Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_477513                                                              18    1935
XP_005246329                                                           18    1935
NP_001269389                                                           17    3301
NP_000119                                                              17    4312
NP_003283                                                              17    4312
NP_001275707" target = "next">NP_001275707                                                           17    4312
NP_001275705" target = "next">NP_001275705                                                           17    4312
NP_004415                                                              17    4312
NP_067067                                                              17    4312
XP_006720921                                                           17    4312
XP_006720920                                                           17    4312
XP_005255213                                                           17    4312
XP_005255212                                                           17    4312
XP_005262880                                                           17    4312
XP_005262879                                                           17    4312
XP_006714200                                                           17    4312
XP_005262878                                                           17    4312
XP_005245528                                                           17    4312
NP_775899                                                              16    5631
NP_079374                                                              16    5631
XP_005267426                                                           16    7355
NP_689660                                                              16    7355
NP_057427                                                              15    9605
NP_001139791                                                           15    9605
NP_001139794                                                           15    9605
NP_001139793                                                           15    9605
NP_076416                                                              15    9605
NP_001139792                                                           15    9605
XP_005272122                                                           15    9605
XP_005272121                                                           15    9605
XP_005272120                                                           15    9605
XP_005272119                                                           15    9605
XP_005272118                                                           15    9605
XP_005272117                                                           15    9605
XP_005272116                                                           15    9605
XP_005272115                                                           15    9605
XP_005272114                                                           15    9605
XP_005271929                                                           15    9605
NP_001139669                                                           15    9605
NP_001275                                                              15    9605
>NP_477513
          Length = 335

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   VQNKLQK 8
           VQNKLQK
Sbjct: 247 VQNKLQK 253
>XP_005246329
          Length = 334

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   VQNKLQK 8
           VQNKLQK
Sbjct: 246 VQNKLQK 252
>NP_001269389
          Length = 587

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVQNKLQK 8
           +VQNKL K
Sbjct: 495 IVQNKLHK 502
>NP_000119
          Length = 625

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VQNKLQKA 9
           +QN LQKA
Sbjct: 528 IQNTLQKA 535
>NP_003283
          Length = 2363

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VQNKLQK 8
          VQNKL+K
Sbjct: 21 VQNKLEK 27
>NP_001275707" target = "next">NP_001275707
          Length = 607

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VQNKLQKA 9
          VQ+K+QKA
Sbjct: 74 VQHKIQKA 81
>NP_001275705" target = "next">NP_001275705
          Length = 654

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VQNKLQKA 9
          VQ+K+QKA
Sbjct: 74 VQHKIQKA 81
>NP_004415
          Length = 784

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VQNKLQKA 9
          VQ+K+QKA
Sbjct: 74 VQHKIQKA 81
>NP_067067
          Length = 400

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VQNKLQK 8
           VQN+LQK
Sbjct: 380 VQNRLQK 386
>XP_006720921
          Length = 783

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VQNKLQKA 9
          VQ+K+QKA
Sbjct: 74 VQHKIQKA 81
>XP_006720920
          Length = 785

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VQNKLQKA 9
          VQ+K+QKA
Sbjct: 75 VQHKIQKA 82
>XP_005255213
          Length = 836

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VQNKLQKA 9
           VQ+K+QKA
Sbjct: 127 VQHKIQKA 134
>XP_005255212
          Length = 837

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VQNKLQKA 9
           VQ+K+QKA
Sbjct: 127 VQHKIQKA 134
>XP_005262880
          Length = 536

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VQNKLQKA 9
           +QN LQKA
Sbjct: 439 IQNTLQKA 446
>XP_005262879
          Length = 594

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VQNKLQKA 9
           +QN LQKA
Sbjct: 497 IQNTLQKA 504
>XP_006714200
          Length = 610

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VQNKLQKA 9
           +QN LQKA
Sbjct: 513 IQNTLQKA 520
>XP_005262878
          Length = 626

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VQNKLQKA 9
           +QN LQKA
Sbjct: 529 IQNTLQKA 536
>XP_005245528
          Length = 2439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VQNKLQK 8
           VQNKL+K
Sbjct: 97  VQNKLEK 103
>NP_775899
          Length = 4462

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VQNKLQKA 9
           +QN++QKA
Sbjct: 778 LQNRMQKA 785
>NP_079374
          Length = 334

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VQNKLQK 8
           +QN+LQK
Sbjct: 246 IQNRLQK 252
>XP_005267426
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VVQNKLQK 8
           V  NKLQK
Sbjct: 202 VTSNKLQK 209
>NP_689660
          Length = 719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VVQNKLQK 8
           V  NKLQK
Sbjct: 202 VTSNKLQK 209
>NP_057427
          Length = 3114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    QNKLQK 8
            QNK+QK
Sbjct: 1139 QNKMQK 1144
>NP_001139791
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 435 IQNNLQK 441
>NP_001139794
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 404 IQNNLQK 410
>NP_001139793
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 428 IQNNLQK 434
>NP_076416
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 420 IQNNLQK 426
>NP_001139792
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 316 IQNNLQK 322
>XP_005272122
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 403 IQNNLQK 409
>XP_005272121
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 403 IQNNLQK 409
>XP_005272120
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 404 IQNNLQK 410
>XP_005272119
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 405 IQNNLQK 411
>XP_005272118
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 405 IQNNLQK 411
>XP_005272117
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 421 IQNNLQK 427
>XP_005272116
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 429 IQNNLQK 435
>XP_005272115
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 434 IQNNLQK 440
>XP_005272114
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNKLQK 8
           +QN LQK
Sbjct: 435 IQNNLQK 441
>XP_005271929
          Length = 262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QNKLQKA 9
           QNKL+K+
Sbjct: 244 QNKLEKS 250
>NP_001139669
          Length = 7081

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    VVQNKL 6
            VVQNKL
Sbjct: 3849 VVQNKL 3854
>NP_001275
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QNKLQKA 9
           QNKL+K+
Sbjct: 144 QNKLEKS 150
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.119    0.279 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 428,088
Number of extensions: 558
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package