Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              20     509
XP_005250103                                                           20     509
XP_005250102                                                           20     509
NP_891989                                                              17    3301
NP_065972                                                              17    3301
NP_891991                                                              17    3301
NP_000594                                                              17    3301
NP_001243793                                                           17    3301
NP_001243794                                                           17    3301
NP_055602                                                              17    3301
XP_006720223                                                           17    3301
XP_005250117                                                           17    3301
XP_006716064                                                           17    3301
XP_006716063                                                           17    3301
NP_003583                                                              17    3301
NP_852478                                                              16    5631
NP_079535                                                              16    5631
NP_751898                                                              16    5631
NP_002432                                                              16    5631
NP_751897                                                              16    5631
NP_689500                                                              16    5631
NP_001106997                                                           16    5631
NP_714544                                                              16    5631
XP_005256385                                                           16    5631
XP_006721400                                                           16    5631
XP_005256381                                                           16    5631
NP_001503                                                              16    7355
NP_001028222                                                           16    7355
NP_079474                                                              16    7355
NP_870987                                                              16    7355
XP_006719676                                                           16    7355
XP_006719675                                                           16    7355
XP_006716781                                                           16    7355
XP_005251409                                                           16    7355
XP_005251408                                                           16    7355
XP_006716780                                                           16    7355
XP_005249092                                                           16    7355
NP_056324                                                              16    7355
NP_001005619                                                           15    9605
NP_001005731                                                           15    9605
NP_006054                                                              15    9605
NP_003676                                                              15    9605
NP_000204                                                              15    9605
NP_003845                                                              15    9605
NP_689606                                                              15    9605
NP_001273171                                                           15    9605
NP_001511                                                              15    9605
NP_001888                                                              15    9605
NP_001182345                                                           15    9605
NP_004725                                                              15    9605
NP_001182344                                                           15    9605
NP_005236                                                              15    9605
NP_009139                                                              15    9605
XP_005259725                                                           15    9605
XP_005257369                                                           15    9605
XP_005257368                                                           15    9605
XP_006721933                                                           15    9605
XP_006721932                                                           15    9605
XP_006721931                                                           15    9605
XP_006721930                                                           15    9605
XP_005257366                                                           15    9605
XP_006721929                                                           15    9605
XP_006721105                                                           15    9605
XP_006719956                                                           15    9605
XP_005266649                                                           15    9605
XP_006714202                                                           15    9605
XP_005262892                                                           15    9605
XP_005262891                                                           15    9605
XP_005264923                                                           15    9605
XP_006712885                                                           15    9605
XP_006712884                                                           15    9605
XP_006712883                                                           15    9605
XP_005264093                                                           15    9605
XP_005264092                                                           15    9605
XP_006710913                                                           15    9605
NP_056066                                                              15    9605
>NP_004324
          Length = 766

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VYRIQDGLK 9
           VYRIQDG K
Sbjct: 197 VYRIQDGEK 205
>XP_005250103
          Length = 758

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VYRIQDGLK 9
           VYRIQDG K
Sbjct: 197 VYRIQDGEK 205
>XP_005250102
          Length = 767

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VYRIQDGLK 9
           VYRIQDG K
Sbjct: 197 VYRIQDGEK 205
>NP_891989
          Length = 2046

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VYRIQDGLK 9
            V+R+QD LK
Sbjct: 1287 VFRLQDELK 1295
>NP_065972
          Length = 2133

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VYRIQDGLK 9
            V+R+QD LK
Sbjct: 1287 VFRLQDELK 1295
>NP_891991
          Length = 2090

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VYRIQDGLK 9
            V+R+QD LK
Sbjct: 1287 VFRLQDELK 1295
>NP_000594
          Length = 1203

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YRIQDGL 8
           YR QDGL
Sbjct: 962 YRTQDGL 968
>NP_001243793
          Length = 970

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YRIQDG 7
           YR+QDG
Sbjct: 334 YRVQDG 339
>NP_001243794
          Length = 900

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YRIQDG 7
           YR+QDG
Sbjct: 264 YRVQDG 269
>NP_055602
          Length = 913

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YRIQDG 7
           YR+QDG
Sbjct: 277 YRVQDG 282
>XP_006720223
          Length = 1989

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VYRIQDGLK 9
            V+R+QD LK
Sbjct: 1287 VFRLQDELK 1295
>XP_005250117
          Length = 776

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VYRIQDGL 8
           V RIQDGL
Sbjct: 326 VSRIQDGL 333
>XP_006716064
          Length = 997

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YRIQDGL 8
           YR QDGL
Sbjct: 756 YRTQDGL 762
>XP_006716063
          Length = 1203

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YRIQDGL 8
           YR QDGL
Sbjct: 962 YRTQDGL 968
>NP_003583
          Length = 776

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VYRIQDGL 8
           V RIQDGL
Sbjct: 326 VSRIQDGL 333
>NP_852478
          Length = 1179

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VYRIQDG 7
           +YR++DG
Sbjct: 467 IYRMEDG 473
>NP_079535
          Length = 822

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYRIQDGLK 9
           VY++  GLK
Sbjct: 258 VYKVASGLK 266
>NP_751898
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYRIQDGLK 9
           VY++  GLK
Sbjct: 241 VYKVASGLK 249
>NP_002432
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYRIQDGLK 9
           VY++  GLK
Sbjct: 241 VYKVASGLK 249
>NP_751897
          Length = 835

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYRIQDGLK 9
           VY++  GLK
Sbjct: 241 VYKVASGLK 249
>NP_689500
          Length = 539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VYRIQDGLK 9
           VYR  DG+K
Sbjct: 369 VYRGADGMK 377
>NP_001106997
          Length = 614

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VYRIQDGLK 9
           VYR  DG+K
Sbjct: 444 VYRGADGMK 452
>NP_714544
          Length = 1775

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    YRIQDGLK 9
            +R++DG+K
Sbjct: 1101 FRVKDGVK 1108
>XP_005256385
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VYRIQDGLK 9
           VYR  DG+K
Sbjct: 230 VYRGADGMK 238
>XP_006721400
          Length = 539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VYRIQDGLK 9
           VYR  DG+K
Sbjct: 369 VYRGADGMK 377
>XP_005256381
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VYRIQDGLK 9
           VYR  DG+K
Sbjct: 427 VYRGADGMK 435
>NP_001503
          Length = 222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  VYRIQDG 7
          +Y++QDG
Sbjct: 41 LYKLQDG 47
>NP_001028222
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YRIQDG 7
           YRI+DG
Sbjct: 342 YRIKDG 347
>NP_079474
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YRIQDG 7
           YRI+DG
Sbjct: 342 YRIKDG 347
>NP_870987
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RIQDGL 8
           R+QDGL
Sbjct: 382 RVQDGL 387
>XP_006719676
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YRIQDG 7
           YRI+DG
Sbjct: 342 YRIKDG 347
>XP_006719675
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YRIQDG 7
           YRI+DG
Sbjct: 342 YRIKDG 347
>XP_006716781
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RIQDGL 8
           R+QDGL
Sbjct: 208 RVQDGL 213
>XP_005251409
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RIQDGL 8
           R+QDGL
Sbjct: 382 RVQDGL 387
>XP_005251408
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RIQDGL 8
           R+QDGL
Sbjct: 382 RVQDGL 387
>XP_006716780
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RIQDGL 8
           R+QDGL
Sbjct: 382 RVQDGL 387
>XP_005249092
          Length = 222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  VYRIQDG 7
          +Y++QDG
Sbjct: 41 LYKLQDG 47
>NP_056324
          Length = 275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  VYRIQDG 7
          V RIQDG
Sbjct: 93 VIRIQDG 99
>NP_001005619
          Length = 1805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    YRIQDG 7
            YR QDG
Sbjct: 1026 YRTQDG 1031
>NP_001005731
          Length = 1752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    YRIQDG 7
            YR QDG
Sbjct: 1026 YRTQDG 1031
>NP_006054
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  IQDGLK 9
          +QDGLK
Sbjct: 19 LQDGLK 24
>NP_003676
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YRIQDGL 8
           YR+ DG+
Sbjct: 149 YRVPDGM 155
>NP_000204
          Length = 1822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    YRIQDG 7
            YR QDG
Sbjct: 1026 YRTQDG 1031
>NP_003845
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IQDGLK 9
           IQDG+K
Sbjct: 477 IQDGMK 482
>NP_689606
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  IQDGLK 9
          +QDGLK
Sbjct: 19 LQDGLK 24
>NP_001273171
          Length = 2084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IQDGLK 9
           IQDG+K
Sbjct: 680 IQDGIK 685
>NP_001511
          Length = 2109

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IQDGLK 9
           IQDG+K
Sbjct: 680 IQDGIK 685
>NP_001888
          Length = 2322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YRIQDGLK 9
           +R+ DGL+
Sbjct: 640 FRVSDGLQ 647
>NP_001182345
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VYRIQDGLK 9
           VY  QDG K
Sbjct: 212 VYEHQDGSK 220
>NP_004725
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VYRIQDGLK 9
           VY  QDG K
Sbjct: 519 VYEHQDGSK 527
>NP_001182344
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VYRIQDGLK 9
           VY  QDG K
Sbjct: 212 VYEHQDGSK 220
>NP_005236
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    VYRIQDG 7
            VY I+DG
Sbjct: 1698 VYEIKDG 1704
>NP_009139
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYRIQDGLK 9
           +YR + GLK
Sbjct: 264 IYRTEYGLK 272
>XP_005259725
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YRIQDGL 8
           YR+ DG+
Sbjct: 149 YRVPDGM 155
>XP_005257369
          Length = 1752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    YRIQDG 7
            YR QDG
Sbjct: 1026 YRTQDG 1031
>XP_005257368
          Length = 1875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    YRIQDG 7
            YR QDG
Sbjct: 1026 YRTQDG 1031
>XP_006721933
          Length = 1787

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    YRIQDG 7
            YR QDG
Sbjct: 1061 YRTQDG 1066
>XP_006721932
          Length = 1821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   YRIQDG 7
           YR QDG
Sbjct: 972 YRTQDG 977
>XP_006721931
          Length = 1840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    YRIQDG 7
            YR QDG
Sbjct: 1061 YRTQDG 1066
>XP_006721930
          Length = 1857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    YRIQDG 7
            YR QDG
Sbjct: 1061 YRTQDG 1066
>XP_005257366
          Length = 1875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    YRIQDG 7
            YR QDG
Sbjct: 1026 YRTQDG 1031
>XP_006721929
          Length = 1910

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    YRIQDG 7
            YR QDG
Sbjct: 1061 YRTQDG 1066
>XP_006721105
          Length = 2046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IQDGLK 9
           IQDG+K
Sbjct: 680 IQDGIK 685
>XP_006719956
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VYRIQDGLK 9
           VY  QDG K
Sbjct: 519 VYEHQDGSK 527
>XP_005266649
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VYRIQDGLK 9
           VY  QDG K
Sbjct: 519 VYEHQDGSK 527
>XP_006714202
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    VYRIQDG 7
            VY I+DG
Sbjct: 1698 VYEIKDG 1704
>XP_005262892
          Length = 4600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    VYRIQDG 7
            VY I+DG
Sbjct: 1698 VYEIKDG 1704
>XP_005262891
          Length = 4600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    VYRIQDG 7
            VY I+DG
Sbjct: 1698 VYEIKDG 1704
>XP_005264923
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  IQDGLK 9
          +QDGLK
Sbjct: 19 LQDGLK 24
>XP_006712885
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IQDGLK 9
           IQDG+K
Sbjct: 326 IQDGMK 331
>XP_006712884
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IQDGLK 9
           IQDG+K
Sbjct: 410 IQDGMK 415
>XP_006712883
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IQDGLK 9
           IQDG+K
Sbjct: 411 IQDGMK 416
>XP_005264093
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IQDGLK 9
           IQDG+K
Sbjct: 477 IQDGMK 482
>XP_005264092
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IQDGLK 9
           IQDG+K
Sbjct: 505 IQDGMK 510
>XP_006710913
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YRIQDGLK 9
           YR++ GLK
Sbjct: 625 YRVKFGLK 632
>NP_056066
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   YRIQDGL 8
           +R+QDG+
Sbjct: 109 HRLQDGI 115
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.152    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 597,318
Number of extensions: 1145
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package