Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              19     665
XP_005266703                                                           19     665
NP_055059                                                              17    3301
NP_055690                                                              17    3301
NP_055986                                                              17    4312
NP_001257869                                                           17    4312
XP_005255257                                                           17    4312
XP_005255256                                                           17    4312
XP_005255255                                                           17    4312
XP_005255254                                                           17    4312
XP_005255252                                                           17    4312
NP_620279                                                              16    5631
NP_001245258                                                           16    5631
NP_001245260                                                           16    5631
NP_079490                                                              16    5631
NP_001137301                                                           16    5631
NP_071361                                                              16    5631
NP_001245259                                                           16    5631
NP_818932                                                              16    5631
NP_036288                                                              16    5631
XP_005260382                                                           16    5631
XP_005260381                                                           16    5631
XP_006723804                                                           16    5631
XP_005260380                                                           16    5631
XP_006723803                                                           16    5631
XP_005260379                                                           16    5631
XP_005260378                                                           16    5631
XP_005260377                                                           16    5631
XP_006723802                                                           16    5631
XP_005260376                                                           16    5631
XP_006723801                                                           16    5631
XP_006723800                                                           16    5631
XP_006723799                                                           16    5631
XP_006723798                                                           16    5631
XP_005266829                                                           16    5631
XP_006722615                                                           16    5631
NP_060128                                                              16    7355
XP_005267827                                                           16    7355
XP_005267826                                                           16    7355
NP_001268231                                                           15    9605
NP_115756                                                              15    9605
NP_733792                                                              15    9605
NP_060811                                                              15    9605
NP_001265461                                                           15    9605
NP_003282                                                              15    9605
NP_003250                                                              15    9605
NP_061980                                                              15    9605
XP_006725075                                                           15    9605
XP_006725074                                                           15    9605
XP_006725073                                                           15    9605
XP_005254130                                                           15    9605
XP_005254129                                                           15    9605
XP_005254128                                                           15    9605
XP_005254127                                                           15    9605
XP_005267103                                                           15    9605
XP_006715573                                                           15    9605
XP_006715572                                                           15    9605
XP_006714784                                                           15    9605
>NP_443179
          Length = 2170

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VTIATEVRP 9
            VTIATEV P
Sbjct: 1011 VTIATEVHP 1019
>XP_005266703
          Length = 1501

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VTIATEVRP 9
           VTIATEV P
Sbjct: 342 VTIATEVHP 350
>NP_055059
          Length = 1211

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TIATEVRP 9
            T+A EVRP
Sbjct: 1127 TVAMEVRP 1134
>NP_055690
          Length = 1648

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VTIATEVRP 9
           VT+A  VRP
Sbjct: 359 VTVAVRVRP 367
>NP_055986
          Length = 1125

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VTIATEVRP 9
           V++AT VRP
Sbjct: 682 VSLATTVRP 690
>NP_001257869
          Length = 1111

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VTIATEVRP 9
           V++AT VRP
Sbjct: 668 VSLATTVRP 676
>XP_005255257
          Length = 774

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VTIATEVRP 9
           V++AT VRP
Sbjct: 331 VSLATTVRP 339
>XP_005255256
          Length = 780

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VTIATEVRP 9
           V++AT VRP
Sbjct: 337 VSLATTVRP 345
>XP_005255255
          Length = 951

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VTIATEVRP 9
           V++AT VRP
Sbjct: 508 VSLATTVRP 516
>XP_005255254
          Length = 1051

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VTIATEVRP 9
           V++AT VRP
Sbjct: 608 VSLATTVRP 616
>XP_005255252
          Length = 1124

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VTIATEVRP 9
           V++AT VRP
Sbjct: 681 VSLATTVRP 689
>NP_620279
          Length = 269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VTIATEVRP 9
           +TI  EVRP
Sbjct: 185 ITIMFEVRP 193
>NP_001245258
          Length = 880

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 774 TVATEIR 780
>NP_001245260
          Length = 779

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 673 TVATEIR 679
>NP_079490
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VTIATEVRP 9
          VT+ TE+ P
Sbjct: 4  VTVTTEIPP 12
>NP_001137301
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VTIATEVRP 9
          VT+ TE+ P
Sbjct: 4  VTVTTEIPP 12
>NP_071361
          Length = 525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TIATEVRP 9
          T AT+VRP
Sbjct: 81 TSATDVRP 88
>NP_001245259
          Length = 701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 595 TVATEIR 601
>NP_818932
          Length = 779

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 673 TVATEIR 679
>NP_036288
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 775 TVATEIR 781
>XP_005260382
          Length = 732

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 626 TVATEIR 632
>XP_005260381
          Length = 744

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 638 TVATEIR 644
>XP_006723804
          Length = 819

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 713 TVATEIR 719
>XP_005260380
          Length = 841

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 735 TVATEIR 741
>XP_006723803
          Length = 853

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 747 TVATEIR 753
>XP_005260379
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 761 TVATEIR 767
>XP_005260378
          Length = 868

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 762 TVATEIR 768
>XP_005260377
          Length = 869

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 763 TVATEIR 769
>XP_006723802
          Length = 880

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 774 TVATEIR 780
>XP_005260376
          Length = 880

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 774 TVATEIR 780
>XP_006723801
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 775 TVATEIR 781
>XP_006723800
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 775 TVATEIR 781
>XP_006723799
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 775 TVATEIR 781
>XP_006723798
          Length = 916

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIATEVR 8
           T+ATE+R
Sbjct: 810 TVATEIR 816
>XP_005266829
          Length = 288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VTIATEVRP 9
          VT+ TE+ P
Sbjct: 4  VTVTTEIPP 12
>XP_006722615
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VTIATEVRP 9
          VT+ TE+ P
Sbjct: 4  VTVTTEIPP 12
>NP_060128
          Length = 571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IATEVRP 9
           IAT VRP
Sbjct: 339 IATNVRP 345
>XP_005267827
          Length = 571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IATEVRP 9
           IAT VRP
Sbjct: 339 IATNVRP 345
>XP_005267826
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IATEVRP 9
           IAT VRP
Sbjct: 353 IATNVRP 359
>NP_001268231
          Length = 811

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   VTIATEVRP 9
           VT+  E RP
Sbjct: 621 VTVEVEARP 629
>NP_115756
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   VTIATEVRP 9
           VT+  E RP
Sbjct: 589 VTVEVEARP 597
>NP_733792
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   VTIATEVRP 9
           VT+  E RP
Sbjct: 542 VTVEVEARP 550
>NP_060811
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VTIATEVR 8
           VT+A+E+R
Sbjct: 550 VTVASELR 557
>NP_001265461
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VTIATEVR 8
           VT+A+E+R
Sbjct: 424 VTVASELR 431
>NP_003282
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  VTIATEVRP 9
          V  ATEV P
Sbjct: 76 VNTATEVEP 84
>NP_003250
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   VTIATEVRP 9
           VT+  E RP
Sbjct: 738 VTVGVEYRP 746
>NP_061980
          Length = 173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TIATEVRP 9
          T+A +VRP
Sbjct: 37 TVAFDVRP 44
>XP_006725075
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VTIATEVR 8
           VT+A+E+R
Sbjct: 424 VTVASELR 431
>XP_006725074
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VTIATEVR 8
           VT+A+E+R
Sbjct: 550 VTVASELR 557
>XP_006725073
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VTIATEVR 8
           VT+A+E+R
Sbjct: 560 VTVASELR 567
>XP_005254130
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  VTIATEVRP 9
          V  ATEV P
Sbjct: 76 VNTATEVEP 84
>XP_005254129
          Length = 1262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  VTIATEVRP 9
          V  ATEV P
Sbjct: 76 VNTATEVEP 84
>XP_005254128
          Length = 1291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  VTIATEVRP 9
          V  ATEV P
Sbjct: 76 VNTATEVEP 84
>XP_005254127
          Length = 1304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  VTIATEVRP 9
          V  ATEV P
Sbjct: 76 VNTATEVEP 84
>XP_005267103
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VTIATEVR 8
           VT+A+E+R
Sbjct: 424 VTVASELR 431
>XP_006715573
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VTIATEVR 8
           VT+A+E+R
Sbjct: 550 VTVASELR 557
>XP_006715572
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VTIATEVR 8
           VT+A+E+R
Sbjct: 560 VTVASELR 567
>XP_006714784
          Length = 734

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   VTIATEVRP 9
           VT+  E RP
Sbjct: 544 VTVEVEARP 552
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.129    0.341 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 372,045
Number of extensions: 626
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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