Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              21     175
NP_078948                                                              17    2528
NP_037472                                                              17    2528
XP_005263278                                                           17    2528
XP_005263277                                                           17    2528
NP_001265473                                                           17    4312
NP_000057                                                              17    4312
NP_001265472                                                           17    4312
XP_005271223                                                           17    4312
XP_006710936                                                           17    4312
NP_079350                                                              16    7355
NP_006217                                                              16    7355
NP_872384                                                              16    7355
NP_001092805                                                           16    7355
NP_055574                                                              16    7355
XP_006716479                                                           16    7355
XP_006714380                                                           16    7355
XP_006714379                                                           16    7355
XP_006714378                                                           16    7355
XP_006714377                                                           16    7355
XP_005246701                                                           16    7355
XP_005246700                                                           16    7355
XP_005245152                                                           16    7355
NP_001175                                                              15    9605
NP_005492                                                              15    9605
NP_002195                                                              15    9605
NP_001265723                                                           15    9605
NP_061325                                                              15    9605
NP_780778                                                              15    9605
NP_940998                                                              15    9605
NP_001155313                                                           15    9605
NP_005963                                                              15    9605
NP_056127                                                              15    9605
NP_001135392                                                           15    9605
NP_001135391                                                           15    9605
NP_689835                                                              15    9605
NP_002421                                                              15    9605
NP_001265724                                                           15    9605
XP_005274644                                                           15    9605
XP_005261913                                                           15    9605
XP_005261910                                                           15    9605
XP_005261905                                                           15    9605
XP_006723893                                                           15    9605
XP_005260515                                                           15    9605
XP_006723892                                                           15    9605
XP_006723891                                                           15    9605
XP_006723890                                                           15    9605
XP_005257365                                                           15    9605
XP_005277701                                                           15    9605
XP_006717608                                                           15    9605
XP_005248505                                                           15    9605
XP_006714407                                                           15    9605
XP_006714406                                                           15    9605
XP_006714405                                                           15    9605
XP_005263349                                                           15    9605
XP_005263348                                                           15    9605
XP_005263347                                                           15    9605
XP_005263346                                                           15    9605
XP_005263345                                                           15    9605
XP_005263344                                                           15    9605
XP_005263343                                                           15    9605
XP_005263342                                                           15    9605
XP_005263341                                                           15    9605
XP_005263340                                                           15    9605
XP_005263339                                                           15    9605
NP_004852                                                              15    9605
>NP_004351
          Length = 882

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  YFSLNTRFK 9
          YFSL+TRFK
Sbjct: 68 YFSLDTRFK 76
>NP_078948
          Length = 903

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YFSLNTRFK 9
           Y++L TR+K
Sbjct: 638 YYNLETRYK 646
>NP_037472
          Length = 818

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YFSLNTRF 8
           YF L+TRF
Sbjct: 177 YFHLHTRF 184
>XP_005263278
          Length = 620

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YFSLNTRFK 9
           Y++L TR+K
Sbjct: 355 YYNLETRYK 363
>XP_005263277
          Length = 759

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YFSLNTRFK 9
           Y++L TR+K
Sbjct: 494 YYNLETRYK 502
>NP_001265473
          Length = 529

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YFSLNTRFK 9
           ++ LNTRF+
Sbjct: 141 HYILNTRFR 149
>NP_000057
          Length = 591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YFSLNTRFK 9
           ++ LNTRF+
Sbjct: 203 HYILNTRFR 211
>NP_001265472
          Length = 539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YFSLNTRFK 9
           ++ LNTRF+
Sbjct: 151 HYILNTRFR 159
>XP_005271223
          Length = 628

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YFSLNTRFK 9
           ++ LNTRF+
Sbjct: 240 HYILNTRFR 248
>XP_006710936
          Length = 630

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YFSLNTRFK 9
           ++ LNTRF+
Sbjct: 242 HYILNTRFR 250
>NP_079350
          Length = 4012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLNT F+
Sbjct: 3660 YSLNTEFQ 3667
>NP_006217
          Length = 1095

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YFSLNTR 7
           YFS NT+
Sbjct: 706 YFSANTK 712
>NP_872384
          Length = 247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SLNTRFK 9
           SLN RFK
Sbjct: 185 SLNIRFK 191
>NP_001092805
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFSLNTRF 8
           +FS NT F
Sbjct: 183 FFSCNTEF 190
>NP_055574
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFSLNTRF 8
           +FS NT F
Sbjct: 183 FFSCNTEF 190
>XP_006716479
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFSLNTRF 8
           +FS NT F
Sbjct: 183 FFSCNTEF 190
>XP_006714380
          Length = 3897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLNT F+
Sbjct: 3545 YSLNTEFQ 3552
>XP_006714379
          Length = 3936

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLNT F+
Sbjct: 3584 YSLNTEFQ 3591
>XP_006714378
          Length = 3965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLNT F+
Sbjct: 3613 YSLNTEFQ 3620
>XP_006714377
          Length = 4010

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLNT F+
Sbjct: 3658 YSLNTEFQ 3665
>XP_005246701
          Length = 1016

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YFSLNTR 7
           YFS NT+
Sbjct: 627 YFSANTK 633
>XP_005246700
          Length = 1021

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YFSLNTR 7
           YFS NT+
Sbjct: 632 YFSANTK 638
>XP_005245152
          Length = 247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SLNTRFK 9
           SLN RFK
Sbjct: 185 SLNIRFK 191
>NP_001175
          Length = 2644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LNTRFK 9
            LNTR+K
Sbjct: 1458 LNTRYK 1463
>NP_005492
          Length = 1066

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  FSLNTRF 8
          F+L+TRF
Sbjct: 33 FNLDTRF 39
>NP_002195
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  FSLNTRF 8
          F+L+TRF
Sbjct: 33 FNLDTRF 39
>NP_001265723
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YFSLNTRFK 9
           Y  LNT FK
Sbjct: 322 YGFLNTNFK 330
>NP_061325
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YFSLNT 6
           YF LNT
Sbjct: 781 YFDLNT 786
>NP_780778
          Length = 180

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YFSLNTR 7
           YF LN R
Sbjct: 162 YFKLNNR 168
>NP_940998
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YFSLNT 6
           YF LNT
Sbjct: 781 YFDLNT 786
>NP_001155313
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YFSLNT 6
           YF LNT
Sbjct: 781 YFDLNT 786
>NP_005963
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YFSLNTRFK 9
           Y  LNT FK
Sbjct: 322 YGFLNTNFK 330
>NP_056127
          Length = 5005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 3155 YSLNLQFK 3162
>NP_001135392
          Length = 181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YFSLNTR 7
           YF LN R
Sbjct: 163 YFKLNNR 169
>NP_001135391
          Length = 195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YFSLNTR 7
           YF LN R
Sbjct: 177 YFKLNNR 183
>NP_689835
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFSLNTRF 8
           YF+  TRF
Sbjct: 331 YFAQQTRF 338
>NP_002421
          Length = 1320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SLNTRFK 9
          S+NT FK
Sbjct: 29 SMNTHFK 35
>NP_001265724
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YFSLNTRFK 9
           Y  LNT FK
Sbjct: 322 YGFLNTNFK 330
>XP_005274644
          Length = 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YFSLNTR 7
           YF LN R
Sbjct: 178 YFKLNNR 184
>XP_005261913
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YFSLNTR 7
           YF LN R
Sbjct: 275 YFKLNAR 281
>XP_005261910
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YFSLNTR 7
           YF LN R
Sbjct: 275 YFKLNAR 281
>XP_005261905
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YFSLNTR 7
           YF LN R
Sbjct: 275 YFKLNAR 281
>XP_006723893
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YFSLNT 6
           YF LNT
Sbjct: 781 YFDLNT 786
>XP_005260515
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YFSLNT 6
           YF LNT
Sbjct: 781 YFDLNT 786
>XP_006723892
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YFSLNT 6
           YF LNT
Sbjct: 782 YFDLNT 787
>XP_006723891
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YFSLNT 6
           YF LNT
Sbjct: 782 YFDLNT 787
>XP_006723890
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YFSLNT 6
           YF LNT
Sbjct: 782 YFDLNT 787
>XP_005257365
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  FSLNTRF 8
          F+L+TRF
Sbjct: 33 FNLDTRF 39
>XP_005277701
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YFSLNTRFK 9
           Y  LNT FK
Sbjct: 322 YGFLNTNFK 330
>XP_006717608
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YFSLNTRFK 9
           Y  LNT FK
Sbjct: 322 YGFLNTNFK 330
>XP_005248505
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YFSLNTRF 8
           YF+  TRF
Sbjct: 332 YFAQQTRF 339
>XP_006714407
          Length = 5004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 3154 YSLNLQFK 3161
>XP_006714406
          Length = 3680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 3155 YSLNLQFK 3162
>XP_006714405
          Length = 4103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 2232 YSLNLQFK 2239
>XP_005263349
          Length = 4410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 2539 YSLNLQFK 2546
>XP_005263348
          Length = 4443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 2572 YSLNLQFK 2579
>XP_005263347
          Length = 4640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 3155 YSLNLQFK 3162
>XP_005263346
          Length = 4983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 3112 YSLNLQFK 3119
>XP_005263345
          Length = 4991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 3155 YSLNLQFK 3162
>XP_005263344
          Length = 5005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 3155 YSLNLQFK 3162
>XP_005263343
          Length = 5009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 3138 YSLNLQFK 3145
>XP_005263342
          Length = 5025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 3154 YSLNLQFK 3161
>XP_005263341
          Length = 5026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 3155 YSLNLQFK 3162
>XP_005263340
          Length = 5026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 3155 YSLNLQFK 3162
>XP_005263339
          Length = 5026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FSLNTRFK 9
            +SLN +FK
Sbjct: 3155 YSLNLQFK 3162
>NP_004852
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YFSLNTR 7
           YF LN R
Sbjct: 275 YFKLNAR 281
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.143    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 399,586
Number of extensions: 681
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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