Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           19     869
NP_001185763                                                           19     869
NP_055459                                                              19     869
XP_006726410                                                           19     869
XP_006711719                                                           19     869
XP_006711718                                                           19     869
XP_006711717                                                           19     869
XP_006711716                                                           19     869
XP_006711715                                                           19     869
XP_006711714                                                           19     869
XP_006711713                                                           19     869
XP_006711711                                                           19     869
XP_006711710                                                           19     869
XP_006711709                                                           19     869
XP_005277503                                                           19     869
XP_005273038                                                           19     869
XP_005277500                                                           19     869
XP_006711707                                                           19     869
XP_005277499                                                           19     869
XP_006711706                                                           19     869
XP_006711705                                                           19     869
XP_006711164                                                           19     869
XP_005276153                                                           19     869
XP_003846805                                                           19     869
XP_006726412                                                           17    2528
XP_006711760                                                           17    2528
NP_653272                                                              17    3301
NP_001171468                                                           17    3301
NP_001171467                                                           17    3301
XP_006719320                                                           17    3301
NP_061978                                                              17    4312
NP_078886                                                              16    5631
XP_005247818                                                           16    5631
NP_056046                                                              16    7355
NP_116045                                                              16    7355
XP_005253647                                                           16    7355
XP_006718233                                                           16    7355
NP_001013657                                                           15    9605
NP_955373                                                              15    9605
NP_787055                                                              15    9605
NP_062831                                                              15    9605
NP_001137474                                                           15    9605
XP_006724566                                                           15    9605
XP_005274619                                                           15    9605
XP_006723268                                                           15    9605
XP_005259506                                                           15    9605
XP_006723267                                                           15    9605
>NP_001185761
          Length = 2240

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 1942 VAEVRALRG 1950
>NP_001185763
          Length = 2362

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2048 VAEVRALRG 2056
>NP_055459
          Length = 2346

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2048 VAEVRALRG 2056
>XP_006726410
          Length = 2087

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 1789 VAEVRALRG 1797
>XP_006711719
          Length = 2302

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2004 VAEVRALRG 2012
>XP_006711718
          Length = 1436

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 1055 VAEVRALRG 1063
>XP_006711717
          Length = 2385

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2004 VAEVRALRG 2012
>XP_006711716
          Length = 2411

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2113 VAEVRALRG 2121
>XP_006711715
          Length = 2428

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2047 VAEVRALRG 2055
>XP_006711714
          Length = 2429

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2048 VAEVRALRG 2056
>XP_006711713
          Length = 2432

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2051 VAEVRALRG 2059
>XP_006711711
          Length = 2482

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2101 VAEVRALRG 2109
>XP_006711710
          Length = 2494

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2113 VAEVRALRG 2121
>XP_006711709
          Length = 2495

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2114 VAEVRALRG 2122
>XP_005277503
          Length = 2498

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2211 VAEVRALRG 2219
>XP_005273038
          Length = 2509

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2211 VAEVRALRG 2219
>XP_005277500
          Length = 2525

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2211 VAEVRALRG 2219
>XP_006711707
          Length = 2553

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2211 VAEVRALRG 2219
>XP_005277499
          Length = 2561

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2211 VAEVRALRG 2219
>XP_006711706
          Length = 2591

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2210 VAEVRALRG 2218
>XP_006711705
          Length = 2592

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 2211 VAEVRALRG 2219
>XP_006711164
          Length = 2087

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVEVRALRG 9
            V EVRALRG
Sbjct: 1789 VAEVRALRG 1797
>XP_005276153
          Length = 267

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VVEVRALRG 9
          V EVRALRG
Sbjct: 44 VAEVRALRG 52
>XP_003846805
          Length = 306

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VVEVRALRG 9
          V EVRALRG
Sbjct: 44 VAEVRALRG 52
>XP_006726412
          Length = 140

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VVEVRALRG 9
           V EVR LRG
Sbjct: 120 VAEVRGLRG 128
>XP_006711760
          Length = 140

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VVEVRALRG 9
           V EVR LRG
Sbjct: 120 VAEVRGLRG 128
>NP_653272
          Length = 249

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EVRALRG 9
           E+RALRG
Sbjct: 234 EIRALRG 240
>NP_001171468
          Length = 249

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EVRALRG 9
           E+RALRG
Sbjct: 234 EIRALRG 240
>NP_001171467
          Length = 262

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EVRALRG 9
           E+RALRG
Sbjct: 247 EIRALRG 253
>XP_006719320
          Length = 249

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EVRALRG 9
           E+RALRG
Sbjct: 234 EIRALRG 240
>NP_061978
          Length = 4242

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VEVRALRG 9
           V VRALRG
Sbjct: 818 VTVRALRG 825
>NP_078886
          Length = 488

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VVEVRALR 8
           VVE++ALR
Sbjct: 341 VVEIQALR 348
>XP_005247818
          Length = 460

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VVEVRALR 8
           VVE++ALR
Sbjct: 313 VVEIQALR 320
>NP_056046
          Length = 1436

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    EVRALRG 9
            EVR LRG
Sbjct: 1111 EVRTLRG 1117
>NP_116045
          Length = 1157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEVRALRG 9
           ++E+R LRG
Sbjct: 885 MMEIRRLRG 893
>XP_005253647
          Length = 1175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEVRALRG 9
           ++E+R LRG
Sbjct: 885 MMEIRRLRG 893
>XP_006718233
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EVRALRG 9
           EVR LRG
Sbjct: 457 EVRTLRG 463
>NP_001013657
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  EVRALRG 9
          +VRA+RG
Sbjct: 57 DVRAMRG 63
>NP_955373
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VEVRALRG 9
           +EVR LRG
Sbjct: 658 LEVRNLRG 665
>NP_787055
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VRALRG 9
           VRALRG
Sbjct: 201 VRALRG 206
>NP_062831
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VRALRG 9
           VRALRG
Sbjct: 201 VRALRG 206
>NP_001137474
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VRALRG 9
           VRALRG
Sbjct: 201 VRALRG 206
>XP_006724566
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VRALRG 9
           VRALRG
Sbjct: 201 VRALRG 206
>XP_005274619
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VRALRG 9
           VRALRG
Sbjct: 201 VRALRG 206
>XP_006723268
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VEVRALRG 9
           +EVR LRG
Sbjct: 658 LEVRNLRG 665
>XP_005259506
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VEVRALRG 9
           +EVR LRG
Sbjct: 671 LEVRNLRG 678
>XP_006723267
          Length = 947

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VEVRALRG 9
           +EVR LRG
Sbjct: 685 LEVRNLRG 692
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.146    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 275,843
Number of extensions: 388
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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