Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              21     175
NP_001263689                                                           21     175
NP_001119584                                                           21     175
NP_001119590                                                           21     175
NP_001263690                                                           21     175
NP_001119587                                                           21     175
NP_001263626                                                           21     175
NP_114480                                                              19     869
NP_114481                                                              19     869
NP_061737                                                              19     869
NP_001836                                                              17    4312
NP_066000                                                              17    4312
XP_006713781                                                           17    4312
NP_997196                                                              16    7355
NP_536859                                                              16    7355
NP_859052                                                              16    7355
NP_002579                                                              16    7355
NP_115778                                                              16    7355
XP_006721755                                                           16    7355
NP_689969                                                              15    9605
NP_001272368                                                           15    9605
NP_031361                                                              15    9605
NP_001035100                                                           15    9605
NP_001276903                                                           15    9605
NP_061917                                                              15    9605
XP_003960167                                                           15    9605
XP_006720934                                                           15    9605
XP_006714526                                                           15    9605
XP_005265687                                                           15    9605
XP_006712663                                                           15    9605
XP_006712662                                                           15    9605
XP_006712661                                                           15    9605
XP_006712660                                                           15    9605
XP_003846269                                                           15    9605
XP_003846670                                                           15    9605
>NP_000537
          Length = 393

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YFTLRIRGR 9
           YFTL+IRGR
Sbjct: 327 YFTLQIRGR 335
>NP_001263689
          Length = 354

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YFTLRIRGR 9
           YFTL+IRGR
Sbjct: 288 YFTLQIRGR 296
>NP_001119584
          Length = 393

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YFTLRIRGR 9
           YFTL+IRGR
Sbjct: 327 YFTLQIRGR 335
>NP_001119590
          Length = 354

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YFTLRIRGR 9
           YFTL+IRGR
Sbjct: 288 YFTLQIRGR 296
>NP_001263690
          Length = 354

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YFTLRIRGR 9
           YFTL+IRGR
Sbjct: 288 YFTLQIRGR 296
>NP_001119587
          Length = 261

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YFTLRIRGR 9
           YFTL+IRGR
Sbjct: 195 YFTLQIRGR 203
>NP_001263626
          Length = 234

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YFTLRIRGR 9
           YFTL+IRGR
Sbjct: 168 YFTLQIRGR 176
>NP_114480
          Length = 837

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   YFTLRIRGR 9
           YF+L++RGR
Sbjct: 178 YFSLQLRGR 186
>NP_114481
          Length = 750

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   YFTLRIRGR 9
           YF+L++RGR
Sbjct: 178 YFSLQLRGR 186
>NP_061737
          Length = 935

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   YFTLRIRGR 9
           YF+L++RGR
Sbjct: 178 YFSLQLRGR 186
>NP_001836
          Length = 1669

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YFTLRIRG 8
           YF LR++G
Sbjct: 534 YFDLRLKG 541
>NP_066000
          Length = 771

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YFTLRIR 7
           Y+T+RIR
Sbjct: 541 YYTMRIR 547
>XP_006713781
          Length = 771

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YFTLRIR 7
           Y+T+RIR
Sbjct: 541 YYTMRIR 547
>NP_997196
          Length = 984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YFTLRIRGR 9
           +FTLR++ +
Sbjct: 239 HFTLRVKAK 247
>NP_536859
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TLRIRGR 9
           TLR RGR
Sbjct: 616 TLRTRGR 622
>NP_859052
          Length = 698

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YFTLRIRGR 9
           YF  R+R R
Sbjct: 679 YFFFRVRSR 687
>NP_002579
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YFTLRIRGR 9
           YF LR++ R
Sbjct: 179 YFALRVQTR 187
>NP_115778
          Length = 863

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YFTLRIRGR 9
           YF LR++ R
Sbjct: 179 YFALRVQTR 187
>XP_006721755
          Length = 978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YFTLRIRGR 9
           +FTLR++ +
Sbjct: 233 HFTLRVKAK 241
>NP_689969
          Length = 1708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LRIRGR 9
          LR+RGR
Sbjct: 13 LRVRGR 18
>NP_001272368
          Length = 1732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LRIRGR 9
          LR+RGR
Sbjct: 13 LRVRGR 18
>NP_031361
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TLRIRGR 9
            TLR+RG+
Sbjct: 1736 TLRLRGQ 1742
>NP_001035100
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  FTLRIR 7
          FTLR+R
Sbjct: 45 FTLRVR 50
>NP_001276903
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YFTLRIRGR 9
           Y  LR+RG+
Sbjct: 565 YRVLRLRGK 573
>NP_061917
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  YFTLRIRG 8
          YF  RI+G
Sbjct: 39 YFRARIKG 46
>XP_003960167
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YFTLRIRGR 9
           Y  LR+RG+
Sbjct: 648 YRVLRLRGK 656
>XP_006720934
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  FTLRIR 7
          FTLR+R
Sbjct: 29 FTLRVR 34
>XP_006714526
          Length = 1670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LRIRGR 9
          LR+RGR
Sbjct: 13 LRVRGR 18
>XP_005265687
          Length = 1758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TLRIRGR 9
            TLR+RG+
Sbjct: 1739 TLRLRGQ 1745
>XP_006712663
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFTLRIRG 8
           YF  RI+G
Sbjct: 95  YFRARIKG 102
>XP_006712662
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFTLRIRG 8
           YF  RI+G
Sbjct: 95  YFRARIKG 102
>XP_006712661
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFTLRIRG 8
           YF  RI+G
Sbjct: 95  YFRARIKG 102
>XP_006712660
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFTLRIRG 8
           YF  RI+G
Sbjct: 95  YFRARIKG 102
>XP_003846269
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YFTLRIRGR 9
           Y  LR+RG+
Sbjct: 648 YRVLRLRGK 656
>XP_003846670
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YFTLRIRGR 9
           Y  LR+RG+
Sbjct: 655 YRVLRLRGK 663
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.349    0.164    0.517 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 426,968
Number of extensions: 696
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package