Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           21     229
NP_000170                                                              21     229
NP_001268422                                                           21     229
NP_001268423                                                           21     229
XP_005264328                                                           21     229
NP_055325                                                              17    3301
NP_149015                                                              17    3301
NP_001184216                                                           17    3301
XP_006715989                                                           17    3301
NP_039224                                                              17    3301
NP_001013372                                                           17    3301
NP_001005239                                                           17    3301
NP_060037                                                              17    4312
NP_001161437                                                           17    4312
NP_689711                                                              17    4312
NP_001182760                                                           17    4312
NP_054777                                                              17    4312
NP_037423                                                              17    4312
XP_006716613                                                           17    4312
XP_006716612                                                           17    4312
XP_006716611                                                           17    4312
XP_006710447                                                           17    4312
XP_006710446                                                           17    4312
XP_006710445                                                           17    4312
XP_005270577                                                           17    4312
NP_060552                                                              16    5631
NP_004645                                                              16    5631
NP_055068                                                              16    5631
NP_001156750                                                           16    5631
NP_001156751                                                           16    5631
NP_001034680                                                           16    5631
NP_001034679                                                           16    5631
NP_001154180                                                           16    5631
NP_001094385                                                           16    5631
NP_002627                                                              16    5631
XP_006724788                                                           16    5631
XP_005272733                                                           16    5631
XP_005272732                                                           16    5631
XP_005255865                                                           16    5631
XP_006721206                                                           16    5631
XP_006719561                                                           16    5631
NP_004963                                                              16    7355
NP_001019554                                                           16    7355
NP_055718                                                              16    7355
NP_001245207                                                           16    7355
NP_001245205                                                           16    7355
NP_001013712                                                           16    7355
NP_001245206                                                           16    7355
NP_443138                                                              16    7355
XP_006724187                                                           16    7355
XP_006724186                                                           16    7355
XP_005261381                                                           16    7355
XP_006719739                                                           16    7355
XP_006719738                                                           16    7355
XP_005269272                                                           16    7355
XP_005268927                                                           16    7355
XP_005268734                                                           16    7355
XP_005251512                                                           16    7355
XP_005266874                                                           16    7355
XP_005266873                                                           16    7355
NP_689653                                                              16    7355
NP_443145                                                              16    7355
NP_899068                                                              15    9605
NP_055240                                                              15    9605
NP_073622                                                              15    9605
NP_699188                                                              15    9605
NP_037472                                                              15    9605
XP_006724360                                                           15    9605
XP_006724359                                                           15    9605
XP_005261762                                                           15    9605
XP_005261761                                                           15    9605
XP_005256545                                                           15    9605
XP_005251980                                                           15    9605
XP_006710290                                                           15    9605
NP_942153                                                              15    9605
>NP_001268421
          Length = 1230

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VTGNGALKR 9
           VTGNG+LKR
Sbjct: 174 VTGNGSLKR 182
>NP_000170
          Length = 1360

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VTGNGALKR 9
           VTGNG+LKR
Sbjct: 304 VTGNGSLKR 312
>NP_001268422
          Length = 1058

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  VTGNGALKR 9
          VTGNG+LKR
Sbjct: 2  VTGNGSLKR 10
>NP_001268423
          Length = 1058

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  VTGNGALKR 9
          VTGNG+LKR
Sbjct: 2  VTGNGSLKR 10
>XP_005264328
          Length = 1261

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VTGNGALKR 9
           VTGNG+LKR
Sbjct: 205 VTGNGSLKR 213
>NP_055325
          Length = 4935

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VTGNGALKR 9
            VTG G L+R
Sbjct: 1658 VTGGGGLRR 1666
>NP_149015
          Length = 5142

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VTGNGALKR 9
            VTG G L+R
Sbjct: 1658 VTGGGGLRR 1666
>NP_001184216
          Length = 326

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VTGNGAL 7
          +TGNGA+
Sbjct: 54 ITGNGAI 60
>XP_006715989
          Length = 5148

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VTGNGALKR 9
            VTG G L+R
Sbjct: 1658 VTGGGGLRR 1666
>NP_039224
          Length = 307

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  VTGNGAL 7
          VTGNGA+
Sbjct: 37 VTGNGAV 43
>NP_001013372
          Length = 326

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VTGNGAL 7
          +TGNGA+
Sbjct: 54 ITGNGAI 60
>NP_001005239
          Length = 326

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VTGNGAL 7
          +TGNGA+
Sbjct: 54 ITGNGAI 60
>NP_060037
          Length = 390

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VTGNGALKR 9
          VTG+GA+ R
Sbjct: 14 VTGSGAVPR 22
>NP_001161437
          Length = 698

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VTGNGALK 8
           VTGNG  K
Sbjct: 171 VTGNGMFK 178
>NP_689711
          Length = 698

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VTGNGALK 8
           VTGNG  K
Sbjct: 171 VTGNGMFK 178
>NP_001182760
          Length = 1283

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VTGNGALK 8
           VTGNG  K
Sbjct: 171 VTGNGMFK 178
>NP_054777
          Length = 423

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VTGNGALK 8
           VTG GALK
Sbjct: 313 VTGFGALK 320
>NP_037423
          Length = 1443

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VTGNGALK 8
           VTG GAL+
Sbjct: 955 VTGRGALR 962
>XP_006716613
          Length = 785

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VTGNGALK 8
           VTG GAL+
Sbjct: 297 VTGRGALR 304
>XP_006716612
          Length = 1365

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VTGNGALK 8
           VTG GAL+
Sbjct: 877 VTGRGALR 884
>XP_006716611
          Length = 1440

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VTGNGALK 8
           VTG GAL+
Sbjct: 955 VTGRGALR 962
>XP_006710447
          Length = 1192

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VTGNGALK 8
           VTGNG  K
Sbjct: 171 VTGNGMFK 178
>XP_006710446
          Length = 1239

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VTGNGALK 8
           VTGNG  K
Sbjct: 160 VTGNGMFK 167
>XP_006710445
          Length = 1250

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VTGNGALK 8
           VTGNG  K
Sbjct: 171 VTGNGMFK 178
>XP_005270577
          Length = 1250

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VTGNGALK 8
           VTGNG  K
Sbjct: 171 VTGNGMFK 178
>NP_060552
          Length = 1133

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGNGALKR 9
           TGN +LKR
Sbjct: 421 TGNWSLKR 428
>NP_004645
          Length = 2555

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    GNGALKR 9
            GNG LKR
Sbjct: 2408 GNGDLKR 2414
>NP_055068
          Length = 2725

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VTGNGALKR 9
            ++ NG LKR
Sbjct: 1612 ISSNGVLKR 1620
>NP_001156750
          Length = 2732

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VTGNGALKR 9
            ++ NG LKR
Sbjct: 1619 ISSNGVLKR 1627
>NP_001156751
          Length = 2731

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VTGNGALKR 9
            ++ NG LKR
Sbjct: 1618 ISSNGVLKR 1626
>NP_001034680
          Length = 2554

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    GNGALKR 9
            GNG LKR
Sbjct: 2407 GNGDLKR 2413
>NP_001034679
          Length = 2570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    GNGALKR 9
            GNG LKR
Sbjct: 2407 GNGDLKR 2413
>NP_001154180
          Length = 1075

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGNGALKR 9
           TGN +LKR
Sbjct: 363 TGNWSLKR 370
>NP_001094385
          Length = 926

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VTGNGAL 7
           +TGNG L
Sbjct: 318 ITGNGVL 324
>NP_002627
          Length = 457

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGNGALKR 9
           TG+GAL R
Sbjct: 343 TGDGALTR 350
>XP_006724788
          Length = 2570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VTGNGALKR 9
            ++ NG LKR
Sbjct: 1457 ISSNGVLKR 1465
>XP_005272733
          Length = 2559

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    GNGALKR 9
            GNG LKR
Sbjct: 2412 GNGDLKR 2418
>XP_005272732
          Length = 2575

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    GNGALKR 9
            GNG LKR
Sbjct: 2412 GNGDLKR 2418
>XP_005255865
          Length = 917

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VTGNGAL 7
           +TGNG L
Sbjct: 318 ITGNGVL 324
>XP_006721206
          Length = 921

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VTGNGAL 7
           +TGNG L
Sbjct: 313 ITGNGVL 319
>XP_006719561
          Length = 875

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGNGALKR 9
           TGN +LKR
Sbjct: 421 TGNWSLKR 428
>NP_004963
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VTGNGALK 8
           +TGNG ++
Sbjct: 290 ITGNGGIQ 297
>NP_001019554
          Length = 2385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TGNGALK 8
           TGNGA++
Sbjct: 609 TGNGAVQ 615
>NP_055718
          Length = 2363

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TGNGALK 8
           TGNGA++
Sbjct: 609 TGNGAVQ 615
>NP_001245207
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VTGNGALKR 9
          +TG  ALKR
Sbjct: 8  ITGLAALKR 16
>NP_001245205
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VTGNGALKR 9
          +TG  ALKR
Sbjct: 8  ITGLAALKR 16
>NP_001013712
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VTGNGALK 8
           V G GALK
Sbjct: 394 VAGQGALK 401
>NP_001245206
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VTGNGALKR 9
          +TG  ALKR
Sbjct: 8  ITGLAALKR 16
>NP_443138
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGNGALKR 9
           TG GAL+R
Sbjct: 591 TGPGALER 598
>XP_006724187
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGNGALKR 9
           TG GAL+R
Sbjct: 591 TGPGALER 598
>XP_006724186
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGNGALKR 9
           TG GAL+R
Sbjct: 591 TGPGALER 598
>XP_005261381
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGNGALKR 9
           TG GAL+R
Sbjct: 591 TGPGALER 598
>XP_006719739
          Length = 2306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TGNGALK 8
           TGNGA++
Sbjct: 552 TGNGAVQ 558
>XP_006719738
          Length = 2340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TGNGALK 8
           TGNGA++
Sbjct: 586 TGNGAVQ 592
>XP_005269272
          Length = 2356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TGNGALK 8
           TGNGA++
Sbjct: 609 TGNGAVQ 615
>XP_005268927
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VTGNGALK 8
           V G GALK
Sbjct: 394 VAGQGALK 401
>XP_005268734
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VTGNGAL 7
           VTG GAL
Sbjct: 105 VTGRGAL 111
>XP_005251512
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VTGNGALK 8
           +TGNG ++
Sbjct: 290 ITGNGGIQ 297
>XP_005266874
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VTGNGALKR 9
          +TG  ALKR
Sbjct: 8  ITGLAALKR 16
>XP_005266873
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VTGNGALKR 9
          +TG  ALKR
Sbjct: 8  ITGLAALKR 16
>NP_689653
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VTGNGAL 7
           VTG GAL
Sbjct: 105 VTGRGAL 111
>NP_443145
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VTGNGALKR 9
          +TG  ALKR
Sbjct: 8  ITGLAALKR 16
>NP_899068
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  VTGNGALK 8
          + GN ALK
Sbjct: 34 IVGNSALK 41
>NP_055240
          Length = 1065

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  VTGNGALK 8
          + GN ALK
Sbjct: 34 IVGNSALK 41
>NP_073622
          Length = 1501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GNGALKR 9
           GNG L+R
Sbjct: 863 GNGILRR 869
>NP_699188
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   VTGNGA 6
           +TGNGA
Sbjct: 170 LTGNGA 175
>NP_037472
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GNGALKR 9
           GNG+L R
Sbjct: 745 GNGSLSR 751
>XP_006724360
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GNGALKR 9
           GNG L+R
Sbjct: 161 GNGILRR 167
>XP_006724359
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GNGALKR 9
           GNG L+R
Sbjct: 863 GNGILRR 869
>XP_005261762
          Length = 1481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GNGALKR 9
           GNG L+R
Sbjct: 757 GNGILRR 763
>XP_005261761
          Length = 1587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GNGALKR 9
           GNG L+R
Sbjct: 863 GNGILRR 869
>XP_005256545
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   VTGNGA 6
           +TGNGA
Sbjct: 146 LTGNGA 151
>XP_005251980
          Length = 1084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  VTGNGALK 8
          + GN ALK
Sbjct: 34 IVGNSALK 41
>XP_006710290
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  VTGNGAL 7
          +TG GAL
Sbjct: 6  ITGEGAL 12
>NP_942153
          Length = 1349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GNGALKR 9
           GNG L+R
Sbjct: 711 GNGILRR 717
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.134    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 768,681
Number of extensions: 1129
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package