Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              20     390
NP_653080                                                              20     390
XP_005267292                                                           20     390
XP_005267291                                                           20     390
XP_005267290                                                           20     390
NP_002652                                                              18    1935
NP_061130                                                              17    3301
NP_001231118                                                           17    4312
NP_001231121                                                           17    4312
NP_055564                                                              17    4312
NP_001231119                                                           17    4312
NP_001231120                                                           17    4312
NP_001231122                                                           17    4312
XP_006720406                                                           17    4312
XP_006720405                                                           17    4312
XP_006720404                                                           17    4312
XP_006720403                                                           17    4312
XP_006720402                                                           17    4312
XP_006720400                                                           17    4312
XP_006720399                                                           17    4312
NP_056355                                                              16    7355
NP_004609                                                              16    7355
NP_006746                                                              16    7355
NP_055299                                                              16    7355
XP_005256833                                                           16    7355
XP_006720533                                                           16    7355
XP_006720532                                                           16    7355
XP_005254354                                                           16    7355
XP_005245161                                                           16    7355
NP_037485                                                              16    7355
NP_055978                                                              15    9605
NP_443210                                                              15    9605
NP_001940                                                              15    9605
NP_001230005                                                           15    9605
NP_073143                                                              15    9605
NP_001937                                                              15    9605
NP_689619                                                              15    9605
NP_001139809                                                           15    9605
XP_006720401                                                           15    9605
XP_005267359                                                           15    9605
XP_005267358                                                           15    9605
XP_006720081                                                           15    9605
XP_006720080                                                           15    9605
XP_005248925                                                           15    9605
XP_005248923                                                           15    9605
XP_005248922                                                           15    9605
XP_005268430                                                           15    9605
>NP_005091
          Length = 1782

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YDAVEMEKM 9
           YDAVE EKM
Sbjct: 852 YDAVEREKM 860
>NP_653080
          Length = 1684

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YDAVEMEKM 9
           YDAVE EKM
Sbjct: 754 YDAVEREKM 762
>XP_005267292
          Length = 1677

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YDAVEMEKM 9
           YDAVE EKM
Sbjct: 747 YDAVEREKM 755
>XP_005267291
          Length = 1684

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YDAVEMEKM 9
           YDAVE EKM
Sbjct: 754 YDAVEREKM 762
>XP_005267290
          Length = 1782

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YDAVEMEKM 9
           YDAVE EKM
Sbjct: 852 YDAVEREKM 860
>NP_002652
          Length = 1265

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YDAVEMEKM 9
           YDAV+M+ M
Sbjct: 306 YDAVDMQDM 314
>NP_061130
          Length = 513

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DAVEMEKM 9
           DAVEM++M
Sbjct: 161 DAVEMDEM 168
>NP_001231118
          Length = 1644

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1334 HDAVEME 1340
>NP_001231121
          Length = 1504

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1237 HDAVEME 1243
>NP_055564
          Length = 1472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1205 HDAVEME 1211
>NP_001231119
          Length = 1533

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1266 HDAVEME 1272
>NP_001231120
          Length = 1463

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1196 HDAVEME 1202
>NP_001231122
          Length = 1347

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1141 HDAVEME 1147
>XP_006720406
          Length = 1591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1281 HDAVEME 1287
>XP_006720405
          Length = 1347

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1281 HDAVEME 1287
>XP_006720404
          Length = 1477

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1281 HDAVEME 1287
>XP_006720403
          Length = 1486

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1281 HDAVEME 1287
>XP_006720402
          Length = 1487

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1281 HDAVEME 1287
>XP_006720400
          Length = 1526

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1281 HDAVEME 1287
>XP_006720399
          Length = 1548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEME
Sbjct: 1281 HDAVEME 1287
>NP_056355
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DAVEMEKM 9
           D VE+EK+
Sbjct: 330 DTVELEKL 337
>NP_004609
          Length = 1001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DAVEMEKM 9
           D VE+EK+
Sbjct: 328 DTVELEKL 335
>NP_006746
          Length = 337

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAVEMEKM 9
           DAV++E+M
Sbjct: 318 DAVKLERM 325
>NP_055299
          Length = 460

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YDAVEMEKM 9
           YD VEM  +
Sbjct: 114 YDVVEMSNL 122
>XP_005256833
          Length = 906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DAVEMEKM 9
           D VE+EK+
Sbjct: 233 DTVELEKL 240
>XP_006720533
          Length = 1098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DAVEMEKM 9
          D VE+EK+
Sbjct: 35 DTVELEKL 42
>XP_006720532
          Length = 1333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DAVEMEKM 9
           D VE+EK+
Sbjct: 270 DTVELEKL 277
>XP_005254354
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DAVEMEKM 9
           D VE+EK+
Sbjct: 330 DTVELEKL 337
>XP_005245161
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DAVEME 7
           DAVEME
Sbjct: 257 DAVEME 262
>NP_037485
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DAVEME 7
           DAVEME
Sbjct: 296 DAVEME 301
>NP_055978
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YDAVEMEKM 9
          YD ++++KM
Sbjct: 60 YDYLDLDKM 68
>NP_443210
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YDAVEMEKM 9
          YD ++++KM
Sbjct: 60 YDYLDLDKM 68
>NP_001940
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YDAVEMEKM 9
           +DA ++EK+
Sbjct: 448 FDAYDLEKL 456
>NP_001230005
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YDAVEMEKM 9
           +DA ++EK+
Sbjct: 317 FDAYDLEKL 325
>NP_073143
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YDAVEMEK 8
           YD V+M+K
Sbjct: 174 YDIVKMKK 181
>NP_001937
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YDAVEMEK 8
           YD V+M+K
Sbjct: 320 YDIVKMKK 327
>NP_689619
          Length = 768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YDAVEMEKM 9
           YD V  EKM
Sbjct: 557 YDDVPYEKM 565
>NP_001139809
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YDAVEMEKM 9
           YD V  EKM
Sbjct: 557 YDDVPYEKM 565
>XP_006720401
          Length = 1504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    YDAVEME 7
            +DAVEM+
Sbjct: 1281 HDAVEMD 1287
>XP_005267359
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YDAVEMEKM 9
          YD ++++KM
Sbjct: 60 YDYLDLDKM 68
>XP_005267358
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YDAVEMEKM 9
          YD ++++KM
Sbjct: 60 YDYLDLDKM 68
>XP_006720081
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YDAVEMEKM 9
          YD ++++KM
Sbjct: 60 YDYLDLDKM 68
>XP_006720080
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YDAVEMEKM 9
          YD ++++KM
Sbjct: 60 YDYLDLDKM 68
>XP_005248925
          Length = 224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YDAVEMEKM 9
           +DA ++EK+
Sbjct: 207 FDAYDLEKL 215
>XP_005248923
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YDAVEMEKM 9
           +DA ++EK+
Sbjct: 318 FDAYDLEKL 326
>XP_005248922
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YDAVEMEKM 9
           +DA ++EK+
Sbjct: 323 FDAYDLEKL 331
>XP_005268430
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YDAVEMEKM 9
           YD V  EKM
Sbjct: 524 YDDVPYEKM 532
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.124    0.318 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 464,348
Number of extensions: 895
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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