Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000262                                                              17    4312
NP_055739                                                              17    4312
XP_006722542                                                           17    4312
XP_005258336                                                           17    4312
XP_005258335                                                           17    4312
XP_005258334                                                           17    4312
NP_037521                                                              16    5631
NP_001139150                                                           16    5631
NP_001095118                                                           16    5631
XP_006714651                                                           16    5631
NP_001165882                                                           16    7355
NP_573403                                                              16    7355
NP_001165883                                                           16    7355
NP_620409                                                              16    7355
NP_060052                                                              16    7355
NP_060217                                                              16    7355
NP_877496                                                              16    7355
NP_065741                                                              16    7355
XP_005260559                                                           16    7355
XP_005260558                                                           16    7355
XP_006723918                                                           16    7355
XP_005260557                                                           16    7355
XP_005260556                                                           16    7355
XP_005260555                                                           16    7355
XP_005260554                                                           16    7355
XP_006723917                                                           16    7355
XP_005260553                                                           16    7355
XP_005245372                                                           16    7355
XP_006710999                                                           16    7355
XP_006710998                                                           16    7355
NP_000278                                                              15    9605
NP_001040                                                              15    9605
NP_001127845                                                           15    9605
NP_036361                                                              15    9605
NP_005841                                                              15    9605
NP_057228                                                              15    9605
XP_006717787                                                           15    9605
XP_006717786                                                           15    9605
XP_005269703                                                           15    9605
XP_006717785                                                           15    9605
XP_005269700                                                           15    9605
XP_006717784                                                           15    9605
XP_005269699                                                           15    9605
XP_005269702                                                           15    9605
XP_005269701                                                           15    9605
XP_005269697                                                           15    9605
XP_005269698                                                           15    9605
XP_005269696                                                           15    9605
XP_005269695                                                           15    9605
XP_005269694                                                           15    9605
XP_005269693                                                           15    9605
XP_005269692                                                           15    9605
XP_005269691                                                           15    9605
XP_005269690                                                           15    9605
XP_005269689                                                           15    9605
XP_005249237                                                           15    9605
XP_005277388                                                           15    9605
>NP_000262
          Length = 1278

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AVSLVNII 9
            AVSLVN++
Sbjct: 1151 AVSLVNLV 1158
>NP_055739
          Length = 492

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA  LVNI+
Sbjct: 309 YATQLVNIL 317
>XP_006722542
          Length = 1273

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AVSLVNII 9
            AVSLVN++
Sbjct: 1168 AVSLVNLV 1175
>XP_005258336
          Length = 1286

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AVSLVNII 9
            AVSLVN++
Sbjct: 1151 AVSLVNLV 1158
>XP_005258335
          Length = 1295

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AVSLVNII 9
            AVSLVN++
Sbjct: 1168 AVSLVNLV 1175
>XP_005258334
          Length = 1303

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AVSLVNII 9
            AVSLVN++
Sbjct: 1168 AVSLVNLV 1175
>NP_037521
          Length = 1359

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    AVSLVNII 9
            AVSL+N++
Sbjct: 1192 AVSLINLV 1199
>NP_001139150
          Length = 1275

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YAVSLVNI 8
           YA++LVN+
Sbjct: 457 YAMNLVNV 464
>NP_001095118
          Length = 1332

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    AVSLVNII 9
            AVSL+N++
Sbjct: 1165 AVSLINLV 1172
>XP_006714651
          Length = 1280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   YAVSLVNI 8
           YA++LVN+
Sbjct: 457 YAMNLVNV 464
>NP_001165882
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YAVSLV+ +
Sbjct: 220 YAVSLVDAL 228
>NP_573403
          Length = 720

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YA++L+N +
Sbjct: 234 YAIALINAL 242
>NP_001165883
          Length = 524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YAVSLV+ +
Sbjct: 222 YAVSLVDAL 230
>NP_620409
          Length = 524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YAVSLV+ +
Sbjct: 222 YAVSLVDAL 230
>NP_060052
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YAVSLVN 7
           YAV LVN
Sbjct: 274 YAVELVN 280
>NP_060217
          Length = 2542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    YAVSLVNII 9
            YAV L+N +
Sbjct: 1754 YAVQLINAL 1762
>NP_877496
          Length = 720

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YA++L+N +
Sbjct: 234 YAIALINAL 242
>NP_065741
          Length = 2617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    YAVSLVNII 9
            YAV L+N +
Sbjct: 1754 YAVQLINAL 1762
>XP_005260559
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YAVSLVNII 9
          YA++L+N +
Sbjct: 51 YAIALINAL 59
>XP_005260558
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YAVSLVNII 9
          YA++L+N +
Sbjct: 51 YAIALINAL 59
>XP_006723918
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YA++L+N +
Sbjct: 146 YAIALINAL 154
>XP_005260557
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YA++L+N +
Sbjct: 146 YAIALINAL 154
>XP_005260556
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YA++L+N +
Sbjct: 146 YAIALINAL 154
>XP_005260555
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YA++L+N +
Sbjct: 146 YAIALINAL 154
>XP_005260554
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YA++L+N +
Sbjct: 146 YAIALINAL 154
>XP_006723917
          Length = 720

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YA++L+N +
Sbjct: 234 YAIALINAL 242
>XP_005260553
          Length = 720

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YA++L+N +
Sbjct: 234 YAIALINAL 242
>XP_005245372
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YAVSLVN 7
           YAV LVN
Sbjct: 274 YAVELVN 280
>XP_006710999
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YAVSLV+ +
Sbjct: 161 YAVSLVDAL 169
>XP_006710998
          Length = 524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YAVSLVNII 9
           YAVSLV+ +
Sbjct: 222 YAVSLVDAL 230
>NP_000278
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSLVNII 9
           +VSLVN++
Sbjct: 895 SVSLVNVL 902
>NP_001040
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YAVSLVNI 8
           Y V LVN+
Sbjct: 288 YVVQLVNV 295
>NP_001127845
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 461 YAASFINLL 469
>NP_036361
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 461 YAASFINLL 469
>NP_005841
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YAVSLVNII 9
          YA+ ++N+I
Sbjct: 69 YAIKIMNMI 77
>NP_057228
          Length = 202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AVSLVNII 9
          AVSL+N I
Sbjct: 18 AVSLINAI 25
>XP_006717787
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 270 YAASFINLL 278
>XP_006717786
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 270 YAASFINLL 278
>XP_005269703
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 270 YAASFINLL 278
>XP_006717785
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 270 YAASFINLL 278
>XP_005269700
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 270 YAASFINLL 278
>XP_006717784
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 270 YAASFINLL 278
>XP_005269699
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 270 YAASFINLL 278
>XP_005269702
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 270 YAASFINLL 278
>XP_005269701
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 270 YAASFINLL 278
>XP_005269697
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 270 YAASFINLL 278
>XP_005269698
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 270 YAASFINLL 278
>XP_005269696
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 432 YAASFINLL 440
>XP_005269695
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 437 YAASFINLL 445
>XP_005269694
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 440 YAASFINLL 448
>XP_005269693
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 461 YAASFINLL 469
>XP_005269692
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 469 YAASFINLL 477
>XP_005269691
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 469 YAASFINLL 477
>XP_005269690
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 469 YAASFINLL 477
>XP_005269689
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YAVSLVNII 9
           YA S +N++
Sbjct: 469 YAASFINLL 477
>XP_005249237
          Length = 892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSLVNII 9
           +VSLVN++
Sbjct: 807 SVSLVNVL 814
>XP_005277388
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YAVSLVNII 9
          YA+ ++N+I
Sbjct: 69 YAIKIMNMI 77
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.144    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 318,688
Number of extensions: 736
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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