Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           21     229
NP_036462                                                              21     229
NP_001243397                                                           21     229
XP_005269721                                                           21     229
NP_001092882                                                           20     509
NP_006757                                                              20     509
NP_001092883                                                           20     509
XP_005273706                                                           20     509
NP_149112                                                              17    2528
XP_005254041                                                           17    2528
XP_005254039                                                           17    2528
XP_005254038                                                           17    2528
XP_005254037                                                           17    2528
NP_056054                                                              17    3301
NP_001273646                                                           17    3301
NP_001273644                                                           17    3301
XP_005251906                                                           17    3301
XP_005251905                                                           17    3301
XP_005251904                                                           17    3301
NP_006764                                                              17    3301
NP_543150                                                              16    5631
NP_110379                                                              16    5631
NP_001008897                                                           16    5631
XP_005262817                                                           16    5631
XP_005262816                                                           16    5631
NP_009126                                                              16    7355
XP_005258249                                                           16    7355
XP_006722441                                                           16    7355
XP_006722440                                                           16    7355
XP_005258245                                                           16    7355
XP_006722439                                                           16    7355
NP_795363                                                              16    7355
NP_001182728                                                           15    9605
NP_001182727                                                           15    9605
NP_000518                                                              15    9605
NP_001182732                                                           15    9605
NP_001182729                                                           15    9605
NP_065941                                                              15    9605
NP_005392                                                              15    9605
NP_001107578                                                           15    9605
NP_001036065                                                           15    9605
NP_001245271                                                           15    9605
NP_001245269                                                           15    9605
NP_689582                                                              15    9605
NP_001245270                                                           15    9605
NP_001245272                                                           15    9605
NP_115604                                                              15    9605
NP_055309                                                              15    9605
NP_009112                                                              15    9605
NP_008827                                                              15    9605
XP_006723056                                                           15    9605
XP_006721103                                                           15    9605
XP_005255314                                                           15    9605
XP_006721102                                                           15    9605
XP_005255313                                                           15    9605
XP_005255312                                                           15    9605
XP_006721101                                                           15    9605
XP_005255311                                                           15    9605
XP_005255310                                                           15    9605
XP_005269821                                                           15    9605
XP_005247739                                                           15    9605
XP_006713779                                                           15    9605
XP_005270500                                                           15    9605
XP_005270499                                                           15    9605
XP_005270498                                                           15    9605
XP_005270497                                                           15    9605
NP_001121687                                                           15    9605
>NP_001243398
          Length = 1781

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    YNVNSVNM 9
            YNVNSVNM
Sbjct: 1685 YNVNSVNM 1692
>NP_036462
          Length = 2073

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    YNVNSVNM 9
            YNVNSVNM
Sbjct: 1977 YNVNSVNM 1984
>NP_001243397
          Length = 1890

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    YNVNSVNM 9
            YNVNSVNM
Sbjct: 1794 YNVNSVNM 1801
>XP_005269721
          Length = 2073

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    YNVNSVNM 9
            YNVNSVNM
Sbjct: 1977 YNVNSVNM 1984
>NP_001092882
          Length = 2004

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    YNVNSVNM 9
            YNVNS+NM
Sbjct: 1909 YNVNSMNM 1916
>NP_006757
          Length = 2004

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    YNVNSVNM 9
            YNVNS+NM
Sbjct: 1909 YNVNSMNM 1916
>NP_001092883
          Length = 2004

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    YNVNSVNM 9
            YNVNS+NM
Sbjct: 1909 YNVNSMNM 1916
>XP_005273706
          Length = 1997

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    YNVNSVNM 9
            YNVNS+NM
Sbjct: 1902 YNVNSMNM 1909
>NP_149112
          Length = 590

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VYNVNSVNM 9
           VY VN+VN+
Sbjct: 268 VYTVNNVNV 276
>XP_005254041
          Length = 503

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VYNVNSVNM 9
           VY VN+VN+
Sbjct: 180 VYTVNNVNV 188
>XP_005254039
          Length = 589

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VYNVNSVNM 9
           VY VN+VN+
Sbjct: 268 VYTVNNVNV 276
>XP_005254038
          Length = 590

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VYNVNSVNM 9
           VY VN+VN+
Sbjct: 268 VYTVNNVNV 276
>XP_005254037
          Length = 591

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VYNVNSVNM 9
           VY VN+VN+
Sbjct: 268 VYTVNNVNV 276
>NP_056054
          Length = 1186

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY+ NSVN
Sbjct: 185 VYSANSVN 192
>NP_001273646
          Length = 1238

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY+ NSVN
Sbjct: 237 VYSANSVN 244
>NP_001273644
          Length = 1278

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY+ NSVN
Sbjct: 237 VYSANSVN 244
>XP_005251906
          Length = 1108

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VYNVNSVN 8
          VY+ NSVN
Sbjct: 67 VYSANSVN 74
>XP_005251905
          Length = 1226

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY+ NSVN
Sbjct: 185 VYSANSVN 192
>XP_005251904
          Length = 1226

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY+ NSVN
Sbjct: 185 VYSANSVN 192
>NP_006764
          Length = 670

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   VYNVNSVNM 9
           ++NVN++N+
Sbjct: 598 IFNVNNLNL 606
>NP_543150
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YNVNSVNM 9
           YNVN+V +
Sbjct: 94  YNVNAVTL 101
>NP_110379
          Length = 556

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YNVNSVNM 9
           Y VNSVN+
Sbjct: 190 YPVNSVNI 197
>NP_001008897
          Length = 401

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  YNVNSVNM 9
          Y VNSVN+
Sbjct: 35 YPVNSVNI 42
>XP_005262817
          Length = 305

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YNVNSVNM 9
          YNVN+V +
Sbjct: 70 YNVNAVTL 77
>XP_005262816
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YNVNSVNM 9
           YNVN+V +
Sbjct: 94  YNVNAVTL 101
>NP_009126
          Length = 740

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYNVNSVNM 9
           VYN  S+N+
Sbjct: 182 VYNNQSINL 190
>XP_005258249
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYNVNSVNM 9
           VYN  S+N+
Sbjct: 182 VYNNQSINL 190
>XP_006722441
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYNVNSVNM 9
           VYN  S+N+
Sbjct: 182 VYNNQSINL 190
>XP_006722440
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYNVNSVNM 9
           VYN  S+N+
Sbjct: 114 VYNNQSINL 122
>XP_005258245
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYNVNSVNM 9
           VYN  S+N+
Sbjct: 114 VYNNQSINL 122
>XP_006722439
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYNVNSVNM 9
           VYN  S+N+
Sbjct: 114 VYNNQSINL 122
>NP_795363
          Length = 323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  VYNVNSV 7
          VYN NSV
Sbjct: 87 VYNQNSV 93
>NP_001182728
          Length = 819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   NVNSVN 8
           N+NS+N
Sbjct: 776 NINSIN 781
>NP_001182727
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   NVNSVN 8
           N+NS+N
Sbjct: 817 NINSIN 822
>NP_000518
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   NVNSVN 8
           N+NS+N
Sbjct: 817 NINSIN 822
>NP_001182732
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   NVNSVN 8
           N+NS+N
Sbjct: 639 NINSIN 644
>NP_001182729
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   NVNSVN 8
           N+NS+N
Sbjct: 649 NINSIN 654
>NP_065941
          Length = 905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YNVNSV 7
           YN+NSV
Sbjct: 97  YNLNSV 102
>NP_005392
          Length = 1187

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VYNVNSVN 8
           V++VNS+N
Sbjct: 391 VHSVNSLN 398
>NP_001107578
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY++NS N
Sbjct: 144 VYSLNSFN 151
>NP_001036065
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VYNVNSVNM 9
           VY++N+V M
Sbjct: 545 VYSINNVLM 553
>NP_001245271
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY++NS N
Sbjct: 108 VYSLNSFN 115
>NP_001245269
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY++NS N
Sbjct: 144 VYSLNSFN 151
>NP_689582
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY++NS N
Sbjct: 96  VYSLNSFN 103
>NP_001245270
          Length = 620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY++NS N
Sbjct: 112 VYSLNSFN 119
>NP_001245272
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  VYNVNSVN 8
          VY++NS N
Sbjct: 76 VYSLNSFN 83
>NP_115604
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYNVNSVNM 9
           V+N  +VNM
Sbjct: 400 VWNTENVNM 408
>NP_055309
          Length = 1962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YNVNSVNM 9
            YN  +VNM
Sbjct: 1014 YNYKNVNM 1021
>NP_009112
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VYNVNSVNM 9
           VY++N+V M
Sbjct: 545 VYSINNVLM 553
>NP_008827
          Length = 230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  VYNVNS 6
          +YNVNS
Sbjct: 54 LYNVNS 59
>XP_006723056
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VYNVNSVNM 9
           VY++N+V M
Sbjct: 545 VYSINNVLM 553
>XP_006721103
          Length = 1597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YNVNSVNM 9
           YN  +VNM
Sbjct: 982 YNYKNVNM 989
>XP_005255314
          Length = 1709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YNVNSVNM 9
           YN  +VNM
Sbjct: 761 YNYKNVNM 768
>XP_006721102
          Length = 1820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YNVNSVNM 9
           YN  +VNM
Sbjct: 872 YNYKNVNM 879
>XP_005255313
          Length = 1822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YNVNSVNM 9
           YN  +VNM
Sbjct: 982 YNYKNVNM 989
>XP_005255312
          Length = 1871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YNVNSVNM 9
           YN  +VNM
Sbjct: 982 YNYKNVNM 989
>XP_006721101
          Length = 1907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YNVNSVNM 9
           YN  +VNM
Sbjct: 982 YNYKNVNM 989
>XP_005255311
          Length = 1913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YNVNSVNM 9
            YN  +VNM
Sbjct: 1014 YNYKNVNM 1021
>XP_005255310
          Length = 1919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YNVNSVNM 9
           YN  +VNM
Sbjct: 982 YNYKNVNM 989
>XP_005269821
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YNVNSVNM 9
           +N N++NM
Sbjct: 254 FNTNNMNM 261
>XP_005247739
          Length = 880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YNVNSV 7
           YN+NSV
Sbjct: 97  YNLNSV 102
>XP_006713779
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YNVNSV 7
           YN+NSV
Sbjct: 96  YNLNSV 101
>XP_005270500
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  VYNVNSVN 8
          VY++NS N
Sbjct: 64 VYSLNSFN 71
>XP_005270499
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY++NS N
Sbjct: 144 VYSLNSFN 151
>XP_005270498
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY++NS N
Sbjct: 96  VYSLNSFN 103
>XP_005270497
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VYNVNSVN 8
           VY++NS N
Sbjct: 112 VYSLNSFN 119
>NP_001121687
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YNVNSVNM 9
           +N N++NM
Sbjct: 279 FNTNNMNM 286
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.122    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 441,078
Number of extensions: 898
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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