Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              19     665
XP_006718908                                                           19     665
XP_005271621                                                           19     665
XP_006718907                                                           19     665
XP_006718906                                                           19     665
XP_005271619                                                           19     665
XP_005271618                                                           19     665
NP_001229236                                                           17    4312
NP_001186851                                                           16    5631
NP_733746                                                              16    5631
NP_003240                                                              16    5631
NP_002825                                                              16    7355
XP_006719590                                                           16    7355
XP_006719589                                                           16    7355
NP_000103                                                              15    9605
NP_005992                                                              15    9605
NP_006073                                                              15    9605
NP_001257329                                                           15    9605
NP_001257328                                                           15    9605
NP_006000                                                              15    9605
NP_525125                                                              15    9605
NP_001185863                                                           15    9605
NP_258261                                                              15    9605
NP_005890                                                              15    9605
NP_114068                                                              15    9605
NP_114064                                                              15    9605
NP_001017365                                                           15    9605
NP_001034485                                                           15    9605
NP_056502                                                              15    9605
NP_001276916                                                           15    9605
NP_060827                                                              15    9605
NP_001273608                                                           15    9605
XP_006721018                                                           15    9605
XP_005248772                                                           15    9605
XP_005248771                                                           15    9605
XP_005248770                                                           15    9605
XP_005249527                                                           15    9605
XP_006715303                                                           15    9605
XP_005272075                                                           15    9605
XP_005247884                                                           15    9605
XP_005247883                                                           15    9605
XP_005247882                                                           15    9605
XP_005247881                                                           15    9605
XP_005247880                                                           15    9605
XP_005273311                                                           15    9605
XP_005273310                                                           15    9605
NP_114436                                                              15    9605
NP_057688                                                              15    9605
NP_001017367                                                           15    9605
NP_001017364                                                           15    9605
NP_001017366                                                           15    9605
NP_000707                                                              15    9605
>NP_000042
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YEQVGVQKQ 9
            YEQV VQKQ
Sbjct: 1529 YEQVEVQKQ 1537
>XP_006718908
          Length = 1708

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YEQVGVQKQ 9
           YEQV VQKQ
Sbjct: 181 YEQVEVQKQ 189
>XP_005271621
          Length = 2708

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YEQVGVQKQ 9
            YEQV VQKQ
Sbjct: 1181 YEQVEVQKQ 1189
>XP_006718907
          Length = 3050

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YEQVGVQKQ 9
            YEQV VQKQ
Sbjct: 1523 YEQVEVQKQ 1531
>XP_006718906
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YEQVGVQKQ 9
            YEQV VQKQ
Sbjct: 1529 YEQVEVQKQ 1537
>XP_005271619
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YEQVGVQKQ 9
            YEQV VQKQ
Sbjct: 1529 YEQVEVQKQ 1537
>XP_005271618
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YEQVGVQKQ 9
            YEQV VQKQ
Sbjct: 1529 YEQVEVQKQ 1537
>NP_001229236
          Length = 1038

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YEQVGV 6
           YEQVGV
Sbjct: 662 YEQVGV 667
>NP_001186851
          Length = 488

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YEQVGVQKQ 9
           Y+Q+ VQK+
Sbjct: 391 YQQIQVQKK 399
>NP_733746
          Length = 523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YEQVGVQKQ 9
           Y+Q+ VQK+
Sbjct: 426 YQQIQVQKK 434
>NP_003240
          Length = 689

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YEQVGVQK 8
          Y+QVG Q+
Sbjct: 48 YDQVGTQE 55
>NP_002825
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YEQVGVQKQ 9
           YE VG+ +Q
Sbjct: 580 YENVGLMQQ 588
>XP_006719590
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YEQVGVQKQ 9
           YE VG+ +Q
Sbjct: 546 YENVGLMQQ 554
>XP_006719589
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YEQVGVQKQ 9
           YE VG+ +Q
Sbjct: 584 YENVGLMQQ 592
>NP_000103
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YEQVGVQ 7
           YE +G+Q
Sbjct: 674 YEAIGIQ 680
>NP_005992
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEQVGV 6
           YE+VGV
Sbjct: 432 YEEVGV 437
>NP_006073
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEQVGV 6
           YE+VGV
Sbjct: 432 YEEVGV 437
>NP_001257329
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEQVGV 6
           YE+VGV
Sbjct: 397 YEEVGV 402
>NP_001257328
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEQVGV 6
           YE+VGV
Sbjct: 432 YEEVGV 437
>NP_006000
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEQVGV 6
           YE+VGV
Sbjct: 432 YEEVGV 437
>NP_525125
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEQVGV 6
           YE+VGV
Sbjct: 432 YEEVGV 437
>NP_001185863
          Length = 1492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEQVGV 6
           Y+QVGV
Sbjct: 416 YQQVGV 421
>NP_258261
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEQVGV 6
           Y+QVGV
Sbjct: 373 YQQVGV 378
>NP_005890
          Length = 966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EQVGVQKQ 9
           EQV +QKQ
Sbjct: 285 EQVRLQKQ 292
>NP_114068
          Length = 966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EQVGVQKQ 9
           EQV +QKQ
Sbjct: 285 EQVRLQKQ 292
>NP_114064
          Length = 966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EQVGVQKQ 9
           EQV +QKQ
Sbjct: 285 EQVRLQKQ 292
>NP_001017365
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YEQVGVQKQ 9
           Y  VGVQ+Q
Sbjct: 169 YYLVGVQEQ 177
>NP_001034485
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  EQVGVQK 8
          ++VGVQK
Sbjct: 27 DEVGVQK 33
>NP_056502
          Length = 1213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQVGVQKQ 9
           EQ+G+Q Q
Sbjct: 259 EQLGLQSQ 266
>NP_001276916
          Length = 1216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQVGVQKQ 9
           EQ+G+Q Q
Sbjct: 262 EQLGLQSQ 269
>NP_060827
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YEQVGVQK 8
           Y QVG Q+
Sbjct: 250 YSQVGTQE 257
>NP_001273608
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  YEQVGVQK 8
          Y QVG Q+
Sbjct: 66 YSQVGTQE 73
>XP_006721018
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EQVGVQKQ 9
           E+VGVQ++
Sbjct: 390 EEVGVQQR 397
>XP_005248772
          Length = 1154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQVGVQKQ 9
           EQ+G+Q Q
Sbjct: 259 EQLGLQSQ 266
>XP_005248771
          Length = 1177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQVGVQKQ 9
           EQ+G+Q Q
Sbjct: 259 EQLGLQSQ 266
>XP_005248770
          Length = 1213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EQVGVQKQ 9
           EQ+G+Q Q
Sbjct: 259 EQLGLQSQ 266
>XP_005249527
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEQVGV 6
           Y+QVGV
Sbjct: 416 YQQVGV 421
>XP_006715303
          Length = 1463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEQVGV 6
           Y+QVGV
Sbjct: 416 YQQVGV 421
>XP_005272075
          Length = 1561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YEQVGVQ 7
            YE+ GVQ
Sbjct: 1463 YEEYGVQ 1469
>XP_005247884
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EQVGVQ 7
           EQ+GVQ
Sbjct: 211 EQIGVQ 216
>XP_005247883
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EQVGVQ 7
           EQ+GVQ
Sbjct: 211 EQIGVQ 216
>XP_005247882
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EQVGVQ 7
           EQ+GVQ
Sbjct: 211 EQIGVQ 216
>XP_005247881
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EQVGVQ 7
           EQ+GVQ
Sbjct: 211 EQIGVQ 216
>XP_005247880
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EQVGVQ 7
           EQ+GVQ
Sbjct: 211 EQIGVQ 216
>XP_005273311
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YEQVGVQKQ 9
           Y  VGVQ+Q
Sbjct: 169 YYLVGVQEQ 177
>XP_005273310
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YEQVGVQKQ 9
           Y  VGVQ+Q
Sbjct: 169 YYLVGVQEQ 177
>NP_114436
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EQVGVQ 7
           EQ+GVQ
Sbjct: 211 EQIGVQ 216
>NP_057688
          Length = 1761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    YEQVGVQ 7
            YE+ GVQ
Sbjct: 1663 YEEYGVQ 1669
>NP_001017367
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YEQVGVQKQ 9
           Y  VGVQ+Q
Sbjct: 169 YYLVGVQEQ 177
>NP_001017364
          Length = 251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YEQVGVQKQ 9
           Y  VGVQ+Q
Sbjct: 168 YYLVGVQEQ 176
>NP_001017366
          Length = 251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YEQVGVQKQ 9
           Y  VGVQ+Q
Sbjct: 168 YYLVGVQEQ 176
>NP_000707
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YEQVGVQKQ 9
           Y  VGVQ+Q
Sbjct: 169 YYLVGVQEQ 177
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.126    0.329 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 546,823
Number of extensions: 1240
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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