Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              20     509
NP_001273188                                                           17    4312
NP_075556                                                              17    4312
NP_872309                                                              17    4312
XP_006723676                                                           17    4312
XP_006723675                                                           17    4312
XP_006723674                                                           17    4312
XP_006723673                                                           17    4312
NP_002833                                                              16    5631
NP_001154912                                                           16    5631
XP_006723375                                                           16    5631
NP_001258625                                                           16    7355
NP_001258627                                                           16    7355
NP_004290                                                              16    7355
NP_001258628                                                           16    7355
NP_001258626                                                           16    7355
NP_689652                                                              16    7355
NP_116124                                                              16    7355
NP_001269542                                                           16    7355
XP_006719318                                                           16    7355
XP_006719317                                                           16    7355
XP_006719316                                                           16    7355
XP_006719315                                                           16    7355
XP_006719314                                                           16    7355
NP_060624                                                              15    9605
NP_054753                                                              15    9605
NP_653319                                                              15    9605
NP_067051                                                              15    9605
NP_001735                                                              15    9605
NP_060123                                                              15    9605
NP_776152                                                              15    9605
NP_001122099                                                           15    9605
NP_001122098                                                           15    9605
NP_689724                                                              15    9605
NP_064533                                                              15    9605
XP_005261425                                                           15    9605
XP_005261424                                                           15    9605
XP_005261423                                                           15    9605
XP_006724211                                                           15    9605
XP_005259179                                                           15    9605
XP_006722555                                                           15    9605
XP_006722554                                                           15    9605
XP_006722553                                                           15    9605
XP_006722552                                                           15    9605
XP_006722551                                                           15    9605
XP_006722550                                                           15    9605
XP_006722549                                                           15    9605
XP_006722548                                                           15    9605
XP_005258179                                                           15    9605
XP_005258178                                                           15    9605
XP_006722396                                                           15    9605
XP_005269575                                                           15    9605
XP_006713578                                                           15    9605
XP_005246710                                                           15    9605
NP_061921                                                              15    9605
NP_061751                                                              15    9605
NP_115782                                                              15    9605
>NP_004351
          Length = 882

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VTAADAPNT 9
           VT ADAPNT
Sbjct: 398 VTDADAPNT 406
>NP_001273188
          Length = 144

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VTAADAPNT 9
           + +AD PNT
Sbjct: 93  IASADLPNT 101
>NP_075556
          Length = 1709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    TAADAPNT 9
            TAA  PNT
Sbjct: 1216 TAASVPNT 1223
>NP_872309
          Length = 191

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VTAADAPNT 9
           + +AD PNT
Sbjct: 140 IASADLPNT 148
>XP_006723676
          Length = 1385

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TAADAPNT 9
           TAA  PNT
Sbjct: 892 TAASVPNT 899
>XP_006723675
          Length = 1623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    TAADAPNT 9
            TAA  PNT
Sbjct: 1130 TAASVPNT 1137
>XP_006723674
          Length = 1701

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    TAADAPNT 9
            TAA  PNT
Sbjct: 1216 TAASVPNT 1223
>XP_006723673
          Length = 1709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    TAADAPNT 9
            TAA  PNT
Sbjct: 1216 TAASVPNT 1223
>NP_002833
          Length = 1115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VTAADAPN 8
           +TAA APN
Sbjct: 559 LTAATAPN 566
>NP_001154912
          Length = 937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VTAADAPN 8
           +TAA APN
Sbjct: 381 LTAATAPN 388
>XP_006723375
          Length = 1137

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VTAADAPN 8
           +TAA APN
Sbjct: 581 LTAATAPN 588
>NP_001258625
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ADAPNT 9
           +DAPNT
Sbjct: 179 SDAPNT 184
>NP_001258627
          Length = 726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ADAPNT 9
           +DAPNT
Sbjct: 153 SDAPNT 158
>NP_004290
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ADAPNT 9
           +DAPNT
Sbjct: 180 SDAPNT 185
>NP_001258628
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ADAPNT 9
           +DAPNT
Sbjct: 140 SDAPNT 145
>NP_001258626
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ADAPNT 9
           +DAPNT
Sbjct: 139 SDAPNT 144
>NP_689652
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTAADAP 7
           +TAA+AP
Sbjct: 292 ITAAEAP 298
>NP_116124
          Length = 668

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTAADAP 7
           +TAA+AP
Sbjct: 505 ITAAEAP 511
>NP_001269542
          Length = 562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTAADAP 7
           +TAA+AP
Sbjct: 399 ITAAEAP 405
>XP_006719318
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTAADAP 7
           +TAA+AP
Sbjct: 343 ITAAEAP 349
>XP_006719317
          Length = 540

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTAADAP 7
           +TAA+AP
Sbjct: 377 ITAAEAP 383
>XP_006719316
          Length = 562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTAADAP 7
           +TAA+AP
Sbjct: 399 ITAAEAP 405
>XP_006719315
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTAADAP 7
           +TAA+AP
Sbjct: 427 ITAAEAP 433
>XP_006719314
          Length = 661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VTAADAP 7
           +TAA+AP
Sbjct: 498 ITAAEAP 504
>NP_060624
          Length = 202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  VTAADAPN 8
          V  ADAPN
Sbjct: 73 VFQADAPN 80
>NP_054753
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  VTAADAPN 8
          V  ADAPN
Sbjct: 73 VFQADAPN 80
>NP_653319
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TAADAPN 8
           T+AD PN
Sbjct: 319 TSADLPN 325
>NP_067051
          Length = 1312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TAADAPNT 9
            TAA AP+T
Sbjct: 1050 TAAAAPST 1057
>NP_001735
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VTAADAPNT 9
          VTA+ AP T
Sbjct: 17 VTASAAPGT 25
>NP_060123
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           A+DAPN
Sbjct: 297 ASDAPN 302
>NP_776152
          Length = 1154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           +ADAPN
Sbjct: 603 SADAPN 608
>NP_001122099
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  TAADAPN 8
          T +DAPN
Sbjct: 89 TESDAPN 95
>NP_001122098
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TAADAPN 8
           T +DAPN
Sbjct: 209 TESDAPN 215
>NP_689724
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VTAADAPNT 9
          V  AD+PN+
Sbjct: 69 VPVADSPNS 77
>NP_064533
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TAADAPN 8
           T +DAPN
Sbjct: 209 TESDAPN 215
>XP_005261425
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VTAADAPNT 9
          V  AD+PN+
Sbjct: 69 VPVADSPNS 77
>XP_005261424
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VTAADAPNT 9
          V  AD+PN+
Sbjct: 69 VPVADSPNS 77
>XP_005261423
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VTAADAPNT 9
          V  AD+PN+
Sbjct: 69 VPVADSPNS 77
>XP_006724211
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VTAADAPNT 9
          V  AD+PN+
Sbjct: 69 VPVADSPNS 77
>XP_005259179
          Length = 1312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TAADAPNT 9
            TAA AP+T
Sbjct: 1050 TAAAAPST 1057
>XP_006722555
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           A+DAPN
Sbjct: 297 ASDAPN 302
>XP_006722554
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           A+DAPN
Sbjct: 297 ASDAPN 302
>XP_006722553
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           A+DAPN
Sbjct: 297 ASDAPN 302
>XP_006722552
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           A+DAPN
Sbjct: 297 ASDAPN 302
>XP_006722551
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           A+DAPN
Sbjct: 297 ASDAPN 302
>XP_006722550
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           A+DAPN
Sbjct: 296 ASDAPN 301
>XP_006722549
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           A+DAPN
Sbjct: 296 ASDAPN 301
>XP_006722548
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           A+DAPN
Sbjct: 297 ASDAPN 302
>XP_005258179
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TAADAPN 8
           T +DAPN
Sbjct: 209 TESDAPN 215
>XP_005258178
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TAADAPN 8
           T +DAPN
Sbjct: 101 TESDAPN 107
>XP_006722396
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TAADAPN 8
           T +DAPN
Sbjct: 209 TESDAPN 215
>XP_005269575
          Length = 1113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           +ADAPN
Sbjct: 562 SADAPN 567
>XP_006713578
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TAADAPN 8
           T+AD PN
Sbjct: 319 TSADLPN 325
>XP_005246710
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           AAD+PN
Sbjct: 393 AADSPN 398
>NP_061921
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AADAPN 8
           AAD+PN
Sbjct: 393 AADSPN 398
>NP_061751
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VTAADAPN 8
           VTA+DA N
Sbjct: 425 VTASDAGN 432
>NP_115782
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VTAADAPN 8
           VTA+DA N
Sbjct: 425 VTASDAGN 432
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.109    0.294 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 618,019
Number of extensions: 543
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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