Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              21     175
XP_005273257                                                           21     175
NP_056506                                                              19     869
NP_001101                                                              17    4312
NP_060483                                                              17    4312
XP_005254174                                                           17    4312
XP_006717512                                                           17    4312
XP_005252522                                                           17    4312
XP_005267098                                                           17    4312
NP_001091671                                                           16    5631
NP_001496                                                              16    5631
NP_001035055                                                           16    5631
NP_055832                                                              16    5631
NP_963920                                                              16    5631
NP_963918                                                              16    5631
XP_005270706                                                           16    5631
XP_005270705                                                           16    5631
NP_001177694                                                           16    5631
NP_006280                                                              16    7355
NP_060236                                                              16    7355
NP_001073312                                                           16    7355
NP_694691                                                              16    7355
NP_694690                                                              16    7355
NP_066576                                                              16    7355
XP_005261866                                                           16    7355
XP_005261865                                                           16    7355
XP_005261864                                                           16    7355
XP_005261863                                                           16    7355
XP_005261862                                                           16    7355
XP_005261861                                                           16    7355
XP_005261860                                                           16    7355
XP_006716915                                                           16    7355
XP_005251621                                                           16    7355
XP_006710775                                                           16    7355
XP_005263536                                                           16    7355
NP_001116229                                                           15    9605
NP_000297                                                              15    9605
NP_115759                                                              15    9605
NP_001180350                                                           15    9605
NP_996744                                                              15    9605
NP_775756                                                              15    9605
NP_004146                                                              15    9605
NP_056484                                                              15    9605
XP_003846529                                                           15    9605
XP_006723760                                                           15    9605
XP_006717618                                                           15    9605
XP_005269456                                                           15    9605
XP_006717617                                                           15    9605
XP_006717616                                                           15    9605
XP_006717615                                                           15    9605
XP_005269454                                                           15    9605
XP_005269453                                                           15    9605
XP_006717614                                                           15    9605
XP_006717613                                                           15    9605
XP_006717612                                                           15    9605
XP_005269452                                                           15    9605
XP_005269451                                                           15    9605
XP_006717611                                                           15    9605
XP_005269450                                                           15    9605
XP_005269449                                                           15    9605
XP_005269448                                                           15    9605
XP_005269447                                                           15    9605
XP_005269446                                                           15    9605
XP_005269445                                                           15    9605
XP_005249241                                                           15    9605
XP_005247891                                                           15    9605
XP_006713851                                                           15    9605
NP_075066                                                              15    9605
>NP_064450
          Length = 1722

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VTSAFKNSC 9
           V+SAFKNSC
Sbjct: 845 VSSAFKNSC 853
>XP_005273257
          Length = 1726

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VTSAFKNSC 9
           V+SAFKNSC
Sbjct: 849 VSSAFKNSC 857
>NP_056506
          Length = 1092

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VTSAFKNSC 9
           +T +FKNSC
Sbjct: 174 LTDSFKNSC 182
>NP_001101
          Length = 748

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TSAFKNSC 9
           TSA KN+C
Sbjct: 215 TSAEKNTC 222
>NP_060483
          Length = 873

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AFKNSC 9
           AFKN+C
Sbjct: 215 AFKNNC 220
>XP_005254174
          Length = 717

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TSAFKNSC 9
           TSA KN+C
Sbjct: 215 TSAEKNTC 222
>XP_006717512
          Length = 797

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VTSAFKNSC 9
           +T A+K++C
Sbjct: 521 ITDAYKSAC 529
>XP_005252522
          Length = 835

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VTSAFKNSC 9
           +T A+K++C
Sbjct: 559 ITDAYKSAC 567
>XP_005267098
          Length = 924

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AFKNSC 9
           AFKN+C
Sbjct: 266 AFKNNC 271
>NP_001091671
          Length = 375

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SAFKNSC 9
           +AF NSC
Sbjct: 312 AAFSNSC 318
>NP_001496
          Length = 375

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SAFKNSC 9
           +AF NSC
Sbjct: 312 AAFSNSC 318
>NP_001035055
          Length = 375

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SAFKNSC 9
           +AF NSC
Sbjct: 312 AAFSNSC 318
>NP_055832
          Length = 942

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SAFKNSC 9
          SAF+N C
Sbjct: 33 SAFRNHC 39
>NP_963920
          Length = 828

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SAFKNSC 9
          SAF+N C
Sbjct: 33 SAFRNHC 39
>NP_963918
          Length = 911

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3 SAFKNSC 9
         SAF+N C
Sbjct: 2 SAFRNHC 8
>XP_005270706
          Length = 851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SAFKNSC 9
          SAF+N C
Sbjct: 33 SAFRNHC 39
>XP_005270705
          Length = 934

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SAFKNSC 9
          SAF+N C
Sbjct: 33 SAFRNHC 39
>NP_001177694
          Length = 207

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VTSAFKNSC 9
          +T +FKN C
Sbjct: 8  MTLSFKNRC 16
>NP_006280
          Length = 2541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA  NSC
Sbjct: 1502 TSALCNSC 1509
>NP_060236
          Length = 1166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   TSAFKNSC 9
           T  FKN C
Sbjct: 618 TFTFKNKC 625
>NP_001073312
          Length = 1759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   TSAFKNSC 9
           T  FKN C
Sbjct: 618 TFTFKNKC 625
>NP_694691
          Length = 1161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VTSAFKN 7
           VTS FKN
Sbjct: 157 VTSRFKN 163
>NP_694690
          Length = 1170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VTSAFKN 7
           VTS FKN
Sbjct: 157 VTSRFKN 163
>NP_066576
          Length = 1198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VTSAFKN 7
           VTS FKN
Sbjct: 157 VTSRFKN 163
>XP_005261866
          Length = 1069

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  VTSAFKN 7
          VTS FKN
Sbjct: 19 VTSRFKN 25
>XP_005261865
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VTSAFKN 7
           VTS FKN
Sbjct: 170 VTSRFKN 176
>XP_005261864
          Length = 1183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VTSAFKN 7
           VTS FKN
Sbjct: 170 VTSRFKN 176
>XP_005261863
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VTSAFKN 7
           VTS FKN
Sbjct: 157 VTSRFKN 163
>XP_005261862
          Length = 1211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VTSAFKN 7
           VTS FKN
Sbjct: 170 VTSRFKN 176
>XP_005261861
          Length = 1220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VTSAFKN 7
           VTS FKN
Sbjct: 170 VTSRFKN 176
>XP_005261860
          Length = 1220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VTSAFKN 7
           VTS FKN
Sbjct: 170 VTSRFKN 176
>XP_006716915
          Length = 2542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA  NSC
Sbjct: 1502 TSALCNSC 1509
>XP_005251621
          Length = 2542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA  NSC
Sbjct: 1502 TSALCNSC 1509
>XP_006710775
          Length = 1759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   TSAFKNSC 9
           T  FKN C
Sbjct: 618 TFTFKNKC 625
>XP_005263536
          Length = 1783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   TSAFKNSC 9
           T  FKN C
Sbjct: 642 TFTFKNKC 649
>NP_001116229
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   AFKNSC 9
           +FKN+C
Sbjct: 205 SFKNAC 210
>NP_000297
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   AFKNSC 9
           +FKN+C
Sbjct: 179 SFKNAC 184
>NP_115759
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   AFKNSC 9
           AFK SC
Sbjct: 550 AFKESC 555
>NP_001180350
          Length = 1031

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   TSAFKNSC 9
           TSA  N C
Sbjct: 670 TSALSNGC 677
>NP_996744
          Length = 2948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1174 TSALRESC 1181
>NP_775756
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   TSAFKNSC 9
           TSA  N C
Sbjct: 673 TSALSNGC 680
>NP_004146
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   SAFKNSC 9
           S FK SC
Sbjct: 102 STFKESC 108
>NP_056484
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TSAFKNS 8
           T+AF+NS
Sbjct: 785 TAAFRNS 791
>XP_003846529
          Length = 174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VTSAFKNSC 9
          VTS ++ SC
Sbjct: 72 VTSCYQPSC 80
>XP_006723760
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   TSAFKNSC 9
           TSA  N C
Sbjct: 677 TSALSNGC 684
>XP_006717618
          Length = 2826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1174 TSALRESC 1181
>XP_005269456
          Length = 2846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_006717617
          Length = 2887

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_006717616
          Length = 2891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_006717615
          Length = 2903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_005269454
          Length = 2912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_005269453
          Length = 2922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_006717614
          Length = 2938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_006717613
          Length = 2948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1174 TSALRESC 1181
>XP_006717612
          Length = 2950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_005269452
          Length = 2954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_005269451
          Length = 2957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_006717611
          Length = 2964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_005269450
          Length = 2968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_005269449
          Length = 2969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_005269448
          Length = 2979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1174 TSALRESC 1181
>XP_005269447
          Length = 2980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_005269446
          Length = 2999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_005269445
          Length = 2999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TSAFKNSC 9
            TSA + SC
Sbjct: 1194 TSALRESC 1201
>XP_005249241
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   SAFKNSC 9
           S FK SC
Sbjct: 102 STFKESC 108
>XP_005247891
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   AFKNSC 9
           AFK SC
Sbjct: 550 AFKESC 555
>XP_006713851
          Length = 942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   AFKNSC 9
           AFK SC
Sbjct: 550 AFKESC 555
>NP_075066
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SAFKNSC 9
          +AF NSC
Sbjct: 90 TAFVNSC 96
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.116    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 452,697
Number of extensions: 534
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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