Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              22      79
NP_001075109                                                           22      79
NP_612200                                                              20     299
NP_056083                                                              20     299
XP_005247302                                                           20     299
NP_065974                                                              17    3301
NP_001272478                                                           17    3301
XP_005255340                                                           17    3301
XP_006712719                                                           17    3301
XP_005246770                                                           17    3301
XP_005246768                                                           17    3301
XP_005246769                                                           17    3301
NP_006720                                                              17    4312
NP_009293                                                              17    4312
NP_647479                                                              17    4312
NP_443141                                                              17    4312
XP_006714509                                                           17    4312
NP_001030014                                                           17    4312
NP_543135                                                              17    4312
NP_001011657                                                           16    5631
XP_006726449                                                           16    5631
XP_005262271                                                           16    5631
XP_006724773                                                           16    5631
XP_005262270                                                           16    5631
XP_005262269                                                           16    5631
XP_005260640                                                           16    5631
XP_005260639                                                           16    5631
XP_006712222                                                           16    5631
NP_003601                                                              16    5631
NP_001015885                                                           16    5631
NP_001123577                                                           16    7355
NP_005704                                                              16    7355
NP_112729                                                              16    7355
NP_444283                                                              16    7355
XP_006714576                                                           16    7355
NP_000375                                                              15    9605
NP_001191128                                                           15    9605
NP_003126                                                              15    9605
NP_976054                                                              15    9605
NP_001207413                                                           15    9605
NP_000115                                                              15    9605
NP_001248319                                                           15    9605
NP_005822                                                              15    9605
NP_001248320                                                           15    9605
NP_001265660                                                           15    9605
NP_001265661                                                           15    9605
NP_036340                                                              15    9605
NP_001263987                                                           15    9605
NP_001191122                                                           15    9605
NP_001191123                                                           15    9605
NP_055516                                                              15    9605
NP_001180418                                                           15    9605
NP_001092314                                                           15    9605
NP_001263988                                                           15    9605
NP_001248324                                                           15    9605
XP_006720208                                                           15    9605
XP_006720207                                                           15    9605
XP_006720206                                                           15    9605
XP_006714841                                                           15    9605
XP_006714840                                                           15    9605
>NP_008835
          Length = 4128

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    WNNDVRAEL 9
            W+NDVRAEL
Sbjct: 3588 WSNDVRAEL 3596
>NP_001075109
          Length = 4097

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    WNNDVRAEL 9
            W+NDVRAEL
Sbjct: 3588 WSNDVRAEL 3596
>NP_612200
          Length = 339

 Score = 20.4 bits (41), Expect =   299
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  WNNDVRAEL 9
          W+NDVRA L
Sbjct: 18 WSNDVRASL 26
>NP_056083
          Length = 2243

 Score = 20.4 bits (41), Expect =   299
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    WNNDVRAEL 9
            WNN  RAEL
Sbjct: 1644 WNNSTRAEL 1652
>XP_005247302
          Length = 2248

 Score = 20.4 bits (41), Expect =   299
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    WNNDVRAEL 9
            WNN  RAEL
Sbjct: 1649 WNNSTRAEL 1657
>NP_065974
          Length = 2354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    WNNDVR 6
            W+ND+R
Sbjct: 2035 WDNDIR 2040
>NP_001272478
          Length = 2352

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    WNNDVR 6
            W+ND+R
Sbjct: 2033 WDNDIR 2038
>XP_005255340
          Length = 525

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   WNNDVRA 7
           WN+++RA
Sbjct: 515 WNDEIRA 521
>XP_006712719
          Length = 2354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    WNNDVR 6
            W+ND+R
Sbjct: 2035 WDNDIR 2040
>XP_005246770
          Length = 2354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    WNNDVR 6
            W+ND+R
Sbjct: 2035 WDNDIR 2040
>XP_005246768
          Length = 2354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    WNNDVR 6
            W+ND+R
Sbjct: 2035 WDNDIR 2040
>XP_005246769
          Length = 2354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    WNNDVR 6
            W+ND+R
Sbjct: 2035 WDNDIR 2040
>NP_006720
          Length = 1101

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NDVRAEL 9
           ND+RAE+
Sbjct: 396 NDIRAEM 402
>NP_009293
          Length = 1096

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NDVRAEL 9
           ND+RAE+
Sbjct: 396 NDIRAEM 402
>NP_647479
          Length = 988

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   WNNDVRAE 8
           WNN  +AE
Sbjct: 828 WNNVTKAE 835
>NP_443141
          Length = 1271

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    WNNDVRA 7
            W++D+RA
Sbjct: 1231 WSSDIRA 1237
>XP_006714509
          Length = 1627

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    WNNDVRA 7
            W++D+RA
Sbjct: 1587 WSSDIRA 1593
>NP_001030014
          Length = 767

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   WNNDVRAEL 9
           W+ DVR +L
Sbjct: 668 WDKDVRQKL 676
>NP_543135
          Length = 316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   WNNDVRAEL 9
           WN DV+  L
Sbjct: 294 WNRDVQGAL 302
>NP_001011657
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  WNNDVRAEL 9
          WN   +AEL
Sbjct: 44 WNEQEKAEL 52
>XP_006726449
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   WNNDVRAE 8
           W +DVR+E
Sbjct: 768 WLHDVRSE 775
>XP_005262271
          Length = 695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   WNNDVRAEL 9
           WN   +AEL
Sbjct: 101 WNEQEKAEL 109
>XP_006724773
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   WNNDVRAEL 9
           WN   +AEL
Sbjct: 101 WNEQEKAEL 109
>XP_005262270
          Length = 717

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   WNNDVRAEL 9
           WN   +AEL
Sbjct: 101 WNEQEKAEL 109
>XP_005262269
          Length = 718

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   WNNDVRAEL 9
           WN   +AEL
Sbjct: 101 WNEQEKAEL 109
>XP_005260640
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   WNNDVR 6
           W NDVR
Sbjct: 100 WANDVR 105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   WNNDVRAEL 9
           W+ D R +L
Sbjct: 338 WDKDARTKL 346
>XP_005260639
          Length = 434

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   WNNDVR 6
           W NDVR
Sbjct: 128 WANDVR 133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   WNNDVRAEL 9
           W+ D R +L
Sbjct: 366 WDKDARTKL 374
>XP_006712222
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   WNNDVRAE 8
           W +DVR+E
Sbjct: 768 WLHDVRSE 775
>NP_003601
          Length = 368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  WNNDVR 6
          W NDVR
Sbjct: 62 WANDVR 67

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   WNNDVRAEL 9
           W+ D R +L
Sbjct: 300 WDKDARTKL 308
>NP_001015885
          Length = 368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  WNNDVR 6
          W NDVR
Sbjct: 62 WANDVR 67

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   WNNDVRAEL 9
           W+ D R +L
Sbjct: 300 WDKDARTKL 308
>NP_001123577
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   WNNDVR 6
           WN DVR
Sbjct: 591 WNVDVR 596
>NP_005704
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   WNNDVR 6
           WN DVR
Sbjct: 463 WNVDVR 468
>NP_112729
          Length = 598

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   WNNDVR 6
           WN DVR
Sbjct: 437 WNVDVR 442
>NP_444283
          Length = 240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1  WNNDVR 6
          WN D+R
Sbjct: 53 WNKDLR 58
>XP_006714576
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   WNNDVR 6
           WN DVR
Sbjct: 463 WNVDVR 468
>NP_000375
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1    WNNDVR 6
            W N+VR
Sbjct: 3633 WKNEVR 3638
>NP_001191128
          Length = 101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1  WNNDVR 6
          WN DV+
Sbjct: 72 WNRDVQ 77
>NP_003126
          Length = 144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1  WNNDVR 6
          WN DV+
Sbjct: 72 WNRDVQ 77
>NP_976054
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   WNNDVR 6
           WN +VR
Sbjct: 676 WNKEVR 681
>NP_001207413
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   WNNDVR 6
           WN +VR
Sbjct: 676 WNKEVR 681
>NP_000115
          Length = 1493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   WNNDVRAE 8
           W +D+R E
Sbjct: 355 WESDMRPE 362
>NP_001248319
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NNDVRAEL 9
           N+D++AEL
Sbjct: 194 NSDMQAEL 201
>NP_005822
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NNDVRAEL 9
           N+D++AEL
Sbjct: 170 NSDMQAEL 177
>NP_001248320
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NNDVRAEL 9
           N+D++AEL
Sbjct: 191 NSDMQAEL 198
>NP_001265660
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   WNNDVRAEL 9
           W++ ++AE+
Sbjct: 408 WDSGIKAEM 416
>NP_001265661
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   WNNDVRAEL 9
           W++ ++AE+
Sbjct: 289 WDSGIKAEM 297
>NP_036340
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   WNNDVRAEL 9
           W++ ++AE+
Sbjct: 433 WDSGIKAEM 441
>NP_001263987
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   WNNDVRAE 8
           W +D+R E
Sbjct: 355 WESDMRPE 362
>NP_001191122
          Length = 110

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1  WNNDVR 6
          WN DV+
Sbjct: 72 WNRDVQ 77
>NP_001191123
          Length = 120

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1  WNNDVR 6
          WN DV+
Sbjct: 48 WNRDVQ 53
>NP_055516
          Length = 1056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  WNNDVR 6
          +NND+R
Sbjct: 73 YNNDIR 78
>NP_001180418
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  WNNDVR 6
          +NND+R
Sbjct: 73 YNNDIR 78
>NP_001092314
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DVRAEL 9
           DVRAEL
Sbjct: 232 DVRAEL 237
>NP_001263988
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   WNNDVRAE 8
           W +D+R E
Sbjct: 355 WESDMRPE 362
>NP_001248324
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NNDVRAEL 9
           N+D++AEL
Sbjct: 98  NSDMQAEL 105
>XP_006720208
          Length = 892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   WNNDVR 6
           WN +VR
Sbjct: 676 WNKEVR 681
>XP_006720207
          Length = 892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   WNNDVR 6
           WN +VR
Sbjct: 676 WNKEVR 681
>XP_006720206
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   WNNDVR 6
           WN +VR
Sbjct: 676 WNKEVR 681
>XP_006714841
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   WNNDVRAEL 9
           W++ ++AE+
Sbjct: 408 WDSGIKAEM 416
>XP_006714840
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   WNNDVRAEL 9
           W++ ++AE+
Sbjct: 441 WDSGIKAEM 449
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.130    0.451 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 555,912
Number of extensions: 926
Number of successful extensions: 64
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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