESIP 9
          GS+ ES+P
Sbjct: 20 GSSSESVP 27
>NP_001186583
          Length = 207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GSARESIP 9
          GS+ ES+P
Sbjct: 20 GSSSESVP 27
>NP_065202
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YGSARES 7
           YGS+RE+
Sbjct: 237 YGSSREA 243
>NP_001186591
          Length = 211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GSARESIP 9
          GS+ ES+P
Sbjct: 20 GSSSESVP 27
>NP_001186592
          Length = 175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GSARESIP 9
          GS+ ES+P
Sbjct: 20 GSSSESVP 27
>NP_001186590
          Length = 220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GSARESIP 9
          GS+ ES+P
Sbjct: 20 GSSSESVP 27
>NP_001186593
          Length = 142

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GSARESIP 9
          GS+ ES+P
Sbjct: 20 GSSSESVP 27
>XP_006724179
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GSARESIP 9
          GSARE+ P
Sbjct: 70 GSAREADP 77
>XP_006724178
          Length = 356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           GSARE+ P
Sbjct: 259 GSAREADP 266
>XP_006724177
          Length = 383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           GSARE+ P
Sbjct: 99  GSAREADP 106
>XP_006720856
          Length = 1101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARESIP 9
          S+RES+P
Sbjct: 46 SSRESVP 52
>XP_005271064
          Length = 339

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G A+E+IP
Sbjct: 250 GQAKETIP 257
>NP_002309
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YGSARESI 8
           +GSA+E++
Sbjct: 369 FGSAKEAV 376
>NP_001157666
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  YGSARESIP 9
          Y S +ES P
Sbjct: 46 YASTKESYP 54
>NP_001157661
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  YGSARESIP 9
          Y S +ES P
Sbjct: 46 YASTKESYP 54
>NP_005808
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  YGSARESIP 9
          Y S +ES P
Sbjct: 46 YASTKESYP 54
>NP_775267
          Length = 967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YGSARESI 8
           YG ARE +
Sbjct: 418 YGIAREDV 425
>NP_775268
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YGSARESI 8
           YG ARE +
Sbjct: 418 YGIAREDV 425
>NP_003238
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GSARES 7
           GSARES
Sbjct: 195 GSARES 200
>NP_775266
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YGSARESI 8
           YG ARE +
Sbjct: 418 YGIAREDV 425
>NP_004094
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YGSARESI 8
           YG ARE +
Sbjct: 418 YGIAREDV 425
>NP_001273661
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G+AR S+P
Sbjct: 310 GAARGSVP 317
>NP_940931
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GSARESI 8
           GS+RES+
Sbjct: 597 GSSRESV 603
>NP_001138525
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GSARESI 8
           GS+RES+
Sbjct: 541 GSSRESV 547
>NP_542173
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  YGSARE 6
          YG+ARE
Sbjct: 44 YGAARE 49
>NP_060586
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G+A ESIP
Sbjct: 498 GAAVESIP 505
>XP_006721944
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GSARESI 8
           GS+RES+
Sbjct: 597 GSSRESV 603
>XP_006721943
          Length = 1456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GSARESI 8
           GS+RES+
Sbjct: 597 GSSRESV 603
>XP_006721942
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GSARESI 8
           GS+RES+
Sbjct: 597 GSSRESV 603
>XP_006720042
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G+AR S+P
Sbjct: 207 GAARGSVP 214
>XP_005268391
          Length = 266

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G+AR S+P
Sbjct: 232 GAARGSVP 239
>XP_005268390
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G+AR S+P
Sbjct: 257 GAARGSVP 264
>XP_005273505
          Length = 997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YGSARESI 8
           YG ARE +
Sbjct: 418 YGIAREDV 425
>XP_005273504
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YGSARESI 8
           YG ARE +
Sbjct: 418 YGIAREDV 425
>XP_006711487
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G+A ESIP
Sbjct: 320 GAAVESIP 327
>XP_006711486
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G+A ESIP
Sbjct: 320 GAAVESIP 327
>XP_006711484
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G+A ESIP
Sbjct: 443 GAAVESIP 450
>XP_006711483
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G+A ESIP
Sbjct: 474 GAAVESIP 481
>XP_006711475
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSARESIP 9
           G+A ESIP
Sbjct: 525 GAAVESIP 532
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.128    0.360 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 533,428
Number of extensions: 1265
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package