Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002462                                                              17    2528
XP_006720215                                                           17    2528
XP_006720214                                                           17    2528
XP_005267751                                                           17    2528
XP_005270509                                                           17    4312
XP_005270508                                                           17    4312
NP_000248                                                              16    5631
NP_055140                                                              16    5631
NP_001098707                                                           16    5631
NP_001263400                                                           16    5631
NP_996836                                                              16    5631
NP_996837                                                              16    5631
NP_996838                                                              16    5631
NP_996839                                                              16    5631
NP_006106                                                              16    5631
NP_056170                                                              16    5631
NP_620636                                                              16    5631
NP_003062                                                              16    5631
XP_006725465                                                           16    5631
XP_006721857                                                           16    5631
XP_005258011                                                           16    5631
XP_005267753                                                           16    5631
XP_006716009                                                           16    5631
XP_005250353                                                           16    5631
XP_006716008                                                           16    5631
XP_006716007                                                           16    5631
XP_006716006                                                           16    5631
XP_006716003                                                           16    5631
XP_006716002                                                           16    5631
XP_005250348                                                           16    5631
XP_005247781                                                           16    5631
NP_112176                                                              16    7355
NP_001252511                                                           16    7355
NP_001129419                                                           16    7355
NP_001073922                                                           16    7355
NP_005724                                                              16    7355
XP_006723846                                                           16    7355
XP_006714577                                                           16    7355
NP_001157903                                                           16    7355
NP_001073932                                                           15    9605
NP_001368                                                              15    9605
NP_001157281                                                           15    9605
NP_001157145                                                           15    9605
NP_689561                                                              15    9605
NP_001157283                                                           15    9605
NP_060887                                                              15    9605
NP_001161221                                                           15    9605
NP_060004                                                              15    9605
NP_065924                                                              15    9605
NP_001093582                                                           15    9605
NP_005954                                                              15    9605
NP_060003                                                              15    9605
XP_006725317                                                           15    9605
XP_005256707                                                           15    9605
XP_005256511                                                           15    9605
XP_006718966                                                           15    9605
XP_005265408                                                           15    9605
XP_006711533                                                           15    9605
XP_005245422                                                           15    9605
XP_005245387                                                           15    9605
XP_005245386                                                           15    9605
XP_006711512                                                           15    9605
NP_065821                                                              15    9605
>NP_002462
          Length = 1939

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    KKNLLRL 9
            KKNLLRL
Sbjct: 1860 KKNLLRL 1866
>XP_006720215
          Length = 1968

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    KKNLLRL 9
            KKNLLRL
Sbjct: 1889 KKNLLRL 1895
>XP_006720214
          Length = 1978

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    KKNLLRL 9
            KKNLLRL
Sbjct: 1899 KKNLLRL 1905
>XP_005267751
          Length = 1979

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    KKNLLRL 9
            KKNLLRL
Sbjct: 1900 KKNLLRL 1906
>XP_005270509
          Length = 349

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VVKKNLL 7
           +VKKNLL
Sbjct: 341 IVKKNLL 347
>XP_005270508
          Length = 430

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VVKKNLL 7
           +VKKNLL
Sbjct: 422 IVKKNLL 428
>NP_000248
          Length = 1935

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KKNLLRL 9
            +KNLLRL
Sbjct: 1858 RKNLLRL 1864
>NP_055140
          Length = 474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VVKKNLL 7
           VVKKN+L
Sbjct: 404 VVKKNIL 410
>NP_001098707
          Length = 527

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VVKKNLL 7
           VVKKN+L
Sbjct: 457 VVKKNIL 463
>NP_001263400
          Length = 474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VVKKNLL 7
           VVKKN+L
Sbjct: 404 VVKKNIL 410
>NP_996836
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KKNLLRL 9
           KKN+LRL
Sbjct: 202 KKNVLRL 208
>NP_996837
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KKNLLRL 9
           KKN+LRL
Sbjct: 202 KKNVLRL 208
>NP_996838
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KKNLLRL 9
           KKN+LRL
Sbjct: 202 KKNVLRL 208
>NP_996839
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KKNLLRL 9
           KKN+LRL
Sbjct: 202 KKNVLRL 208
>NP_006106
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KKNLLRL 9
           KKN+LRL
Sbjct: 202 KKNVLRL 208
>NP_056170
          Length = 739

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VVKKNLLR 8
           ++KKNL R
Sbjct: 647 IIKKNLCR 654
>NP_620636
          Length = 1009

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VKKNLLR 8
           VKKNLL+
Sbjct: 323 VKKNLLK 329
>NP_003062
          Length = 1009

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VKKNLLR 8
           VKKNLL+
Sbjct: 323 VKKNLLK 329
>XP_006725465
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KKNLLRL 9
           KKN+LRL
Sbjct: 202 KKNVLRL 208
>XP_006721857
          Length = 603

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VVKKNLLR 8
           ++KKNL R
Sbjct: 511 IIKKNLCR 518
>XP_005258011
          Length = 716

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VVKKNLLR 8
           ++KKNL R
Sbjct: 624 IIKKNLCR 631
>XP_005267753
          Length = 1935

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KKNLLRL 9
            +KNLLRL
Sbjct: 1858 RKNLLRL 1864
>XP_006716009
          Length = 596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  VVKKNLLRL 9
          ++K+N LR+
Sbjct: 4  IIKRNFLRI 12
>XP_005250353
          Length = 969

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  VVKKNLLRL 9
          ++K+N LR+
Sbjct: 4  IIKRNFLRI 12
>XP_006716008
          Length = 988

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  VVKKNLLRL 9
          ++K+N LR+
Sbjct: 4  IIKRNFLRI 12
>XP_006716007
          Length = 989

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  VVKKNLLRL 9
          ++K+N LR+
Sbjct: 4  IIKRNFLRI 12
>XP_006716006
          Length = 990

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  VVKKNLLRL 9
          ++K+N LR+
Sbjct: 4  IIKRNFLRI 12
>XP_006716003
          Length = 1009

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  VVKKNLLRL 9
          ++K+N LR+
Sbjct: 4  IIKRNFLRI 12
>XP_006716002
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  VVKKNLLRL 9
          ++K+N LR+
Sbjct: 4  IIKRNFLRI 12
>XP_005250348
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  VVKKNLLRL 9
          ++K+N LR+
Sbjct: 4  IIKRNFLRI 12
>XP_005247781
          Length = 1008

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VKKNLLR 8
           VKKNLL+
Sbjct: 323 VKKNLLK 329
>NP_112176
          Length = 101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VKKNLLR 8
          +KKNLL+
Sbjct: 45 IKKNLLK 51
>NP_001252511
          Length = 63

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VKKNLLR 8
          +KKNLL+
Sbjct: 45 IKKNLLK 51
>NP_001129419
          Length = 146

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VKKNLLR 8
          +KKNLL+
Sbjct: 45 IKKNLLK 51
>NP_001073922
          Length = 2190

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VKKNLLRL 9
           V +NLLRL
Sbjct: 346 VSRNLLRL 353
>NP_005724
          Length = 890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  VVKKNLL 7
          VV+KNLL
Sbjct: 34 VVRKNLL 40
>XP_006723846
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  KKNLLRL 9
          +KNLLRL
Sbjct: 59 QKNLLRL 65
>XP_006714577
          Length = 890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  VVKKNLL 7
          VV+KNLL
Sbjct: 34 VVRKNLL 40
>NP_001157903
          Length = 674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  KKNLLRL 9
          +KNLLRL
Sbjct: 59 QKNLLRL 65
>NP_001073932
          Length = 4314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VKKNLLR 8
            +KKNL+R
Sbjct: 3843 LKKNLMR 3849
>NP_001368
          Length = 4307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VKKNLLR 8
            +KKNL+R
Sbjct: 3836 LKKNLMR 3842
>NP_001157281
          Length = 1941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VKKNLLRL 9
            V +NLLRL
Sbjct: 1245 VARNLLRL 1252
>NP_001157145
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VKKNLLRL 9
          V +NLLRL
Sbjct: 42 VARNLLRL 49
>NP_689561
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VKKNLLRL 9
           V +NLLRL
Sbjct: 194 VARNLLRL 201
>NP_001157283
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VKKNLLRL 9
          V +NLLRL
Sbjct: 18 VARNLLRL 25
>NP_060887
          Length = 1610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KNLLRL 9
           KNLLRL
Sbjct: 246 KNLLRL 251
>NP_001161221
          Length = 1457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  KNLLRL 9
          KNLLRL
Sbjct: 93 KNLLRL 98
>NP_060004
          Length = 1941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KKNLLRL 9
            +KN+LRL
Sbjct: 1864 RKNILRL 1870
>NP_065924
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KNLLRL 9
           KNLLRL
Sbjct: 167 KNLLRL 172
>NP_001093582
          Length = 1941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KKNLLRL 9
            +KN+LRL
Sbjct: 1864 RKNILRL 1870
>NP_005954
          Length = 1939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KKNLLRL 9
            +KN+LRL
Sbjct: 1862 RKNILRL 1868
>NP_060003
          Length = 1939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KKNLLRL 9
            +KN+LRL
Sbjct: 1862 RKNILRL 1868
>XP_006725317
          Length = 1745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VKKNLLRL 9
            V +NLLRL
Sbjct: 1244 VARNLLRL 1251
>XP_005256707
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KKNLLRL 9
            +KN+LRL
Sbjct: 1863 RKNILRL 1869
>XP_005256511
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VKKNLLRL 9
            V +NLLRL
Sbjct: 1245 VARNLLRL 1252
>XP_006718966
          Length = 4300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VKKNLLR 8
            +KKNL+R
Sbjct: 3829 LKKNLMR 3835
>XP_005265408
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KNLLRL 9
           KNLLRL
Sbjct: 167 KNLLRL 172
>XP_006711533
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVKKNLLR 8
           V+KK LLR
Sbjct: 629 VLKKELLR 636
>XP_005245422
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVKKNLLR 8
           V+KK LLR
Sbjct: 629 VLKKELLR 636
>XP_005245387
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KNLLRL 9
           KNLLRL
Sbjct: 246 KNLLRL 251
>XP_005245386
          Length = 1518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KNLLRL 9
           KNLLRL
Sbjct: 154 KNLLRL 159
>XP_006711512
          Length = 1547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KNLLRL 9
           KNLLRL
Sbjct: 246 KNLLRL 251
>NP_065821
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVKKNLLR 8
           V+KK LLR
Sbjct: 629 VLKKELLR 636
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.148    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 439,515
Number of extensions: 643
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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