Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              20     299
XP_005248577                                                           20     299
XP_005248576                                                           20     299
NP_009054                                                              18    1935
NP_996816                                                              18    1935
NP_064522                                                              18    1935
XP_005272685                                                           18    1935
NP_001129477                                                           17    4312
NP_001129478                                                           17    4312
NP_000810                                                              17    4312
XP_006726907                                                           17    4312
XP_006724053                                                           17    4312
XP_006724052                                                           17    4312
XP_005260998                                                           17    4312
XP_006724051                                                           17    4312
NP_780294                                                              17    4312
NP_072179                                                              16    5631
NP_002881                                                              16    5631
NP_005948                                                              16    5631
NP_877950                                                              16    5631
NP_877953                                                              16    5631
NP_689616                                                              16    5631
NP_001192230                                                           16    5631
NP_002266                                                              16    5631
NP_055685                                                              16    5631
XP_005257402                                                           16    5631
XP_005263520                                                           16    5631
XP_005263519                                                           16    5631
XP_005263518                                                           16    5631
XP_005263517                                                           16    5631
XP_005263515                                                           16    5631
NP_001077090                                                           16    5631
NP_001132914                                                           16    7355
NP_872348                                                              16    7355
XP_005251785                                                           16    7355
XP_005251786                                                           16    7355
XP_006717030                                                           16    7355
XP_006717029                                                           16    7355
NP_612206                                                              16    7355
NP_078951                                                              15    9605
NP_001710                                                              15    9605
NP_060257                                                              15    9605
NP_001077382                                                           15    9605
NP_002228                                                              15    9605
NP_001131147                                                           15    9605
NP_056034                                                              15    9605
NP_001269266                                                           15    9605
NP_001269267                                                           15    9605
NP_001269242                                                           15    9605
NP_001013861                                                           15    9605
NP_001138771                                                           15    9605
NP_001138770                                                           15    9605
NP_001138769                                                           15    9605
NP_004498                                                              15    9605
NP_001165806                                                           15    9605
NP_001129497                                                           15    9605
NP_005023                                                              15    9605
XP_006723849                                                           15    9605
XP_006723848                                                           15    9605
XP_006721852                                                           15    9605
XP_006721851                                                           15    9605
XP_006721850                                                           15    9605
XP_006721849                                                           15    9605
NP_839943                                                              15    9605
>NP_005912
          Length = 1512

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VEDTLDGQ 9
           VEDTLDGQ
Sbjct: 873 VEDTLDGQ 880
>XP_005248577
          Length = 1349

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VEDTLDGQ 9
           VEDTLDGQ
Sbjct: 710 VEDTLDGQ 717
>XP_005248576
          Length = 1375

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VEDTLDGQ 9
           VEDTLDGQ
Sbjct: 736 VEDTLDGQ 743
>NP_009054
          Length = 1546

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           V+E T+DGQ
Sbjct: 164 VIEKTVDGQ 172
>NP_996816
          Length = 5202

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           V+E T+DGQ
Sbjct: 164 VIEKTVDGQ 172
>NP_064522
          Length = 841

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VEDTLDGQ 9
           V+DT+DGQ
Sbjct: 593 VKDTVDGQ 600
>XP_005272685
          Length = 815

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VEDTLDGQ 9
           V+DT+DGQ
Sbjct: 567 VKDTVDGQ 574
>NP_001129477
          Length = 1010

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           V+E+ LDG+
Sbjct: 188 VIEELLDGE 196
>NP_001129478
          Length = 1010

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           V+E+ LDG+
Sbjct: 188 VIEELLDGE 196
>NP_000810
          Length = 1010

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           V+E+ LDG+
Sbjct: 188 VIEELLDGE 196
>XP_006726907
          Length = 337

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           +V +TLDGQ
Sbjct: 286 LVGETLDGQ 294
>XP_006724053
          Length = 1010

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           V+E+ LDG+
Sbjct: 188 VIEELLDGE 196
>XP_006724052
          Length = 1010

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           V+E+ LDG+
Sbjct: 188 VIEELLDGE 196
>XP_005260998
          Length = 1010

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           V+E+ LDG+
Sbjct: 188 VIEELLDGE 196
>XP_006724051
          Length = 1026

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           V+E+ LDG+
Sbjct: 204 VIEELLDGE 212
>NP_780294
          Length = 433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           V+E+ LDG+
Sbjct: 188 VIEELLDGE 196
>NP_072179
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           V+ DT+DG+
Sbjct: 272 VLNDTVDGK 280
>NP_002881
          Length = 1047

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           V+ DT+DG+
Sbjct: 449 VLNDTVDGK 457
>NP_005948
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VVEDTLD 7
           VVEDTL+
Sbjct: 635 VVEDTLE 641
>NP_877950
          Length = 775

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           +VED +DG+
Sbjct: 759 LVEDAVDGK 767
>NP_877953
          Length = 152

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVEDTLDGQ 9
           +VED +DG+
Sbjct: 136 LVEDAVDGK 144
>NP_689616
          Length = 1009

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VVEDTLDGQ 9
            +VED +DG+
Sbjct: 993  LVEDAVDGK 1001
>NP_001192230
          Length = 1017

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VVEDTLDGQ 9
            +VED +DG+
Sbjct: 1001 LVEDAVDGK 1009
>NP_002266
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VEDTLDGQ 9
           VE+++DGQ
Sbjct: 440 VEESVDGQ 447
>NP_055685
          Length = 1239

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    VEDTLDG 8
            VED LDG
Sbjct: 1223 VEDLLDG 1229
>XP_005257402
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VEDTLDGQ 9
           VE+++DGQ
Sbjct: 440 VEESVDGQ 447
>XP_005263520
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VVEDTLD 7
           VVEDTL+
Sbjct: 553 VVEDTLE 559
>XP_005263519
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VVEDTLD 7
           VVEDTL+
Sbjct: 635 VVEDTLE 641
>XP_005263518
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VVEDTLD 7
           VVEDTL+
Sbjct: 635 VVEDTLE 641
>XP_005263517
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VVEDTLD 7
           VVEDTL+
Sbjct: 635 VVEDTLE 641
>XP_005263515
          Length = 697

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VVEDTLD 7
           VVEDTL+
Sbjct: 676 VVEDTLE 682
>NP_001077090
          Length = 1239

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    VEDTLDG 8
            VED LDG
Sbjct: 1223 VEDLLDG 1229
>NP_001132914
          Length = 800

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   EDTLDGQ 9
           ED LDG+
Sbjct: 596 EDALDGE 602
>NP_872348
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   VVEDTLDGQ 9
           ++ED+L+G+
Sbjct: 520 ILEDSLEGR 528
>XP_005251785
          Length = 477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   EDTLDGQ 9
           ED LDG+
Sbjct: 273 EDALDGE 279
>XP_005251786
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   EDTLDGQ 9
           ED LDG+
Sbjct: 319 EDALDGE 325
>XP_006717030
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   EDTLDGQ 9
           ED LDG+
Sbjct: 506 EDALDGE 512
>XP_006717029
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   EDTLDGQ 9
           ED LDG+
Sbjct: 506 EDALDGE 512
>NP_612206
          Length = 287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VVEDTLDG 8
           V  DTLDG
Sbjct: 239 VSSDTLDG 246
>NP_078951
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DTLDGQ 9
           DTLDG+
Sbjct: 360 DTLDGR 365
>NP_001710
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DTLDGQ 9
           +TLDGQ
Sbjct: 250 ETLDGQ 255
>NP_060257
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VVEDTLDG 8
           +++D LDG
Sbjct: 272 LIDDALDG 279
>NP_001077382
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VVEDTLDG 8
           +++D LDG
Sbjct: 293 LIDDALDG 300
>NP_002228
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VVEDTLDG 8
           + ED LDG
Sbjct: 156 IAEDHLDG 163
>NP_001131147
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVEDTLDGQ 9
           VVE  +DGQ
Sbjct: 302 VVECVVDGQ 310
>NP_056034
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VVEDTLDG 8
           +++D LDG
Sbjct: 316 LIQDALDG 323
>NP_001269266
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVEDTLDGQ 9
           V+ED  DGQ
Sbjct: 496 VLEDLGDGQ 504
>NP_001269267
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVEDTLDGQ 9
           V+ED  DGQ
Sbjct: 464 VLEDLGDGQ 472
>NP_001269242
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VVEDTLDG 8
           +++D LDG
Sbjct: 306 LIQDALDG 313
>NP_001013861
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VVEDTLDG 8
           +++D LDG
Sbjct: 347 LIQDALDG 354
>NP_001138771
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VVEDTLDG 8
           +++D LDG
Sbjct: 370 LIQDALDG 377
>NP_001138770
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VVEDTLDG 8
           +++D LDG
Sbjct: 339 LIQDALDG 346
>NP_001138769
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VVEDTLDG 8
           +++D LDG
Sbjct: 398 LIQDALDG 405
>NP_004498
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VVEDTLDGQ 9
           V+E  LDG+
Sbjct: 181 VIEANLDGE 189
>NP_001165806
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVEDTLDGQ 9
           V+ED  DGQ
Sbjct: 482 VLEDLGDGQ 490
>NP_001129497
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVEDTLDGQ 9
           V+ED  DGQ
Sbjct: 509 VLEDLGDGQ 517
>NP_005023
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VVEDTLDGQ 9
           V+ED  DGQ
Sbjct: 509 VLEDLGDGQ 517
>XP_006723849
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VVEDTLDG 8
           + ED LDG
Sbjct: 156 IAEDHLDG 163
>XP_006723848
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VVEDTLDG 8
           + ED LDG
Sbjct: 156 IAEDHLDG 163
>XP_006721852
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VVEDTLDG 8
           +++D LDG
Sbjct: 316 LIQDALDG 323
>XP_006721851
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VVEDTLDG 8
           +++D LDG
Sbjct: 339 LIQDALDG 346
>XP_006721850
          Length = 697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VVEDTLDG 8
           +++D LDG
Sbjct: 347 LIQDALDG 354
>XP_006721849
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VVEDTLDG 8
           +++D LDG
Sbjct: 370 LIQDALDG 377
>NP_839943
          Length = 1631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VVEDTL 6
           VVEDTL
Sbjct: 222 VVEDTL 227
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.135    0.355 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 656,955
Number of extensions: 1267
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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