Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              18    1935
XP_005266703                                                           18    1935
NP_056234                                                              17    3301
XP_005274542                                                           17    3301
NP_000184                                                              16    5631
NP_000516                                                              16    5631
NP_001159762                                                           16    5631
NP_006188                                                              16    5631
XP_006718289                                                           16    5631
XP_006716413                                                           16    5631
XP_006716412                                                           16    5631
XP_005273578                                                           16    5631
XP_005273577                                                           16    5631
XP_005273576                                                           16    5631
XP_006716411                                                           16    5631
XP_006716410                                                           16    5631
XP_006716409                                                           16    5631
XP_005273569                                                           16    5631
XP_005273566                                                           16    5631
XP_006716408                                                           16    5631
XP_006716407                                                           16    5631
XP_006716406                                                           16    5631
XP_006716405                                                           16    5631
XP_006716404                                                           16    5631
XP_006716403                                                           16    5631
XP_006716402                                                           16    5631
XP_006716401                                                           16    5631
XP_006716400                                                           16    5631
XP_006716399                                                           16    5631
NP_066990                                                              16    7355
NP_001139129                                                           16    7355
NP_001139130                                                           16    7355
NP_055535                                                              16    7355
NP_002876                                                              16    7355
NP_061756                                                              16    7355
XP_005270358                                                           16    7355
XP_006717014                                                           16    7355
XP_006710870                                                           16    7355
XP_005246013                                                           16    7355
XP_006710869                                                           16    7355
XP_005246012                                                           16    7355
XP_005246011                                                           16    7355
XP_006710868                                                           16    7355
XP_006710867                                                           16    7355
NP_061993                                                              16    7355
NP_001851                                                              16    7355
NP_001165907                                                           15    9605
NP_002628                                                              15    9605
NP_001116142                                                           15    9605
NP_000738                                                              15    9605
NP_055458                                                              15    9605
NP_056070                                                              15    9605
NP_000597                                                              15    9605
XP_006724724                                                           15    9605
XP_005249023                                                           15    9605
XP_005249022                                                           15    9605
>NP_443179
          Length = 2170

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VSVVAETDG 9
            VSVVAET G
Sbjct: 1193 VSVVAETAG 1201
>XP_005266703
          Length = 1501

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSVVAETDG 9
           VSVVAET G
Sbjct: 524 VSVVAETAG 532
>NP_056234
          Length = 2828

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    VSVVAETD 8
            VSV AETD
Sbjct: 1863 VSVTAETD 1870
>XP_005274542
          Length = 2853

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    VSVVAETD 8
            VSV AETD
Sbjct: 1888 VSVTAETD 1895
>NP_000184
          Length = 462

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSVVAETDG 9
           V VVAE DG
Sbjct: 315 VYVVAERDG 323
>NP_000516
          Length = 390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSVVAETDG 9
           V +VAE DG
Sbjct: 316 VPIVAEEDG 324
>NP_001159762
          Length = 303

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSVVAETDG 9
           V +VAE DG
Sbjct: 229 VPIVAEEDG 237
>NP_006188
          Length = 2024

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 320 SVVAETAG 327
>XP_006718289
          Length = 303

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSVVAETDG 9
           V +VAE DG
Sbjct: 229 VPIVAEEDG 237
>XP_006716413
          Length = 1598

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>XP_006716412
          Length = 1970

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 320 SVVAETAG 327
>XP_005273578
          Length = 2016

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 320 SVVAETAG 327
>XP_005273577
          Length = 2048

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 320 SVVAETAG 327
>XP_005273576
          Length = 2048

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 320 SVVAETAG 327
>XP_006716411
          Length = 2064

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>XP_006716410
          Length = 2072

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>XP_006716409
          Length = 2076

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>XP_005273569
          Length = 2086

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 359 SVVAETAG 366
>XP_005273566
          Length = 2087

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 359 SVVAETAG 366
>XP_006716408
          Length = 2117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 389 SVVAETAG 396
>XP_006716407
          Length = 2126

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>XP_006716406
          Length = 2131

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>XP_006716405
          Length = 2138

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>XP_006716404
          Length = 2142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>XP_006716403
          Length = 2146

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>XP_006716402
          Length = 2149

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>XP_006716401
          Length = 2150

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>XP_006716400
          Length = 2150

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>XP_006716399
          Length = 2150

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVVAET G
Sbjct: 422 SVVAETAG 429
>NP_066990
          Length = 269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSVVAETDG 9
           VSV+ E DG
Sbjct: 155 VSVIDEQDG 163
>NP_001139129
          Length = 681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVV ET+G
Sbjct: 603 SVVEETEG 610
>NP_001139130
          Length = 727

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVV ET+G
Sbjct: 641 SVVEETEG 648
>NP_055535
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SVVAETD 8
           SVVA+TD
Sbjct: 655 SVVADTD 661
>NP_002876
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVV ET+G
Sbjct: 577 SVVEETEG 584
>NP_061756
          Length = 798

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SVVAETDG 9
          SVV ET+G
Sbjct: 35 SVVEETEG 42
>XP_005270358
          Length = 1204

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SVVAETD 8
           SVVA+TD
Sbjct: 655 SVVADTD 661
>XP_006717014
          Length = 199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VAETDG 9
           +AETDG
Sbjct: 123 IAETDG 128
>XP_006710870
          Length = 779

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVV ET+G
Sbjct: 693 SVVEETEG 700
>XP_005246013
          Length = 800

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVV ET+G
Sbjct: 714 SVVEETEG 721
>XP_006710869
          Length = 812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVV ET+G
Sbjct: 726 SVVEETEG 733
>XP_005246012
          Length = 818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVV ET+G
Sbjct: 740 SVVEETEG 747
>XP_005246011
          Length = 826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVV ET+G
Sbjct: 740 SVVEETEG 747
>XP_006710868
          Length = 877

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVV ET+G
Sbjct: 799 SVVEETEG 806
>XP_006710867
          Length = 885

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           SVV ET+G
Sbjct: 799 SVVEETEG 806
>NP_061993
          Length = 801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SVVAETDG 9
          SVV ET+G
Sbjct: 35 SVVEETEG 42
>NP_001851
          Length = 143

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  VAETDG 9
          +AETDG
Sbjct: 67 IAETDG 72
>NP_001165907
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VSVVAETD 8
           VS++AET+
Sbjct: 442 VSILAETE 449
>NP_002628
          Length = 1223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VSVVAETD 8
           VS++AET+
Sbjct: 442 VSILAETE 449
>NP_001116142
          Length = 1210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VSVVAETD 8
           VS++AET+
Sbjct: 442 VSILAETE 449
>NP_000738
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VSVVAETDG 9
           +SVV  +DG
Sbjct: 129 ISVVVSSDG 137
>NP_055458
          Length = 1163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SVVAETDG 9
            SVV E+DG
Sbjct: 1121 SVVFESDG 1128
>NP_056070
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SVVAETDG 9
            S VAET+G
Sbjct: 1009 SPVAETEG 1016
>NP_000597
          Length = 202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VVAETD 8
           VVAETD
Sbjct: 126 VVAETD 131
>XP_006724724
          Length = 1164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VSVVAETD 8
           VS++AET+
Sbjct: 442 VSILAETE 449
>XP_005249023
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVVAETDG 9
           S VAET+G
Sbjct: 306 SPVAETEG 313
>XP_005249022
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SVVAETDG 9
            S VAET+G
Sbjct: 1009 SPVAETEG 1016
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.121    0.297 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 439,360
Number of extensions: 862
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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