Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1482
NP_671714                                                              18    1482
XP_006715890                                                           18    1482
XP_005250160                                                           18    1482
XP_005250159                                                           18    1482
XP_006714139                                                           18    1482
NP_775082                                                              16    5631
NP_003377                                                              16    5631
NP_001284                                                              16    5631
NP_001177779                                                           16    5631
NP_001177776                                                           16    5631
NP_037448                                                              16    5631
NP_001008226                                                           16    5631
NP_001177778                                                           16    5631
NP_001177777                                                           16    5631
NP_573568                                                              16    5631
XP_005259549                                                           16    5631
NP_055935                                                              16    7355
NP_006651                                                              16    7355
NP_060522                                                              16    7355
NP_060439                                                              16    7355
XP_005259586                                                           16    7355
XP_005256097                                                           16    7355
XP_006712689                                                           16    7355
XP_005263764                                                           16    7355
NP_036567                                                              16    7355
NP_116221                                                              15    9605
NP_002069                                                              15    9605
NP_001166184                                                           15    9605
XP_006715647                                                           15    9605
XP_006715646                                                           15    9605
XP_005265132                                                           15    9605
XP_005265131                                                           15    9605
XP_006713173                                                           15    9605
XP_005265130                                                           15    9605
XP_005265129                                                           15    9605
XP_005265128                                                           15    9605
XP_005265127                                                           15    9605
XP_005265126                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVRTEDALK 9
            VV TEDALK
Sbjct: 2467 VVLTEDALK 2475
>NP_671714
          Length = 3899

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVRTEDALK 9
            VV TEDALK
Sbjct: 2459 VVLTEDALK 2467
>XP_006715890
          Length = 3860

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVRTEDALK 9
            VV TEDALK
Sbjct: 2420 VVLTEDALK 2428
>XP_005250160
          Length = 3939

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVRTEDALK 9
            VV TEDALK
Sbjct: 2499 VVLTEDALK 2507
>XP_005250159
          Length = 3952

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVRTEDALK 9
            VV TEDALK
Sbjct: 2512 VVLTEDALK 2520
>XP_006714139
          Length = 950

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VVRTEDALK 9
           +V TEDALK
Sbjct: 939 IVSTEDALK 947
>NP_775082
          Length = 2721

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VRTEDAL 8
            V+TEDAL
Sbjct: 2499 VKTEDAL 2505
>NP_003377
          Length = 2812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VRTEDAL 8
            V+TEDAL
Sbjct: 2499 VKTEDAL 2505
>NP_001284
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRTEDALK 9
           VRTED+++
Sbjct: 205 VRTEDSIR 212
>NP_001177779
          Length = 713

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRTEDALK 9
           +R+EDAL+
Sbjct: 164 IRSEDALR 171
>NP_001177776
          Length = 642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRTEDALK 9
           +R+EDAL+
Sbjct: 164 IRSEDALR 171
>NP_037448
          Length = 639

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRTEDALK 9
           +R+EDAL+
Sbjct: 164 IRSEDALR 171
>NP_001008226
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRTEDALK 9
           +R+EDAL+
Sbjct: 164 IRSEDALR 171
>NP_001177778
          Length = 710

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRTEDALK 9
           +R+EDAL+
Sbjct: 164 IRSEDALR 171
>NP_001177777
          Length = 575

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRTEDALK 9
           +R+EDAL+
Sbjct: 164 IRSEDALR 171
>NP_573568
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVRTEDAL 8
           V +TEDAL
Sbjct: 115 VTKTEDAL 122
>XP_005259549
          Length = 1349

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVRTEDAL 8
           V +TEDAL
Sbjct: 115 VTKTEDAL 122
>NP_055935
          Length = 4169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TEDALK 9
            TEDALK
Sbjct: 2163 TEDALK 2168
>NP_006651
          Length = 633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TEDALK 9
           TEDALK
Sbjct: 543 TEDALK 548
>NP_060522
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VVRTEDALK 9
           +++TED+LK
Sbjct: 725 LLQTEDSLK 733
>NP_060439
          Length = 819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TEDALK 9
           TEDALK
Sbjct: 174 TEDALK 179
>XP_005259586
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVRTEDAL 8
           VVRT+D L
Sbjct: 383 VVRTKDVL 390
>XP_005256097
          Length = 754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VVRTEDALK 9
           +++TED+LK
Sbjct: 697 LLQTEDSLK 705
>XP_006712689
          Length = 823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TEDALK 9
           TEDALK
Sbjct: 179 TEDALK 184
>XP_005263764
          Length = 824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TEDALK 9
           TEDALK
Sbjct: 179 TEDALK 184
>NP_036567
          Length = 582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVRTEDAL 8
           VVRT+D L
Sbjct: 540 VVRTKDVL 547
>NP_116221
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   VVRTEDAL 8
           ++RT+D+L
Sbjct: 104 IIRTKDSL 111
>NP_002069
          Length = 2230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVRTEDALK 9
           + RTE ALK
Sbjct: 747 IQRTEKALK 755
>NP_001166184
          Length = 2243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVRTEDALK 9
           + RTE ALK
Sbjct: 769 IQRTEKALK 777
>XP_006715647
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   VVRTEDAL 8
           ++RT+D+L
Sbjct: 104 IIRTKDSL 111
>XP_006715646
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   VVRTEDAL 8
           ++RT+D+L
Sbjct: 104 IIRTKDSL 111
>XP_005265132
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVRTEDALK 9
           + RTE ALK
Sbjct: 731 IQRTEKALK 739
>XP_005265131
          Length = 2245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVRTEDALK 9
           + RTE ALK
Sbjct: 769 IQRTEKALK 777
>XP_006713173
          Length = 2250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVRTEDALK 9
           + RTE ALK
Sbjct: 767 IQRTEKALK 775
>XP_005265130
          Length = 2252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVRTEDALK 9
           + RTE ALK
Sbjct: 769 IQRTEKALK 777
>XP_005265129
          Length = 2269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVRTEDALK 9
           + RTE ALK
Sbjct: 786 IQRTEKALK 794
>XP_005265128
          Length = 2278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVRTEDALK 9
           + RTE ALK
Sbjct: 802 IQRTEKALK 810
>XP_005265127
          Length = 2283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVRTEDALK 9
           + RTE ALK
Sbjct: 802 IQRTEKALK 810
>XP_005265126
          Length = 2285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVRTEDALK 9
           + RTE ALK
Sbjct: 802 IQRTEKALK 810
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.129    0.314 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 444,204
Number of extensions: 576
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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