Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              20     390
NP_005913                                                              20     390
XP_005267046                                                           20     390
XP_005267045                                                           20     390
NP_077719                                                              17    4312
NP_001186978                                                           17    4312
XP_005270959                                                           17    4312
XP_005270958                                                           17    4312
XP_006710730                                                           17    4312
NP_714915                                                              16    5631
NP_001135773                                                           16    5631
XP_006716750                                                           16    5631
XP_006716749                                                           16    5631
XP_006716748                                                           16    5631
NP_001743                                                              16    7355
NP_002572                                                              16    7355
NP_057287                                                              16    7355
NP_077747                                                              16    7355
NP_001035723                                                           16    7355
NP_004090                                                              16    7355
NP_001257456                                                           16    7355
NP_001257455                                                           16    7355
XP_005250066                                                           16    7355
XP_005250064                                                           16    7355
XP_005250063                                                           16    7355
XP_005250062                                                           16    7355
XP_005250061                                                           16    7355
XP_006716084                                                           16    7355
XP_005250060                                                           16    7355
XP_005250059                                                           16    7355
NP_001030025                                                           15    9605
NP_000319                                                              15    9605
NP_115518                                                              15    9605
NP_057405                                                              15    9605
XP_005272690                                                           15    9605
XP_006724601                                                           15    9605
XP_006722394                                                           15    9605
XP_005258167                                                           15    9605
XP_006722393                                                           15    9605
XP_006722392                                                           15    9605
XP_006722391                                                           15    9605
XP_006722390                                                           15    9605
XP_005258166                                                           15    9605
XP_006722389                                                           15    9605
XP_005258165                                                           15    9605
XP_005258164                                                           15    9605
>NP_006715
          Length = 1558

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VVGIKNLSD 9
           V+GIKNLSD
Sbjct: 413 VLGIKNLSD 421
>NP_005913
          Length = 1608

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VVGIKNLSD 9
           V+GIKNLSD
Sbjct: 413 VLGIKNLSD 421
>XP_005267046
          Length = 1554

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VVGIKNLSD 9
           V+GIKNLSD
Sbjct: 413 VLGIKNLSD 421
>XP_005267045
          Length = 1604

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VVGIKNLSD 9
           V+GIKNLSD
Sbjct: 413 VLGIKNLSD 421
>NP_077719
          Length = 2471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VGIKNLS 8
            VG+KNLS
Sbjct: 1735 VGLKNLS 1741
>NP_001186978
          Length = 2715

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VVGIKNLSD 9
            VVG K LSD
Sbjct: 1491 VVGSKGLSD 1499
>XP_005270959
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VGIKNLS 8
            VG+KNLS
Sbjct: 1696 VGLKNLS 1702
>XP_005270958
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VGIKNLS 8
            VG+KNLS
Sbjct: 1696 VGLKNLS 1702
>XP_006710730
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VGIKNLS 8
            VG+KNLS
Sbjct: 1696 VGLKNLS 1702
>NP_714915
          Length = 995

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVGIKNLS 8
           VVG KNL+
Sbjct: 701 VVGFKNLA 708
>NP_001135773
          Length = 914

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVGIKNLS 8
           VVG KNL+
Sbjct: 620 VVGFKNLA 627
>XP_006716750
          Length = 795

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVGIKNLS 8
           VVG KNL+
Sbjct: 501 VVGFKNLA 508
>XP_006716749
          Length = 894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVGIKNLS 8
           VVG KNL+
Sbjct: 600 VVGFKNLA 607
>XP_006716748
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVGIKNLS 8
           VVG KNL+
Sbjct: 686 VVGFKNLA 693
>NP_001743
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   GIKNLS 8
           GIKNLS
Sbjct: 241 GIKNLS 246
>NP_002572
          Length = 1627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVGIKNLSD 9
           VVGI  +SD
Sbjct: 154 VVGIHTISD 162
>NP_057287
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVGIKNLSD 9
           +VGI +LSD
Sbjct: 541 IVGIISLSD 549
>NP_077747
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVGIKNLSD 9
           +VGI +LSD
Sbjct: 300 IVGIISLSD 308
>NP_001035723
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVGIKNLSD 9
           +VGI +LSD
Sbjct: 497 IVGIISLSD 505
>NP_004090
          Length = 288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVGIKNLS 8
           V+G KNLS
Sbjct: 154 VLGTKNLS 161
>NP_001257456
          Length = 168

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVGIKNLS 8
           V+G KNLS
Sbjct: 154 VLGTKNLS 161
>NP_001257455
          Length = 197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVGIKNLS 8
           V+G KNLS
Sbjct: 154 VLGTKNLS 161
>XP_005250066
          Length = 358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVGIKNLSD 9
           +VGI +LSD
Sbjct: 280 IVGIISLSD 288
>XP_005250064
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVGIKNLSD 9
           +VGI +LSD
Sbjct: 416 IVGIISLSD 424
>XP_005250063
          Length = 495

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVGIKNLSD 9
           +VGI +LSD
Sbjct: 417 IVGIISLSD 425
>XP_005250062
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVGIKNLSD 9
           +VGI +LSD
Sbjct: 540 IVGIISLSD 548
>XP_005250061
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVGIKNLSD 9
           +VGI +LSD
Sbjct: 497 IVGIISLSD 505
>XP_006716084
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVGIKNLSD 9
           +VGI +LSD
Sbjct: 537 IVGIISLSD 545
>XP_005250060
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVGIKNLSD 9
           +VGI +LSD
Sbjct: 540 IVGIISLSD 548
>XP_005250059
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVGIKNLSD 9
           +VGI +LSD
Sbjct: 541 IVGIISLSD 549
>NP_001030025
          Length = 1152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VGIKNLSD 9
           +G+KN+S+
Sbjct: 172 IGLKNVSN 179
>NP_000319
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VGIKNLSD 9
           +G+KN+S+
Sbjct: 172 IGLKNVSN 179
>NP_115518
          Length = 2537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    GIKNLSD 9
            G+K LSD
Sbjct: 1888 GVKKLSD 1894
>NP_057405
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VVGIKNL 7
           VVG++NL
Sbjct: 119 VVGVENL 125
>XP_005272690
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VGIKNLSD 9
           +G+KN+S+
Sbjct: 172 IGLKNVSN 179
>XP_006724601
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VGIKNLSD 9
           +G+KN+S+
Sbjct: 172 IGLKNVSN 179
>XP_006722394
          Length = 1845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    GIKNLSD 9
            G+K LSD
Sbjct: 1195 GVKKLSD 1201
>XP_005258167
          Length = 1856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    GIKNLSD 9
            G+K LSD
Sbjct: 1206 GVKKLSD 1212
>XP_006722393
          Length = 2199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    GIKNLSD 9
            G+K LSD
Sbjct: 1549 GVKKLSD 1555
>XP_006722392
          Length = 2444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    GIKNLSD 9
            G+K LSD
Sbjct: 1794 GVKKLSD 1800
>XP_006722391
          Length = 2448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    GIKNLSD 9
            G+K LSD
Sbjct: 1798 GVKKLSD 1804
>XP_006722390
          Length = 2467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    GIKNLSD 9
            G+K LSD
Sbjct: 1818 GVKKLSD 1824
>XP_005258166
          Length = 2468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    GIKNLSD 9
            G+K LSD
Sbjct: 1818 GVKKLSD 1824
>XP_006722389
          Length = 2506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    GIKNLSD 9
            G+K LSD
Sbjct: 1888 GVKKLSD 1894
>XP_005258165
          Length = 2534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    GIKNLSD 9
            G+K LSD
Sbjct: 1884 GVKKLSD 1890
>XP_005258164
          Length = 2538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    GIKNLSD 9
            G+K LSD
Sbjct: 1888 GVKKLSD 1894
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.139    0.360 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 451,987
Number of extensions: 776
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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