Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              19     665
XP_006713721                                                           19     665
NP_001265249                                                           17    3301
NP_001094379                                                           17    3301
NP_001012417                                                           17    3301
XP_005267752                                                           16    5631
NP_000646                                                              16    7355
XP_006718987                                                           16    7355
NP_006824                                                              16    7355
NP_115495                                                              15    9605
NP_006260                                                              15    9605
NP_055722                                                              15    9605
NP_110400                                                              15    9605
XP_006712050                                                           15    9605
>NP_006209
          Length = 1068

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  VSVTEEAER 9
          VSVT+EAER
Sbjct: 71 VSVTQEAER 79
>XP_006713721
          Length = 1068

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  VSVTEEAER 9
          VSVT+EAER
Sbjct: 71 VSVTQEAER 79
>NP_001265249
          Length = 93

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  SVTEEAE 8
          SVTEEAE
Sbjct: 84 SVTEEAE 90
>NP_001094379
          Length = 112

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   SVTEEAE 8
           SVTEEAE
Sbjct: 103 SVTEEAE 109
>NP_001012417
          Length = 152

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   SVTEEAE 8
           SVTEEAE
Sbjct: 143 SVTEEAE 149
>XP_005267752
          Length = 993

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSVTEEAER 9
           V+ T+EAER
Sbjct: 943 VAATKEAER 951
>NP_000646
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SVTEEAE 8
           S+TEEAE
Sbjct: 119 SLTEEAE 125
>XP_006718987
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VSVTEEAER 9
          VSVT+E  R
Sbjct: 15 VSVTQEGRR 23
>NP_006824
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TEEAER 9
           TEEAER
Sbjct: 192 TEEAER 197
>NP_115495
          Length = 6306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    VTEEAER 9
            VTE AER
Sbjct: 4813 VTENAER 4819
>NP_006260
          Length = 2156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    VSVTEEAE 8
            +++TEEA+
Sbjct: 1170 IAITEEAD 1177
>NP_055722
          Length = 1578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VSVTEEAER 9
           V +TEE+E+
Sbjct: 447 VELTEESEK 455
>NP_110400
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VTEEAE 8
           VTEEAE
Sbjct: 438 VTEEAE 443
>XP_006712050
          Length = 1716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VSVTEEAER 9
            + +T+EAER
Sbjct: 1601 LDLTDEAER 1609
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.289    0.107    0.232 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 456,959
Number of extensions: 463
Number of successful extensions: 14
Number of sequences better than 10000.0: 14
Number of HSP's gapped: 14
Number of HSP's successfully gapped: 14
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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