Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              19     665
NP_001035957                                                           19     665
XP_006721990                                                           19     665
XP_006721989                                                           19     665
XP_005258041                                                           19     665
XP_006721988                                                           19     665
XP_006721987                                                           19     665
XP_006721986                                                           19     665
XP_005258040                                                           19     665
XP_006721985                                                           19     665
NP_001561                                                              17    3301
NP_001020414                                                           17    4312
NP_001020413                                                           17    4312
NP_001560                                                              17    4312
XP_005274725                                                           17    4312
NP_000086                                                              16    5631
NP_660186                                                              16    5631
NP_149094                                                              16    5631
NP_055753                                                              16    5631
XP_005272547                                                           16    5631
XP_005272546                                                           16    5631
XP_006722863                                                           16    5631
XP_006719357                                                           16    5631
XP_006719356                                                           16    5631
XP_006719355                                                           16    5631
XP_006719354                                                           16    5631
XP_006719353                                                           16    5631
NP_003001                                                              16    7355
NP_001268364                                                           16    7355
NP_001013725                                                           16    7355
NP_065962                                                              16    7355
NP_002510                                                              16    7355
XP_005256812                                                           16    7355
XP_006721631                                                           16    7355
XP_005256810                                                           16    7355
XP_005254450                                                           16    7355
XP_005254449                                                           16    7355
XP_005250743                                                           16    7355
XP_006716234                                                           16    7355
NP_002817                                                              15    9605
NP_001004128                                                           15    9605
NP_006862                                                              15    9605
NP_055572                                                              15    9605
NP_620590                                                              15    9605
NP_056284                                                              15    9605
NP_060846                                                              15    9605
XP_006725141                                                           15    9605
XP_006725140                                                           15    9605
XP_006716592                                                           15    9605
XP_006716591                                                           15    9605
>NP_000258
          Length = 2818

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VSQSNVLLD 9
            VS+SNVLLD
Sbjct: 2577 VSESNVLLD 2585
>NP_001035957
          Length = 2839

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VSQSNVLLD 9
            VS+SNVLLD
Sbjct: 2598 VSESNVLLD 2606
>XP_006721990
          Length = 2823

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VSQSNVLLD 9
            VS+SNVLLD
Sbjct: 2608 VSESNVLLD 2616
>XP_006721989
          Length = 2823

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VSQSNVLLD 9
            VS+SNVLLD
Sbjct: 2608 VSESNVLLD 2616
>XP_005258041
          Length = 2836

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VSQSNVLLD 9
            VS+SNVLLD
Sbjct: 2577 VSESNVLLD 2585
>XP_006721988
          Length = 2846

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VSQSNVLLD 9
            VS+SNVLLD
Sbjct: 2587 VSESNVLLD 2595
>XP_006721987
          Length = 2849

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VSQSNVLLD 9
            VS+SNVLLD
Sbjct: 2608 VSESNVLLD 2616
>XP_006721986
          Length = 2854

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VSQSNVLLD 9
            VS+SNVLLD
Sbjct: 2595 VSESNVLLD 2603
>XP_005258040
          Length = 2857

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VSQSNVLLD 9
            VS+SNVLLD
Sbjct: 2598 VSESNVLLD 2606
>XP_006721985
          Length = 2867

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VSQSNVLLD 9
            VS+SNVLLD
Sbjct: 2608 VSESNVLLD 2616
>NP_001561
          Length = 625

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           V  SNVLLD
Sbjct: 336 VKSSNVLLD 344
>NP_001020414
          Length = 633

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           +  SNVLLD
Sbjct: 341 IKSSNVLLD 349
>NP_001020413
          Length = 682

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           +  SNVLLD
Sbjct: 341 IKSSNVLLD 349
>NP_001560
          Length = 712

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           +  SNVLLD
Sbjct: 341 IKSSNVLLD 349
>XP_005274725
          Length = 708

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           +  SNVLLD
Sbjct: 367 IKSSNVLLD 375
>NP_000086
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSQSNVLLD 9
           V+ SNV+LD
Sbjct: 706 VADSNVVLD 714
>NP_660186
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           V  SN+LLD
Sbjct: 244 VKPSNILLD 252
>NP_149094
          Length = 686

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSQSNVLLD 9
           VSQ N+LL+
Sbjct: 207 VSQQNLLLE 215
>NP_055753
          Length = 919

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VSQSNVLL 8
           VSQSNV++
Sbjct: 604 VSQSNVVI 611
>XP_005272547
          Length = 426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           V  SN+LLD
Sbjct: 244 VKPSNILLD 252
>XP_005272546
          Length = 435

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           V  SN+LLD
Sbjct: 260 VKPSNILLD 268
>XP_006722863
          Length = 442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           V  SN+LLD
Sbjct: 260 VKPSNILLD 268
>XP_006719357
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VSQSNVLL 8
           VSQSNV++
Sbjct: 211 VSQSNVVI 218
>XP_006719356
          Length = 708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VSQSNVLL 8
           VSQSNV++
Sbjct: 604 VSQSNVVI 611
>XP_006719355
          Length = 920

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VSQSNVLL 8
           VSQSNV++
Sbjct: 604 VSQSNVVI 611
>XP_006719354
          Length = 959

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VSQSNVLL 8
           VSQSNV++
Sbjct: 604 VSQSNVVI 611
>XP_006719353
          Length = 960

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VSQSNVLL 8
           VSQSNV++
Sbjct: 604 VSQSNVVI 611
>NP_003001
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           +  SN+LLD
Sbjct: 230 IKPSNILLD 238
>NP_001268364
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           +  SN+LLD
Sbjct: 241 IKPSNILLD 249
>NP_001013725
          Length = 1649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSQSNVLLD 9
           +S SNVL+D
Sbjct: 426 LSASNVLVD 434
>NP_065962
          Length = 1894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VSQSNVLL 8
           VSQ NVLL
Sbjct: 570 VSQYNVLL 577
>NP_002510
          Length = 1427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VSQSNVLL 8
           VSQSNV++
Sbjct: 882 VSQSNVVV 889
>XP_005256812
          Length = 253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VSQSNVLLD 9
          +  SN+LLD
Sbjct: 84 IKPSNILLD 92
>XP_006721631
          Length = 281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           +  SN+LLD
Sbjct: 112 IKPSNILLD 120
>XP_005256810
          Length = 281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VSQSNVLLD 9
           +  SN+LLD
Sbjct: 112 IKPSNILLD 120
>XP_005254450
          Length = 1505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSQSNVLLD 9
           +S SNVL+D
Sbjct: 426 LSASNVLVD 434
>XP_005254449
          Length = 1626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSQSNVLLD 9
           +S SNVL+D
Sbjct: 426 LSASNVLVD 434
>XP_005250743
          Length = 1894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VSQSNVLL 8
           VSQ NVLL
Sbjct: 570 VSQYNVLL 577
>XP_006716234
          Length = 1894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VSQSNVLL 8
           VSQ NVLL
Sbjct: 570 VSQYNVLL 577
>NP_002817
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SQSNVLLD 9
           S SN++LD
Sbjct: 536 SPSNIILD 543
>NP_001004128
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SQSNVLLD 9
           S SN++LD
Sbjct: 536 SPSNIILD 543
>NP_006862
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SNVLLD 9
           SNVLLD
Sbjct: 146 SNVLLD 151
>NP_055572
          Length = 1016

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VSQSNVLLD 9
           +SQSN++ D
Sbjct: 235 ISQSNLMPD 243
>NP_620590
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SNVLLD 9
           SNVLLD
Sbjct: 141 SNVLLD 146
>NP_056284
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSQSNVLL 8
           VSQ N+LL
Sbjct: 231 VSQQNMLL 238
>NP_060846
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSQSNVLL 8
           VSQ N+LL
Sbjct: 231 VSQQNMLL 238
>XP_006725141
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SNVLLD 9
           SNVLLD
Sbjct: 160 SNVLLD 165
>XP_006725140
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SNVLLD 9
           SNVLLD
Sbjct: 160 SNVLLD 165
>XP_006716592
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SNVLLD 9
           SNVLLD
Sbjct: 160 SNVLLD 165
>XP_006716591
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SNVLLD 9
           SNVLLD
Sbjct: 160 SNVLLD 165
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.124    0.289 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 330,335
Number of extensions: 354
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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