Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_919047                                                              18    1482
XP_005250598                                                           18    1482
NP_004514                                                              18    1935
NP_001128144                                                           17    3301
NP_071346                                                              17    3301
XP_006718002                                                           17    3301
XP_005270081                                                           17    3301
NP_689472                                                              17    4312
XP_006715556                                                           16    5631
XP_006715555                                                           16    5631
XP_006715554                                                           16    5631
XP_006715552                                                           16    5631
XP_005267054                                                           16    5631
XP_006715551                                                           16    5631
XP_006715550                                                           16    5631
XP_006715548                                                           16    5631
XP_006715546                                                           16    5631
NP_001018125                                                           16    7355
NP_149075                                                              16    7355
XP_006713088                                                           16    7355
XP_006713087                                                           16    7355
XP_005265003                                                           16    7355
XP_006713086                                                           16    7355
XP_006713085                                                           16    7355
XP_006713084                                                           16    7355
NP_001421                                                              15    9605
NP_001012680                                                           15    9605
NP_001012682                                                           15    9605
NP_002385                                                              15    9605
NP_001013269                                                           15    9605
NP_037498                                                              15    9605
NP_001034456                                                           15    9605
NP_001034455                                                           15    9605
NP_001687                                                              15    9605
NP_002239                                                              15    9605
NP_005985                                                              15    9605
NP_008949                                                              15    9605
NP_542384                                                              15    9605
XP_005259964                                                           15    9605
XP_005259963                                                           15    9605
XP_005259962                                                           15    9605
XP_006717721                                                           15    9605
XP_006717396                                                           15    9605
XP_006717395                                                           15    9605
XP_005252375                                                           15    9605
XP_006717394                                                           15    9605
XP_006717393                                                           15    9605
XP_006717391                                                           15    9605
XP_006717390                                                           15    9605
XP_006717007                                                           15    9605
XP_006717005                                                           15    9605
XP_006717004                                                           15    9605
XP_006717003                                                           15    9605
XP_005251736                                                           15    9605
XP_005264691                                                           15    9605
XP_005264690                                                           15    9605
NP_689848                                                              15    9605
>NP_919047
          Length = 520

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGLESR D
Sbjct: 462 VSGLESRPD 470
>XP_005250598
          Length = 457

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGLESR D
Sbjct: 399 VSGLESRPD 407
>NP_004514
          Length = 1056

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGL S+LD
Sbjct: 510 VSGLHSKLD 518
>NP_001128144
          Length = 233

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SGLESRLD 9
           SGLE R+D
Sbjct: 152 SGLEKRID 159
>NP_071346
          Length = 233

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SGLESRLD 9
           SGLE R+D
Sbjct: 152 SGLEKRID 159
>XP_006718002
          Length = 233

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SGLESRLD 9
           SGLE R+D
Sbjct: 152 SGLEKRID 159
>XP_005270081
          Length = 240

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SGLESRLD 9
           SGLE R+D
Sbjct: 159 SGLEKRID 166
>NP_689472
          Length = 1910

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSGLESRLD 9
           V GLE +LD
Sbjct: 942 VDGLEDKLD 950
>XP_006715556
          Length = 1051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSGLESRLD 9
           VSG E RLD
Sbjct: 98  VSGEERRLD 106
>XP_006715555
          Length = 1638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSGLESRLD 9
           VSG E RLD
Sbjct: 98  VSGEERRLD 106
>XP_006715554
          Length = 1768

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSGLESRLD 9
           VSG E RLD
Sbjct: 98  VSGEERRLD 106
>XP_006715552
          Length = 1817

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSGLESRLD 9
           VSG E RLD
Sbjct: 98  VSGEERRLD 106
>XP_005267054
          Length = 1823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSGLESRLD 9
           VSG E RLD
Sbjct: 98  VSGEERRLD 106
>XP_006715551
          Length = 1825

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSGLESRLD 9
           VSG E RLD
Sbjct: 98  VSGEERRLD 106
>XP_006715550
          Length = 1830

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSGLESRLD 9
           VSG E RLD
Sbjct: 98  VSGEERRLD 106
>XP_006715548
          Length = 1831

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSGLESRLD 9
           VSG E RLD
Sbjct: 98  VSGEERRLD 106
>XP_006715546
          Length = 1832

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSGLESRLD 9
           VSG E RLD
Sbjct: 98  VSGEERRLD 106
>NP_001018125
          Length = 1451

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGLES ++
Sbjct: 97  VSGLESYIE 105
>NP_149075
          Length = 1471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGLES ++
Sbjct: 97  VSGLESYIE 105
>XP_006713088
          Length = 1382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGLES ++
Sbjct: 97  VSGLESYIE 105
>XP_006713087
          Length = 1432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGLES ++
Sbjct: 97  VSGLESYIE 105
>XP_005265003
          Length = 1451

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGLES ++
Sbjct: 97  VSGLESYIE 105
>XP_006713086
          Length = 1458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGLES ++
Sbjct: 97  VSGLESYIE 105
>XP_006713085
          Length = 1471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGLES ++
Sbjct: 97  VSGLESYIE 105
>XP_006713084
          Length = 1471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGLES ++
Sbjct: 97  VSGLESYIE 105
>NP_001421
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSGLESRL 8
           VSG+ SRL
Sbjct: 819 VSGMASRL 826
>NP_001012680
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           ++GL+ RLD
Sbjct: 242 LAGLKGRLD 250
>NP_001012682
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           ++GL+ RLD
Sbjct: 179 LAGLKGRLD 187
>NP_002385
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           ++GL+ RLD
Sbjct: 241 LAGLKGRLD 249
>NP_001013269
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           ++GL+ RLD
Sbjct: 140 LAGLKGRLD 148
>NP_037498
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 118 LESRLD 123
>NP_001034456
          Length = 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 166 LESRLD 171
>NP_001034455
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 174 LESRLD 179
>NP_001687
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 196 LESRLD 201
>NP_002239
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 485 LESRLD 490
>NP_005985
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VSGLESR 7
           VSGLES+
Sbjct: 695 VSGLESQ 701
>NP_008949
          Length = 2325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 574 LESRLD 579
>NP_542384
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 196 LESRLD 201
>XP_005259964
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 565 LESRLD 570
>XP_005259963
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 568 LESRLD 573
>XP_005259962
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 571 LESRLD 576
>XP_006717721
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGLES ++
Sbjct: 426 VSGLESLVE 434
>XP_006717396
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SGLESR 7
           SGLESR
Sbjct: 354 SGLESR 359
>XP_006717395
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SGLESR 7
           SGLESR
Sbjct: 382 SGLESR 387
>XP_005252375
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SGLESR 7
           SGLESR
Sbjct: 412 SGLESR 417
>XP_006717394
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SGLESR 7
           SGLESR
Sbjct: 395 SGLESR 400
>XP_006717393
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SGLESR 7
           SGLESR
Sbjct: 412 SGLESR 417
>XP_006717391
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SGLESR 7
           SGLESR
Sbjct: 412 SGLESR 417
>XP_006717390
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SGLESR 7
           SGLESR
Sbjct: 412 SGLESR 417
>XP_006717007
          Length = 1499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 574 LESRLD 579
>XP_006717005
          Length = 1788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LESRLD 9
          LESRLD
Sbjct: 22 LESRLD 27
>XP_006717004
          Length = 2240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 574 LESRLD 579
>XP_006717003
          Length = 2278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 574 LESRLD 579
>XP_005251736
          Length = 2325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 574 LESRLD 579
>XP_005264691
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 196 LESRLD 201
>XP_005264690
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESRLD 9
           LESRLD
Sbjct: 196 LESRLD 201
>NP_689848
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSGLESRLD 9
           VSGLES ++
Sbjct: 426 VSGLESLVE 434
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.132    0.329 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 457,998
Number of extensions: 658
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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