Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              19     869
XP_005271621                                                           19     869
XP_006718907                                                           19     869
XP_006718906                                                           19     869
XP_005271619                                                           19     869
XP_005271618                                                           19     869
NP_006715                                                              18    1935
NP_005913                                                              18    1935
XP_005267046                                                           18    1935
XP_005267045                                                           18    1935
NP_008941                                                              17    2528
NP_001278405                                                           17    2528
XP_006725362                                                           17    2528
XP_006721713                                                           17    2528
NP_055863                                                              17    3301
NP_078918                                                              17    3301
XP_006719359                                                           17    3301
XP_006719358                                                           17    3301
XP_005253915                                                           17    3301
XP_006717350                                                           17    3301
NP_001116108                                                           16    5631
NP_068580                                                              16    5631
NP_006527                                                              16    5631
NP_079216                                                              16    5631
XP_005273708                                                           16    5631
XP_006716465                                                           16    5631
XP_005273707                                                           16    5631
NP_001248339                                                           16    7355
NP_003558                                                              16    7355
NP_001248337                                                           16    7355
NP_001248338                                                           16    7355
NP_004472                                                              16    7355
NP_003765                                                              16    7355
NP_001186710                                                           16    7355
NP_003096                                                              16    7355
NP_001186711                                                           16    7355
NP_054859                                                              15    9605
NP_001120679                                                           15    9605
NP_001073291                                                           15    9605
NP_000417                                                              15    9605
NP_001181                                                              15    9605
NP_064732                                                              15    9605
NP_004477                                                              15    9605
NP_004293                                                              15    9605
NP_872393                                                              15    9605
NP_064733                                                              15    9605
XP_006719748                                                           15    9605
XP_005251989                                                           15    9605
XP_005251988                                                           15    9605
XP_005251987                                                           15    9605
XP_005267039                                                           15    9605
XP_005267038                                                           15    9605
XP_006712620                                                           15    9605
XP_005246688                                                           15    9605
XP_005246689                                                           15    9605
XP_006712515                                                           15    9605
XP_006712514                                                           15    9605
XP_006712513                                                           15    9605
XP_006712512                                                           15    9605
XP_006712511                                                           15    9605
XP_006712510                                                           15    9605
XP_006712509                                                           15    9605
XP_005246533                                                           15    9605
XP_006712508                                                           15    9605
NP_115893                                                              15    9605
>NP_000042
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VSFRAADI 8
           VSFRAADI
Sbjct: 916 VSFRAADI 923
>XP_005271621
          Length = 2708

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VSFRAADI 8
           VSFRAADI
Sbjct: 568 VSFRAADI 575
>XP_006718907
          Length = 3050

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VSFRAADI 8
           VSFRAADI
Sbjct: 916 VSFRAADI 923
>XP_006718906
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VSFRAADI 8
           VSFRAADI
Sbjct: 916 VSFRAADI 923
>XP_005271619
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VSFRAADI 8
           VSFRAADI
Sbjct: 916 VSFRAADI 923
>XP_005271618
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VSFRAADI 8
           VSFRAADI
Sbjct: 916 VSFRAADI 923
>NP_006715
          Length = 1558

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    RAADIW 9
            RAADIW
Sbjct: 1474 RAADIW 1479
>NP_005913
          Length = 1608

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    RAADIW 9
            RAADIW
Sbjct: 1524 RAADIW 1529
>XP_005267046
          Length = 1554

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    RAADIW 9
            RAADIW
Sbjct: 1470 RAADIW 1475
>XP_005267045
          Length = 1604

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    RAADIW 9
            RAADIW
Sbjct: 1520 RAADIW 1525
>NP_008941
          Length = 599

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SFRAADIW 9
           SFRA  IW
Sbjct: 457 SFRAGKIW 464
>NP_001278405
          Length = 491

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SFRAADIW 9
           SFRA  IW
Sbjct: 349 SFRAGKIW 356
>XP_006725362
          Length = 413

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SFRAADIW 9
           SFRA  IW
Sbjct: 271 SFRAGKIW 278
>XP_006721713
          Length = 413

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SFRAADIW 9
           SFRA  IW
Sbjct: 271 SFRAGKIW 278
>NP_055863
          Length = 1923

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSFRAADIW 9
           V+FRA D W
Sbjct: 888 VAFRAFDEW 896
>NP_078918
          Length = 581

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SFRAADIW 9
           S RAA++W
Sbjct: 380 SVRAAEVW 387
>XP_006719359
          Length = 1966

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSFRAADIW 9
           V+FRA D W
Sbjct: 888 VAFRAFDEW 896
>XP_006719358
          Length = 1966

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSFRAADIW 9
           V+FRA D W
Sbjct: 888 VAFRAFDEW 896
>XP_005253915
          Length = 1966

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSFRAADIW 9
           V+FRA D W
Sbjct: 888 VAFRAFDEW 896
>XP_006717350
          Length = 284

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  SFRAADIW 9
          S RAA++W
Sbjct: 83 SVRAAEVW 90
>NP_001116108
          Length = 603

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SFRAADIW 9
           + RAA++W
Sbjct: 397 ALRAAEVW 404
>NP_068580
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  SFRAADIW 9
          + RAA++W
Sbjct: 31 ALRAAEVW 38
>NP_006527
          Length = 943

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   VSFRAADIW 9
           ++FR A +W
Sbjct: 557 LTFRTASLW 565
>NP_079216
          Length = 1870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    VSFRAADIW 9
            + FR  D+W
Sbjct: 1083 IGFRIRDMW 1091
>XP_005273708
          Length = 1032

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   VSFRAADIW 9
           + FR  D+W
Sbjct: 797 IGFRIRDMW 805
>XP_006716465
          Length = 1826

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    VSFRAADIW 9
            + FR  D+W
Sbjct: 1083 IGFRIRDMW 1091
>XP_005273707
          Length = 1847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    VSFRAADIW 9
            + FR  D+W
Sbjct: 1083 IGFRIRDMW 1091
>NP_001248339
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   VSFRAADIW 9
           V+F   D+W
Sbjct: 631 VTFEGTDMW 639
>NP_003558
          Length = 825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   VSFRAADIW 9
           V+F   D+W
Sbjct: 722 VTFEGTDMW 730
>NP_001248337
          Length = 825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   VSFRAADIW 9
           V+F   D+W
Sbjct: 722 VTFEGTDMW 730
>NP_001248338
          Length = 825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   VSFRAADIW 9
           V+F   D+W
Sbjct: 722 VTFEGTDMW 730
>NP_004472
          Length = 571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RAADIW 9
           RAA++W
Sbjct: 383 RAAEVW 388
>NP_003765
          Length = 578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RAADIW 9
           RAA++W
Sbjct: 381 RAAEVW 386
>NP_001186710
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RAADIW 9
           RAA++W
Sbjct: 378 RAAEVW 383
>NP_003096
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VSFRAADI 8
           + FRAAD+
Sbjct: 202 IPFRAADL 209
>NP_001186711
          Length = 406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RAADIW 9
           RAA++W
Sbjct: 209 RAAEVW 214
>NP_054859
          Length = 954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  SFRAADIW 9
          SF+A  IW
Sbjct: 91 SFQAKGIW 98
>NP_001120679
          Length = 954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  SFRAADIW 9
          SF+A  IW
Sbjct: 91 SFQAKGIW 98
>NP_001073291
          Length = 3118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VSFRAADI 8
            VSF+ ADI
Sbjct: 2696 VSFKNADI 2703
>NP_000417
          Length = 3122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VSFRAADI 8
            VSF+ ADI
Sbjct: 2700 VSFKNADI 2707
>NP_001181
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  SFRAADI 8
          SF+AAD+
Sbjct: 31 SFKAADL 37
>NP_064732
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SFRAADIW 9
           SF+ ADI+
Sbjct: 345 SFKCADIY 352
>NP_004477
          Length = 1002

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RAADIW 9
           RAA++W
Sbjct: 509 RAAELW 514
>NP_004293
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SFRAADIW 9
           SF+ ADI+
Sbjct: 397 SFKCADIY 404
>NP_872393
          Length = 3234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2    SFRAADIW 9
            SFR   +W
Sbjct: 1800 SFRRGSVW 1807
>NP_064733
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SFRAADIW 9
           SF+ ADI+
Sbjct: 438 SFKCADIY 445
>XP_006719748
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SFRAADIW 9
           SF+ ADI+
Sbjct: 437 SFKCADIY 444
>XP_005251989
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RAADIW 9
           RAA++W
Sbjct: 482 RAAELW 487
>XP_005251988
          Length = 1002

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RAADIW 9
           RAA++W
Sbjct: 509 RAAELW 514
>XP_005251987
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RAADIW 9
           RAA++W
Sbjct: 536 RAAELW 541
>XP_005267039
          Length = 3206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VSFRAADI 8
            VSF+ ADI
Sbjct: 2784 VSFKNADI 2791
>XP_005267038
          Length = 3210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VSFRAADI 8
            VSF+ ADI
Sbjct: 2788 VSFKNADI 2795
>XP_006712620
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  SFRAADIW 9
          SF+A  IW
Sbjct: 91 SFQAKGIW 98
>XP_005246688
          Length = 954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  SFRAADIW 9
          SF+A  IW
Sbjct: 91 SFQAKGIW 98
>XP_005246689
          Length = 954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  SFRAADIW 9
          SF+A  IW
Sbjct: 91 SFQAKGIW 98
>XP_006712515
          Length = 3232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2    SFRAADIW 9
            SFR   +W
Sbjct: 1798 SFRRGSVW 1805
>XP_006712514
          Length = 2496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2    SFRAADIW 9
            SFR   +W
Sbjct: 1871 SFRRGSVW 1878
>XP_006712513
          Length = 3220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2    SFRAADIW 9
            SFR   +W
Sbjct: 1767 SFRRGSVW 1774
>XP_006712512
          Length = 3237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2    SFRAADIW 9
            SFR   +W
Sbjct: 1803 SFRRGSVW 1810
>XP_006712511
          Length = 3256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2    SFRAADIW 9
            SFR   +W
Sbjct: 1803 SFRRGSVW 1810
>XP_006712510
          Length = 3305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2    SFRAADIW 9
            SFR   +W
Sbjct: 1871 SFRRGSVW 1878
>XP_006712509
          Length = 3319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2    SFRAADIW 9
            SFR   +W
Sbjct: 1866 SFRRGSVW 1873
>XP_005246533
          Length = 3323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2    SFRAADIW 9
            SFR   +W
Sbjct: 1870 SFRRGSVW 1877
>XP_006712508
          Length = 3324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2    SFRAADIW 9
            SFR   +W
Sbjct: 1871 SFRRGSVW 1878
>NP_115893
          Length = 3258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2    SFRAADIW 9
            SFR   +W
Sbjct: 1805 SFRRGSVW 1812
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.134    0.504 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 391,900
Number of extensions: 579
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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