Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              19     869
NP_653080                                                              19     869
XP_005267292                                                           19     869
XP_005267291                                                           19     869
XP_005267290                                                           19     869
NP_001123910                                                           17    2528
NP_003118                                                              17    2528
NP_001182461                                                           17    2528
XP_006717317                                                           17    2528
XP_006717316                                                           17    2528
XP_006717315                                                           17    2528
XP_006717314                                                           17    2528
XP_006717313                                                           17    2528
XP_006717312                                                           17    2528
XP_006717311                                                           17    2528
XP_006717310                                                           17    2528
XP_006717309                                                           17    2528
XP_006717308                                                           17    2528
NP_055731                                                              17    4312
NP_001070254                                                           16    5631
XP_006718387                                                           16    5631
XP_006718386                                                           16    5631
NP_060252                                                              16    7355
NP_055855                                                              16    7355
NP_733751                                                              16    7355
XP_005252540                                                           16    7355
XP_005252539                                                           16    7355
XP_005252538                                                           16    7355
XP_005252537                                                           16    7355
XP_005252535                                                           16    7355
XP_005252534                                                           16    7355
XP_006717515                                                           16    7355
XP_005252533                                                           16    7355
XP_005252532                                                           16    7355
XP_005252531                                                           16    7355
XP_006716142                                                           16    7355
XP_005250088                                                           16    7355
XP_006716141                                                           16    7355
XP_005250085                                                           16    7355
XP_006716140                                                           16    7355
XP_005250084                                                           16    7355
XP_005250083                                                           16    7355
XP_005250082                                                           16    7355
XP_006712426                                                           16    7355
XP_006712425                                                           16    7355
XP_006712424                                                           16    7355
NP_055938                                                              15    9605
NP_060833                                                              15    9605
NP_001242910                                                           15    9605
NP_001026879                                                           15    9605
NP_055796                                                              15    9605
NP_570968                                                              15    9605
NP_001242909                                                           15    9605
NP_001242908                                                           15    9605
NP_001242907                                                           15    9605
XP_005270007                                                           15    9605
XP_005270005                                                           15    9605
XP_005270003                                                           15    9605
XP_005264780                                                           15    9605
XP_006713127                                                           15    9605
XP_006713126                                                           15    9605
XP_005264779                                                           15    9605
XP_005264778                                                           15    9605
XP_005264777                                                           15    9605
XP_006711235                                                           15    9605
NP_803173                                                              15    9605
>NP_005091
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VTENIESSE 9
            VTE+IESSE
Sbjct: 1126 VTESIESSE 1134
>NP_653080
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VTENIESSE 9
            VTE+IESSE
Sbjct: 1028 VTESIESSE 1036
>XP_005267292
          Length = 1677

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VTENIESSE 9
            VTE+IESSE
Sbjct: 1021 VTESIESSE 1029
>XP_005267291
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VTENIESSE 9
            VTE+IESSE
Sbjct: 1028 VTESIESSE 1036
>XP_005267290
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VTENIESSE 9
            VTE+IESSE
Sbjct: 1126 VTESIESSE 1134
>NP_001123910
          Length = 2477

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2405 TENVKSSE 2412
>NP_003118
          Length = 2472

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2400 TENVKSSE 2407
>NP_001182461
          Length = 2452

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2380 TENVKSSE 2387
>XP_006717317
          Length = 2498

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2426 TENVKSSE 2433
>XP_006717316
          Length = 2464

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2392 TENVKSSE 2399
>XP_006717315
          Length = 2469

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2397 TENVKSSE 2404
>XP_006717314
          Length = 2478

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2406 TENVKSSE 2413
>XP_006717313
          Length = 2483

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2411 TENVKSSE 2418
>XP_006717312
          Length = 2484

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2412 TENVKSSE 2419
>XP_006717311
          Length = 2489

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2417 TENVKSSE 2424
>XP_006717310
          Length = 2490

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2418 TENVKSSE 2425
>XP_006717309
          Length = 2505

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2433 TENVKSSE 2440
>XP_006717308
          Length = 2510

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TENIESSE 9
            TEN++SSE
Sbjct: 2438 TENVKSSE 2445
>NP_055731
          Length = 1503

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TENIESSE 9
            TEN+ES E
Sbjct: 1034 TENLESPE 1041
>NP_001070254
          Length = 1735

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            + ENI SSE
Sbjct: 1305 ILENISSSE 1313
>XP_006718387
          Length = 1798

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            + ENI SSE
Sbjct: 1368 ILENISSSE 1376
>XP_006718386
          Length = 1822

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            + ENI SSE
Sbjct: 1368 ILENISSSE 1376
>NP_060252
          Length = 2430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            VTE I SSE
Sbjct: 1499 VTEEIVSSE 1507
>NP_055855
          Length = 2098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            VTE + SSE
Sbjct: 1027 VTEEVTSSE 1035
>NP_733751
          Length = 4911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VTENIE 6
           VTENIE
Sbjct: 649 VTENIE 654
>XP_005252540
          Length = 2430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            VTE I SSE
Sbjct: 1499 VTEEIVSSE 1507
>XP_005252539
          Length = 2430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            VTE I SSE
Sbjct: 1499 VTEEIVSSE 1507
>XP_005252538
          Length = 2430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            VTE I SSE
Sbjct: 1499 VTEEIVSSE 1507
>XP_005252537
          Length = 2430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            VTE I SSE
Sbjct: 1499 VTEEIVSSE 1507
>XP_005252535
          Length = 2430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            VTE I SSE
Sbjct: 1499 VTEEIVSSE 1507
>XP_005252534
          Length = 2521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            VTE I SSE
Sbjct: 1590 VTEEIVSSE 1598
>XP_006717515
          Length = 2521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            VTE I SSE
Sbjct: 1590 VTEEIVSSE 1598
>XP_005252533
          Length = 2521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            VTE I SSE
Sbjct: 1590 VTEEIVSSE 1598
>XP_005252532
          Length = 2430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            VTE I SSE
Sbjct: 1499 VTEEIVSSE 1507
>XP_005252531
          Length = 2670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VTENIESSE 9
            VTE I SSE
Sbjct: 1739 VTEEIVSSE 1747
>XP_006716142
          Length = 4927

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VTENIE 6
           VTENIE
Sbjct: 650 VTENIE 655
>XP_005250088
          Length = 4928

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VTENIE 6
           VTENIE
Sbjct: 650 VTENIE 655
>XP_006716141
          Length = 4959

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VTENIE 6
           VTENIE
Sbjct: 650 VTENIE 655
>XP_005250085
          Length = 4979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VTENIE 6
           VTENIE
Sbjct: 650 VTENIE 655
>XP_006716140
          Length = 4982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VTENIE 6
           VTENIE
Sbjct: 650 VTENIE 655
>XP_005250084
          Length = 4982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VTENIE 6
           VTENIE
Sbjct: 650 VTENIE 655
>XP_005250083
          Length = 4982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VTENIE 6
           VTENIE
Sbjct: 649 VTENIE 654
>XP_005250082
          Length = 4983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VTENIE 6
           VTENIE
Sbjct: 650 VTENIE 655
>XP_006712426
          Length = 1237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VTENIESSE 9
           VTE + SSE
Sbjct: 333 VTEEVTSSE 341
>XP_006712425
          Length = 1349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VTENIESSE 9
           VTE + SSE
Sbjct: 333 VTEEVTSSE 341
>XP_006712424
          Length = 1376

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VTENIESSE 9
           VTE + SSE
Sbjct: 333 VTEEVTSSE 341
>NP_055938
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    ENIESSE 9
            +N+ESSE
Sbjct: 1013 DNLESSE 1019
>NP_060833
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NIESSE 9
           NIESSE
Sbjct: 232 NIESSE 237
>NP_001242910
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTENIES 7
           VTEN+E+
Sbjct: 323 VTENLET 329
>NP_001026879
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NIESSE 9
           NIESSE
Sbjct: 232 NIESSE 237
>NP_055796
          Length = 1946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    ENIESSE 9
            EN+ESS+
Sbjct: 1079 ENLESSQ 1085
>NP_570968
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTENIES 7
           VTEN+E+
Sbjct: 343 VTENLET 349
>NP_001242909
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTENIES 7
           VTEN+E+
Sbjct: 323 VTENLET 329
>NP_001242908
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTENIES 7
           VTEN+E+
Sbjct: 343 VTENLET 349
>NP_001242907
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTENIES 7
           VTEN+E+
Sbjct: 343 VTENLET 349
>XP_005270007
          Length = 232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NIESSE 9
           NIESSE
Sbjct: 149 NIESSE 154
>XP_005270005
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NIESSE 9
           NIESSE
Sbjct: 149 NIESSE 154
>XP_005270003
          Length = 306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NIESSE 9
           NIESSE
Sbjct: 232 NIESSE 237
>XP_005264780
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ENIESSE 9
           +N+ESSE
Sbjct: 665 DNLESSE 671
>XP_006713127
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ENIESSE 9
           +N+ESSE
Sbjct: 724 DNLESSE 730
>XP_006713126
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ENIESSE 9
           +N+ESSE
Sbjct: 959 DNLESSE 965
>XP_005264779
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ENIESSE 9
           +N+ESSE
Sbjct: 968 DNLESSE 974
>XP_005264778
          Length = 1001

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ENIESSE 9
           +N+ESSE
Sbjct: 980 DNLESSE 986
>XP_005264777
          Length = 1003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ENIESSE 9
           +N+ESSE
Sbjct: 982 DNLESSE 988
>XP_006711235
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTENIES 7
           VTEN+E+
Sbjct: 323 VTENLET 329
>NP_803173
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VTENIESSE 9
           +  N+ESSE
Sbjct: 219 IEANVESSE 227
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.275    0.101    0.215 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 365,731
Number of extensions: 502
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.4 bits)
S2: 28 (15.4 bits)

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