Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000043                                                              18    1482
NP_001269153                                                           18    1482
NP_000772                                                              17    2528
NP_001093243                                                           17    2528
XP_006720468                                                           17    2528
XP_006720467                                                           17    2528
NP_064505                                                              17    4312
XP_005248304                                                           17    4312
XP_006712699                                                           17    4312
XP_006712698                                                           17    4312
XP_006712697                                                           17    4312
NP_001191762                                                           16    5631
NP_001191760                                                           16    5631
NP_060545                                                              16    5631
NP_001191761                                                           16    5631
XP_005265322                                                           16    5631
NP_002935                                                              16    7355
NP_056493                                                              16    7355
XP_006719869                                                           16    7355
XP_006719868                                                           16    7355
XP_005266409                                                           16    7355
XP_005266407                                                           16    7355
XP_005266403                                                           16    7355
XP_006719867                                                           16    7355
XP_006719866                                                           16    7355
XP_005266405                                                           16    7355
XP_005266404                                                           16    7355
XP_006715611                                                           16    7355
NP_001191126                                                           16    7355
NP_001121371                                                           15    9605
NP_001269092                                                           15    9605
NP_001121370                                                           15    9605
NP_000075                                                              15    9605
NP_006717                                                              15    9605
NP_001186211                                                           15    9605
NP_563615                                                              15    9605
XP_005263433                                                           15    9605
XP_005263432                                                           15    9605
XP_005263431                                                           15    9605
XP_006714492                                                           15    9605
XP_005263430                                                           15    9605
XP_005263429                                                           15    9605
>NP_000043
          Length = 1500

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VTASMTMRW 9
           VTAS+T+ W
Sbjct: 92  VTASLTLPW 100
>NP_001269153
          Length = 1422

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VTASMTMRW 9
           VTAS+T+ W
Sbjct: 92  VTASLTLPW 100
>NP_000772
          Length = 521

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TASMTMRW 9
           T SMT++W
Sbjct: 330 TTSMTLQW 337
>NP_001093243
          Length = 363

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TASMTMRW 9
           T SMT++W
Sbjct: 172 TTSMTLQW 179
>XP_006720468
          Length = 433

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TASMTMRW 9
           T SMT++W
Sbjct: 242 TTSMTLQW 249
>XP_006720467
          Length = 450

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TASMTMRW 9
           T SMT++W
Sbjct: 259 TTSMTLQW 266
>NP_064505
          Length = 1555

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  VTASMTMRW 9
          +T S+T +W
Sbjct: 47 ITTSLTTKW 55
>XP_005248304
          Length = 267

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  ASMTMRW 9
          A+MTM W
Sbjct: 10 AAMTMEW 16
>XP_006712699
          Length = 1544

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  VTASMTMRW 9
          +T S+T +W
Sbjct: 36 ITTSLTTKW 44
>XP_006712698
          Length = 1547

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  VTASMTMRW 9
          +T S+T +W
Sbjct: 47 ITTSLTTKW 55
>XP_006712697
          Length = 1549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  VTASMTMRW 9
          +T S+T +W
Sbjct: 41 ITTSLTTKW 49
>NP_001191762
          Length = 549

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ASMTMRW 9
           A+MT RW
Sbjct: 155 ANMTYRW 161
>NP_001191760
          Length = 627

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ASMTMRW 9
           A+MT RW
Sbjct: 266 ANMTYRW 272
>NP_060545
          Length = 660

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ASMTMRW 9
           A+MT RW
Sbjct: 266 ANMTYRW 272
>NP_001191761
          Length = 594

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ASMTMRW 9
           A+MT RW
Sbjct: 200 ANMTYRW 206
>XP_005265322
          Length = 621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ASMTMRW 9
           A+MT RW
Sbjct: 266 ANMTYRW 272
>NP_002935
          Length = 2347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   SMTMRW 9
           +MT+RW
Sbjct: 114 NMTLRW 119
>NP_056493
          Length = 2946

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    TASMTMRW 9
            +++MT RW
Sbjct: 2282 SSNMTQRW 2289
>XP_006719869
          Length = 2943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    TASMTMRW 9
            +++MT RW
Sbjct: 2279 SSNMTQRW 2286
>XP_006719868
          Length = 2938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    TASMTMRW 9
            +++MT RW
Sbjct: 2279 SSNMTQRW 2286
>XP_005266409
          Length = 1430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TASMTMRW 9
           +++MT RW
Sbjct: 745 SSNMTQRW 752
>XP_005266407
          Length = 2641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    TASMTMRW 9
            +++MT RW
Sbjct: 1956 SSNMTQRW 1963
>XP_005266403
          Length = 2941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    TASMTMRW 9
            +++MT RW
Sbjct: 2282 SSNMTQRW 2289
>XP_006719867
          Length = 2961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    TASMTMRW 9
            +++MT RW
Sbjct: 2276 SSNMTQRW 2283
>XP_006719866
          Length = 2962

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    TASMTMRW 9
            +++MT RW
Sbjct: 2282 SSNMTQRW 2289
>XP_005266405
          Length = 2964

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    TASMTMRW 9
            +++MT RW
Sbjct: 2279 SSNMTQRW 2286
>XP_005266404
          Length = 2967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    TASMTMRW 9
            +++MT RW
Sbjct: 2282 SSNMTQRW 2289
>XP_006715611
          Length = 2342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   SMTMRW 9
           +MT+RW
Sbjct: 123 NMTLRW 128
>NP_001191126
          Length = 739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  TASMTMRW 9
          +++MT RW
Sbjct: 75 SSNMTQRW 82
>NP_001121371
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   VTASMTMRW 9
           + A+MT +W
Sbjct: 609 MAAAMTSKW 617
>NP_001269092
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   VTASMTMRW 9
           + A+MT +W
Sbjct: 559 MAAAMTSKW 567
>NP_001121370
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   VTASMTMRW 9
           + A+MT +W
Sbjct: 609 MAAAMTSKW 617
>NP_000075
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   VTASMTMRW 9
           + A+MT +W
Sbjct: 539 MAAAMTSKW 547
>NP_006717
          Length = 2863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    ASMTMRW 9
            ++MT RW
Sbjct: 2209 SNMTQRW 2215
>NP_001186211
          Length = 2851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    ASMTMRW 9
            ++MT RW
Sbjct: 2198 SNMTQRW 2204
>NP_563615
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   VTASMTMRW 9
           +TAS  + W
Sbjct: 308 ITASSVLEW 316
>XP_005263433
          Length = 2832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    ASMTMRW 9
            ++MT RW
Sbjct: 2173 SNMTQRW 2179
>XP_005263432
          Length = 2852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    ASMTMRW 9
            ++MT RW
Sbjct: 2198 SNMTQRW 2204
>XP_005263431
          Length = 2857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    ASMTMRW 9
            ++MT RW
Sbjct: 2198 SNMTQRW 2204
>XP_006714492
          Length = 2867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    ASMTMRW 9
            ++MT RW
Sbjct: 2209 SNMTQRW 2215
>XP_005263430
          Length = 2868

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    ASMTMRW 9
            ++MT RW
Sbjct: 2209 SNMTQRW 2215
>XP_005263429
          Length = 2868

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    ASMTMRW 9
            ++MT RW
Sbjct: 2209 SNMTQRW 2215
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.112    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 285,478
Number of extensions: 340
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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