Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              19     869
XP_006717990                                                           19     869
XP_006717989                                                           19     869
NP_006837                                                              17    4312
NP_001121675                                                           17    4312
NP_009000                                                              17    4312
XP_006718489                                                           17    4312
NP_001121170                                                           17    4312
NP_001121171                                                           17    4312
NP_004123                                                              16    5631
NP_689777                                                              16    5631
NP_060360                                                              16    5631
NP_001171131                                                           16    5631
NP_071328                                                              16    5631
NP_001002909                                                           16    5631
XP_005260633                                                           16    5631
XP_006721846                                                           16    5631
XP_006721845                                                           16    5631
XP_006721844                                                           16    5631
XP_006716779                                                           16    5631
XP_006716573                                                           16    5631
XP_005250858                                                           16    5631
XP_005250857                                                           16    5631
XP_005272199                                                           16    5631
XP_006714215                                                           16    5631
XP_006714214                                                           16    5631
XP_005262915                                                           16    5631
NP_055806                                                              16    5631
NP_055644                                                              16    5631
NP_001017420                                                           16    7355
NP_005434                                                              16    7355
NP_004661                                                              16    7355
NP_001074003                                                           16    7355
NP_001015880                                                           16    7355
XP_005254452                                                           16    7355
XP_005254451                                                           16    7355
XP_006716360                                                           16    7355
NP_997235                                                              15    9605
NP_003850                                                              15    9605
NP_001264243                                                           15    9605
NP_001277935                                                           15    9605
NP_073568                                                              15    9605
NP_055554                                                              15    9605
NP_001264242                                                           15    9605
NP_001070909                                                           15    9605
NP_001009565                                                           15    9605
XP_005260659                                                           15    9605
XP_005260658                                                           15    9605
XP_005260657                                                           15    9605
XP_005267295                                                           15    9605
XP_005267294                                                           15    9605
XP_005267293                                                           15    9605
XP_006714247                                                           15    9605
XP_005262992                                                           15    9605
XP_006712066                                                           15    9605
XP_005245510                                                           15    9605
XP_005245422                                                           15    9605
NP_065821                                                              15    9605
NP_001070908                                                           15    9605
>NP_000305
          Length = 403

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VSRNKRRSQ 9
          VSRNKRR Q
Sbjct: 9  VSRNKRRYQ 17
>XP_006717990
          Length = 175

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VSRNKRRSQ 9
          VSRNKRR Q
Sbjct: 9  VSRNKRRYQ 17
>XP_006717989
          Length = 388

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VSRNKRRSQ 9
          VSRNKRR Q
Sbjct: 9  VSRNKRRYQ 17
>NP_006837
          Length = 1064

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SRNKRRSQ 9
           SRNKR+S+
Sbjct: 421 SRNKRQSK 428
>NP_001121675
          Length = 162

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRNKRRSQ 9
           SRNKR+ Q
Sbjct: 155 SRNKRQKQ 162
>NP_009000
          Length = 162

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRNKRRSQ 9
           SRNKR+ Q
Sbjct: 155 SRNKRQKQ 162
>XP_006718489
          Length = 162

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRNKRRSQ 9
           SRNKR+ Q
Sbjct: 155 SRNKRQKQ 162
>NP_001121170
          Length = 1094

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SRNKRRSQ 9
           SRNKR+S+
Sbjct: 421 SRNKRQSK 428
>NP_001121171
          Length = 916

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SRNKRRSQ 9
           SRNKR+S+
Sbjct: 421 SRNKRQSK 428
>NP_004123
          Length = 560

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SRNKRRSQ 9
           SR+KRRS+
Sbjct: 166 SRHKRRSK 173
>NP_689777
          Length = 3997

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SRNKRRS 8
            SRN+RRS
Sbjct: 1442 SRNERRS 1448
>NP_060360
          Length = 4022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SRNKRRS 8
            SRN+RRS
Sbjct: 1467 SRNERRS 1473
>NP_001171131
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SRNKRRSQ 9
           SR+KRRS+
Sbjct: 140 SRHKRRSK 147
>NP_071328
          Length = 904

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VSRNKRRSQ 9
           VSR KRRS+
Sbjct: 731 VSRLKRRSK 739
>NP_001002909
          Length = 1502

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SRNKRRSQ 9
           SR+KRRS+
Sbjct: 968 SRSKRRSR 975
>XP_005260633
          Length = 1364

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2 SRNKRR 7
         SRNKRR
Sbjct: 3 SRNKRR 8
>XP_006721846
          Length = 1424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SRNKRRSQ 9
           SR+KRRS+
Sbjct: 890 SRSKRRSR 897
>XP_006721845
          Length = 1424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SRNKRRSQ 9
           SR+KRRS+
Sbjct: 890 SRSKRRSR 897
>XP_006721844
          Length = 1424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SRNKRRSQ 9
           SR+KRRS+
Sbjct: 890 SRSKRRSR 897
>XP_006716779
          Length = 2399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VSRNKRRSQ 9
           ++RNKR+ Q
Sbjct: 409 LTRNKRKKQ 417
>XP_006716573
          Length = 1776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SRNKRRS 8
            SRN+RRS
Sbjct: 1467 SRNERRS 1473
>XP_005250858
          Length = 4022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SRNKRRS 8
            SRN+RRS
Sbjct: 1467 SRNERRS 1473
>XP_005250857
          Length = 4022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SRNKRRS 8
            SRN+RRS
Sbjct: 1467 SRNERRS 1473
>XP_005272199
          Length = 1032

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SRNKRRSQ 9
          SR+KRRS+
Sbjct: 54 SRDKRRSR 61
>XP_006714215
          Length = 3544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    VSRNKRRSQ 9
            ++++KRRSQ
Sbjct: 2094 IAQSKRRSQ 2102
>XP_006714214
          Length = 3544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    VSRNKRRSQ 9
            ++++KRRSQ
Sbjct: 2094 IAQSKRRSQ 2102
>XP_005262915
          Length = 3544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    VSRNKRRSQ 9
            ++++KRRSQ
Sbjct: 2094 IAQSKRRSQ 2102
>NP_055806
          Length = 3526

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    VSRNKRRSQ 9
            ++++KRRSQ
Sbjct: 2076 IAQSKRRSQ 2084
>NP_055644
          Length = 1031

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SRNKRRSQ 9
          SR+KRRS+
Sbjct: 54 SRDKRRSR 61
>NP_001017420
          Length = 601

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSRNKRRSQ 9
           VSRN R S+
Sbjct: 158 VSRNSRNSK 166
>NP_005434
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  VSRNKR 6
          VSRNKR
Sbjct: 35 VSRNKR 40
>NP_004661
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  VSRNKR 6
          VSRNKR
Sbjct: 25 VSRNKR 30
>NP_001074003
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VSRNKRRSQ 9
            V +NKRR++
Sbjct: 1249 VGKNKRRTK 1257
>NP_001015880
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  VSRNKR 6
          VSRNKR
Sbjct: 25 VSRNKR 30
>XP_005254452
          Length = 2188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VSRNKRRSQ 9
            V +NKRR++
Sbjct: 1249 VGKNKRRTK 1257
>XP_005254451
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VSRNKRRSQ 9
            V +NKRR++
Sbjct: 1249 VGKNKRRTK 1257
>XP_006716360
          Length = 601

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSRNKRRSQ 9
           VSRN R S+
Sbjct: 158 VSRNSRNSK 166
>NP_997235
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SRNKRRS 8
           S+NKRR+
Sbjct: 292 SKNKRRA 298
>NP_003850
          Length = 260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VSRNKRRSQ 9
          VSR+ RRS+
Sbjct: 6  VSRSPRRSR 14
>NP_001264243
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SRNKRRS 8
           +RNKRR+
Sbjct: 454 TRNKRRA 460
>NP_001277935
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSRNKRRSQ 9
           VSRN  RS+
Sbjct: 310 VSRNPMRSE 318
>NP_073568
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  SRNKRRS 8
          ++NKRRS
Sbjct: 44 AKNKRRS 50
>NP_055554
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SRNKRRSQ 9
          SR+K RSQ
Sbjct: 11 SRSKSRSQ 18
>NP_001264242
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SRNKRRS 8
           +RNKRR+
Sbjct: 454 TRNKRRA 460
>NP_001070909
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SRNKRRSQ 9
          SR+K RSQ
Sbjct: 11 SRSKSRSQ 18
>NP_001009565
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RNKRRSQ 9
           RN+RR Q
Sbjct: 303 RNRRRQQ 309
>XP_005260659
          Length = 189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VSRNKRRSQ 9
          VSR+ RRS+
Sbjct: 6  VSRSPRRSR 14
>XP_005260658
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VSRNKRRSQ 9
          VSR+ RRS+
Sbjct: 6  VSRSPRRSR 14
>XP_005260657
          Length = 287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VSRNKRRSQ 9
          VSR+ RRS+
Sbjct: 6  VSRSPRRSR 14
>XP_005267295
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SRNKRRSQ 9
          SR+K RSQ
Sbjct: 11 SRSKSRSQ 18
>XP_005267294
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SRNKRRSQ 9
          SR+K RSQ
Sbjct: 11 SRSKSRSQ 18
>XP_005267293
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SRNKRRSQ 9
          SR+K RSQ
Sbjct: 11 SRSKSRSQ 18
>XP_006714247
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SRNKRRS 8
           S+NKRR+
Sbjct: 160 SKNKRRA 166
>XP_005262992
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SRNKRRS 8
           S+NKRR+
Sbjct: 292 SKNKRRA 298
>XP_006712066
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RNKRRSQ 9
           RN+RR Q
Sbjct: 303 RNRRRQQ 309
>XP_005245510
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  SRNKRRS 8
          ++NKRRS
Sbjct: 44 AKNKRRS 50
>XP_005245422
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SRNKRRSQ 9
           + NK+RSQ
Sbjct: 950 AENKKRSQ 957
>NP_065821
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SRNKRRSQ 9
           + NK+RSQ
Sbjct: 950 AENKKRSQ 957
>NP_001070908
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SRNKRRSQ 9
          SR+K RSQ
Sbjct: 11 SRSKSRSQ 18
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.115    0.277 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 470,234
Number of extensions: 707
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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