Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           20     509
NP_004561                                                              20     509
NP_001275703                                                           20     509
XP_005253450                                                           20     509
XP_006719151                                                           20     509
NP_001025226                                                           18    1482
NP_001164                                                              18    1482
XP_005267693                                                           18    1482
XP_005267692                                                           18    1482
NP_116222                                                              18    1935
XP_005245608                                                           18    1935
NP_001138462                                                           17    3301
NP_003550                                                              17    4312
NP_005019                                                              17    4312
NP_038475                                                              17    4312
NP_001257981                                                           17    4312
XP_006725427                                                           17    4312
XP_006725426                                                           17    4312
XP_005259943                                                           17    4312
XP_005259942                                                           17    4312
XP_005259941                                                           17    4312
XP_006722194                                                           17    4312
XP_006722193                                                           17    4312
NP_001018081                                                           16    7355
NP_001243793                                                           16    7355
NP_001243794                                                           16    7355
NP_055602                                                              16    7355
NP_001072990                                                           16    7355
NP_001257943                                                           16    7355
NP_004977                                                              16    7355
XP_006720204                                                           16    7355
XP_006720203                                                           16    7355
XP_006720202                                                           16    7355
XP_006720201                                                           16    7355
XP_005245487                                                           16    7355
XP_005245486                                                           16    7355
NP_001072989                                                           16    7355
NP_001269528                                                           15    9605
NP_001167558                                                           15    9605
NP_858045                                                              15    9605
NP_006525                                                              15    9605
NP_001167559                                                           15    9605
NP_001138135                                                           15    9605
NP_004054                                                              15    9605
NP_065816                                                              15    9605
NP_005522                                                              15    9605
NP_001193496                                                           15    9605
NP_001092909                                                           15    9605
NP_114141                                                              15    9605
XP_006717077                                                           15    9605
XP_006717076                                                           15    9605
XP_006711353                                                           15    9605
XP_005245184                                                           15    9605
XP_006710647                                                           15    9605
XP_006710573                                                           15    9605
XP_006710572                                                           15    9605
XP_006710571                                                           15    9605
XP_006710570                                                           15    9605
XP_006710569                                                           15    9605
XP_006710568                                                           15    9605
XP_006710567                                                           15    9605
XP_006710566                                                           15    9605
XP_005245859                                                           15    9605
>NP_001275701
          Length = 1486

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VSEMHTIL 8
           VSEMHTIL
Sbjct: 747 VSEMHTIL 754
>NP_004561
          Length = 1445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VSEMHTIL 8
           VSEMHTIL
Sbjct: 706 VSEMHTIL 713
>NP_001275703
          Length = 1264

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VSEMHTIL 8
           VSEMHTIL
Sbjct: 525 VSEMHTIL 532
>XP_005253450
          Length = 1486

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VSEMHTIL 8
           VSEMHTIL
Sbjct: 747 VSEMHTIL 754
>XP_006719151
          Length = 1486

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VSEMHTIL 8
           VSEMHTIL
Sbjct: 747 VSEMHTIL 754
>NP_001025226
          Length = 1502

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VSEMHTILS 9
           +SE+HT+LS
Sbjct: 515 MSEIHTVLS 523
>NP_001164
          Length = 1501

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VSEMHTILS 9
           +SE+HT+LS
Sbjct: 515 MSEIHTVLS 523
>XP_005267693
          Length = 1502

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VSEMHTILS 9
           +SE+HT+LS
Sbjct: 515 MSEIHTVLS 523
>XP_005267692
          Length = 1502

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VSEMHTILS 9
           +SE+HT+LS
Sbjct: 515 MSEIHTVLS 523
>NP_116222
          Length = 713

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSEMHTILS 9
           +SE HT+LS
Sbjct: 598 ISECHTLLS 606
>XP_005245608
          Length = 670

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSEMHTILS 9
           +SE HT+LS
Sbjct: 598 ISECHTLLS 606
>NP_001138462
          Length = 1742

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EMHTILS 9
           EMHTIL+
Sbjct: 754 EMHTILA 760
>NP_003550
          Length = 416

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           V+EMH IL
Sbjct: 157 VAEMHNIL 164
>NP_005019
          Length = 406

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           V+EMH IL
Sbjct: 152 VAEMHNIL 159
>NP_038475
          Length = 823

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEMHTILS 9
           SEMHT+ S
Sbjct: 803 SEMHTLSS 810
>NP_001257981
          Length = 765

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEMHTILS 9
           SEMHT+ S
Sbjct: 745 SEMHTLSS 752
>XP_006725427
          Length = 352

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           V+EMH IL
Sbjct: 93  VAEMHNIL 100
>XP_006725426
          Length = 352

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           V+EMH IL
Sbjct: 93  VAEMHNIL 100
>XP_005259943
          Length = 551

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEMHTILS 9
           SEMHT+ S
Sbjct: 531 SEMHTLSS 538
>XP_005259942
          Length = 834

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEMHTILS 9
           SEMHT+ S
Sbjct: 814 SEMHTLSS 821
>XP_005259941
          Length = 892

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEMHTILS 9
           SEMHT+ S
Sbjct: 872 SEMHTLSS 879
>XP_006722194
          Length = 352

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           V+EMH IL
Sbjct: 93  VAEMHNIL 100
>XP_006722193
          Length = 352

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           V+EMH IL
Sbjct: 93  VAEMHNIL 100
>NP_001018081
          Length = 1309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSEMHTILS 9
           VSEMH + S
Sbjct: 516 VSEMHRLSS 524
>NP_001243793
          Length = 970

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           +S MHT+L
Sbjct: 894 LSTMHTVL 901
>NP_001243794
          Length = 900

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           +S MHT+L
Sbjct: 824 LSTMHTVL 831
>NP_055602
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           +S MHT+L
Sbjct: 837 LSTMHTVL 844
>NP_001072990
          Length = 1306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    EMHTIL 8
            EMHT+L
Sbjct: 1104 EMHTLL 1109
>NP_001257943
          Length = 1329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    EMHTIL 8
            EMHT+L
Sbjct: 1127 EMHTLL 1132
>NP_004977
          Length = 1300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    EMHTIL 8
            EMHT+L
Sbjct: 1098 EMHTLL 1103
>XP_006720204
          Length = 1298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    EMHTIL 8
            EMHT+L
Sbjct: 1068 EMHTLL 1073
>XP_006720203
          Length = 1328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    EMHTIL 8
            EMHT+L
Sbjct: 1098 EMHTLL 1103
>XP_006720202
          Length = 1329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    EMHTIL 8
            EMHT+L
Sbjct: 1127 EMHTLL 1132
>XP_006720201
          Length = 1357

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    EMHTIL 8
            EMHT+L
Sbjct: 1127 EMHTLL 1132
>XP_005245487
          Length = 110

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SEMHTIL 8
          SE+HT++
Sbjct: 13 SELHTVM 19
>XP_005245486
          Length = 133

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SEMHTIL 8
          SE+HT++
Sbjct: 36 SELHTVM 42
>NP_001072989
          Length = 1357

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    EMHTIL 8
            EMHT+L
Sbjct: 1127 EMHTLL 1132
>NP_001269528
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  SEMHTI 7
          SEMHT+
Sbjct: 22 SEMHTM 27
>NP_001167558
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    VSEMHTILS 9
            + ++HT+LS
Sbjct: 1054 LDQLHTLLS 1062
>NP_858045
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    VSEMHTILS 9
            + ++HT+LS
Sbjct: 1054 LDQLHTLLS 1062
>NP_006525
          Length = 1420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    VSEMHTILS 9
            + ++HT+LS
Sbjct: 1054 LDQLHTLLS 1062
>NP_001167559
          Length = 1415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    VSEMHTILS 9
            + ++HT+LS
Sbjct: 1049 LDQLHTLLS 1057
>NP_001138135
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VSEMHTIL 8
           VSE H IL
Sbjct: 650 VSEFHLIL 657
>NP_004054
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VSEMHTIL 8
           VSE H IL
Sbjct: 650 VSEFHLIL 657
>NP_065816
          Length = 5183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VSEMHTI 7
            +SE+HT+
Sbjct: 1842 LSELHTV 1848
>NP_005522
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           +SEMH+ +
Sbjct: 379 ISEMHSFI 386
>NP_001193496
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           +SEMH+ +
Sbjct: 323 ISEMHSFI 330
>NP_001092909
          Length = 1008

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEMHTILS 9
           S++H+ILS
Sbjct: 894 SQIHSILS 901
>NP_114141
          Length = 5635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SEMHTILS 9
            SE+H IL+
Sbjct: 3995 SELHVILN 4002
>XP_006717077
          Length = 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VSEMHTIL 8
           VSE++T+L
Sbjct: 263 VSEVYTVL 270
>XP_006717076
          Length = 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VSEMHTIL 8
           VSE++T+L
Sbjct: 263 VSEVYTVL 270
>XP_006711353
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           +SEMH+ +
Sbjct: 383 ISEMHSFI 390
>XP_005245184
          Length = 789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VSEMHTIL 8
           +SEMH+ +
Sbjct: 383 ISEMHSFI 390
>XP_006710647
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEMHTILS 9
           S++H+ILS
Sbjct: 389 SQIHSILS 396
>XP_006710573
          Length = 5177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VSEMHTI 7
            +SE+HT+
Sbjct: 1842 LSELHTV 1848
>XP_006710572
          Length = 5188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VSEMHTI 7
            +SE+HT+
Sbjct: 1842 LSELHTV 1848
>XP_006710571
          Length = 5194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VSEMHTI 7
            +SE+HT+
Sbjct: 1842 LSELHTV 1848
>XP_006710570
          Length = 5195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VSEMHTI 7
            +SE+HT+
Sbjct: 1842 LSELHTV 1848
>XP_006710569
          Length = 5212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VSEMHTI 7
            +SE+HT+
Sbjct: 1842 LSELHTV 1848
>XP_006710568
          Length = 5221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VSEMHTI 7
            +SE+HT+
Sbjct: 1842 LSELHTV 1848
>XP_006710567
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VSEMHTI 7
            +SE+HT+
Sbjct: 1842 LSELHTV 1848
>XP_006710566
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VSEMHTI 7
            +SE+HT+
Sbjct: 1842 LSELHTV 1848
>XP_005245859
          Length = 5223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VSEMHTI 7
            +SE+HT+
Sbjct: 1842 LSELHTV 1848
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.121    0.301 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 492,211
Number of extensions: 665
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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