Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     509
XP_006718907                                                           20     509
XP_006718906                                                           20     509
XP_005271619                                                           20     509
XP_005271618                                                           20     509
NP_001013758                                                           17    3301
NP_689844                                                              17    3301
NP_852091                                                              16    5631
NP_001124396                                                           16    5631
NP_001010866                                                           16    5631
XP_006710481                                                           16    5631
XP_006710480                                                           16    5631
NP_997716                                                              16    7355
NP_001130015                                                           16    7355
NP_001275648                                                           16    7355
NP_001275647                                                           16    7355
NP_001275649                                                           16    7355
NP_003143                                                              16    7355
NP_055192                                                              16    7355
NP_001123359                                                           16    7355
NP_001130010                                                           16    7355
XP_005257681                                                           16    7355
NP_079523                                                              16    7355
NP_000731                                                              15    9605
NP_001107578                                                           15    9605
NP_001245271                                                           15    9605
NP_001245269                                                           15    9605
NP_689582                                                              15    9605
NP_001245270                                                           15    9605
NP_001245272                                                           15    9605
NP_001077362                                                           15    9605
XP_005273091                                                           15    9605
XP_005273090                                                           15    9605
XP_006711795                                                           15    9605
XP_005273089                                                           15    9605
XP_005270500                                                           15    9605
XP_005270499                                                           15    9605
XP_005270498                                                           15    9605
XP_005270497                                                           15    9605
>NP_000042
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YFIKRANRR 9
           YFIK ANRR
Sbjct: 103 YFIKCANRR 111
>XP_006718907
          Length = 3050

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YFIKRANRR 9
           YFIK ANRR
Sbjct: 103 YFIKCANRR 111
>XP_006718906
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YFIKRANRR 9
           YFIK ANRR
Sbjct: 103 YFIKCANRR 111
>XP_005271619
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YFIKRANRR 9
           YFIK ANRR
Sbjct: 103 YFIKCANRR 111
>XP_005271618
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YFIKRANRR 9
           YFIK ANRR
Sbjct: 103 YFIKCANRR 111
>NP_001013758
          Length = 1035

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YFIKRANRR 9
          YF KR +RR
Sbjct: 29 YFAKRKHRR 37
>NP_689844
          Length = 645

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  YFIKRANRR 9
          YF KR +RR
Sbjct: 29 YFAKRKHRR 37
>NP_852091
          Length = 941

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YFIKRANRR 9
           YFIK+A+ +
Sbjct: 513 YFIKKAHSK 521
>NP_001124396
          Length = 666

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YFIKRANRR 9
           Y+IK  NR+
Sbjct: 173 YYIKHQNRQ 181
>NP_001010866
          Length = 392

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YFIKRANRR 9
           Y+IK  NR+
Sbjct: 173 YYIKHQNRQ 181
>XP_006710481
          Length = 542

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YFIKRANRR 9
           Y+IK  NR+
Sbjct: 173 YYIKHQNRQ 181
>XP_006710480
          Length = 642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YFIKRANRR 9
           Y+IK  NR+
Sbjct: 173 YYIKHQNRQ 181
>NP_997716
          Length = 227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  IKRANR 8
          IKRANR
Sbjct: 64 IKRANR 69
>NP_001130015
          Length = 179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  IKRANR 8
          IKRANR
Sbjct: 16 IKRANR 21
>NP_001275648
          Length = 764

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKRANRR 9
           IKRA+RR
Sbjct: 394 IKRADRR 400
>NP_001275647
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKRANRR 9
           IKRA+RR
Sbjct: 424 IKRADRR 430
>NP_001275649
          Length = 763

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKRANRR 9
           IKRA+RR
Sbjct: 424 IKRADRR 430
>NP_003143
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKRANRR 9
           IKRA+RR
Sbjct: 424 IKRADRR 430
>NP_055192
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  FIKRANR 8
          F+KR NR
Sbjct: 38 FVKRRNR 44
>NP_001123359
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  FIKRANR 8
          F+KR NR
Sbjct: 38 FVKRRNR 44
>NP_001130010
          Length = 1090

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YFIKRANR 8
           Y+I+ ANR
Sbjct: 331 YYIRLANR 338
>XP_005257681
          Length = 761

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKRANRR 9
           IKRA+RR
Sbjct: 424 IKRADRR 430
>NP_079523
          Length = 1059

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YFIKRANR 8
           Y+I+ ANR
Sbjct: 300 YYIRLANR 307
>NP_000731
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IKRANRR 9
           +KR+NRR
Sbjct: 300 MKRSNRR 306
>NP_001107578
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIKRANR 8
           F+KR+N+
Sbjct: 621 FVKRSNK 627
>NP_001245271
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIKRANR 8
           F+KR+N+
Sbjct: 585 FVKRSNK 591
>NP_001245269
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIKRANR 8
           F+KR+N+
Sbjct: 620 FVKRSNK 626
>NP_689582
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIKRANR 8
           F+KR+N+
Sbjct: 573 FVKRSNK 579
>NP_001245270
          Length = 620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIKRANR 8
           F+KR+N+
Sbjct: 588 FVKRSNK 594
>NP_001245272
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIKRANR 8
           F+KR+N+
Sbjct: 553 FVKRSNK 559
>NP_001077362
          Length = 797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IKRANR 8
           +KRANR
Sbjct: 365 VKRANR 370
>XP_005273091
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IKRANRR 9
           +KR+NRR
Sbjct: 300 MKRSNRR 306
>XP_005273090
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IKRANRR 9
           +KR+NRR
Sbjct: 300 MKRSNRR 306
>XP_006711795
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IKRANRR 9
           +KR+NRR
Sbjct: 300 MKRSNRR 306
>XP_005273089
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IKRANRR 9
           +KR+NRR
Sbjct: 300 MKRSNRR 306
>XP_005270500
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIKRANR 8
           F+KR+N+
Sbjct: 541 FVKRSNK 547
>XP_005270499
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIKRANR 8
           F+KR+N+
Sbjct: 542 FVKRSNK 548
>XP_005270498
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIKRANR 8
           F+KR+N+
Sbjct: 573 FVKRSNK 579
>XP_005270497
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIKRANR 8
           F+KR+N+
Sbjct: 589 FVKRSNK 595
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.149    0.452 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 360,259
Number of extensions: 551
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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