Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              20     299
NP_001087241                                                           20     299
XP_005265799                                                           20     299
XP_005265798                                                           20     299
XP_005265797                                                           20     299
NP_057292                                                              17    3301
NP_898880                                                              17    3301
XP_005272381                                                           17    3301
XP_006716641                                                           17    3301
XP_005272380                                                           17    3301
XP_006716640                                                           17    3301
NP_065169                                                              16    5631
XP_006723898                                                           16    5631
XP_006723897                                                           16    5631
XP_005260524                                                           16    5631
NP_060997                                                              16    7355
NP_001104268                                                           16    7355
NP_078837                                                              16    7355
NP_620074                                                              16    7355
NP_001269070                                                           16    7355
NP_001124332                                                           16    7355
NP_055625                                                              16    7355
NP_055614                                                              16    7355
NP_476516                                                              16    7355
XP_006724785                                                           16    7355
XP_006724784                                                           16    7355
XP_006724783                                                           16    7355
XP_006724782                                                           16    7355
XP_005266579                                                           16    7355
XP_006719929                                                           16    7355
XP_005263293                                                           16    7355
XP_006711734                                                           16    7355
XP_006711733                                                           16    7355
XP_006711732                                                           16    7355
XP_006711731                                                           16    7355
XP_006711730                                                           16    7355
XP_006711729                                                           16    7355
XP_005245695                                                           16    7355
NP_000775                                                              15    9605
NP_003375                                                              15    9605
NP_001020279                                                           15    9605
NP_002276                                                              15    9605
NP_060371                                                              15    9605
NP_001406                                                              15    9605
XP_006723595                                                           15    9605
XP_005268098                                                           15    9605
XP_006720310                                                           15    9605
XP_006719528                                                           15    9605
XP_005253963                                                           15    9605
XP_005253962                                                           15    9605
XP_005264002                                                           15    9605
XP_005264000                                                           15    9605
XP_006712586                                                           15    9605
XP_005263999                                                           15    9605
NP_001137291                                                           15    9605
>NP_000213
          Length = 976

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YAEAALYKN 9
           +AEAALYKN
Sbjct: 697 HAEAALYKN 705
>NP_001087241
          Length = 972

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YAEAALYKN 9
           +AEAALYKN
Sbjct: 693 HAEAALYKN 701
>XP_005265799
          Length = 973

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YAEAALYKN 9
           +AEAALYKN
Sbjct: 694 HAEAALYKN 702
>XP_005265798
          Length = 976

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YAEAALYKN 9
           +AEAALYKN
Sbjct: 698 HAEAALYKN 706
>XP_005265797
          Length = 977

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YAEAALYKN 9
           +AEAALYKN
Sbjct: 698 HAEAALYKN 706
>NP_057292
          Length = 221

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  YAEAALYKN 9
          Y E  LYKN
Sbjct: 21 YEEVKLYKN 29
>NP_898880
          Length = 233

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  YAEAALYKN 9
          Y E  LYKN
Sbjct: 21 YEEVKLYKN 29
>XP_005272381
          Length = 204

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  YAEAALYKN 9
          Y E  LYKN
Sbjct: 21 YEEVKLYKN 29
>XP_006716641
          Length = 204

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  YAEAALYKN 9
          Y E  LYKN
Sbjct: 21 YEEVKLYKN 29
>XP_005272380
          Length = 216

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  YAEAALYKN 9
          Y E  LYKN
Sbjct: 21 YEEVKLYKN 29
>XP_006716640
          Length = 216

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  YAEAALYKN 9
          Y E  LYKN
Sbjct: 21 YEEVKLYKN 29
>NP_065169
          Length = 1053

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EAALYKN 9
           EAALYK+
Sbjct: 376 EAALYKH 382
>XP_006723898
          Length = 951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EAALYKN 9
           EAALYK+
Sbjct: 274 EAALYKH 280
>XP_006723897
          Length = 951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EAALYKN 9
           EAALYK+
Sbjct: 274 EAALYKH 280
>XP_005260524
          Length = 951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EAALYKN 9
           EAALYK+
Sbjct: 274 EAALYKH 280
>NP_060997
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YAEAALYKN 9
           Y+E  LY+N
Sbjct: 189 YSELILYQN 197
>NP_001104268
          Length = 429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YAEAALYKN 9
           Y+E  LY+N
Sbjct: 189 YSELILYQN 197
>NP_078837
          Length = 864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YAEAALYKN 9
           Y+E  LY+N
Sbjct: 189 YSELILYQN 197
>NP_620074
          Length = 1212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YAEAALYKN 9
            +AE+ LY+N
Sbjct: 1059 HAESFLYRN 1067
>NP_001269070
          Length = 969

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YAEAALYKN 9
           +AE+ LY+N
Sbjct: 816 HAESFLYRN 824
>NP_001124332
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YAEAALYKN 9
            +AE+ LY+N
Sbjct: 1008 HAESFLYRN 1016
>NP_055625
          Length = 3117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YAEAALYKN 9
            Y+E++ YKN
Sbjct: 1529 YSESSGYKN 1537
>NP_055614
          Length = 891

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YAEAALYKN 9
           +AE+ LY+N
Sbjct: 738 HAESFLYRN 746
>NP_476516
          Length = 866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YAEAALYKN 9
           Y+E  LY+N
Sbjct: 189 YSELLLYQN 197
>XP_006724785
          Length = 1161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YAEAALYKN 9
            +AE+ LY+N
Sbjct: 1008 HAESFLYRN 1016
>XP_006724784
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YAEAALYKN 9
           +AE+ LY+N
Sbjct: 705 HAESFLYRN 713
>XP_006724783
          Length = 1049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YAEAALYKN 9
           +AE+ LY+N
Sbjct: 897 HAESFLYRN 905
>XP_006724782
          Length = 1050

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YAEAALYKN 9
           +AE+ LY+N
Sbjct: 897 HAESFLYRN 905
>XP_005266579
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YAEAALYKN 9
           Y+E  LY+N
Sbjct: 189 YSELILYQN 197
>XP_006719929
          Length = 804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YAEAALYKN 9
           Y+E  LY+N
Sbjct: 189 YSELILYQN 197
>XP_005263293
          Length = 865

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YAEAALYKN 9
           Y+E  LY+N
Sbjct: 189 YSELLLYQN 197
>XP_006711734
          Length = 3136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YAEAALYKN 9
            Y+E++ YKN
Sbjct: 1507 YSESSGYKN 1515
>XP_006711733
          Length = 3137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YAEAALYKN 9
            Y+E++ YKN
Sbjct: 1508 YSESSGYKN 1516
>XP_006711732
          Length = 3154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YAEAALYKN 9
            Y+E++ YKN
Sbjct: 1525 YSESSGYKN 1533
>XP_006711731
          Length = 3157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YAEAALYKN 9
            Y+E++ YKN
Sbjct: 1528 YSESSGYKN 1536
>XP_006711730
          Length = 3157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YAEAALYKN 9
            Y+E++ YKN
Sbjct: 1528 YSESSGYKN 1536
>XP_006711729
          Length = 3158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YAEAALYKN 9
            Y+E++ YKN
Sbjct: 1529 YSESSGYKN 1537
>XP_005245695
          Length = 3158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    YAEAALYKN 9
            Y+E++ YKN
Sbjct: 1529 YSESSGYKN 1537
>NP_000775
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AEAALY 7
           AEAALY
Sbjct: 169 AEAALY 174
>NP_003375
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YAEAALYKN 9
           Y E  LY+N
Sbjct: 311 YTEKPLYEN 319
>NP_001020279
          Length = 1251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    YAEAAL 6
            YAEAAL
Sbjct: 1029 YAEAAL 1034
>NP_002276
          Length = 1226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    YAEAAL 6
            YAEAAL
Sbjct: 1004 YAEAAL 1009
>NP_060371
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  YAEAALY 7
          Y EAA+Y
Sbjct: 71 YQEAAIY 77
>NP_001406
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  YAEAALYK 8
          YA A +YK
Sbjct: 83 YANAKIYK 90
>XP_006723595
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EAALYKN 9
           EAALY N
Sbjct: 166 EAALYGN 172
>XP_005268098
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YAEAALYKN 9
           Y E  LY+N
Sbjct: 311 YTEKPLYEN 319
>XP_006720310
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YAEAALYKN 9
           Y E  LY+N
Sbjct: 311 YTEKPLYEN 319
>XP_006719528
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YAEAALY 7
           Y EAA+Y
Sbjct: 143 YQEAAIY 149
>XP_005253963
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1 YAEAALY 7
         Y EAA+Y
Sbjct: 3 YQEAAIY 9
>XP_005253962
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YAEAALY 7
           Y EAA+Y
Sbjct: 143 YQEAAIY 149
>XP_005264002
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YAEAAL 6
           YAEAAL
Sbjct: 673 YAEAAL 678
>XP_005264000
          Length = 1226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    YAEAAL 6
            YAEAAL
Sbjct: 1004 YAEAAL 1009
>XP_006712586
          Length = 1262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    YAEAAL 6
            YAEAAL
Sbjct: 1056 YAEAAL 1061
>XP_005263999
          Length = 1278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    YAEAAL 6
            YAEAAL
Sbjct: 1056 YAEAAL 1061
>NP_001137291
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YAEAALY 7
           Y EAA+Y
Sbjct: 143 YQEAAIY 149
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.121    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 412,863
Number of extensions: 636
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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