Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              21     175
XP_006717990                                                           21     175
XP_006717989                                                           21     175
NP_000074                                                              18    1935
NP_001035214                                                           17    3301
NP_060235                                                              17    3301
NP_001035215                                                           17    3301
NP_055816                                                              17    3301
NP_001274460                                                           17    3301
XP_006710774                                                           17    3301
XP_006710773                                                           17    3301
XP_005245973                                                           17    3301
XP_005245972                                                           17    3301
NP_002963                                                              17    4312
NP_060517                                                              17    4312
XP_005261992                                                           17    4312
XP_005261991                                                           17    4312
XP_005261989                                                           17    4312
XP_005261988                                                           17    4312
XP_005268536                                                           17    4312
NP_116206                                                              16    5631
NP_055086                                                              16    5631
NP_001238811                                                           16    5631
NP_004615                                                              16    5631
NP_085046                                                              16    5631
NP_001001851                                                           16    5631
NP_001238813                                                           16    5631
NP_001238814                                                           16    5631
XP_005274498                                                           16    5631
XP_005265498                                                           16    5631
XP_005265496                                                           16    5631
XP_005265495                                                           16    5631
XP_005265494                                                           16    5631
NP_722520                                                              16    7355
NP_001157853                                                           16    7355
NP_003809                                                              16    7355
NP_056485                                                              16    7355
NP_055208                                                              16    7355
NP_001157857                                                           16    7355
NP_001157856                                                           16    7355
NP_001157852                                                           16    7355
NP_001157854                                                           16    7355
XP_006723723                                                           16    7355
NP_002227                                                              16    7355
NP_005261                                                              15    9605
NP_001783                                                              15    9605
NP_065681                                                              15    9605
NP_066124                                                              15    9605
NP_000120                                                              15    9605
NP_004854                                                              15    9605
NP_068761                                                              15    9605
NP_001137296                                                           15    9605
NP_859052                                                              15    9605
NP_660358                                                              15    9605
NP_055336                                                              15    9605
NP_001003681                                                           15    9605
NP_951008                                                              15    9605
NP_060488                                                              15    9605
XP_006726512                                                           15    9605
XP_006725120                                                           15    9605
XP_006724164                                                           15    9605
XP_006724163                                                           15    9605
XP_005258239                                                           15    9605
XP_005258238                                                           15    9605
XP_005269054                                                           15    9605
XP_006717999                                                           15    9605
XP_005250800                                                           15    9605
XP_005250799                                                           15    9605
XP_006716274                                                           15    9605
XP_005266942                                                           15    9605
XP_006715073                                                           15    9605
XP_006712486                                                           15    9605
XP_006712485                                                           15    9605
NP_060797                                                              15    9605
>NP_000305
          Length = 403

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   FYGEVRTR 9
           FYGEVRTR
Sbjct: 154 FYGEVRTR 161
>XP_006717990
          Length = 175

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   FYGEVRTR 9
           FYGEVRTR
Sbjct: 139 FYGEVRTR 146
>XP_006717989
          Length = 388

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   FYGEVRTR 9
           FYGEVRTR
Sbjct: 139 FYGEVRTR 146
>NP_000074
          Length = 988

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YFYGEVRT 8
           Y YGE+RT
Sbjct: 620 YTYGELRT 627
>NP_001035214
          Length = 291

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YFYGEVRTR 9
           YFY + RTR
Sbjct: 116 YFYYKFRTR 124
>NP_060235
          Length = 291

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YFYGEVRTR 9
           YFY + RTR
Sbjct: 116 YFYYKFRTR 124
>NP_001035215
          Length = 226

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YFYGEVRTR 9
          YFY + RTR
Sbjct: 51 YFYYKFRTR 59
>NP_055816
          Length = 3664

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    YFYGEVRT 8
            Y YG++RT
Sbjct: 3306 YRYGDIRT 3313
>NP_001274460
          Length = 180

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YFYGEVRTR 9
          YFY + RTR
Sbjct: 5  YFYYKFRTR 13
>XP_006710774
          Length = 180

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YFYGEVRTR 9
          YFY + RTR
Sbjct: 5  YFYYKFRTR 13
>XP_006710773
          Length = 180

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YFYGEVRTR 9
          YFY + RTR
Sbjct: 5  YFYYKFRTR 13
>XP_005245973
          Length = 291

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YFYGEVRTR 9
           YFY + RTR
Sbjct: 116 YFYYKFRTR 124
>XP_005245972
          Length = 330

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YFYGEVRTR 9
           YFY + RTR
Sbjct: 155 YFYYKFRTR 163
>NP_002963
          Length = 1893

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FYGEVRT 8
           FYG+V+T
Sbjct: 686 FYGDVQT 692
>NP_060517
          Length = 420

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YFYGEVRT 8
           Y +GE+RT
Sbjct: 253 YQFGEIRT 260
>XP_005261992
          Length = 1867

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FYGEVRT 8
           FYG+V+T
Sbjct: 686 FYGDVQT 692
>XP_005261991
          Length = 1868

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FYGEVRT 8
           FYG+V+T
Sbjct: 687 FYGDVQT 693
>XP_005261989
          Length = 1891

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FYGEVRT 8
           FYG+V+T
Sbjct: 684 FYGDVQT 690
>XP_005261988
          Length = 1894

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FYGEVRT 8
           FYG+V+T
Sbjct: 687 FYGDVQT 693
>XP_005268536
          Length = 539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YFYGEVRT 8
           Y +GE+RT
Sbjct: 372 YQFGEIRT 379
>NP_116206
          Length = 728

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FYGEVRT 8
           FY E+RT
Sbjct: 260 FYDEIRT 266
>NP_055086
          Length = 696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  FYGEVRT 8
          FYG +RT
Sbjct: 56 FYGYIRT 62
>NP_001238811
          Length = 416

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FYGEVRT 8
           FYG V+T
Sbjct: 97  FYGSVKT 103
>NP_004615
          Length = 457

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FYGEVRT 8
           FYG V+T
Sbjct: 138 FYGSVKT 144
>NP_085046
          Length = 942

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FYGEVRT 8
           FY E+RT
Sbjct: 474 FYDEIRT 480
>NP_001001851
          Length = 702

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FYGEVRT 8
           FY E+RT
Sbjct: 474 FYDEIRT 480
>NP_001238813
          Length = 409

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  FYGEVRT 8
          FYG V+T
Sbjct: 90 FYGSVKT 96
>NP_001238814
          Length = 430

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FYGEVRT 8
           FYG V+T
Sbjct: 111 FYGSVKT 117
>XP_005274498
          Length = 696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  FYGEVRT 8
          FYG +RT
Sbjct: 56 FYGYIRT 62
>XP_005265498
          Length = 273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FYGEVRT 8
           FYG V+T
Sbjct: 138 FYGSVKT 144
>XP_005265496
          Length = 410

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  FYGEVRT 8
          FYG V+T
Sbjct: 91 FYGSVKT 97
>XP_005265495
          Length = 416

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FYGEVRT 8
           FYG V+T
Sbjct: 97  FYGSVKT 103
>XP_005265494
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FYGEVRT 8
           FYG V+T
Sbjct: 137 FYGSVKT 143
>NP_722520
          Length = 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FYGEVRTR 9
           F+G V+TR
Sbjct: 118 FHGSVQTR 125
>NP_001157853
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FYGEVRTR 9
           F+GE +TR
Sbjct: 125 FFGEGKTR 132
>NP_003809
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFYGEVRT 8
           +FYGE  T
Sbjct: 139 FFYGETVT 146
>NP_056485
          Length = 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YFYGEVRTR 9
           +FY ++RT+
Sbjct: 428 FFYDKLRTK 436
>NP_055208
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FYGEVRTR 9
           F+GE +TR
Sbjct: 125 FFGEGKTR 132
>NP_001157857
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FYGEVRTR 9
           F+GE +TR
Sbjct: 119 FFGEGKTR 126
>NP_001157856
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FYGEVRTR 9
           F+GE +TR
Sbjct: 125 FFGEGKTR 132
>NP_001157852
          Length = 570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FYGEVRTR 9
           F+GE +TR
Sbjct: 157 FFGEGKTR 164
>NP_001157854
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  FYGEVRTR 9
          F+GE +TR
Sbjct: 53 FFGEGKTR 60
>XP_006723723
          Length = 394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFYGEVRT 8
           +FYGE  T
Sbjct: 139 FFYGETVT 146
>NP_002227
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YFYGEVRTR 9
           Y++GEV  +
Sbjct: 93  YYFGEVHMK 101
>NP_005261
          Length = 1586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 1    YFYGEV 6
            Y+YG++
Sbjct: 1446 YYYGQI 1451
>NP_001783
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 387 FYGEV 391
>NP_065681
          Length = 1072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  YFYGEVRTR 9
          + YG  RTR
Sbjct: 71 HLYGTYRTR 79
>NP_066124
          Length = 1114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  YFYGEVRTR 9
          + YG  RTR
Sbjct: 71 HLYGTYRTR 79
>NP_000120
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 214 FYGEV 218
>NP_004854
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YGEVRTR 9
           YG+ RTR
Sbjct: 298 YGQPRTR 304
>NP_068761
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YFYGEVR 7
           Y+Y E+R
Sbjct: 199 YYYTEIR 205
>NP_001137296
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 390 FYGEV 394
>NP_859052
          Length = 698

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YFYGEVRTR 9
           YF+  VR+R
Sbjct: 679 YFFFRVRSR 687
>NP_660358
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFYGEVRT 8
           Y YG+V T
Sbjct: 133 YVYGDVGT 140
>NP_055336
          Length = 963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   YFYGEVRT 8
           Y Y  VRT
Sbjct: 753 YIYASVRT 760
>NP_001003681
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 1  YFYGEV 6
          Y+YG++
Sbjct: 83 YYYGDI 88
>NP_951008
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YFYGEVR 7
           Y+Y E+R
Sbjct: 199 YYYTEIR 205
>NP_060488
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 390 FYGEV 394
>XP_006726512
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YFYGEVRTR 9
           + YG+ R+R
Sbjct: 255 FLYGKTRSR 263
>XP_006725120
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YFYGEVRTR 9
           + YG+ R+R
Sbjct: 232 FLYGKTRSR 240
>XP_006724164
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 1   YFYGEV 6
           Y+YG++
Sbjct: 126 YYYGDI 131
>XP_006724163
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 1   YFYGEV 6
           Y+YG++
Sbjct: 126 YYYGDI 131
>XP_005258239
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 356 FYGEV 360
>XP_005258238
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 369 FYGEV 373
>XP_005269054
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 390 FYGEV 394
>XP_006717999
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YFYGEVRTR 9
           + YG  RTR
Sbjct: 164 HLYGTYRTR 172
>XP_005250800
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YFYGEVRTR 9
           + YG+ R+R
Sbjct: 232 FLYGKTRSR 240
>XP_005250799
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YFYGEVRTR 9
           + YG+ R+R
Sbjct: 272 FLYGKTRSR 280
>XP_006716274
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YFYGEVRTR 9
           + YG+ R+R
Sbjct: 232 FLYGKTRSR 240
>XP_005266942
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFYGEVRT 8
           Y YG+V T
Sbjct: 100 YVYGDVGT 107
>XP_006715073
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 214 FYGEV 218
>XP_006712486
          Length = 1504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 1    YFYGEV 6
            Y+YG++
Sbjct: 1364 YYYGQI 1369
>XP_006712485
          Length = 1569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 1    YFYGEV 6
            Y+YG++
Sbjct: 1429 YYYGQI 1434
>NP_060797
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YGEVRTR 9
           YG+ RTR
Sbjct: 290 YGQPRTR 296
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.152    0.485 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 594,136
Number of extensions: 881
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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