Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005304                                                              17    3301
NP_037536                                                              17    4312
NP_005814                                                              17    4312
NP_001170826                                                           17    4312
NP_001092286                                                           17    4312
XP_005255091                                                           17    4312
XP_006720900                                                           17    4312
XP_006720899                                                           17    4312
XP_006718561                                                           17    4312
XP_006712935                                                           17    4312
XP_006712934                                                           17    4312
XP_006712933                                                           17    4312
NP_852118                                                              17    4312
NP_001073946                                                           16    7355
NP_001258593                                                           16    7355
NP_001107867                                                           16    7355
NP_060208                                                              16    7355
NP_001269076                                                           16    7355
NP_001001413                                                           16    7355
NP_060296                                                              16    7355
NP_001185839                                                           16    7355
NP_705833                                                              16    7355
XP_006726624                                                           16    7355
XP_006726623                                                           16    7355
XP_006725630                                                           16    7355
XP_006725629                                                           16    7355
XP_006725599                                                           16    7355
XP_006726291                                                           16    7355
XP_006726290                                                           16    7355
XP_006725238                                                           16    7355
XP_006720863                                                           16    7355
XP_006720862                                                           16    7355
XP_006720860                                                           16    7355
XP_006720859                                                           16    7355
XP_006720858                                                           16    7355
XP_006720426                                                           16    7355
XP_006716856                                                           16    7355
XP_005251549                                                           16    7355
XP_006714321                                                           16    7355
XP_006714320                                                           16    7355
XP_006714319                                                           16    7355
XP_005247174                                                           16    7355
NP_114091                                                              15    9605
NP_071920                                                              15    9605
NP_003365                                                              15    9605
NP_003611                                                              15    9605
NP_055635                                                              15    9605
NP_525023                                                              15    9605
NP_115812                                                              15    9605
NP_075463                                                              15    9605
NP_001157617                                                           15    9605
NP_001157616                                                           15    9605
XP_006725236                                                           15    9605
XP_006721856                                                           15    9605
XP_006721855                                                           15    9605
XP_006721854                                                           15    9605
XP_006721853                                                           15    9605
XP_005256139                                                           15    9605
XP_005256138                                                           15    9605
XP_005256137                                                           15    9605
XP_006720423                                                           15    9605
XP_005266254                                                           15    9605
XP_006719812                                                           15    9605
XP_005272132                                                           15    9605
XP_006714351                                                           15    9605
XP_005263235                                                           15    9605
XP_006710043                                                           15    9605
NP_543146                                                              15    9605
NP_001003                                                              15    9605
>NP_005304
          Length = 505

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YEKNAK 6
           YEKNAK
Sbjct: 269 YEKNAK 274
>NP_037536
          Length = 630

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EKNAKLST 9
          +KN KLST
Sbjct: 91 QKNVKLST 98
>NP_005814
          Length = 622

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EKNAKLST 9
          +KN KLST
Sbjct: 91 QKNVKLST 98
>NP_001170826
          Length = 622

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EKNAKLST 9
          +KN KLST
Sbjct: 91 QKNVKLST 98
>NP_001092286
          Length = 2769

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YEKNAKLST 9
            Y K+AKL+T
Sbjct: 1530 YAKDAKLNT 1538
>XP_005255091
          Length = 621

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EKNAKLST 9
          +KN KLST
Sbjct: 90 QKNVKLST 97
>XP_006720900
          Length = 622

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EKNAKLST 9
          +KN KLST
Sbjct: 91 QKNVKLST 98
>XP_006720899
          Length = 622

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EKNAKLST 9
          +KN KLST
Sbjct: 91 QKNVKLST 98
>XP_006718561
          Length = 2794

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YEKNAKLST 9
            Y K+AKL+T
Sbjct: 1555 YAKDAKLNT 1563
>XP_006712935
          Length = 977

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YEKNAKLST 9
           YE+N KLS+
Sbjct: 694 YEENNKLSS 702
>XP_006712934
          Length = 1583

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YEKNAKLST 9
           YE+N KLS+
Sbjct: 590 YEENNKLSS 598
>XP_006712933
          Length = 1687

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YEKNAKLST 9
           YE+N KLS+
Sbjct: 694 YEENNKLSS 702
>NP_852118
          Length = 1684

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YEKNAKLST 9
           YE+N KLS+
Sbjct: 691 YEENNKLSS 699
>NP_001073946
          Length = 2699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    YEKNAKLS 8
            Y K+AKLS
Sbjct: 1465 YAKDAKLS 1472
>NP_001258593
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 209 EKNAKL 214
>NP_001107867
          Length = 391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EKNAKLST 9
           E+N KLST
Sbjct: 245 EENKKLST 252
>NP_060208
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EKNAKLST 9
           E+N KLST
Sbjct: 245 EENKKLST 252
>NP_001269076
          Length = 225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YEKNAKLS 8
           +EKN K+S
Sbjct: 196 FEKNKKIS 203
>NP_001001413
          Length = 668

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 221 EKNAKL 226
>NP_060296
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YEKNAKLS 8
           +EKN K+S
Sbjct: 196 FEKNKKIS 203
>NP_001185839
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YEKNAKLS 8
           +EKN K+S
Sbjct: 273 FEKNKKIS 280
>NP_705833
          Length = 2970

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YEKNAK 6
            Y+KNAK
Sbjct: 1766 YQKNAK 1771
>XP_006726624
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 203 EKNAKL 208
>XP_006726623
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 203 EKNAKL 208
>XP_006725630
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 203 EKNAKL 208
>XP_006725629
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 203 EKNAKL 208
>XP_006725599
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 221 EKNAKL 226
>XP_006726291
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 203 EKNAKL 208
>XP_006726290
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 203 EKNAKL 208
>XP_006725238
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 221 EKNAKL 226
>XP_006720863
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 203 EKNAKL 208
>XP_006720862
          Length = 570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 209 EKNAKL 214
>XP_006720860
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 197 EKNAKL 202
>XP_006720859
          Length = 603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 197 EKNAKL 202
>XP_006720858
          Length = 651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 197 EKNAKL 202
>XP_006720426
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EKNAKL 7
           EKNAKL
Sbjct: 221 EKNAKL 226
>XP_006716856
          Length = 1343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EKNAKLST 9
           E+N KLST
Sbjct: 182 EENKKLST 189
>XP_005251549
          Length = 1405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EKNAKLST 9
           E+N KLST
Sbjct: 245 EENKKLST 252
>XP_006714321
          Length = 2713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    YEKNAKLS 8
            Y K+AKLS
Sbjct: 1479 YAKDAKLS 1486
>XP_006714320
          Length = 2720

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    YEKNAKLS 8
            Y K+AKLS
Sbjct: 1486 YAKDAKLS 1493
>XP_006714319
          Length = 2721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    YEKNAKLS 8
            Y K+AKLS
Sbjct: 1487 YAKDAKLS 1494
>XP_005247174
          Length = 2679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YEKNAK 6
            Y+KNAK
Sbjct: 1475 YQKNAK 1480
>NP_114091
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEKNAK 6
           YE+NAK
Sbjct: 355 YEENAK 360
>NP_071920
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YEKNAKL 7
           Y+KN KL
Sbjct: 293 YKKNGKL 299
>NP_003365
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKNAKLST 9
           +KNAK+ T
Sbjct: 109 KKNAKIKT 116
>NP_003611
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKNAKLST 9
           +KN K+ST
Sbjct: 510 QKNLKMST 517
>NP_055635
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   EKNAKLST 9
           EKN  LST
Sbjct: 147 EKNVDLST 154
>NP_525023
          Length = 1617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YEKNAK 6
            Y+KNAK
Sbjct: 1039 YKKNAK 1044
>NP_115812
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  YEKNAKL 7
          Y+K+AKL
Sbjct: 55 YQKSAKL 61
>NP_075463
          Length = 3013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EKNAKLS 8
            EKN KLS
Sbjct: 2177 EKNPKLS 2183
>NP_001157617
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  YEKNAKL 7
          Y+K+AKL
Sbjct: 55 YQKSAKL 61
>NP_001157616
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  YEKNAKL 7
          Y+K+AKL
Sbjct: 55 YQKSAKL 61
>XP_006725236
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EKNAKLST 9
           +KNAK+S+
Sbjct: 153 KKNAKISS 160
>XP_006721856
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEKNAK 6
           Y+KNAK
Sbjct: 722 YKKNAK 727
>XP_006721855
          Length = 1551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YEKNAK 6
            Y+KNAK
Sbjct: 1039 YKKNAK 1044
>XP_006721854
          Length = 1577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YEKNAK 6
            Y+KNAK
Sbjct: 1039 YKKNAK 1044
>XP_006721853
          Length = 1617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    YEKNAK 6
            Y+KNAK
Sbjct: 1039 YKKNAK 1044
>XP_005256139
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEKNAK 6
           YE+NAK
Sbjct: 355 YEENAK 360
>XP_005256138
          Length = 510

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEKNAK 6
           YE+NAK
Sbjct: 355 YEENAK 360
>XP_005256137
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YEKNAK 6
           YE+NAK
Sbjct: 355 YEENAK 360
>XP_006720423
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EKNAKLST 9
           +KNAK+S+
Sbjct: 153 KKNAKISS 160
>XP_005266254
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  YEKNAKL 7
          Y+K+AKL
Sbjct: 55 YQKSAKL 61
>XP_006719812
          Length = 3019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EKNAKLS 8
            EKN KLS
Sbjct: 2174 EKNPKLS 2180
>XP_005272132
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKNAKLST 9
           +KNAK+ T
Sbjct: 109 KKNAKIKT 116
>XP_006714351
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YEKNAKL 7
           Y+KN KL
Sbjct: 293 YKKNGKL 299
>XP_005263235
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YEKNAKL 7
           Y+KN KL
Sbjct: 293 YKKNGKL 299
>XP_006710043
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EKNAKLST 9
           +KNAK+S+
Sbjct: 153 KKNAKISS 160
>NP_543146
          Length = 1393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YEKNAKLST 9
          Y+K  +LST
Sbjct: 35 YQKTGELST 43
>NP_001003
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EKNAKLST 9
           +KNAK+S+
Sbjct: 153 KKNAKISS 160
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.293    0.109    0.267 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 407,043
Number of extensions: 597
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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